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| 1 | Controllable Synthesis of Fluorescent Carbon Dots and Their Detection Application as Nanoprobes显示文摘Carbon dots(CDs), as a new member of carbon nanomaterial family, have aroused great interest since their discovery in 2004. Because of their outstanding water solubility, high sensitivity and selectivity to target analytes, low toxicity, favorable biocompatibility, and excellent photostability, researchers from diverse disciplines have come together to further develop the fundamental properties of CDs. Many methods for the production of CDs have been reported, therein, hydrothermal and solvothermal technology needs simple equipments, and microwave synthesis needs less reaction time, hence these methods become current common synthesis methods, in which many precursors have been applied to produce CDs. Due to their excellent fluorescence, CDs have made impressive strides in sensitivity and selectivity to a diverse array of salt ions,organic/biological molecules and target gases. The development of CDs as nanoprobes is still in its infancy, but continued progress may lead to their integration into environmental and biological applications. Hydrothermal,solvothermal, and microwave synthesis of fluorescent carbon dots and their detection applications as nanoprobes in salt ions, organic/biological molecules, and target gases will be reviewed. | Zhi Yang Zhaohui Li Minghan Xu Yujie Ma Jing Zhang Yanjie Su Feng Gao Hao Wei Liying Zhang | 2013 | Nano-Micro Letters2013，5，4： | 12 |
| 2 | Effect of melt superheating treatment on the cast structure of K465 nickel-based superalloy显示文摘The cast structure of a K465 nickel-based superalloy with different temperatures of melt superheating treatment was studied. It is shown that melt superheating treatment plays a significant role in the grain size and carbide morphology. With increasing melt superheating temperature (below 2023 K),the grain size increases obviously and the carbide morphology is changed from a blocky to a script-like shape. However,when the melt superheating temperature is between 2023 K and 2123 K,the grain size decreases gradually,and the morphology of the MC carbide changes back to the blocky appearance. The content of W is also influenced by melt superheating treatment. | Pei, Zhongye Zhao, Minghan Tian, Yanwen Li, Juntao Chen, Xingfu Wu, Jiantao | 2009 | Rare Metals2009，28，2： | 5 |
| 3 | Co-metabolic and biochar-promoted biodegradation of mixed PAHs by highly efficient microbial consortium QY1显示文摘Polycyclic aromatic hydrocarbons(PAHs), typical representatives of the persistent organic pollutants(POPs), have become ubiquitous in the environment.In this study, a novel microbial consortium QY1 that performed outstanding PAHs-degrading capacity has been enriched.The degradation characteristics of single and mixed PAHs treated with QY1 were studied, and the effect of biochar on biodegradation of mixed PAHs and the potential of biochar in PAHs-heavy metal combined pollution bioremediation were also investigated.Results showed that, in single substrate system, QY1 degraded 94.5% of 500 mg/L phenanthrene(PHE) and 17.8% of 10 mg/L pyrene(PYR) after 7 days, while in PHE-PYR mixture system, the biodegradation efficiencies of PHE(500 mg/L) and PYR(10 mg/L) reached 94.0%and 96.2%, respectively, since PHE served as co-metabolic substrate to have significantly improved PYR biodegradation.Notably, with the cooperation of biochar, the biodegradations of PHE and PYR were greatly accelerated.Further, biochar could reduce the adverse impact of heavy metals(Cd^(2+), Cu^(2+), Cr_(2)O_(7)^(2-)) on PYR biodegradation remarkably.The sequencing analysis revealed that Methylobacterium, Burkholderia and Stenotrophomonas were the dominant genera of QY1 in almost all treatments, indicating that these genera might play key roles in PAHs biodegradation.Overall, this study provided new insights into the efficient bioremediation of PAHs-contaminated site. | Min Li Hua Yin Minghan Zhu Yuanyuan Yu Guining Lu Zhi Dang | 2021 | Journal of Environmental Sciences2021，33，9： | 4 |
