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| 1 | Comprehensive Evaluation of Ski Resort Development Conditions in Northern China显示文摘China′s bid for the 2022 Winter Olympic Games will promote rapid development of domestic ski tourism. More than 10 provinces in the northern China list ski tourism as a new source of growth in the tourism industry. Formulating a scientific evaluation system is an important foundation for ski resort development. By referring to the conditions of existing international ski resorts, a comprehensive index system for evaluating ski resort development was developed based on natural factors, human factors, athletic sports, and popular ski tourism. The system was composed of one target layer, two indices, seven sub-indices and twenty-five basic indices. Based on data collected during a field investigation in 2012 and on a statistical model, the development conditions of the following ski resorts were quantified: Yabuli Ski Resort in Heilongjiang Province and Beidahu Ski Resort in Jilin Province in Northeast China, Wanlong Ski Resort in Hebei Province and Nanshan Ski Resort in Beijing in the northern China, and Silk Road International Ski Resort in Uygur Autonomous Region of Xinjiang in the northwestern China. The resulting index values of development conditions at Beidahu, Yabuli, Wanlong, Nanshan, and Silk Road International Ski Resorts were 0.304, 0.278, 0.270, 0.214, and –0.025, respectively. Various natural and human factors exert positive and negative effects on the development potential of ski resorts. The development conditions of the five ski resorts were inferior to those of first-class international resorts. Therefore, the development conditions of the five ski resorts should be improved with future construction. | LI Yu ZHAO Minyan GUO Peng ZHENG Ji LI Zehong LI Fujia SHI Yuanyuan DONG Suocheng | 2016 | Chinese Geographical Science2016，26，3： | 10 |
| 2 | Gα_s Relays Sphingosine-1-Phosphate Receptor 1 Signaling to Stabilize Vascular Endothelial-Cadherin at Endothelial Junctions to Control Mouse Embryonic Vascular Integrity显示文摘Sphingosine-1-phosphate receptor 1(S1PR1),a G protein-coupled receptor(GPCR),controls vascular stability by stabilizing vascular endothelial(VE)-cadherin junctional localization and inhibiting vascular endothelial growth factor receptor 2(VEGFR2) signaling.However,the molecular mechanisms that link S 1PR1 signaling to intracellular effectors remain unknown,In this study,we demonstrate that the heterotrimeric G protein subfamily member Gα_s,encoded by GNAS,acts as a relay mediator of S1PR1 signaling to control vascular integrity by stabilizing VE-cadherin at endothelial junctions.The endothelial cell-specific deletion of Gαs in mice causes early embryonic lethality with massive hemorrhage and a disorganized vasculature.The immunostalning results revealed that Gα_s deletion remarkably reduces the junctional localization of VE-cadherin,whereas the mural cell coverage of the vessels is not impaired.In addition,we found that Gαs depletion blocks the S1PRl-activation induced VE-cadherin stabilization at junctions,supporting that Gα_s acts downstream of S1PR1 signaling,Thus,our results demonstrate that Gα_s is an essential mediator to relay S1PR1 signaling and maintain vascular integrity. | Ximing Shao Ke Liu Yi Fan Zhihao Ding Min Chen Minyan Zhu Lee S.Weinstein Hongchang Li Huashun Li | 2015 | Journal of Genetics and Genomics2015，42，11： | 8 |
| 3 | Incorporating S-shaped testing-effort functions into NHPP software reliability model with imperfect debugging显示文摘Testing-effort(TE) and imperfect debugging(ID) in the reliability modeling process may further improve the fitting and prediction results of software reliability growth models(SRGMs). For describing the S-shaped varying trend of TE increasing rate more accurately, first, two S-shaped testing-effort functions(TEFs), i.e.,delayed S-shaped TEF(DS-TEF) and inflected S-shaped TEF(IS-TEF), are proposed. Then these two TEFs are incorporated into various types(exponential-type, delayed S-shaped and inflected S-shaped) of non-homogeneous Poisson process(NHPP)SRGMs with two forms of ID respectively for obtaining a series of new NHPP SRGMs which consider S-shaped TEFs as well as ID. Finally these new SRGMs and several comparison NHPP SRGMs are applied into four real failure data-sets respectively for investigating the fitting and prediction power of these new SRGMs.The experimental results show that:(i) the proposed IS-TEF is more suitable and flexible for describing the consumption of TE than the previous TEFs;(ii) incorporating TEFs into the inflected S-shaped NHPP SRGM may be more effective and appropriate compared with the exponential-type and the delayed S-shaped NHPP SRGMs;(iii) the inflected S-shaped NHPP SRGM considering both IS-TEF and ID yields the most accurate fitting and prediction results than the other comparison NHPP SRGMs. | Qiuying Li Haifeng Li Minyan Lu | 2015 | Journal of Systems Engineering and Electronics2015，26，1： | 7 |
