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| 1 | Wheat straw pretreatment with KOH for enhancing biomethane production and fertilizer value in anaerobic digestion显示文摘Wheat straw biodegradability during anaerobic digestion was improved by treatment with potassium hydroxide(KOH)to decrease digestion time and enhance biomethane production and fertility value.KOH concentrations of1%(K1),3%(K2),6%(K3)and 9%(K4)were tested for wheat straw pretreatment at ambient temperature with a C:N ratio of 25:1.86% of total solids(TS),89% of volatile solids(VS)and 22% of lignocellulose,cellulose and hemicellulose(LCH)(22%)were decomposed effectively with the wheat straw pretreated by 6% KOH.Enhanced biogas production and cumulative biomethane yield of 258 ml·(g VS)^(-1)were obtained increased by 45% and 41%respectively,compared with untreated wheat straw.Pretreated wheat straw digestion also yielded a digestate with higher fertilizer values potassium(138%),calcium(22%)and magnesium(16%).These results show that TS,VS and LCH can be effectively removed from wheat straw pretreated with KOH,improving biodegradability biomethane production and fertilizer value. | Muhammad Jaffar Yunzhi Pang Hairong Yuan Dexun Zou Yanping Liu Baoning Zhu Rashid Mustafa Korai Xiujin Li | 2016 | Chinese Journal of Chemical Engineering2016，24，3： | 11 |
| 2 | The emerging roles of the DDX41 protein in immunity and diseases显示文摘RNA helicases 涉及几乎 RNA 的每个方面,从抄写到 RNA 腐烂。DExD/H-box helicases 包括最大的 SF2 helicase 总科,它被二个保存象 RecA 一样领域描绘。在最近的年里,这些蛋白质的越来越多的意外功能被发现了。他们不仅在天生的有免疫力的反应而且在象癌症和长期的丙肝一样的疾病起重要作用。在这评论,我们在 SF2 总科的一个成员上总结最近的文学,死了盒子的蛋白质 DDX41。在细菌或病毒的感染以后, DNA 或 cyclic-di-GMP 被释放到房间。在由 BTK kinase 的 Tyr414 的 phosphorylation 以后, DDX41 将充当一个传感器认出侵略者,由类型的正式就职列在后面我干扰素(IFN ) 。在有免疫力的反应以后, DDX41 被 E3 ligase TRIM21 降级,用象 ubiquitination 地点的 DDX41 的 Lys9 和 Lys115。除在天生的免疫的角色以外, DDX41 也与疾病有关。越来越多的在 DDX41 继承了并且获得变化基因从 myelodysplastic 症候群或尖锐 myeloid 白血病(MDS/AML ) 被识别病人。评论在果蝇集中于 DDX41,以及它的相当或相同的事物 Abstrakt,它是重要的因为幸存根本全部上演苍蝇的生命周期。 | Yan Jiang Yanping Zhu Zhi-Jie Liu Songying Ouyang | 2017 | Protein & Cell2017，8，2： | 6 |
| 3 | Effects of nitrogen ion implantation on Ca^(2+) concentration and membrane potential of pollen cell显示文摘The effects of low energy nitrogen ion implantation on Ca2+ concentration and membrane potential of illy (Mum davidii Duch) pollen cell have been studied. The results showed that the Ca2+ concentration was increased when pollen grain was implanted by nitrogen ion with energy 100 keV and dose 1013 ions/cm2. However, the increase of Ca2+ concentration was partly inhibited by the addition of Ca2+ channel inhibitor depending on dose. And nitrogen ion implantation caused depolarization of pollen cell membrane potential. In other words, membrane potential was increased, but the effect decreased by adding Ca2+ channel inhibitor. However, it was still significantly higher than the membrane potential of control cells. It was indicated that the depolarization of cell membrane potential opened the calcium channel on the membrane that caused the increasing of intracel-lular calcium concentration. This might be an earlier step of the effect of low energy nitrogen ion implantation on pollen germination. | HUANG Zhonglian, JING Yanping, ZHU Guoli, LU Ting, ZHOU Hongyu & REN Haiyun1. Key Laboratory of Cell Proliferation and Regulation Biology of the Ministry of Education, Beijing Normal University, Beijing 100875, China 2. Key Laboratory of Plant Physiology and Biochemistry of the Ministry of Agriculture, China Agriculture University, Beijing 100094, China 3. Institution of Low Energy Nuclear Physics, Beijing Normal University, Beijing 100875, China | 2001 | Chinese Science Bulletin2001，46，20： | 5 |
