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| 1 | Suppression of bcl-2 Gene by RNA Interference Increases Chemosensitivity to Cisplatin in Nasopharyngeal Carcinoma Cell Line CNE1显示文摘To explore the effect of suppressing BCL-2 expression using RNA interference (RNAi) technique in nasopharyngeal carcinoma cell line CNE 1. CNE 1 cell lines stably expressing shRNAs targeted bcl-2 and GL3 gene were established and gene expression inhibition was assessed by Western blotting analysis. The effect of suppressing bcl-2 by RNAi on cell growth was studied, the apoptosis induction and the sensitization of CNE 1 cells to cisplatin were quantified by MTT assay and flow cytometry. The results showed that: stable transfection of CNE 1 cells with vectors expressing shRNAs against bcl-2 decreased the expression of BCL-2 protein; suppression of BCL-2 expression did not affect cell proliferation but could increase the chemosensitivity to cisplatin in CNE 1 cells. This will help physicians to make some clinical trials of gene therapy on nasopharyngeal carcinoma by RNAi. | Zhi-HuaYIN Cai-PingREN FengLI Xu-YuYANG HuiLI MingZHAO Kai-TaiYAO | 2004 | Acta Biochimica et Biophysica Sinica2004，36，11： | 17 |
| 2 | Deterministic Approach to Achieve Full-Polarization Cloak显示文摘Achieving full-polarization(σ)invisibility on an arbitrary three-dimensional(3D)platform is a long-held knotty issue yet extremely promising in real-world stealth applications.However,state-of-the-art invisibility cloaks typically work under a specific polarization because the anisotropy and orientation-selective resonant nature of artificial materials made theσ-immune operation elusive and terribly challenging.Here,we report a deterministic approach to engineer a metasurface skin cloak working under an arbitrary polarization state by theoretically synergizing two cloaking phase patterns required,respectively,at spin-up(σ+)and spin-down(σ−)states.Therein,the wavefront of any light impinging on the cloak can be well preserved since it is a superposition ofσ+andσ−wave.To demonstrate the effectiveness and applicability,several proof-of-concept metasurface cloaks are designed to wrap over a 3D triangle platform at microwave frequency.Results show that our cloaks are essentially capable of restoring the amplitude and phase of reflected beams as if light was incident on a flat mirror or an arbitrarily predesigned shape under full polarization states with a desirable bandwidth of~17.9%,conceiving or deceiving an arbitrary object placed inside.Our approach,deterministic and robust in terms of accurate theoretical design,reconciles the milestone dilemma in stealth discipline and opens up an avenue for the extreme capability of ultrathin 3D cloaking of an arbitrary shape,paving up the road for real-world applications. | He-Xiu Xu Yanzhao Wang Chaohui Wang Mingzhao Wang Shaojie Wang Fei Ding Yongjun Huang Xiaokuan Zhang Haiwen Liu Xiaohui Ling Wei Huang | 2021 | Research2021，，1： | 5 |
| 3 | Numerical comparison of two modes of gas-solid riser operation: Fluid catalytic cracking vs CFB combustor显示文摘 | Yifeng Mei Mingzhao Zhao Bona Lu Sheng Chen Wei Wang | 2017 | Particuology2017，15，2： | 4 |
| 4 | The complicated role of NF-κB in T-cell selection显示文摘原子因素(NF )- 魏 B 抄写因素家庭戏在免疫系统的重要角色。发信号的异常 NF-魏 B 经常与发炎和自体免疫的疾病被联系,但是内在的机制充分没被理解。最近的研究证明 NF-魏 B 在 T 房间中央忍耐起一个关键作用。二 NF-魏 B 发信号小径被识别了:正规小径和其他的小径。在 T 房间中央忍耐的建立,其他的小径看起来是在为他们的发展和功能的 thymic stromal 房间的关键发信号部件,当正规小径在自治 T 房间选择更施加它的功能时。这评论打算总结为未来的未解决的吸引人的问题工作的在建立 T 房间中央忍耐和热点的 NF-魏 B 的角色的当前的理解。 | Mingzhao Zhu Yangxin Fu | 2010 | Cellular & Molecular Immunology2010，7，2： | 3 |
| 5 | Lymphotoxin signalling in tertiary lymphoid structures and immunotherapy显示文摘Tertiary lymphoid structures(TLS)often develop at sites of persistent inflammation,including cancers and autoimmune diseases.In most cases,the presence of TLS correlates with active immune responses.Because of their proximity to pathological loci,TLS are an intriguing target for the manipulation of immune responses.For several years,it has become clear that lymphotoxin(LT)signalling plays critical roles in lymphoid tissue organogenesis and maintenance.In the current review,we will discuss the role of LT signalling in the development of TLS.With a focus on cancers and autoimmune diseases,we will highlight the correlations between TLS and disease progression.We will also discuss the current efforts and potential directions for manipulating TLS for immunotherapies. | Haidong Tang Mingzhao Zhu Jian Qiao Yang-Xin Fu | 2017 | Cellular & Molecular Immunology2017，14，10： | 3 |
