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| 1 | Significance of preoperative C-reactive protein as a parameter of the perioperative course and long-term prognosis in squamous cell carcinoma and adenocarcinoma of the oesophagus显示文摘瞄准:C 反应的蛋白质(CRP ) 是尖锐阶段的反应物和瘤的恶意的潜力的已知的指示物。这研究的目的是作为起作用的仙子的一个参数调查外科手术前的 CRP 的意义在有有鳞的房间癌和食道的腺癌的病人的路线和长期的预后。方法:浆液 CRP 在从 1989 年 12 月为癌症经历 oesophagectomy 到 2004 年 3 月的 371 个病人中的 291 个外科手术前地被决定。中部的耐心的年龄是 59 (28-79 ) 年, 82.5% 病人是男性。有鳞的房间癌在 151 被诊断(51.9%) 并且在 122 个病人的腺癌。Transhiatal oesophagectomy 在 151 被做(51.9%) 病人并且 134 (46.0%) 病人们经历了腹胸的过程。结果:(43.6%) 在 127,外科手术前的浆液 CRP 集中在正常以内的病人变化(<
5 mg/dL ) ,提高的 CRP 层次在 164 被测量(56.4%) 病人。瘤扩展(P <
0.0005 ) 并且淋巴节点的数字由变形传播影响了(P = 0.015 ) 显著地与提高的 CRP 层次在这个组被增加。在起作用的仙子之中参数两输血的数字(P = 0.006 ) 并且一般复杂并发症率(P = 0.002 ) 在有提高的外科手术前的 CRP 层次的病人是更高的。13.6 的长期的幸存率(0-109.8 ) 瞬间在有与 18.9 相比的提高的 CRP 层次的组是更差的(0-155.4 ) 在有正常 CRP 的组的瞬间铺平(木头等级测试:P = 0.107 ) 。有向后的变量选择的 Multivariate 分析与食道的癌在病人作为长期的预后的一个独立预示的因素识别了外科手术前的 CRP,与 1.182 的危险比率(95% 信心间隔:1.030-1.356 ) 。结论:外科手术前的浆液 CRP 水平是在有有鳞的房间癌和食道的腺癌的病人的一个容易坚定的独立预示的标记。 | Ines Gockel Kathrin Dirksen Claudia M Messow Theodor Junginger | 2006 | World Journal of Gastroenterology2006，12，23： | 12 |
| 2 | 海上风电场降低成本前景分析显示文摘目前,海上风电场的经济效益比陆上风电场稍逊一筹。为加强海上风电场的竞争力,迫切需要大幅降低成本。海上风电场大约70%的成本来自于最初的投资成本,包括风机、海上地基、内部和外部电网安装和连接等等。文章分析了海上和陆上风电的技术发展和成本要素,并参考了海上油、汽开发以及高压海底输电的工程信息,肯定海上风电场的成本是可以降低的。分析了影响成本降低的主要因素;提出在不同的增长设想下,到2020年海上风电场的投资成本将降低25%~39%。 | Martin Junginger Andre Faaij Wim C.Turkenburg 吕斌 | 2007 | 上海电力2007，20，4： | 11 |
| 3 | Protective effects of ischemic preconditioning and application of lipoic acid prior to 90 min of hepatic ischemia in a rat model显示文摘AIM: To compare different preconditioning strategies to protect the liver from ischemia/reperfusion injury focusing on the expression of pro- and anti-apoptotic proteins. Interventions comprised different modes of ischemic preconditioning (IP) as well as pharmacologic pretreatment by α-lipoic acid (LA). METHODS: Several groups of rats were compared: sham operated animals, non-pretreated animals (nt), animals receiving IP (10 min of ischemia by clamping of the portal triad and 10 min of reperfusion) prior to sustained ischemia, animals receiving selective ischemic preconditioning (IPsel, 10 min of ischemia by selective clamping of the ischemic lobe and 10 min of reperfusion) prior to sustained ichemia, and animals receiving 500 μmol α-LA injected i.v. 15 min prior to the induction of 90 min of selective ischemia. RESULTS: Cellular damage was decreased only in the LA group. TUNEL-positive hepatocytes as well as necrotic hepatocyte injury were also decreased only by LA (19 ± 2 vs 10 ± 1, P < 0.05 and 29 ± 5 vs 12 ± 1, P < 0.05). Whereas caspase 3- activities in liver tissue were unchanged, caspase 9- activity in liver tissue was decreased only by LA pretreatment (3.1 ± 0.3 vs 1.8 ± 0.2, P < 0.05). Survival rate as the endpoint of liver function was increased after IP and LA pretreatment but not after IPsel. Levels of lipid peroxidation (LPO) in liver tissue were decreased in the IP as well as in the LA group compared to the nt group. Determination of pro- and anti-apoptotic proteins showed a shift towardsanti-apoptotic proteins by LA. In contrast, both our IP strategies failed to influence apototic cell death. CONCLUSION: IP, consisting