| 4 | Microwave-Assisted Synthesis of NiCo_2O_4 Double-Shelled Hollow Spheres for High-Performance Sodium Ion Batteries显示文摘The ternary transitional metal oxide NiCo_2O_4 is a promising anode material for sodium ion batteries due to its high theoretical capacity and superior electrical conductivity. However, its sodium storage capability is severely limited by the sluggish sodiation/desodiation reaction kinetics. Herein, NiCo_2O_4 double-shelled hollow spheres were synthesized via a microwave-assisted, fast solvothermal synthetic procedure in a mixture of isopropanol and glycerol, followed by annealing. Isopropanol played a vital role in the precipitation of nickel and cobalt,and the shrinkage of the glycerol quasi-emulsion under heat treatment was responsible for the formation of the double-shelled nanostructure. The as-synthesized productwas tested as an anode material in a sodium ion battery,was found to exhibit a high reversible specific capacity of 511 m Ahg^(-1) at 100 m Ag^(-1), and deliver high capacity retention after 100 cycles. | Xiong Zhang Yanping Zhou Bin Luo Huacheng Zhu Wei Chu Kama Huang | 2018 | Nano-Micro Letters2018，10，1： | 5 |
| 5 | Interaction of polyhydroxy fullerenes with ferrihydrite:adsorption and aggregation显示文摘The rapid development of nanoscience and nanotechnology, with thousands types of nanomaterials being produced, will lead to various environmental impacts. Thus,understanding the behaviors and fate of these nanomaterials is essential. This study focused on the interaction between polyhydroxy fullerenes(PHF) and ferrihydrite(Fh), a widespread iron(oxyhydr)oxide nanomineral and geosorbent. Our results showed that PHF were effectively adsorbed by Fh. The adsorption isotherm fitted the D-R model well, with an adsorption capacity of 67.1 mg/g. The adsorption mean free energy of 10.72 k J/mol suggested that PHF were chemisorbed on Fh. An increase in the solution p H and a decrease of the Fh surface zeta potential were observed after the adsorption of PHF on Fh; moreover, increasing initial solution p H led to a reduction of adsorption. The Fourier transform infrared spectra detected a red shift of C–O stretching from 1075 to 1062 cm-1 and a decrease of Fe–O bending, implying the interaction between PHF oxygenic functional groups and Fh surface hydroxyls. On the other hand, PHF affected the aggregation and reactivity of Fh by changing its surface physicochemical properties. Aggregation of PHF and Fh with individual particle sizes increasing from 2 nm to larger than 5 nm was measured by atomic force microscopy. The uniform distribution of C and Fe suggested that the aggregates of Fh were possibly bridged by PHF. Our results indicated that the interaction between PHF and Fh could evidently influence the migration of PHF, as well as the aggregation and reactivity of Fh. | Jing Liu Runliang Zhu Tianyuan Xu Mingwang Laipan Yanping Zhu Qing Zhou Jianxi Zhu Hongping He | 2018 | Journal of Environmental Sciences2018，30，2： | 5 |
| 6 | TiO_2/Schwertmannite nanocomposites as superior co-catalysts in heterogeneous photo-Fenton process显示文摘The heterogeneous photo-Fenton reaction is an effective technique in combating organic contaminants for both soil and water remediation,and extensive studies have focused on enhancing its efficiency and reducing its costs.In this work,we developed novel photoFenton catalysts by simply milling commercially available TiO_2(P25)with Schwertmannite(Sh),a natural iron-oxyhydroxysulfate nanomineral.We expect that the photo-generated electrons from TiO_2could continuously migrate to Sh,which then could enhance the separation of electron-hole pairs on TiO_2and accelerate the reduction of Fe(III)to Fe(II)on Sh,leading to high degradation efficiency of the target organic contaminants.SEM and TEM results showed the distribution of TiO_2on Sh surface for the nanocomposites(TiO_2/Sh).Under simulated sunlight irradiation,the much higher content of Fe(II)was determined on TiO_2/Sh than on Sh via a common method in the iron ore,and the consumption of H_2O_2and the production of·OH were more significant in the TiO_2/Sh system than those in the TiO_2and Sh systems.These results well support our hypothesis that the photo-generated electrons could migrate from TiO_2to Sh on the composites,and can also explain the much higher degradation efficiency of Rhodamine B(RhB)in the TiO_2/Sh system.Besides,TiO_2/Sh had lower Fe dissolution as compared with Sh,and retained high catalytic stability after four repeated cycles.Above merits of the TiO_2/Sh composites,in combining with their simple synthesis method and low-cost property,indicated that they should have promising applications as heterogeneous photo-Fenton catalysts. | Yanping Zhu Chun Zeng Runliang Zhu Yin Xu Xingyan Wang Huijun Zhou Jianxi Zhu Hongping He | 2019 | Journal of Environmental Sciences2019，31，6： | 5 |