| 4 | YTHDF2 is essential for spermatogenesis and fertility by mediating a wave of transcriptional transition in spermatogenic cells显示文摘The dynamic and reversible regulation roles of m^(6)A modification and the characterization of m^(6)A readers have provided new insights into spermatogenesis at the post-transcriptional level.YTHDF2,as an m^(6)A reader,has been reported to mediate the m^(6)A-containing transcript decay during the mouse oocyte maturation,embryonic stem cell differentiation,neural development,and zebrafish maternal-to-zygotic transition.However,the roles of YTHDF2 in mammalian spermatogenesis are uncertain.Here,we generated germ cell-specific Ythdf2 mutants(Ythdf2-vKO)at a C57BL/6J background and demonstrated that YTHDF2 is essential for mouse spermatogenesis and fertility.Ythdf2-vKO provides oligoasthenoteratozoospermia phenotype with increased apoptosis in germ cells.High-throughput RNA-seq analysis showed that a group of mRNAs is upregulated in Ythdf2-vKO mouse testis;further analysis and MeRIP-qPCR data showed that most of the upregulated genes in Ythdf2-vKO mouse testis are modified with m^(6)A and are YTHDF2 candidate binding genes.Interestingly,RNA-seq analysis combined with our previous single-cell transcriptomics data of mouse spermatogenesis pointed out the failure of a wave of transcript transition during the spermatogenesis of Ythdf2-vKO mice,which was confirmed by gene expression analysis using qPCR of diplotene spermatocytes and round spermatids obtained through fluorescence-activated cell sorting.Our study demonstrates the fundamental role of YTHDF2 during mouse spermatogenesis and provides a potential candidate for the diagnosis of male infertility with the oligoasthenoteratozoospermia syndrome. | Xinxi Zhao Zhen Lin Yong Fan Wenzhi Li Yujie Zhang Fei Li Tong Hong Hua Feng Minghan Tong Ningling Wang Yanping Kuang Qifeng Lyu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，12： | 2 |
| 5 | Single-cell RNA sequencing reveals Nestin+active neural stem cells outside the central canal after spinal cord injury显示文摘Neural stem cells(NSCs)in the spinal cord hold great potential for repair after spinal cord injury(SCI).The ependyma in the central canal(CC)region has been considered as the NSCs source in the spinal cord.However,the ependyma function as NSCs after SCI is still under debate.We used Nestin as a marker to isolate potential NSCs and their immediate progeny,and characterized the cells before and after SCI by single-cell RNA-sequencing(scRNA-seq).We identified two subgroups of NSCs:the subgroup located within the CC cannot prime to active NSCs after SCI,while the subgroup located outside the CC were activated and exhibited the active NSCs properties after SCI.We demonstrated the comprehensive dynamic transcriptome of NSCs from quiescent to active NSCs after SCI.This study reveals that Nestin+cells outside CC were NSCs that activated upon SCI and may thus serve as endogenous NSCs for regenerative treatment of SCI in the future. | Muya Shu Xiaoyu Xue Hu Nie Xianming Wu Minghan Sun Lianyong Qiao Xing Li Bai Xu Zhifeng Xiao Yannan Zhao Yongheng Fan Bing Chen Jixiang Zhang Ya Shi Yaming Yang Falong Lu Jianwu Dai | 2022 | Science China(Life Sciences)2022，65，2： | 2 |