| 4 | Transition-Metal-Free Defluorosilylation of Fluoroalkenes with Silylboronates显示文摘Silylated fluoroalkenes are important synthetic intermediates with complementary reactivity,which play a key role in the construction of natural products,pharmaceuticals,and manmade materials.Converting the normally highly stable fiuoroalkenes into silylated fluoroalkenes by selective defluorosilylation is a challenging task.Herein,we report a simple,inexpensive and robust defluorosilylation of a variety of fluoroalkenes with silylboronates in the presence of alkoxy base to directly synthesize various silylated fluoroalkenes.The protocol features mild and safe reaction conditions that avoid a catalyst,a transition metal,a ligand,and high reaction temperature and tolerates a wide scope of fluoroalkene substrates without compromising the efficiency.Density functional theory calculations show that transient silyl anion complex undergoes an SN2,or SNv substitution,which is responsible for this base-mediated defluorosilylation. | Pan Gao Guoqiang Wang Longlong Xi Minyan Wang Shuhua Li Zhuangzhi Shi | 2019 | Chinese Journal of Chemistry2019，37，10： | 5 |
| 5 | The chromosome-scale genome of Phoebe bournei reveals contrasting fates of terpene synthase (TPS)-a and TPS-b subfamilies显示文摘Terpenoids,including aromatic volatile monoterpenoids and sesquiterpenoids,function in defense against pathogens and herbivores.Phoebe trees are remarkable for their scented wood and decay resistance.Unlike other Lauraceae species investigated to date,Phoebe species predominantly accumulate sesquiterpenoids instead of monoterpenoids.Limited genomic data restrict the elucidation of terpenoid variation and functions.Here,we present a chromosome-scale genome assembly of a Lauraceae tree,Phoebe bournei,and identify 72 full-length terpene synthase(TPS)genes.Genome-level comparison shows pervasive lineage-specific duplication and contraction of TPS subfamilies,which have contributed to the extreme terpenoid variation within Lauraceae species.Although the TPS-a and TPS-b subfamilies were both expanded via tandem duplication in P.bournei,more TPS-a copies were retained and constitutively expressed,whereas more TPS-b copies were lost.The TPS-a genes on chromosome 8 functionally diverged to synthesize eight highly accumulated sesquiterpenes in P.bournei.The essential oil of P.bournei and its main component,b-caryophyllene,exhibited antifungal activities against the three most widespread canker pathogens of trees.The TPS-a and TPS-b subfamilies have experienced contrasting fates over the evolution of P.bournei.The abundant sesquiterpenoids produced by TPS-a proteins contribute to the excellent pathogen resistance of P.bournei trees.Overall,this study sheds light on the evolution and adaptation of terpenoids in Lauraceae and provides valuable resources for boosting plant immunity against pathogens in various trees and crops. | Xiao Han Junhong Zhang Shuang Han Sun Li Chong Guanliang Meng Minyan Song Yang Wang Shengcai Zhou Chengcheng Liu Luhuan Lou Xiongzhen Lou Longjun Cheng Erpei Lin Huahong Huang Qi Yang Zaikang Tong | 2022 | Plant Communications2022，3，6： | 3 |
| 6 | Spatial diversity and combination technology using amplitude and phase weighting method for phase-coherent underwater acoustic communications显示文摘 | LI Jilong HUANG Minyan CHENG Shuping TAN Qianlin FENG Haihong | 2018 | Chinese Journal of Acoustics2018，37，1： | 2 |
| 7 | Detection of differentially expressed gertes in hepatocellar carcinoma using DNA microarray 显示文摘 | Li Yao Qiu Minyan Wu Chaoqun | 2001 | DNA Chip''s Application2001，，1： | 1 |
| 8 | Numb regulates vesicular docking for homotypic fusion of early endosomes via membrane recruitment of Monlb显示文摘 | Ximing Shao Yi Liu Qian Yu Zhihao Ding Wenyu Qian Lei Zhang Jianchao Zhang Nan Jiang Linfei Gui Zhiheng Xu Yang Hong Yifan Ma Yanjie Wei Xiaoqing Liu Changan Jiang Minyan Zhu Hongchang Li Huashun Li | 2016 | Cell Research2016，26，5： | 1 |
| 9 | MCSim-based occupational health risk assessment on benzene显示文摘 | LI Minyan HUANG Deyin LIU Mao | 2013 | Journal of Risk Analysis and Crisis Response2013，3，3： | 1 |
| 10 | Detection of differentially expressed genes in hepatocellar carcinoma using NDAmicroarray显示文摘 | Li Yao Qiu Minyan Wu Chaoqun | 2001 | DNA Chip''s Application2001，，1： | 1 |
| 11 | Metallic expandable stents in the management of malignant tracheal stenosisdue to esophageal cancer with lymph node metastasis显示文摘 | Zhaohong Peng Shengde Xu Hua Li Chaobin Sun Minyan Fu | 2013 | Oncology Letters2013，，5： | 1 |
| 12 | Microfiltration process by inorganic membranes for clarification of Tongbi Liquor显示文摘 | Li Bo Huang Minyan Fu Tingming | 2012 | Molecules2012，17，： | 1 |
