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| 1 | STIM1 thermosensitivity defines the optimal preference temperature for warm sensation in mice显示文摘Mammals possess a remarkable ability to sense subtle temperature deviations from the thermoneutral skin temperature of -33 ℃, which ensures precise warm sensation.However,the underlying mechanisms remain unclear.Here we show that STIM1,an endoplasmic reticulum (ER)resident transmembrane protein that responds to both ER Ca^2- depletion and heat,mediates temperature-induced Ca^2+ influx in skin keratinocytes via coupling to Orai Ca^2+ channels in plasma membrane.Behaviorally,the keratinocyte-specific knockout of STIM1 shifts the optimal preference temperature (OPT)of mice from -32 ℃ to -34℃,resulting in a strikingly reversed preference between 32℃ and 34℃.Importantly,the thermally inactive STIM1-△K knock-in mice show altered OPT and warm preference behaviors as well,demonstrating the requirement of STIM1 thermosensitivity for warm sensation. Furthermore,the wild-type and mutant mice prefer temperatures closer to their respective OPTs,but poorly distinguish temperatures that are equally but oppositely deviated from their OPTs.Mechanistically,keratinocyte STIM1 affects the in vivo warm responses of sensory neurons by likely involving TRPA1 as a downstream transduction channel.Collectively,our data suggest that STIM1 serves as a novel in vivo thermosensor in keratinocytes to define the OPT,which might be utilized as a peripheral reference temperature for precise warm sensation. | Xiaoling Liu Haiping Wang Yan Jiang Qin Zheng Matt Petrus Mingmin Zhang Sisi Zheng Christian Schmedt Xinzhong Dong Bailong Xiao | 2019 | Cell Research2019，29，2： | 1 |
| 2 | Characterization of copper oxide supported on ceria-modified anatase显示文摘 | Haiyang Zhu Mingmin Shen Yan Kong Jianming Hong Yuhai Hu Tiandong Liu Lin Dong Yi Chen Can Jian Zhong Liu | 2004 | A, Chemical2004，，1： | 1 |
| 3 | Increased leucine-rich repeats and immunoglobulin- like domains 1 expression enhances chemosensitivity in glioma显示文摘Leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) is an anti-oncogene. LRIG1 is correlated with Bcl-2 in ependymomas. Decreased Bcl-2 and manganese superoxide dismutase expression can improve the chemosensitivity of glioma. In the present study, a tissue microarray of human brain astrocytomas was constructed. To investigate the relationship of LRIG1 with Bcl-2 and manganese superoxide dismutase, LRIG1, Bcl-2 and manganese su-peroxide dismutase expression in our tissue microarray was determined using immunohisto-chemistry. In addition, we constructed the LRIG1-U251 cell line, and its responses to doxoru-bicin and temozolomide were detected using the MTT assay. Results showed that LRIG1 ex-pression was significantly negatively correlated with Bcl-2 and manganese superoxide dismu-tase expression in glioma. Also, proliferation of LRIG1-U251 cells exposed to doxorubicin or temozolomide was significantly inhibited, i.e. in the LRIG1-U251 cell line, the chemosensitivity to doxorubicin and temozolomide was increased. This indicates that increased LRIG1 expres-sion produces a chemosensitivity in glioma. | Baohui Liu Qianxue Chen Daofeng Tian Licluan Wu Junmin Wang Qiang Cai Heng Shen Baowei Ji Long Wang Shenqi Zhang Dong Ruan Xiaonan Zhu Zhentao Guo Huimin Dong Mingmin Yan | 2011 | Neural Regeneration Research2011，6，32： | 1 |
| 4 | Characterization of copper oxide supported on ceria-modified anatase显示文摘 | Haiyang Zhu Mingmin Shen Yan Kong Jianming Hong Yuhai Hu Tiandong Liu Lin Dong Yi Chen Can Jian Zhong Liu | 2004 | Journal of Molecular Catalysis A Chemical2004，，1： | 1 |
| 5 | Schisandrin B protects PC12 cells by decreasing the expression of amyloid precursor protein and vacuolar protein sorting 35显示文摘PC12 cell injury was induced using 20 μM amyloid β-protein 25-35 to establish a model of Alzheimer's disease. The cells were then treated with 5, 10, and 25 μM Schisandrin B. Methylthiazolyldiphenyl-tetrazolium bromide assays and Hoechst 33342 staining results showed that with increasing Schisandrin B concentration, the survival rate of PC12 cells injured by amyloid β-protein 25-35 gradually increased and the rate of apoptosis gradually decreased. Reverse transcription-PCR, immunocytochemical staining and western blot results showed that with increasing Schisandrin B concentration, the mRNA and protein expression of vacuolar protein sorting 35 and amyloid precursor protein were gradually decreased. Vacuolar protein sorting 35 and amyloid precursor protein showed a consistent trend for change. These findings suggest that 5, 10, and 25 μM Schisandrin B antagonizes the cellular injury induced by amyloid β-protein 25-35 in a dose-dependent manner. This may be caused by decreasing the expression of vacuolar protein sorting 35 and amyloid precursor protein. | Mingmin Yan Shanping Mao Huimin Dong Baohui Liu Qian Zhang Gaofeng Pan Zhiping Fu | 2012 | Neural Regeneration Research2012，7，9： | 0 |
| 6 | Biomolecule@COF:Natural-artificial hybrid microcapsules for controllable biocatalysis显示文摘The assembly of biomacromole particles with artificial solid matrixes to fabricate hybrid composites has been demonstrated as an efficient strategy to promote both components'applications.Elaborating matrixes as well as appropriate assembly method is essential for optimal performances of the obtained natural-artificial composites.Herein,we fabricated the Cyt c@COF-42-B microcapsule through a sacrificial templating method and researched their adjustable biocatalysis by precisely adjusting the microenvironments of these assembled enzyme@COF particles.As a result,the hydrophobicity and mass transfer of the COF microcapsule can be controlled by modifying the different amounts of PEG moieties,thus improving the composite's bioactivity.We found that compared with pristine Cyt c@COF-42-B without PEG,the Cyt c@COF-42-B-PEG exhibited a~2.2 times higher activity.This study provides a significant step toward designing customizable functional natural-artificial composites for enhanced biomacromolecule's activity. | Shan Qiao Mingmin Li Jiangyue Yu Sainan Zhang Dong Yan Zhenjie Zhang Yao Chen | 2022 | Particuology2022，20，5： | 0 |
| 7 | ZYX promotes invasion and metastasis of gastric cancer cells via WNK1/SNAI1axis显示文摘Gastric cancer(GC)is the third most common cause of cancer death globally and a large portion of patients are diagnosed at advanced stages with cancer invasion and metastasis1,2.However,the mechanisms underlying the invasion and metastasis of GC remain to be delineated.ZYX plays critical roles in cell mobility via cytoskeleton regulation in various cell types.3 In this study,we further reported that ZYX promoted migration,invasion,and metastasis of GC cells.Mechanistically,ZYX promoted WNK1 activation and SNAl1 up-regulation,inducing epithelial-mesenchymal transition(EMT)to enhance the mobility of GC cells.Inhibition of WNK1 impaired the mobility of GC cells.Therefore,ZYX/WNK1 could be potential therapeutic targets for GC treatment. | Yi Jiang Dongfang Xiang Xianmei Wen Mingmin He Yan Qin Xiaoxue Yao Zexuan Yan Xiuli Geng Yong Ren Xiongwei Cai Youhong Cui Yan Wang | 2024 | Genes & Diseases2024，11，2： | 0 |
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