| 7 | Numerical and Experimental Study on Aerodynamic Performance of Small Axial Flow Fan with Splitter Blades显示文摘To improve the aerodynamic performance of small axial flow fan, in this paper the design of a small axial flow fan with splitter blades is studied. The RNG k-ε turbulence model and SIMPLE algorithm were applied to the steady simulation calculation of the flow field, and its result was used as the initial field of the large eddy simulation to calculate the unsteady pressure field. The FW-H noise model was adopted to predict aerodynamic noise in the six monitoring points. Fast Fourier transform algorithm was applied to process the pressure signal. Experiment of noise testing was done to further investigate the aerodynamic noise of fans. And then the results obtained from the numerical simulation and experiment were described and analyzed. The results show that the static characteristics of small axial fan with splitter blades are similar with the prototype fan, and the static characteristics are improved within a certain range of flux. The power spectral density at the six monitoring points of small axial flow fan with splitter blades have decreased to some extent. The experimental results show sound pressure level of new fan has reduced in most frequency bands by comparing with prototype fan. The research results will provide a proof for parameter optimization and noise prediction of small axial flow fans with high performance. | Zhu Lifu Jin Yingzi Li Yi Jin Yuzhen Wang Yanping Zhang Li | 2013 | Journal of Thermal Science2013，22，4： | 4 |
| 8 | Observation of double indirect interlayer exciton in MoSe_(2)/WSe_(2) heterostructure显示文摘Interlayer excitons(IXS)are electron–hole pairs bound in the spatial separation layer by the Coulomb effect,and their lifetime is several orders of magnitude longer than that of direct excitons,providing an essential platform for long-lived exciton devices.The recent emergence of the van der Waals heterostructure(HS),which combines two layers of different transitional metal dichalcogenides(TMDs),has created new opportunities for IX research.Herein,we demonstrate the observation of double indirect interlayer excitons in the MoSe_(2)/WSe_(2)HS using photoluminescence(PL)spectroscopy.The intensities of the two peaks are essentially the same,and the energy difference is 22 meV,which is perfectly in line with the calculation result of density functional theory.Furthermore,the experience of variable excitation power also proves that the splitting of the IXs originates from the conduction band spin-splitting of MoSe_(2).The observation results provide a promising platform for further exploring the new physical properties and optoelectronic phenomena of TMD HS. | Biao Wu Yunpeng Wang Jiahong Zhong Cheng Zeng Yassine Madoune Wanting Zhu Zongwen Liu Yanping Liu | 2022 | Nano Research2022，15，3： | 3 |
| 9 | Structure Engineering in Biomass-Derived Carbon Materials for Electrochemical Energy Storage显示文摘Biomass-derived carbon materials(B-d-CMs)are considered as a group of very promising electrode materials for electrochemical energy storage(EES)by virtue of their naturally diverse and intricate microarchitectures,extensive and low-cost source,environmental friendliness,and feasibility to be produced in a large scale.However,the practical application of raw B-d-CMs in EES is limited by their relatively rare storage sites and low diffusion kinetics.In recent years,various strategies from structural design to material composite manipulation have been explored to overcome these problems.In this review,a controllable design of B-d-CM structures boosting their storage sites and diffusion kinetics for EES devices including SIBs,Li-S batteries,and supercapacitors is systematically summarized from the aspects of effects of pseudographic structure,hierarchical pore structure,surface functional groups,and heteroatom doping of B-d-CMs,as well as the composite structure of B-d-CMs,aiming to provide guidance for further rational design of the B-d-CMs for high-performance EES devices.Besides,the contemporary challenges and perspectives on B-d-CMs and their composites are also proposed for further practical application of B-d-CMs for EES devices. | Ruizi Li Yanping Zhou Wenbin Li Jixin Zhu Wei Huang | 2020 | Research2020，，1： | 3 |