| 6 | Developing new understanding of photoelectrochemical water splitting via in-situ techniques:A review on recent progress显示文摘Photoelectrochemical(PEC) water splitting is a promising technology for solar hydrogen production to build a sustainable, renewable and clean energy economy. Given the complexity of the PEC water splitting processes, it is important to note that developing in-situ techniques for studying PEC water splitting presents a formidable challenge. This review is aimed at highlighting advantages and disadvantages of each technique, while offering a pathway of potentially combining several techniques to address different aspects of interfacial processes in PEC water splitting. We reviewed recent progress in various techniques and approaches utilized to study PEC water splitting, focusing on spectroscopic and scanning-probe methods. | Jiajie Cen Qiyuan Wu Mingzhao Liu Alexander Orlov | 2017 | Green Energy & Environment2017，2，2： | 3 |
| 7 | Ferritin nanoparticle-based SARS-CoV-2 RBD vaccine induces a persistent antibody response and long-term memory in mice显示文摘To date,the global coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has resulted in more than 90 million people infected and over 2 million deaths.A safe and effective vaccine is in high demand.For an effective vaccine,antibody persistence and longterm memory are favorable features. | Wenjun Wang Baoying Huang Yanping Zhu Wenjie Tan Mingzhao Zhu | 2021 | Cellular & Molecular Immunology2021，18，3： | 3 |
| 8 | Development of Magnesium-Insertion Positive Electrode for Rechargeable Magnesium Batteries显示文摘Magnesium-based rechargeable batteries might be an interesting future alternative to lithium-based batteries. It is so far well known that Mg2+ ion insertion into ion-transfer hosts proceeds slowly compared with Li+, so it is necessary to realize fast Mg2+ transport in the host in addition to other requirements as practical cathode materials for magnesium batteries. Positive electrode materials based on inorganic transition-metal oxides, sulfides, and borides are the only ones used up to now to insert magnesium ions. In this paper, the available results of research on materials suitable as possible, for secondary magnesium batteries, are reviewed. | HuatangYUAN LifangJIAO JianshengCAO XiushengLIU MingZHAO YongmeiWANG | 2004 | Journal of Materials Science & Technology2004，20，1： | 3 |
| 9 | Medullary thymic epithelial cells,the indispensable player in central tolerance显示文摘Crosstalk between thymocytes and thymic epithelial cells is critical for T cell development and the establishment of central tolerance.Medullary thymic epithelial cells(mTECs) play important roles in the late stage of T cell development,especially negative selection and Treg generation.The function of mTECs is highly dependent on their characteristic features such as ectopic expression of peripheral tissue restricted antigens(TRAs) and their master regulator-autoimmune regulator(Aire),expression of various chemokines and cytokines.In this review,we summarize the current understanding of cellular and molecular mechanisms of mTEC development and its functions in T cell development and the establishment of central tolerance.The open questions in this field are also discussed.Understanding the function and underlying mechanisms of mTECs will contribute to the better control of autoimmune diseases and the improvement of immune reconstitution during aging or after infection,chemotherapy or radiotherapy. | SHI YaoYao ZHU MingZhao | 2013 | Science China(Life Sciences)2013，56，5： | 2 |
| 10 | RelB intrinsically regulates the development and function of medullary thymic epithelial cells显示文摘Medullary thymic epithelial cells(mTECs) act as one of the major stromal components in the thymus for selection and maturation of both conventional T cells and non-conventional T cells. Extensive efforts have been spent to understand how mTEC development and function are regulated. Although RelB has been well accepted to be a critical transcriptional factor for mTEC development, the underlying mechanisms still remain largely unclear. In this study, by generating thymic epithelial cell specific RelB deficient mice, we found that epithelial intrinsic RelB is required for mTEC homeostatic proliferation. Mechanistically, RelB regulates the expression of genes involved in cell cycle. Functionally, lack of intrinsic RelB in thymic epithelial cells results in dramatically reduced population of mTECs and impaired development of thymic invariant natural killer T(iNKT) cells and intraepithelial lymphocyte precursors(IELPs). This study thus reveals an epithelial intrinsic role of RelB on mTEC development and function. | Caiwei Jin Mingzhao Zhu | 2018 | Science China(Life Sciences)2018，61，9： | 2 |
