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| 1 | Diagenetic and Mineralization Age of the Hehuaping Tin-polymetallic Orefield,Hunan Province显示文摘摘要:Hehuaping 听存款是在地质的调查期间在最近的年里发现的大存款。发现的听存款在在在泥盆纪碳酸盐岩石(Qiziqiao 形成) 和沙岩(Tiaomajian 形成) 之间的 interstratifled 破裂地区开发的差错地区,而且存款包括不仅岩石改变类型存款。发现后者类型的听存款极大地在著名 Nanling polymetallic metallogenetic 区域充实听矿化作用类型并且可以为在这个区域听存款勘探向我们提供新潜在的取向。在 Nanling 区域形成听存款应该与 Yanshanian 有关而不是 Indosinian 花岗石的 magmatism,这通常被相信。系统的锆石 U-Pb 虾在这份报纸标明日期证明听矿化作用忍受了至少二个阶段。早阶段应该与 Wangxianling 花岗石的主要身体的侵入有关,它在 Indosinian 期间是 emplaced 有 diagenetic 和 224.0 | WEI Daofang BAO Zhengyu FU Jianming CAI Minghai | 2007 | Acta Geologica Sinica(English Edition)2007，81，2： | 23 |
| 2 | Traditional Mongolian medicine:Past,present and future显示文摘Traditional Mongolian medicine(TMM)forms an essential part of traditional Chinese medicine(TCM)with its own unique and profound theoretical system,drug resources,processing technologies,and drug usage procedures.TMM has the characteristics of being“raw,simple,inexpensive,and green”.It has unique advantages and remarkable efficacy in treating common diseases,frequently-occurring diseases,and certain rare diseases. | Laxinamujila Bai Minghai Fu | 2022 | Chinese Herbal Medicines2022，14，3： | 0 |
| 3 | Metabolomics investigation on antiobesity effects of Corydalis bungeana on high-fat high-sugar diet-induced obese rats显示文摘Objective:Corydalis bungeana(CB)is a well-used medicinal herb in Mongolian folk medicine and has been traditionally applied as an antiobesity agent.However,the evidence-based pharmacological effects of CB and its specific metabolic alterations in the obese model are not entirely understood.This study aimed to utilize untargeted metabolomic techniques to identify biomarkers and gain mechanistic insight into the serum metabolite alterations associated with weight loss and lipid metabolism in obese rats.Methods:A high-fat high-sugar(HFHS)diet was used to induce obese models in rats.CB extract was orally gavaged at 0.18,0.9 and 1.8 g/kg doses for six weeks,and feed intake,body weight,fat pad weight,and blood indexes were measured.Blood serum metabolites were evaluated by gas chromatography/quadrupole time-of-fight tandem mass spectrometry(GC-TOF/MS).Results:The results showed that compared with the obese group,the administration of CB extract caused significant decreases in body weight(P<0.05),feed intake,Lee’s index,and perirenal,mesenteric,epididymal fat weight.CB extract also reduced blood triglyceride and total cholesterol levels(P<0.05)of obese rats.Metabolomic findings showed that nine differential metabolites,including pyruvic acid,D-glucuronic acid,malic acid,dimethylglycine,oxoglutaric acid,pantothenic acid,sorbitol acid,fumaric acid and glucose 6-phosphate were identified under CB treatment and altered metabolic pathways such as TCA cycle,pantothenate and CoA biosynthesis,and glycolysis/gluconeogenesis.Conclusion:This study demonstrated weight loss and lipid lowering effects of CB on HFHS diet-induced obese rats and identified nine metabolites as potential biomarkers for evaluating the favorable therapeutic mechanism of CB via regulation of lipid and glucose metabolism. | Minghai Fu Terigele Bao Hongzhen Yu LiSha A. HuiFang Li Genna Ba Sungbo Cho | 2022 | Chinese Herbal Medicines2022，14，3： | 0 |
| 4 | Ion channel mechanism of gastrointestinal motility and gastric hypersensitivity in functional dyspepsia:a review显示文摘Functional dyspepsia(FD)is a regularly diagnosed clinical gastrointestinal ailment with a high incidence rate that can considerably impact patients’health and quality of life and impose a substantial financial burden.Modern research on the pathophysiology of functional dyspepsia has not thoroughly explained the underlying reasons.The condition does not manifest any significant organ abnormalities,which raises the disease’s difficulty coefficient.Major pathogenic exceptions in FD include gastrointestinal motor dysfunction,gastrointestinal hormone secretion problem,visceral hypersensitivity,and brain-gut axis.Several ion channels have reportedly been implicated in the pathophysiological process of FD.Therefore,it is crucial to comprehend the probable activities of various ion channels in FD.This study focuses on the current state of research on the possible role of several ion channels in the pathogenesis of FD. | Terigele Bao Feng Lan Guorui Li Xiyele Mu Ta Na Minghai Fu Yongsheng Chen | 2022 | Gastroenterology & Hepatology Research2022，4，3： | 0 |
| 5 | cGAS regulates the DNA damage response to maintain proliferative signaling in gastric cancer cells显示文摘The activation of some oncogenes promote cancer cell proliferation and growth,facilitate cancer progression and metastasis by induce DNA replication stress,even genome instability.Activation of the cyclic GMP-AMP synthase(cGAS)mediates classical DNA sensing,is involved in genome instability,and is linked to various tumor development or therapy.However,the function of cGAS in gastric cancer remains elusive.In this study,the TCGA database and retrospective immunohistochemical analyses revealed substantially high cGAS expression in gastric cancer tissues and cell lines.By employing cGAS high-expression gastric cancer cell lines,including AGS and MKN45,ectopic silencing of cGAS caused a significant reduction in the proliferation of the cells,tumor growth,and mass in xenograft mice.Mechanistically,database analysis predicted a possible involvement of cGAS in the DNA damage response(DDR),further data through cells revealed protein interactions of the cGAS and MRE11-RAD50-NBN(MRN)complex,which activated cell cycle checkpoints,even increased genome instability in gastric cancer cells,thereby contributing to gastric cancer progression and sensitivity to treatment with DNA damaging agents.Furthermore,the upregulation of cGAS significantly exacerbated the prognosis of gastric cancer patients while improving radiotherapeutic outcomes.Therefore,we concluded that cGAS is involved in gastric cancer progression by fueling genome instability,implying that intervening in the cGAS pathway could be a practicable therapeutic approach for gastric cancer. | BIN LIU HAIPENG LIU FEIFEI REN HANGFAN LIU IHTISHAM BUKHARI YUMING FU WANQINGWU MINGHAI ZHAO SHAOGONG ZHU HUI MO FAZHAN LI MICHAEL B.ZHENG YOUCAI TANG PENGYUAN ZHENG YANG MI | 2021 | Oncology Research2021，29，2： | 0 |
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