| 10 | Efficacy and safety of rasagiline in Chinese patients with early Parkinson’s disease:a randomized, double-blind,parallel,placebo-controlled,fixed-dose study显示文摘Background:Rasagiline is a monoamine oxidase-B inhibitor used for Parkinson’s disease(PD)treatment,but its effectiveness on Chinese patients is unclear.This study aimed to evaluate the efficacy and safety of rasagiline monotherapy in Chinese patients with early PD.Methods:A 26-weeks,randomized,double-blind,placebo-controlled study has been performed at 15 sites in China and enrolled outpatients(≥35 years old)with idiopathic PD without a history of using any dopaminergic drugs.Participants were randomized 1:1 to receive rasagiline 1 mg once daily or placebo.The primary endpoint was the change of the Unified Parkinson’s Disease Rating Scale(UPDRS)total score from baseline to 26 weeks treatment.Secondary endpoints included changes in UPDRS subscale scores from part Ⅰ to Ⅲ.Health status was assessed with the PD Questionnaire(PDQ)-39 and EuroQol-Five-Dimension(EQ-5D)questionnaire.Safety profile was collected until 30 weeks after randomization.Results:A total of 130 patients(n=65/group)were recruited,and 127(rasagiline,n=64;placebo,n=63)were included in the full analysis set.Baseline characteristics were comparable between the two groups.The decrease in the mean UPDRS total score was greater in the rasagiline group than in the placebo group(−3.18±0.95 vs.−0.18±0.98,P=0.025),and the mean UPDRS part I non-motor symptoms score(−0.54±0.15 vs.-0.08±0.15,P=0.003)were significantly decreased in the rasagiline group compared with placebo treated patients.An improvement trend was observed in the active treatment group for the subscales evaluation with parts Ⅱ and Ⅲ,while the difference to placebo was not statistically significant.Life quality assessed by the EQ-5D visual analog scale improved in the rasagiline group but worsened in placebo treated patients.The overall incidence of treatment-emergent adverse events(AEs)was slightly lower in the rasagiline group(41.5%)than in the placebo group(46.2%).Conclusions:Rasagiline is effective,safe,and well tolerated as monotherapy for the treatment of Chinese PD patients. | Zhenxin Zhang Jian Wang Shengdi Chen Chunfeng Liu Baorong Zhang Rong Peng Shenggang Sun Xiangru Sun Gang Zhao Qiumin Qu Yansheng Li Suiqiang Zhu Xiaoping Pan Ming Shao Yanping Wang | 2018 | Translational Neurodegeneration2018，7，1： | 3 |
| 11 | Surface disorder engineering in ZnCdS for cocatalyst free visible light driven hydrogen production显示文摘Metal chalcogenide solid solution,especially ZnCdS,has been intensively investigated in photocatalytic H_(2) generation due to their cost-effective synthetic procedure and adjustable band structures.In this work,we report on the defect engineering of ZnCdS with surface disorder layer by simple room temperature Li-ethylenediamine(Li-EDA)treatment.Experimental results confirm the formation of unusual Zn and S dual vacancies,where rich S vacancies(Vs)served as electron trapping sites,meanwhile Zn vacancies(Vzn)served as hole trapping sites.The refined structure significantly facilitates the photo charge carrier transfer and improves photocatalytic properties of ZnCdS.The disordered ZnCdS shows a highest photocatalytic H_(2) production rate of 33.6 mmol·g^(-1)·h^(-1) under visible light with superior photocatalytic stabilities,which is 7.3 times higher than pristine ZnCdS and 7 times of Pt(1 wt.%)loaded ZnCdS. | Enna Ha Shuhong Ruan Danyang Li Yuanmin Zhu Yanping Chen Jiangyuan Qiu Zhaohui Chen Tingting Xu Jingyun Su Luyang Wang Junqing Hu | 2022 | Nano Research2022，15，2： | 3 |