| 11 | TRAF3IP3 at the trans-Golgi network regulates NKT2 maturation via the MEK/ERK signaling pathway显示文摘Thymic natural killer T(NKT)2 cells are a subset of invariant NKT cells with PLZF^(hi)GATA3^(hi)IL-4^(+).The differentiation of NKT2 cells is not fully understood.In the present study,we report an important role of TRAF3-interacting protein 3(TRAF3IP3)in the functional maturation and expansion of committed NKT2s in thymic medulla.Mice with T-cell-specific deletion of TRAF3IP3 had decreased thymic NKT2 cells,decreased IL-4-producing peripheral iNKTs,and defects in response toα-galactosylceramide.Positive selection and high PLZF expression in CD24^(+)CD44^(−) and CCR7^(+)CD44^(−) immature iNKTs were not affected.Only CD44^(hi)NK1.1^(−) iNKTs in Traf3ip3^(−/−) mice showed reduced expression of Egr2,PLZF,and IL-17RB,decreased proliferation,and reduced IL-4 production upon stimulation.This Egr2 and IL-4 expression was augmented by MEK1/ERK activation in iNKTs,and TRAF3IP3 at the trans-Golgi network recruited MEK1 and facilitated ERK phosphorylation and nuclear translocation.LT βR-regulated bone marrow-derived nonlymphoid cells in the medullary thymic microenvironment were required for MEK/ERK activation and NKT2 maturation.These data demonstrate an important functional maturation process in NKT2 differentiation that is regulated by MEK/ERK signaling at the trans-Golgi network. | Xinwei Zhang Ke Wang Weijia Zhao Li Cao Shusong Zhang Rong Jin Xiuyuan Sun Jie Hao Xiaojun Huang Mingzhao Zhu Hounan Wu Hongshan Zhao Qing Ge | 2020 | Cellular & Molecular Immunology2020，17，4： | 2 |
| 12 | Controllable preparation of γ-alumina nanoparticles with bimodal pore size distribution in membrane dispersion microreactor显示文摘In this paper,we present a new method for preparing γ-alumina nanoparticles with a bimodal pore size distribution by using an efficiently mixing membrane dispersion microreactor.NH4HCO3and AI2(SO4)3.18H2Owere reacted under vigorous mixing to give an ammonium aluminum carbonate hydroxide (AACH)precursor.γ-Alumina was obtained by calcination of AACH at 550℃ for 6h.The effects of NH4HCO3concentration,pH during aging,and reaction temperature were investigated.The mechanism of bimodal pore formation was clarified.The results showed that large pores (10-100nm) were mainly formed in the reactor and during aging,and small pores (0-10nm)were mainly formed during calcination.When the concentration of NH4HCO3was 1.5mol/L,the aging pH was 9.2,and the reaction temperature was 80℃,γ-alumina with a specific surface area of 504.7m^2/g and pore volume of 1.76mL/g was obtained.The average size of the large pores was about 30nm,and the average size of the small pores was about 4nm. | Lufan Yang Mingzhao Guo Fan Zhang Yu Jing Yujun Wang Guangsheng Luo | 2018 | Particuology2018，16，6： | 2 |
| 13 | Establishment of Human Embryonic Stem Cell Line Stably Expressing Epstein-Barr Virus-Encoded Nuclear Antigen 1显示文摘Human embryonic stem (hES) cells have the capability of unlimited undifferentiated proliferation, yet maintain the potential to form perhaps any cell type in the body. Based on the high efficiency of the Epstein-Barr virus-based episomal vector in introducing exogenous genes of interest into mammalian cells, we applied this system to hES cells, expecting that this would resolve the problem of poor transfection efficiency existing in current hES cell research. Therefore, the first step was to establish EBNA1-positive hES cells. Using the Fugene 6 transfection reagent, we transfected hES cells with the EBNA1 expression vector and subsequently generated hES cell clones that stably expressed EBNA1 under drug selection. These clones were confirmed to express EBNA1 mRNA by RT-PCR and to express EBNA1 protein by Western blotting. Furthermore, luciferase reporter gene analysis was performed on the EBNA1 clones and revealed that the expressed EBNA1 protein was functional. When the EBNA1-positive cells were injected into severe combined immunodeficient (SCID) mice, they formed teratoma tissues containing all three embryonic germ layers and EBNA1 protein was detected in these teratoma tissues by Western blotting. All the results show that we have successfully created stable EBNAI-hES cells, thus laying a good foundation for further research. | Cai-PingREN MingZHAO Wen-JiaoSHAN Xu-YuYANG Zhi-HuaYIN Xing-JunJIAN Hong-BoZHANG Kai-TaiYAO | 2005 | Acta Biochimica et Biophysica Sinica2005，37，1： | 2 |
