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| 1 | The recommendations of Chinese Parkinson’s disease and movement disorder society consensus on therapeutic management of Parkinson’s disease显示文摘Background:Parkinson’s disease(PD)is a chronic,progressive and debilitating disease,which affects over 2.5 million people in China.PD is characterized clinically by resting tremor,muscular rigidity,bradykinesia and postural instability.As the disease progresses,additional complications can arise such as non-motor and neurobehavioral symptoms.Pharmacological treatment and surgical intervention for PD have been implemented in China.Until 10 years ago,there was lack of standardization for the management of PD in different regions and among different physicians,leading to different treatment levels in different regions and different physicians.Since then,the Chinese Parkinson’s Disease and Movement Disorder Society have published three versions of guidelines for the management of PD in China,in 2006,2009 and 2014,respectively.Correspondingly,the overall level of treatment for PD in China improved.Objectives:To update the treatment guidelines based on current foreign and domestic practice guidelines and clinical evidence,and to improve the treatment options available to physicians in the management of PD.Summary:A variety of treatment recommendations in the treatment guidelines have been proposed,including physical activity and disease-modifying medication,which should be initiated at the early-stage of the disease.The principles of dosage titration should be followed to avoid acute adverse reactions to the drugs,to achieve a satisfactory clinical effect with a low dose and to reduce the incidence of long-term motor complications.Moreover,different treatment strategies should be considered at different stages of the disease.Importantly,treatment guidelines and personalized treatments should be valued equally.A set of treatment recommendations has been developed to assist physicians to improve and optimize clinical outcomes for patients with PD in China. | Shengdi Chen Piu Chan Shenggang Sun Haibo Chen Baorong Zhang Weidong Le Chunfeng Liu Guoguang Peng Beisha Tang Lijuan Wang Yan Cheng Ming Shao Zhenguo Liu Zhenfu Wang Xiaochun Chen Mingwei Wang Xinhua Wan Huifang Shang Yiming Liu Pingyi Xu Jian Wang Tao Feng Xianwen Chen Xingyue Hu Anmu Xie Qin Xiao | 2016 | Translational Neurodegeneration2016，5，1： | 23 |
| 2 | Active disturbance rejection control on first-order plant显示文摘Conventional PI control encounters some problems when dealing with large lag process in the presence of parameter uncertainties.For the typical first-order process,an observerbased linear active disturbance rejection control(LADRC) scheme is presented to cope with the difficulties,and a reduced-order observer scheme is proposed further.Some quantitative dynamic results with regard to non-overshoot characteristics are obtained.Finally,the performance boundaries of LADRC and PI control are explicitly compared with each other,which shows that the former is more superior in most cases. | Ruiguang Yang Mingwei Sun Zengqiang Chen | 2011 | Journal of Systems Engineering and Electronics2011，22，1： | 20 |
| 3 | Sensitivity studies of a high accuracy surface modeling method显示文摘The sensitivities of the initial value and the sampling information to the accuracy of a high accuracy surface modeling(HASM) are investigated and the implementations of this new modeling method are modified and enhanced. Based on the fundamental theorem of surface theory, HASM is developed to correct the error produced in geographical information system and ecological modeling process. However, the earlier version of HASM is theoretically incomplete and its initial value must be produced by other surface modeling methods, such as spline, which limit its promotion. In other words, we must use other interpolators to drive HASM. According to the fundamental theorem of surface theory, we modify HASM, namely HASM.MOD, by adding another important nonlinear equation to make it independent of other methods and, at the same time, have a complete and solid theory foundation. Two mathematic surfaces and monthly mean temperature of 1951–2010 are used to validate the effectiveness of the new method. Experiments show that the modified version of HASM is insensitive to the selection of initial value which is particular important for HASM. We analyze the sensitivities of sampling error and sampling ratio to the simulation accuracy of HASM.MOD. It is found that sampling information plays an important role in the simulation accuracy of HASM.MOD. Another feature of the modified version of HASM is that it is theoretically perfect as it considers the third equation of the surface theory which reflects the local warping of the surface. The modified HASM may be useful with a wide range of spatial interpolation as it would no longer rely on other interpolation methods. | ZHAO Na YUE TianXiang ZHAO MingWei DU ZhengPing FAN ZeMeng CHEN ChuanFa | 2014 | Science China Earth Sciences2014，57，10： | 9 |
