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| 1 | Alkaloid profiling of the traditional Chinese medicine Rhizoma corydalis using high performance liquid chromatography-tandem quadrupole time-of-flight mass spectrometry显示文摘Since alkaloids are the major active constituents of Rhizoma corydalis(RC),a convenient and accurate analytical method is needed for their identification and characterization.Here we report a method to profile the alkaloids in RC based on liquid chromatography-tandem quadrupole time-of-flight mass spectrometry(LC–Q-TOF-MS/MS).A total of 16 alkaloids belonging to four different classes were identified by comparison with authentic standards.The fragmentation pathway of each class of alkaloid was clarified and their differences were elucidated.Furthermore,based on an analysis of fragmentation pathways and alkaloid profiling,a rapid and accurate method for the identification of unknown alkaloids in RC is proposed.The method could also be useful for the quality control of RC. | Mingqian Sun Jianxun Liu Chengren Lin Lan Miao Li Lin | 2014 | Acta Pharmaceutica Sinica B2014，4，3： | 14 |
| 2 | Internalization of NK cells into tumor cells requires ezrin and leads to programmed cell-in-cell death显示文摘细胞毒素的淋巴细胞是在有缺点的房间的有免疫力的反应和消除的组织的关键播放器。我们以前报导了生来的杀手(NK ) 房间进入目标肿瘤房间,导致在肿瘤房间以内的任何一个目标房间死亡或自我毁灭。然而,它留下了至于在成为主观以后的 NK 房间的命运逃犯并且 heterotypic cell-in-cell 过程最近是否与同型的 cell-in-cell 事件的不同,说出 entosis。这里,我们证明 NK 房间在肿瘤房间以内与 apoptosis 的最终的命运经历一个 cell-in-cell 过程并且表明成为主观过程要求肌动朊细胞骨架管理者, ezrin。设想 NK 房间怎么进入肿瘤房间,我们执行了 NK 房间成为主观的即时双颜色成像分析进肿瘤房间。令人惊讶地,大多数 NK 房间在他们的入口以后承诺规划房间死亡进肿瘤房间,它与在同型的 cell-in-cell 过程观察的 entosis 区别地不同。使内在化的 NK 房间的 apoptotic 房间死亡由 caspase 的激活是明显的 3 并且 DNA 破碎。而且,在成为主观以后的 NK 房间死亡被 caspase 禁止者稀释, Z-VAD-FMK,在肿瘤房间以内作为 NK 房间死亡的模式证实 apoptosis。决定为 NK 房间的入口必要的蛋白质因素进肿瘤房间,我们执行了基于 siRNA 的击倒的分析并且在 NK 房间成为主观发现了 ezrin 的一个关键角色。重要地, ezrin 的调停 PKA 的 phosphorylation 支持 NK 房间成为主观过程。我们的调查结果建议 ezrin 由管理 NK 房间成为主观进肿瘤房间的新奇规章的机制。 | Shan Wang Zhen Guo Peng Xia Tingting Liu Jufang Wang Shan Li Lihua Sun Jianxin Lu Qian Wen Mingqian Zhou Li Ma Xia Ding Xiaoning Wang Xuebiao Yao | 2009 | Cell Research2009，19，12： | 6 |
| 3 | A Survey: FPGA-Based Dynamic Scheduling of Hardware Tasks显示文摘To meet the increasing computing needs of various application fields, Field programmable gate array(FPGA) has been widely deployed. In FPGA-based processing, hardware tasks can be better accelerated by allocating appropriate computing resources. Therefore,FPGA-based hardware task scheduling has become one of the mainstream research directions in academia and industry. However, the optimization objectives of existing FPGA-based hardware task scheduling methods are relatively scattered. In this regard, this paper summarizes the research status of hardware task dynamic scheduling from the three essential elements of FPGA processing: time, resources, and power consumption.This paper analyzes, sorts out, categorizes the ideas and implementations of various scheduling methods and analyzes and evaluates optimization effects of various scheduling methods from multiple dimensions. Then, the shortcomings of the existing methods are summarized and some practical applications are introduced. Finally, the research direction of task scheduling based on FPGA is prospected and summarized. | LI Tianyang ZHANG Fan GUO Wei SUN Mingqian CHEN Li | 2021 | Chinese Journal of Electronics2021，30，6： | 2 |
| 4 | Research on pore microstructure features for dredger fill based on mercury intrusion method显示文摘The material composition and microstructure have a comprehensive influence on geological engineering properties of dredger fill.The porosity of the dredger fill is an important characteristic of microscopic structure.Taken dredger fill from Binhai New Area in Tianjin as research object,the distribution trend of pore is obtained by granularmetric analysis,mineral composition analysis and mercury intrusion method.By discussing the variation regulation of dredger fill in two different kinds of processing methods,certain theoretical basis is provided for evaluating the engineering geological properties of dredger fill.It can be concluded from the test results that after drainage treatment,the porosity decreased and the structure unit changed from the relatively loose state to aggregate state.In certain depth range,the consolidation effect of dredger fill with drainage treatment is better than that without drainage treatment. | SUN Mingqian WANG Qing YAN Huan SONG Shengyuan | 2013 | Global Geology2013，16，1： | 0 |
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