| 14 | Distribution of heavy metals during pyrolysis of waste printed circuit boards显示文摘 | Peng Shaohong Chen Lieqiang Cai Mingzhao | 2006 | Journal of Coal Science and Engineering2006，12，1： | 1 |
| 15 | Forming and scavenging of hydrogen bromide during pyrolysis of waste printed circuit boards显示文摘 | Peng Shanhong Chen Lieqiang Cai Mingzhao | 2006 | Journal of South China University of Technology (NaturalScience)2006，34，10： | 1 |
| 16 | Novel Tumor Chemotherapeutic Agents and Tumor Radio-imaging Agents: Potential Tumor Pharmaceuticals of Ternary Copper( II ) Complexes显示文摘 | Wang Mingzhao Meng Zhaoxing Liu Boli | 2005 | Inorg Chem Commun2005，，8： | 1 |
| 17 | Anatomical study of sciatic nerve and common peroneal nerve compression显示文摘BACKGROUND: Many diseases of the common peroneal nerve are a result of sciatic nerve injury. The present study addresses whether anatomical positioning of the sciatic nerve is responsible for these injuries. OBJECTIVE: To analyze anatomical causes of sciatic nerve and common peroneal nerve injury by studying the relationship between the sciatic nerve and piriformis. DESIGN, TIME AND SETTING: Observe and measure repeatedly. The experiment was conducted in the Department of Anatomy, Tianjin Medical College between January and June 2005. MATERIALS: Fifty-two adult cadavers 33 males and 19 females, with a total of 104 hemispheres, and fixed with formaldehyde, were provided by Tianjin Medical College and Tianjin Medical University. METHODS: A posterior cut was made from the lumbosacral region to the upper leg, fully exposing the piriformis and path of the sciatic nerve. MAIN OUTCOME MEASURES: (1) Anatomical characteristics of the tibial nerve and common peroneal nerve. (2) According to different areas where the sciatic nerve crosses the piriformis, the study was divided into two types-normal and abnormal. Normal is considered to be when the sciatic nerve passes through the infrapiriform foramen. Remaining pathways are considered to be abnormal. (3) Observe the relationship between the suprapiriform foramen, infrapiriform foramen, as well as the superior and inferior space of piriformis. RESULTS: (1) The nerve tract inside the common peroneal nerve is smaller and thinner, with less connective tissue than the tibial nerve. When pathological changes or variations of the piriformis, or over-abduction of the hip joint, occur, injury to the common peroneal nerve often arises due to blockage and compression. (2) A total of 76 hemispheres (73.08%) were normal, 28 were abnormal (26.92%). The piriformis can be injured, and the sciatic nerve can become compressed, when the hip joint undergoes intorsion, extorsion, or abduction. (3) The structures between the infrapiriform and suprapiriform foramen are where 'the first threshold' sciatic nerve projects. The structures between the infrapiriform and suprapiriform gap were 'the second threshold'. This became the concept of 'double threshold'. The reduced area caused by pathological changes of 'double threshold' may block and compress the sciatic nerve. Because the common peroneal nerve lies on the anterolateral side of the sciatic nerve, injury to the common peroneal nerve is more serious. CONCLUSION: Anatomical characteristics of the common peroneal nerve, as well as variation of the sciatic nerve, piriformis, and the reduced 'double threshold', are the main causes of sciatic nerve injury, and are especially common in peroneal nerve injury. | Mingzhao Jia Qing Xia Jinmin Sun Qiang Zhou Weidong Wang | 2008 | Neural Regeneration Research2008，3，6： | 1 |
| 18 | Slurry rheology in wet uhrafine grinding of industrial minerals: a review 显示文摘 | HE Mingzhao WANG Yanmin Forssberga E | 2004 | Powder Technology2004，147，1： | 1 |
| 19 | Dynamics and morphology in nanostruetured thermoset network/ block eopolymer blends during network formation 显示文摘 | Jovan Mijovic Shen Mingzhao Jo Wing Sy | 2000 | Macromolecnles2000，33，14： | 1 |
| 20 | Early occurence of RASSF1A hypermethylatin and its mutual exclusion with BRAF mutation in Thyroid Tumorigenesis 显示文摘 | MINGZHAO X YORAM C ELIZABETH M | 2004 | Cancer Research2004，64，： | 1 |
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