| 6 | C-dots assisted synthesis of gold nanoparticles as labels to catalyze copper deposition for ultrasensitive electrochemical sensing of proteins显示文摘We report an ultrasensitive protocol for electrochemical sensing using the hydroxyl-rich C-dots assisted synthesis of gold nanoparticles(C-dots@AuNP) as labels with copper depositon reaction. The C-dots catalyzing copper deposition reaction was implemented for the first time. We constructed a sandwich-type immunosensor on the chitosan modified glassy carbon electrode(GCE) by glutaraldehyde(GA) crosslinking, with C-dots@AuNP as biolabels. Copper was deposited on the catalytic surfaces of second antibody-conjugated C-dots@AuNP nanoparticles through CuSO_4-ascorbic acid reduction, because both C-dots and AuNPs could strongly catalyze the CuSO_4 and ascorbic acid to form Cu particles, which amplified the detection signal. Then the corresponding antigen was quantified based on simultaneous chemical-dissolution/cathodic-preconcentration of copper for insitu analysis using anodic stripping square wave voltammetry(ASSWV) directly on the modified electrode. Under optimized conditions, these electrodes were employed for sandwich-type immunoanaly sis, pushing the lower limits of detection(LODs)down to the fg mL^(-1) level for human immunoglobulin G(IgG) and cardiac troponin I(cTnI), a cardiac biomarker. These novel sensors have good stability and acceptable accuracy and reproducibility, suggesting potential applications in clinical diagnostics. | Xiaoli Qin Yifan Dong Minghan Wang Zhiwei Zhu Meixian Li Xiangjian Chen Di Yang Yuanhua Shao | 2018 | Science China Chemistry2018，61，4： | 2 |
| 7 | Red phosphorescent organic light-emitting diodes based on a novel host material with thermally activated delayed fluorescent properties显示文摘High cost of phosphors and significant efficiency roll-off at high brightness are the two main factors that limit the wide application of phosphorescent organic light-emitting diodes (PHOLEDs). Efforts have been paid to find ways to reduce the phosphors’ concentration and efficiency roll-off of PHOLEDs. In this work, we reported red emission PHOLEDs with low dopant concentration and low efficiency roll-off based on a novel host material 2,4-biscyanophenyl-6-(12-phenylindole[2,3-a]carbazole-11-yl)-1,3,5-triazine (BCPICT), with thermally activated delayed fluorescent(TADF) properties. The device with 1.0% dopant concentration displayed a maximum external quantum efficiency of 10.7%.When the dopant concentration was increased to 2.0%, the device displayed a maximum external quantum efficiency of 10.5% and a low efficiency roll-off of 5.7% at 1000 cd/m2. | Yilang Li Dongdong Zhang Yunge Zhang Minghan Cai Lian Duan | 2016 | Science China Chemistry2016，59，6： | 2 |
| 8 | Hydrother- mal/Solvothermal thermal Synthesis of Graphene Quantum Dots and Their Biological Applications 显示文摘 | Minghan Xu Zhaohui Li Xingzhong Zhu et ol | 2013 | Nano Biorned Eng2013，5，2： | 1 |
| 9 | Intrinsic kinetics of the alkylation of benzene with propylene over β zeolite catalyst显示文摘 | HAN Minghan LI Xiaojin LIN Shixiong | 2001 | Kinetics and Catalysis2001，42，4： | 1 |
| 10 | Ca^(2+)-dependent TaCCD1 cooperates with TaSAUR215 to enhance plasma membrane H^(+)-ATPase activity and alkali stress tolerance by inhibiting PP2C-mediated dephosphorylation of TaHA2 in wheat显示文摘Alkali stress is a major constraint for crop production in many regions of saline-alkali land.However,little is known about the mechanisms through which wheat responds to alkali stress.In this study,we identified a calcium ion-binding protein from wheat,TaCCD1,which is critical for regulating the plasma membrane(PM)H^(+)-ATPase-mediated alkali stress response.PM H+-ATPase activity is closely related to alkali tolerance in the wheat variety Shanrong 4(SR4).We found that two D-clade type 2C protein phosphatases,TaPP2C.D1 and TaPP2C.D8(TaPP2C.D1/8),negatively modulate alkali stress tolerance by dephosphorylating the penultimate threonine residue(Thr926)of TaHA2 and thereby inhibiting PM H+-ATPase activity.Alkali stress induces the expression of TaCCD1 in SR4,and TaCCD1 interacts with TaSAUR215,an early auxin-responsive protein.These responses are both dependent on calcium signaling triggered by alkali stress.TaCCD1 enhances the inhibitory effect of TaSAUR215 on TaPP2C.D1/8 activity,thereby promoting the activity of the PM H^(+)-ATPase TaHA2 and alkali stress tolerance in