| 13 | Extended research on software hybrid testing combining reliability and directed testing显示文摘The software reliability testing has many disadvantages in practice,such as high complexity of constructing operational profiles and poor fault detection efficiency.Oppositely,the directed testing with a high fault detection rate is incapable of estimating reliability quantificationally.To solve this problem,a hybrid testing combining reliability and directed testing as well as a reliability model based on the order statistic(OS) model were presented by Mitchell.An extended research on Mitchell's work is proposed.Firstly,the most proper distribution of the fault's failure rate which tends to be lognormal is suggested,and a detailed form of the OS model based on lognormal and the corresponding parameter estimation method are proposed,respectively.Secondly,an implementing framework for the hybrid testing is proposed.Finally,the hybrid testing and the OS model are applied on a real website system.The experimental results indicate:the hybrid testing has more efficient fault detection power and lower testing cost than the reliability testing;compared with three traditional software reliability growth models,the OS model has a best or pretty estimation or prediction power for each data set;and for the failure data set collected from hybrid testing,the OS model also achieves an acceptable estimation result. | Haifeng Li Yongqi Zhang Minyan Lu | 2011 | Journal of Systems Engineering and Electronics2011，22，5： | 1 |
| 14 | A novel undifferentiated spermatogonia-speci?c surface protein 1(USSP1) in neonatal mice显示文摘Mammalian spermatogenesis is maintained by a rare population of spermatogonial stem cells(SSCs),which are important for male fertility. SSCs remain a subset of undifferentiated spermatogonia, which can be isolated by a combination of surface markers. Specific markers to identify and isolate undifferentiated spermatogonia are lacking. Ussp1, a transcript previously annotated as long noncoding RNA(RIKEN cDNA 4933427D06, Gene ID: 232217), virtually encodes a membrane protein, USSP1, in a highly testisspecific manner in mouse. We demonstrate its expression on the membrane of undifferentiated spermatogonia by a homemade polyclonal rabbit antibody against the protein. In vivo, USSP1^+ clusters consist mainly of As, Apr(GFRa1^+) and Aal(PLZF^+) cells. USSP1^+ cells exhibit enrichment of undifferentiated spermatogonia, as shown by increased expression of SSC self-renewal molecular markers and the potential to form SSC clones in vitro and in vivo. However, Ussp1 knockout did not affect the number of SSCs or spermatogenesis in mice. Thy1^+ cells from Ussp1 null mice did not show any defect in the SSC colony formation capacity, indicating that USSP1 is not essential for SSC self-renewal. Our data demonstrate that Ussp1 is specifically expressed in undifferentiated murine spermatogonia, indicating the potential to sort undifferentiated spermatogonia with USSP1 antibodies. Ussp1 might be a good maker for SSC enrichment in neonatal mice. | Zhuoheng Lin Puping Liang Zhaokai Yao Yuxi Chen Xiya Zhang Rui Huang Zhen Zhang Minyan Li Wenbin Ma Haiyan Zheng Shanbo Cao Guang Shi Xiaoyang Zhao Zhou Songyang Junjiu Huang | 2019 | Science Bulletin2019，64，8： | 0 |
| 15 | Interspecific association of sika deer in terrestrial animal communities of Liancheng National Nature Reserve, China显示文摘The prevention and control of invasive of alien species is an important work for nature reserves.This study analyzes the development trend of the alien species sika deer in Liancheng National Nature Reserve.From October 2019 to June 2020,3523 valid photos and videos of terrestrial animals were acquired from 130 camera traps,and sika deer were recorded in 21 photos from 13 traps.The survival of the sika deer population was investigated by means of morphological identification,population structure analysis,species relative abundance indices,and species spatial association analysis.A total of 13 sika deer individuals were identified by camera trapping,including two kids and three subadults representing the reproductive capacity of the population.Spatially,sika deer is not associated with any local species and was outside the spatial association network of terrestrial animals in Liancheng National Nature Reserve,indicating that the sika deer population has not been integrated into the local community and has failed to perform its ecological function.It is worth noting that the reserve provides habitat suitable for sika deer and that the population has adequate reproductive capacity.Due to the lack of large apex predators in the reserve,the population size of ungulates such as sika deer,red deer,and Siberian roe deer may expand and lead to population outbreaks and the associated problems for the ecosystem.To restore large-and medium-sized carnivores and avoid the population outbreak of the species,the present challenges require immediate attention in Liancheng National Nature Reserve. | Tengwei SU Guofa CUI Zihong MAN Wentao LI Zhihao HUANG Jinfeng CHEN Minyan ZHAO | 2023 | Integrative Zoology2023，18，4： | 0 |
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