of 10 min of ischemia and 10 min of reperfusion, protects only partly against ischemia/reperfusion injury of the liver prior to 90 min of selective ischemia. IPsel did not influence ischemic tolerance of the liver. LA improved tolerance to ischemia, possibly by downregulation of pro-apoptotic Bax. | Friedrich Duenschede Kirsten Erbes Nina Riegler Patrick Ewald Achim Kircher Stefanie Westermann Arno Schad Imke Miesmer Simon Albrecht-Schck Ines Gockel Alexandra K Kiemer Theodor Junginger | 2007 | World Journal of Gastroenterology2007，13，27： | 8 |
| 4 | Reduction of ischemia reperfusion injury after liver resection and hepatic inflow occlusion by α-lipoic acid in humans显示文摘AIM: To evaluate the protective effects of precondition- ing by α-lipoic acid (LA) in patients undergoing hepatic resection under inflow occlusion of the liver. METHODS: Twenty-four patients undergoing liver re- section for various reasons either received 600 mg LA or NaCl 15 min before transection performed under inflow occlusion of the liver. Blood samples and liver wedge bi- opsy samples were obtained after opening of the abdo- men immediately after inflow occlusion of the liver, and 30 min after the end of inflow occlusion of the liver. RESULTS: Serum levels of aspartate transferase and alanine transferase were reduced at all time points in patients who received LA in comparison to those who received NaCL. This was accompanied by reduced histo- morphological features of oncosis. We observed TUNEL- positive hepatocytes in the livers of the untreated patients, especially after 30 min of ischemia. LA attenu- ated this increase of TUNEL-positive hepatocytes. Under preconditioning with LA, ATP content was significantly enhanced after 30 min of ischemia and after 30 min of reperfusion. CONCLUSION: This is the first report on the poten- tial for LA reducing ischemia/reperfusion injury (IRI) of the liver in humans who were undergoing liver surgery. Beside its simple and rapid application, side effects did not occur. LA might therefore represent a new strategy against hepatic IRI in humans. | Fritz Dünschede Kirsten Erbes Achim Kircher Stefanie Westermann Joachim Seifert Arno Schad Kempski Oliver Alexandra K Kiemer Junginger Theodor | 2006 | World Journal of Gastroenterology2006，12，42： | 6 |
| 5 | Coexpression of receptor-tyrosine-kinases in gastric adenocarcinoma-a rationale for a molecular targeting strategy?显示文摘AIM: To define the (co-)expression pattern of target receptor-tyrosine-kinases (RTK) in human gastric adenocarcinoma. METHODS: The (co-)expression pattern of VEGFR1-3,PDGFRα/b and EGFR1 was analyzed by RT-PCR in 51 human gastric adenocarcinomas. In addition,IHC staining was applied for confirmation of expression and analysis of RTK localisation. RESULTS: The majority of samples revealed a VEGFR1 (98%),VEGFR2 (80%),VEGFR3 (67%),PDGFRα (82%) and PDGFRβ(82%) expression,whereas only 62% exhibited an EGFR1 expression. 78% of cancers expressed at least four out of six RTKs. While VEGFR1-3 and PDGFRα revealed a predominantly cytoplasmatic staining in tumor cells,accompanied by an additional nuclear staining for VEGFR3 ,EGFR1 was almost exclusively detected on the membrane of tumor cells. PDGFRβ was restricted to stromal pericytes,which also depicted a PDGFRα expression.receptor-tyrosine-kinases coexpression in gastric adenocarcinoma and might therefore encourage an application of multiple-target RTK-inhibitors within a combination therapy. | Daniel Drescher Markus Moehler Ines Gockel Kirsten Frerichs Annett Müller Friedrich Dünschede Thomas Borschitz Stefan Biesterfeld Martin Holtmann Thomas Wehler Andreas Teufel Kerstin Herzer Thomas Fischer Martin R Berger Theodor Junginger Peter R Galle Carl C Schimanski | 2007 | World Journal of Gastroenterology2007，13，26： | 4 |