wheat.Functional and genetic analyses verified the effects of these genes in response to alkali stress,indicating that TaPP2C.D1/8 function downstream of TaSAUR215 and TaCCD1.Collectively,this study uncovers a new signaling pathway that regulates wheat responses to alkali stress,in which Ca^(2+)-dependent TaCCD1 cooperates with TaSAUR215 to enhance PM H+-ATPase activity and alkali stress tolerance by inhibiting TaPP2C.D1/8-mediated dephosphorylation of PM H+-ATPase TaHA2 in wheat. | Minghan Cui Yanping Li Jianhang Li Fengxiang Yin Xiangyu Chen Lumin Qin Lin Wei Guangmin Xia Shuwei Liu | 2023 | Molecular Plant2023，16，3： | 1 |
| 11 | Biotechnical engineering as an alternative to traditional engineering methods:a biotechnical streambank stabilization design approach显示文摘 | Li Minghan Eddleman K E | 2002 | Landscape and Urban Planning2002，60，： | 1 |
| 12 | The influence of different Tween surfactants on biodesalfurization of ground tire rubber by Sphingomonas so 显示文摘 | Hua Minghan Zhao Suhe Li Chao | 2014 | Polymer Degradation attd Stability2014，107，： | 1 |
| 13 | Injectable cartilage matrix hydrogel loaded with cartilage endplate stem cells engineered to release exosomes for non-invasive treatment of intervertebral disc degeneration显示文摘Low back pain,mainly caused by intervertebral disc degeneration(IVDD),is a common health problem;however,current surgical treatments are less than satisfactory.Thus,it is essential to develop novel non-invasive surgical methods for IVDD treatment.Here,we describe a therapeutic strategy to inhibit IVDD by injecting hydrogels modified with the extracellular matrix of costal cartilage(ECM-Gels)that are loaded with cartilage endplate stem cells(CESCs).After loaded with CESCs overexpressing Sphk2(Lenti-Sphk2-CESCs)and injected near the cartilage endplate(CEP)of rats in vivo,ECM-Gels produced Sphk2-engineered exosomes(Lenti-Sphk2-Exos).These exosomes penetrated the annulus fibrosus(AF)and transported Sphk2 into the nucleus pulposus cells(NPCs).Sphk2 activated the phosphatidylinositol 3-kinase(PI3K)/p-AKT pathway as well as the intracellular autophagy of NPCs,ultimately ameliorating IVDD.This study provides a novel and efficient non-invasive combinational strategy for IVDD treatment using injectable ECM-Gels loaded with CESCs that express Sphk2 with sustained release of functional exosomes. | Liwen Luo Junfeng Gong Zhouguang Wang Yao Liu Jiaming Cao Jinghao Qin Rui Zuo Hongyu Zhang Shuai Wang Ping Zhao Di Yang Mengjie Zhang Yanqiu Wang Junfeng Zhang Yue Zhou Changqing Li Bing Ni Zhiqiang Tian MingHan Liu | 2022 | Bioactive Materials2022，7，9： | 1 |
| 14 | Therapeutic effect of Qinghuayin(清化饮)against chronic atrophic gastritis through the inhibition of toll or interleukin-1 receptor domain-containing adaptor inducing interferon-β signaling pathway显示文摘OBJECTIVE:To examine the efficacy of Qinghuayin(清化饮,QHY)in rat chronic atrophic gastritis(CAG)models and explored the molecular mechanism of QHY in treating CAG.METHODS:In total,65 Wistar rats were randomly divided into the control(n=10)and CAG groups(n=55).CAG model rats were further divided into five groups:model(n=10),vitacoenzyme(n=10),low-dose QHY(n=10),medium-dose QHY(n=10),and high-dose QHY groups(n=10).We analyzed histopathological changes using hematoxylin and eosin staining and measured interleukin(IL)-6 and IL-8 levels in serum using enzyme-linked immunosorbent assay(ELISA)(Boster Bio,Pleasanton,USA).In addition,gastrin(GAS),pepsinogen I(PGI),and PGII expressions were evaluated using ELISA.The protein and m RNA expression of toll-like receptor 4(TLR4)and toll or interleukin-1 receptor domaincontaining adaptor inducing interferon-β(TRIF)was detected by Western blotting and quantitative reverse transcription-polymerase chain reaction,respectively.RESULTS:Our results revealed that histopathological changes in CAG model rates could be restored by low-,medium-,and high-dose QHY.The changes in GAS