| 12 | Assembly of carbon nanodots in graphene-based composite for flexible electro-thermal heater with ultrahigh efficiency显示文摘A high-efficiency electro-thermal heater requires simultaneously high electrical and thermal conductivities to generate and dissipate Joule heat efficiently.A low in put voltage is essential to en sure the heaters safe applications.However,the low voltage gen erally leads to low saturated temperature and heati ng rate and hence a low thermal efficie ncy.How to reduce the in put voltage while maintai ning a high electro-thermal efficiency is still a challenge.Herein,a highly electrical and thermal conductive film was 8nstructed using a graphene-based composite which has an internal three-dimensional(3D)conductive network.In the 3D framework,cellulose nanocrystalline(CNC)phase with chiral liquid crystal manner presents in the form of alig ned helix betwee n the graphe ne oxide(GO)layers.Carbon nano dots(CDs)are assembled泊side the composite as con ductive nano fillers.Subseque nt an neali ng and compressi on results in the formati on of the assembled GO-CNC-CDs film.The carb on ized CNC nano rods(CNR)with the helical alignment act as irrplane and through-pla ne conn ecti ons of n eighbori ng reduced GO(rGO)nano sheets,forming a con ductive network in the composite film.The CDs with ultrafast electr ons tran sfer rates provide additi onal electro ns and phonons tran sport paths for the composite.As a result,the obtai ned graphe ne?based composite film(rGO-CNR-CDs)exhibited a high thermal conductivity of 1,978.6 W m^-1·K^-1 and electrical conductivity of 2,053.4 S·cm^-1,respectively.The composite film showed an outstanding electro-thermal heating efficiency with the saturated temperature of 315℃and maximum heating rate of 44.9℃·s^-1 at a very low in put voltage of 10 V.The freestandi ng graphe ne composite film with the delicate nano structure desig n has a great pote ntial to be integrated into electro-thermal devices. | Xin Meng Tianxing Chen Yao Li Siyuan Liu Hui Pan Yuning Ma Zhixin Chen Yanping Zhang Shenmin Zhu | 2019 | Nano Research2019，12，10： | 3 |
| 13 | Statin therapy improves response to interferon alfa and ribavirin in chronic hepatitis C: A systematic review and meta-analysis显示文摘 | Qianqian Zhu Na Li Qunying Han Pingping Zhang Cuiling Yang Xiaoyan Zeng Yanping Chen Yi Lv Xi Liu Zhengwen Liu | 2013 | Antiviral Research2013，，3： | 3 |
| 14 | Ultrathin nanosheets of cobalt-nickel hydroxides hetero-structure via electrodeposition and precursor adjustment with excellent performance for supercapacitor显示文摘A homogeneous better-dispersed ultrathin nanosheets(ca. 5 nm) of cobalt-nickel layered double hydroxides(LDH) supported on nickel foam scaffold was synthesized using controllable electrodeposition approach for high efficiency electrode materials of new supercapacitor. The morphology and electrochemical performances of the samples can be controlled by adjusting the precursor ratio, i.e., Ni(OAc)_2/Co(NO_3)_2 molar ratio in the electrodeposition approach. With the increase of this molar ratio, the electrochemical performances give a volcano trend. When the optimized molar ratio is 0.64/0.36, the hybrid delivered a high specific capacitance of 1587.5 F g^(-1) at a current density of 0.5 A g^(-1), with good rate capability(1155 F g^(-1) was retained even at 10 A g^(-1)) and a robust recycle stability(remaining 91.5% after 1000 cycles at 5 A g^(-1)). The good performance could be attributed to the enlarged interlayer spacing, ultrathin nanosheets and synergistic effects between Co(OH)_2 and Ni(OH)_2. Furthermore, an asymmetric supercapacitor with a high energy density of 34.5 Wh kg^(-1) at 425 W kg^(-1) and excellent cycling stability of 85.4% after 5000 charge-discharge cycles at 2 A g^(-1) was fabricated. We believe that this fantabulous new electrode material would have encouraging applications in electrochemical energy storage and a wide readership. | Min Wei Qingsong Huang Yanping Zhou Zhu Peng Wei Chu | 2018 | Journal of Energy Chemistry2018，27，2： | 3 |