| 4 | WARFARE COMMAND STRATAGEM ANALYSIS FOR WINNING BASED ON LANCHESTER ATTRITION MODELS显示文摘Lanchester 方程和他们的延期广泛地被用来在战争模型计算摩擦。当攻击方面的全部的战斗能力不比保卫方面的优异时,当前的纸为赢处理战争命令决策问题。为这个问题,相应战争命令计策,能转变战场状况,被考虑战争信息因素的影响求婚并且分析份量上。在军事冲突的申请例子证明建议模型和战争的可行性和有效性为赢命令计策。研究结果可以为战争命令决策提供一本理论参考书。 | Xiangyong CHEN Yuanwei JING Chunji LI Mingwei LI | 2012 | Journal of Systems Science and Systems Engineering2012，21，1： | 8 |
| 5 | A fundamental theorem for eco-environmental surface modelling and its applications显示文摘We propose a fundamental theorem for eco-environmental surface modelling(FTEEM) in order to apply it into the fields of ecology and environmental science more easily after the fundamental theorem for Earth’s surface system modeling(FTESM). The Beijing-Tianjin-Hebei(BTH) region is taken as a case area to conduct empirical studies of algorithms for spatial upscaling, spatial downscaling, spatial interpolation, data fusion and model-data assimilation, which are based on high accuracy surface modelling(HASM), corresponding with corollaries of FTEEM. The case studies demonstrate how eco-environmental surface modelling is substantially improved when both extrinsic and intrinsic information are used along with an appropriate method of HASM. Compared with classic algorithms, the HASM-based algorithm for spatial upscaling reduced the root-meansquare error of the BTH elevation surface by 9 m. The HASM-based algorithm for spatial downscaling reduced the relative error of future scenarios of annual mean temperature by 16%. The HASM-based algorithm for spatial interpolation reduced the relative error of change trend of annual mean precipitation by 0.2%. The HASM-based algorithm for data fusion reduced the relative error of change trend of annual mean temperature by 70%. The HASM-based algorithm for model-data assimilation reduced the relative error of carbon stocks by 40%. We propose five theoretical challenges and three application problems of HASM that need to be addressed to improve FTEEM. | Tianxiang YUE Na ZHAO Yu LIU Yifu WANG Bin ZHANG Zhengping DU Zemeng FAN Wenjiao SHI Chuanfa CHEN Mingwei ZHAO Dunjiang SONG Shihai WANG Yinjun SONG Changqing YAN Qiquan LI Xiaofang SUN Lili ZHANG Yongzhong TIAN Wei WANG Ying’an WANG Shengnan MA Hongsheng HUANG Yimin LU Qing WANG Chenliang WANG Yuzhu WANG Ming LU Wei ZHOU Yi LIU Xiaozhe YIN Zong WANG Zhengyi BAO Miaomiao ZHAO Yapeng ZHAO Yimeng JIAO Ufra NASEER Bin FAN Saibo LI Yang YANG John PWILSON | 2020 | Science China Earth Sciences2020，63，8： | 7 |
| 6 | Cation-mixing stabilized layered oxide cathodes for sodium-ion batteries显示文摘Sodium-ion batteries are promising for large-scale energy storage due to sodium's low cost and infinite abundance. The most popular cathodes for sodium-ion batteries, i.e., the layered sodium-containing oxides, usually exhibit reversible host rearrangement between P-type and O-type stacking upon charge/discharge. Herein we demonstrate that such host rearrangement is unfavorable and can be suppressed by introducing transition-metal ions into sodium layers. The electrode with stabilized P3-type stacking delivers superior rate capability, high energy efficiency, and excellent cycling performance. Owing to the cation-mixing nature, it performs the lowest lattice strain among all reported cathodes for sodium-ion batteries. Our findings highlight the significance of a stable host for sodium-ion storage and moreover underline the fundamental distinction in material design strategy between lithium-and sodium-ion batteries. | Shaohua Guo Yang Sun Pan Liu Jin Yi Ping He Xiaoyu Zhang Yanbei Zhu Ryosuke Senga Kazu Suenaga Mingwei Chen Haoshen Zhou | 2018 | Science Bulletin2018，63，6： | 5 |