and PGI/II expression demonstrated that QHY improved CAG.Serum IL-6 and IL-levels were decreased by QHY administration.TLR4 and TRIF were upregulated at the m RNA and protein levels in the model group but downregulated by QHY administration.CONCLUSION:We concluded that QHY could effectively improve the histopathological changes of the gastric mucosa induced by CAG in rats.The therapeutic mechanism of QHY may be related to inhibition of the inflammatory factors IL-6 and IL-8 and suppression of TLR4/TRIF m RNA and protein expression. | HE Youcheng YAO Xiaoling LI Sihan ZHOU Hongjian XU Ruoying ZHENG Rong XIAO Wendi SU Ning LIN Ping HUANG Minghan | 2022 | Journal of Traditional Chinese Medicine2022，42，2： | 1 |
| 15 | Comparing bioretention designs with and without an internal water storage layer for trea- ting highway runoff显示文摘 | LI Minghan SWAPP M KIM M H | 2014 | Water Environment Research2014，86，5： | 1 |
| 16 | Intrinsic kinetics of the alkylation of benzene with propylele over β zeolite catalyst 显示文摘 | HAN Minghan LI Xiaojin LIN Shixiong | 2001 | Kinetics and Catalysis2001，42，4： | 1 |
| 17 | Effects of Quenching Process on Mechanical Properties and Microstructure of High Strength Steel显示文摘The effects of direct quenching and tempering (DQ-T) process and conventional reheat quenching and tempering (RQ-T) processes on mechanical properties and microstructure of high strength steel were investigated. The DQ process was found to enhance the hardenability of steel effectively. The tensile strength and yield strength of DQ specimen was 975 MPa and 925 MPa respectively, which were higher than those of RQ specimen's of 920 MPa and 871 MPa. In contrast, low temperature toughness (-40 ℃, AKV) of DQ-T specimen (124 J) was generally inferior to that of RQ-T specimen (156 J). The direct quenching temperature was one of the potential process parameters to determine strength/toughness balance of steel manufactured by DQ process. The experimental results showed that excellent strength/toughness balance was obtained when the specimens was quenched at temperature in the range of 850-910 ℃. The yield strength and impact energy (-40 ℃) of DQ steel decreased significantly with increasing of quenching temperature, although the tensile strength was nearly stable. | 段争涛 LI Yanmei ZHANG Mingya SHI Minghan ZHU Fuxian ZHANG Shunhu | 2012 | Journal of Wuhan University of Technology(Materials Science)2012，27，6： | 1 |
| 18 | Survey on rain removal from videos or a single image显示文摘Rain can cause performance degradation of outdoor computer vision tasks.Thus,the exploration of rain removal from videos or a single image has drawn considerable attention in the field of image processing.Recently,various deraining methodologies have been proposed.However,no comprehensive survey work has yet been conducted to summarize existing deraining algorithms and quantitatively compare their generalization ability,and especially,no off-the-shelf toolkit exists for accumulating and categorizing recent representative methods for easy performance reproduction and deraining capability evaluation.In this regard,herein,we present a comprehensive overview of existing video and single image deraining methods as well as reproduce and evaluate current state-of-the-art deraining methods.In particular,these approaches are mainly classified into model-and deep-learning-based methods,and more elaborate branches of each method are presented.Inherent abilities,especially generalization performance,of the state-of-the-art methods have been both quantitatively and visually analyzed through thorough experiments conducted on synthetic and real benchmark datasets.Moreover,to facilitate the reproduction of existing deraining methods for general users,we present a comprehensive repository with detailed classification,including direct links to 85 deraining papers,24 relevant project pages,source codes of 12 and 25 algorithms for video and single image deraining,respectively,5 and 10 real and synthesized datasets,respectively,and 7 frequently used image quality evaluation metrics,along with the corresponding computation codes.Research limitations worthy of further exploration have also been discussed for future research along this direction. | Hong WANG Yichen WU Minghan LI Qian ZHAO Deyu MENG | 2022 | Science China(Information Sciences)2022，65，1： | 0 |