| 15 | Ferritin nanoparticle-based SARS-CoV-2 RBD vaccine induces a persistent antibody response and long-term memory in mice显示文摘To date,the global coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has resulted in more than 90 million people infected and over 2 million deaths.A safe and effective vaccine is in high demand.For an effective vaccine,antibody persistence and longterm memory are favorable features. | Wenjun Wang Baoying Huang Yanping Zhu Wenjie Tan Mingzhao Zhu | 2021 | Cellular & Molecular Immunology2021，18，3： | 3 |
| 16 | Efficacy of Rebixiao Chinese herbal tablets and Chinese formula granules in acute gout arthritis patients:a randomized,multicenter,double-blind,controlled trial显示文摘OBJECTIVE:To evaluate the clinical efficacy and safety of Rebixiao(RBX)Chinese herbal tablets(CHT)and Chinese formula granules(CFG)in the treatment of acute gout arthritis(AGA).METHODS:This randomized,multicenter,double-blind,controlled trial included 165 AGA patients with the damp-heat symptom pattern who were randomly divided into an RBX CHT group and an RBX CFG group and treated for 7 d at three centers.The total effective rates of the joint symptom score,Traditional Chinese Medicine(TCM)symptoms score,erythrocyte sedimentation rate(ESR),and C-reactive protein(CRP)were used to evaluate the clinical efficacy.Safety assessments were also performed.RESULTS:Of the 165 enrolled patients,147 completed the clinical observation.There was no difference in baseline between the two groups.The total effective rates of the joint symptom score were 94.36%and 97.36%,and the total effective rates of the TCM symptoms score were 95.77%and 97.36%in the CFG group and CHT group,respectively.No statistical difference was found between the two groups(P>0.05).Additionally,ESR and CRP were similar in both groups(P>0.05).Furthermore,treatment efficacy regarding TCM and joint symptoms,the ESR,and CRP were consistent within each center and among the different centers(P>0.05).In addition,the incidence of adverse events was 4.22%and 2.63%in the CFG group and CHT group,respectively,and no difference was observed between the two groups(P>0.05).CONCLUSION:RBX CFG and CHT have significant and similar efficacy in the treatment of AGA,and CFG did not increase adverse side effects. | Wang Shasha Zhang Ying Dai Min Yang Min Leng Wenfei Peng Xiufeng Li Guojun Yang Jinbing Gan Jianping Zhu Fenglin Li Yanping Wu Bin | 2020 | Journal of Traditional Chinese Medicine2020，40，4： | 3 |
| 17 | Clinical assessment and genomic landscape of a consanguineous family with three Kallmann syndrome descendants显示文摘尽管引起 Kallmann 症候群(KS ) 的一些基因被传统的连接分析和候选人基因技术识别了,症候群是在遗体糟糕理解的病人的多数的分子的病原学。在这份报纸,我们在场对与三个 KS 后代一起的一个同宗的汉中国家庭的临床的评价。从一个染色体宽的观点理解 KS 的分子的病原学,我们用 Affymetrix 染色体宽的人的 SNP 数组在这个家庭调查了结构的变化的染色体宽的侧面 6.0 站台。结果表明三个影响个人在染色体 1p21.1, 2q32.2, 8q21.13, 14q21.2 和 Xp22.31 上有普通拷贝数字变体(microdeletions ) 。而且, Xp22.31 上的拷贝数字变体位于 KAL1 的 intron,它引起 X 连接 KS。二 PCR 试金在这些区域上被执行验证用薄片获得的结果。另外,在这个区域的 genomic microdeletions 在 29 个汉中国分散的 KS 案例之一和四个另外的家庭案例之一中,然而并非用 26 汉汉语被验证分散的 normosmic 自发的 hypogonadotropic 性腺机能减退案例和 100 无关的汉汉语正常控制。我们的结果提供新奇卓见进对 KS 的分子的病原学的某些拷贝数字变体的相对贡献并且为进一步的研究产生有趣的候选人区域的一张表。 | Shilin Zhang Yanping Tang Tao Wang Jun Yang Ke Rao Lingyun Zhao Wenzhen Zhu Xianghu Meng Shaogang Wang Jihong Liu Weimin Yang Zhangqun Ye | 2011 | Asian Journal of Andrology2011，13，1： | 3 |
| 18 | Transmission and mortality risk assessment of severe fever with thrombocytopenia syndrome in China:results from 11-years’study显示文摘Background: The transmission and fatal risk of severe fever with thrombocytopenia syndrome (SFTS), an emerging infectious disease first discovered in China in 2009, still needed further quantification. This research aimed to analyze the SFTS clusters and assess the transmission and mortality risk for SFTS.Methods: Both epidemiological investigation and case reports regarding SFTS clusters in China during 2011-2021 were obtained from the Public Health Emergency Information Management System of the Chinese Center for Disease Control and Prevention Information System. The transmission risk was