| 7 | High AOA decoupling control for aircraft based on ADRC显示文摘In this paper, a practical decoupling control scheme for fighter aircraft is proposed to achieve high angle of attack(AOA)tracking and super maneuver action by utilizing the thrust vector technology. Firstly, a six degree-of-freedom(DOF) nonlinear model with 12 variables is given. Due to low sufficiency of the aerodynamic actuators at high AOA, a thrust vector model with rotatable engine nozzles is derived. Secondly, the active disturbance rejection control(ADRC) is used to realize a three-channel decoupling control such that a strong coupling between different channels can be treated as total disturbance, which is estimated by the designed extended state observer. The control surface allocation is implemented by the traditional daisy chain method. Finally,the effectiveness of the presented control strategy is demonstrated by some numerical simulation results. | LIU Junjie SUN Mingwei CHEN Zengqiang SUN Qinglin | 2020 | Journal of Systems Engineering and Electronics2020，31，2： | 5 |
| 8 | Germination inhibitors detected in Sapium sebiferum seeds显示文摘This study identifies endogenous inhibitors of germination associated with seed dormancy in Sapium sebiferum,Chinese tallow.Seed extracts were separated into five distinct fractions(petroleum ether,ether,ethyl acetate,methanol,and aqueous)and tested for their effect on germination of cabbage seeds.There were no significant differences in germination percentages and germination index(GI)between the solvents and the control.The five fractions differentially reduced germination percentage and GI values of cabbage seeds.According to the GI results,the greatest inhibition was with the ether fraction followed by methanol,ethyl acetate,petroleum ether,and aqueous fractions.Gas chromatography–mass spectrometry identified the constituents of the four organic fractions.Compared with the mass spectrum of the National Institute of Standards and Technology library,a compound was confirmed,provided it was more than 85%similar.Analysis of ether extracts identified four compounds:butylated hydroxytoluene(BHT;19.7%),1,2-benzenediol(4.1%),phydroxycinnamic acid,ethyl ester(2.8%),and n-hexadecanoic acid(1.4%).Fourteen,20,and 9 compounds were identified in methanol,ethyl acetate,and petroleum ether extracts,respectively.The IC50 of BHT(the concentration at which BHT inhibits radicle growth by 50%)was 54.8 mg/L,indicating that the presence of BHT might be the primary cause of dormancy in S.sebiferum seeds. | Tingting Zhao Cunmeng Qian Yunpeng Gao Li Chen Mingwei Zhu Yueting Pan Shuxian Li | 2019 | Journal of Forestry Research2019，30，6： | 4 |
| 9 | An Improved Filter of Progressive TIN Densification for LiD AR Point Cloud Data显示文摘Based on the classic filter of progressive triangulated irregular network(TIN) densification, an improved filter is proposed in this paper. In this method, we divide ground points into grids with certain size and select the lowest points in the grids to reconstruct TIN in the process of iteration. Compared with the classic filter of progressive TIN densification(PTD), the improved method can filter out attached objects, avoid the interference of low objects and obtain relatively smooth bare-earth. In addition, this proposed filter can reduce memory requirements and be more efficient in processing huge data volume. The experimental results show that the filtering accuracy and efficiency of this method is higher than that of the PTD method. | WANG Huan WANG Shugen CHEN Qi JIN Weihua SUN Mingwei | 2015 | Wuhan University Journal of Natural Sciences2015，20，4： | 3 |
| 10 | Image Distortion Metric Based on Total Bounded Variation显示文摘Image definition measurement plays an important role in various image processing applications.And a reliable objective image definition metrics is critical for evaluating the definition of the restored image.In this paper,a novel image distortion metric based on minimal Total Bounded Variation(TBV) is presented.It is clarified that when the restored image approximates to the original clear image,the smaller the TBV is,the better the definition of the restored image is.Furthermore,the difference between the restored image and the original clear image is the smallest when the TBV is minimum.In numerical results,the TBV of the original clear image,blur image and restored image are presented and compared,and the results demonstrate the validity of the distortion metric proposed. | Cheng Xiaogang An Mingwei Chen Qimei | 2012 | China Communications2012，9，2： | 3 |
| 11 | THE PRINCIPLE OF ROBUSTNESS IN GENERALIZED PREDICTIVE CONTROL显示文摘This paper deeply analyzes the closed-loop nature ofGPCin the fram ework ofinter- nalm odelcontrol(IMC) theory. A new sort ofrelation lies in the feedback structure so that robustreason can be satisfactorily explained. The resultissignificantbecause the previous con- clusions are only applied to open-loop stable plant(orm odel). | Sun Mingwei Chen Zengqiang Yuan Zhuzhi Dept. of Com puterand System Science, NankaiUniv., Tianjin 300071. | 1999 | Applied Mathematics(A Journal of Chinese Universities)1999，14，3： | 3 |