| 6 | Nanoparticles of quaternized chitosan derivatives as a carrier for colon delivery of insulin: Ex vivo and in vivo studies显示文摘 | Akbar Bayat Farid A. Dorkoosh Ahmad Reza Dehpour Leila Moezi Bagher Larijani Hans E. Junginger Morteza Rafiee-Tehrani | 2008 | International Journal of Pharmaceutics2008，，1： | 2 |
| 7 | Cost Reduction Prospects for Offshore Wind Farms显示文摘 | Martin Junginger André Faaij Wim C. Turkenburg | 2009 | Wind Engineering2009，，1： | 2 |
| 8 | Development of fluidized bed combustion—An overview of trends, performance and cost显示文摘 | Joris Koornneef Martin Junginger André Faaij | 2006 | Progress in Energy and Combustion Science2006，，1： | 2 |
| 9 | Complement components and terminal complement complex in oesophageal smooth muscle of patients with achalasia显示文摘 | STORCH W B ECKARDT V F JUNGINGER T | 2002 | Cell Mol Boil2002，48，3： | 1 |
| 10 | Residual Urine Volume after Total Mesorectal excision: An Indicator of Pelvic Autonomic Never Preservation? Results of a Case-Control Study显示文摘 | Kneist W Junginger T | 2004 | Colorectal Dis2004，6，6： | 1 |
| 11 | Chitosan and its derivatives as intestinal absorption enhancers显示文摘 | Thanou M Verhoef JC Junginger HE | 2001 | Adv Drug Del Rev2001，50，： | 1 |
| 12 | Global experience curves for wind farms显示文摘 | JUNGINGER MA FAAIJ WC TURKENBURG | 2005 | EnergyPolicy2005，，33： | 1 |
| 13 | Factors influencing morbidity and mortatlity after pancreaticcoduodenectomy: Critical analysis of 221 resection显示文摘 | Bettger T C Junginger T | 1999 | World J Surg1999，23，2： | 1 |
| 14 | Die Zirkulare Klammeranastomose(EEA)Nach Gastrektomie,Chirurg显示文摘 | JUNGINGER T H WALGENBACH PICHLMAIER H | 1983 | Br J Surg1983，54，1： | 1 |
| 15 | Technique of transanal endoscopic microsurgery显示文摘 | G. Buess K. Kipfmüller D. Hack R. Grü?ner A. Heintz T. Junginger | 1988 | Surgical Endoscopy1988，，2： | 1 |
| 16 | Non-invasive pulmonary aerosol delivery in mice by the endotracheal route显示文摘 | Maytal Bivas-Benita Rapha?l Zwier Hans E. Junginger Gerrit Borchard | 2005 | European Journal of Pharmaceutics and Biopharmaceutics2005，，3： | 1 |
| 17 | Factors influencing morbidity and mortality after pancreatic coduodenectomy :critical analysis of 221 resections显示文摘 | BOTrGER TC JUNGINGER T | 1999 | World J Srug1999，23，2： | 1 |
| 18 | Chitosan and its derivatives as intestinal absorption enhancers显示文摘 | Thanou M Verhoef JC Junginge HE | 2001 | Adv Drug Ddiv Rev2001，50，1： | 1 |
| 19 | Oral drug absorption enhancement by chitesan and its derivatives显示文摘 | Thanou M Verhoef JC Junginge HE | 2001 | Adv Drug Dellv Rev2001，52，2： | 1 |
| 20 | Factors influencing morbidity and morbidity after pancreatic coduodenectomy:critical analysis of 211 resections显示文摘 | Bottger TC Junginger T | 1999 | World J Surg1999，23，： | 1 |
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