evaluated by using the secondary attack rate (SAR) and relative risk (RR). Mortality risk factors were analyzed using a logistic regression model.Results: There were 35 SFTS clusters during 2011-2021 involving 118 patients with a fatality rate of 22.0%. The number of clusters annually increased seasonally from April to September. The clusters mainly occurred in Anhui (16 clusters) and Shandong provinces (8 clusters). The SAR through contact with blood or bloody fluids was much higher than that through contact with non-bloody fluids (50.6% vs 3.0%;χ^(2) = 210.97,P < 0.05), with anRR of 16.61 [95% confidence interval (CI): 10.23-26.97]. There was a statistically significant difference in the SAR between exposure to the blood of a deceased person during burial preparation and exposure to the living patients’ blood (66.7% vs 34.5%;χ^(2)= 6.40,P < 0.05), with anRR of 1.93 (95%CI: 1.11-3.37). The mortality risk factors were a long interval from onset to diagnosis [odds ratio (OR)= 1.385), 95%CI: 1.083-1.772,P= 0.009) and advanced age (OR: 1.095, 95%CI: 1.031-1.163,P= 0.01).Conclusions: The SFTS clusters showed a high mortality rate and resulted in a high SAR. Contact with a bleeding corpse was associated with a higher infection risk, compared with contacting the blood from living patients. It is important to promote early detection and appropriate case management of patients with SFTS, as well as improved handling of their corpses, to prevent further transmission and mortality. | Qiulan Chen Dong Yang Yanping Zhang Mantong Zhu Ning Chen Zainawudong Yushan | 2022 | Infectious Diseases of Poverty2022，11，5： | 2 |
| 19 | Synthesis of novel substituted N-aryl benzamides as hA3G stabilizers and their inhibitory activities against hepatitis C virus replication显示文摘A series of novel amino-substituted N-aryl benzamide analogs were synthesized and evaluated for their ability to inhibit hepatitis C virus(HCV)replication in acutely infected Huh7.5 cells.Most of the substituted N-aryl benzamide compounds showed convincing anti-HCV activities.Compounds 1f,1g and 4c exhibited potent anti-replicative activity at low micromolar levels(IC_(50)=1.0–2.0μM)with selective indices(SI)greater than 40.Mechanistic analysis indicated that the active compounds increased intracellular hA3G protein levels and inhibited HCV replication in a dose-dependent manner.The results demonstrate that this series of substituted Naryl benzamide compounds warrant further investigation as inhibitors of HCV replication. | Yanping Li Zonggen Peng Lanhu Hao Zhouyi Wu Yanping Zhu Laixing Hu Jiandong Jiang Zhuorong Li | 2013 | Acta Pharmaceutica Sinica B2013，3，5： | 2 |
| 20 | Glial scar size, inhibitor concentration, and growth of regenerating axons after spinal cord transection显示文摘A mathematical model has been formulated in accordance with cell chemotaxis and relevant experimental data. A three-dimensional lattice Boltzmann method was used for numerical simulation. The present study observed the effects of glial scar size and inhibitor concentration on regenerative axonal growth following spinal cord transection. The simulation test comprised two parts: (1) when release rates of growth inhibitor and promoter were constant, the effects of glial scar size on axonal growth rate were analyzed, and concentrations of inhibitor and promoters located at the moving growth cones were recorded. (2) When the glial scar size was constant, the effects of inhibitor and promoter release rates on axonal growth rate were analyzed, and inhibitor and promoter concentrations at the moving growth cones were recorded. Results demonstrated that (1) a larger glial scar and a higher release rate of inhibitor resulted in a reduced axonal growth rate. (2) The axonal growth rate depended on the ratio of inhibitor to promoter concentrations at the growth cones. When the average ratio was < 1.5, regenerating axons were able to grow and successfully contact target cells. | Weiping Zhu Yanping Sun Xuning Chen Shiliang Feng | 2012 | Neural Regeneration Research2012，7，20： | 2 |
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