| 12 | Proteomics provides individualized options of precision medicine for patients with gastric cancer显示文摘While precision medicine driven by genome sequencing has revolutionized cancer care,such as lung cancer,its impact on gastric cancer(GC)has been minimal.GC patients are routinely treated with chemotherapy,but only a fraction of them receive the clinical benefit.There is an urgent need to develop biomarkers or algorithms to select chemo-sensitive patients or apply targeted therapy.Here,we carried out retrospective analyses of 1,020 formalin-fixed,paraffin-embedded GC surgical resection samples from 5 hospitals and developed a mass spectrometry-based workflow for proteomic subtyping of GC.We identified two proteomic subtypes:the chemo-sensitive group(CSG)and the chemo-insensitive group(CIG)in the discovery set.The 5-year overall survival of CSG was significantly improved in patients who had received adjuvant chemotherapy after surgery compared with those who received surgery only(64.2%vs.49.6%;Cox P-value=0.002),whereas no such improvement was observed in CIG(50.0%vs.58.6%;Cox P-value=0.495).We validated these results in an independent validation set.Further,differential proteome analysis uncovered 9 FDA-approved drugs that may be applicable for targeted therapy of GC.A prospective study is warranted to test these findings for future GC patient care. | Wenwen Huang Dongdong Zhan Yazhuo Li Nairen Zheng Xin Wei Bin Bai Kecheng Zhang Mingwei Liu Xuefei Zhao Xiaotian Ni Xia Xia Jinwen Shi Cheng Zhang Zhihao Lu Jiafu Ji Juan Wang Shiqi Wang Gang Ji Jipeng Li Yongzhan Nie Wenquan Liang Xiaosong Wu Jianxin Cui Yongsheng Meng Feilin Cao Tieliu Shi Weimin Zhu Yi Wang Lin Chen Qingchuan Zhao Hongwei Wang Lin Shen Jun Qin | 2021 | Science China(Life Sciences)2021，64，8： | 3 |
| 13 | Mechanical Behavior of Metallic Glasses: Microscopic Understanding of Strength and Ductility显示文摘 | Mingwei Chen | 2008 | Annual Review of Materials Research2008，，： | 1 |
| 14 | Load forecasting using support vector machines: a study on EUNITE competition 2001 显示文摘 | CHEN Bojuen CHANG Mingwei LIN Chihjen | 2004 | IEEE Transactions on Power Systems2004，19，4： | 1 |
| 15 | Numeri- cal analysis of LEC growth of GaAs with an axial mag- netic field 显示文摘 | Li Mingwei Hu Wenrui Chen Nuohu | 2002 | International Journal of Heat and Mass Transfer2002，，45： | 1 |
| 16 | Reinforcement learning based parameter optimization of active disturbance rejection control for autonomous underwater vehicle显示文摘This paper proposes a liner active disturbance rejection control(LADRC) method based on the Q-Learning algorithm of reinforcement learning(RL) to control the six-degree-of-freedom motion of an autonomous underwater vehicle(AUV).The number of controllers is increased to realize AUV motion decoupling.At the same time, in order to avoid the oversize of the algorithm, combined with the controlled content, a simplified Q-learning algorithm is constructed to realize the parameter adaptation of the LADRC controller.Finally, through the simulation experiment of the controller with fixed parameters and the controller based on the Q-learning algorithm, the rationality of the simplified algorithm, the effectiveness of parameter adaptation, and the unique advantages of the LADRC controller are verified. | SONG Wanping CHEN Zengqiang SUN Mingwei SUN Qinglin | 2022 | Journal of Systems Engineering and Electronics2022，33，1： | 1 |
| 17 | Load forecasting using support vector machines:a study on EUNITE competition 2001显示文摘 | Chen Bojuen Chang Mingwei Lin Chihjen | 2004 | IEEE Trans on Power Systems2004，19，4： | 1 |
| 18 | The effect of surface acidic and basic properties on the hydrogenation of ar- omatic tings on the supported nickel catalysts显示文摘 | Hu Shenghua Xue Mingwei Chen Hui | 2010 | Chemical Engineering Journal2010，162，1： | 1 |
| 19 | A novel disturbance-observer based friction compensation scheme for ball and plate system显示文摘 | Yongkun Wang Mingwei Sun Zenghui Wang Zhongxin Liu Zengqiang Chen | 2013 | ISA Transactions2013，，： | 1 |
| 20 | Load forecasting using support vector machines:A study on EUNITE competition 2001显示文摘 | Chen Bojuen Chang Mingwei Lin Chihjen | 2004 | IEEE Transactions on Power Systems2004，19，4： | 1 |
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