| 19 | High-performance lithium-ion batteries based on polymer/graphene hybrid cathode material显示文摘Organic and carbon-based lithium-ion batteries possess abundant resources,nontoxicity,environmental friendliness,and high performance,and they have been widely studied in the past decades.However,it remains a challenge to construct such batteries with high capacity,high cycling stability,and high conductivity simultaneously.Here,we elaborately design and integrate organic polymer(p-FcPZ) with graphene network to create a hybrid material(p-FcPZ@G) for high-performance lithium-ion batteries(LIBs).The bi-polar polymer p-FcPZ containing multiple redox-active sites endows p-FcPZ@G with both remarkable cycling stability and high capacity.The porous conductive graphene network with a large surface area facilitates rapid ions/electrons transportation,resulting in superior rate performance.Therefore,the half-cell based on p-FcPZ@G cathode exhibits simultaneously high capacity(~250 mA h g^(-1) at 50 mA g^(-1)),excellent cycling stability(retention of 99.999% per cycle for 10,000 cycles at 2,000 mA g^(-1)) and superior rate performance.Additionally,the graphene-based full cell assembled with p-FcPZ@G cathode and graphene anode also demonstrates comprehensively high electrochemical performance. | Yang Zhao Minghan Ni Nuo Xu Chenxi Li Yanfeng Ma Hongtao Zhang Yongsheng Chen | 2023 | Science China Chemistry2023，66，9： | 0 |
| 20 | Insights from metagenomic,metatranscriptomic,and molecular ecological network analyses into the effects of chromium nanoparticles on activated sludge system显示文摘The objectives of this study were to investigate the influence of chromium nanoparticles(Cr NPs)on the nitrogen and phosphorus removal performance and the bacterial structures of an activated sludge(AS)system.Also,we through molecular ecological networks(MENs)discussed the bacterial interactions.At last we researched the change of the functional genes and their expression patterns related to nitrogen and phosphorus removaT in an AS system.The results showed that long-term exposure to 1 mg/L Cr NPs significantly promoted the denitrifying process and phosphorus removal in the AS system.The relative abundance of denitrifying and phosphorus removal microorganisms,such as Denitratisoma,Thauera,Dechloromonas,and Defluviicoccus,increased significantly.Candidatus Accumulibacter,well-known as polyphosphate-accumulating organisms(PAOs),increased significantly;the relative abundance of Candidatus Competibacter,known as glycogen-accumulating organisms(GAOs),decreased significantly.Furthermore,metagenomic and metatranscriptomic analysis revealed that most of the genera related to denitrifying and phosphorus removal had greatly increased,according to the quantities of denitrifying and phosphorus genes,and the corresponding transcription likewise greatly increased.Lastly,MENs analysis showed that although the overall network became smaller and looser in the presence of Cr NPs,the microbial connections among members related to nitrogen and phosphorus removal were enhanced.The abundance increases of denitrifiers and PAOs,and their increased transcription of functional genes,together with the enhanced interactions may be associated with the promotion of the denitrifying process and phosphorus removal. | Quan Zheng Minglu Zhang Tingting Zhang Xinhui Li Minghan Zhu Xiaohui Wang | 2020 | Frontiers of Environmental Science & Engineering2020，14，4： | 0 |
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