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| 1 | Assessing the host genetic background effects on type 2 diabetes and obesity development in response to mixed–oral bacteria and high-fat diet using the collaborative cross mouse model显示文摘Background: Host genetic background and sex, play central roles in defining the pathogenesis of type 2 diabetes(T2 D), obesity and infectious diseases. Our previous studies demonstrated the utilization of genetically highly diverse inbred mouse lines, namely collaborative cross(CC), for dissecting host susceptibility for the development of T2 D and obesity, showing significant variations following high-fat(42% fat) diet(HFD). Here, we aimed to assessing the host genetic background and sex effects on T2 D and obesity development in response to oral-mixed bacterial infection and HFD using the CC lines.Materials and Methods: Study cohort consists of 97 mice from 2 CC lines(both sexes), maintained on either HFD or Standard diet(CHD) for 12 weeks. At week 5 a group of mice from each diet were infected with Porphyromonas gingivalis(Pg) and Fusobacterium nucleatum(Fn) bacteria(control groups without infection). Body weight(BW) and glucose tolerance ability were assessed at the end time point of the experiment.Results: The CC lines varied(P <.05) at their BW gain and glucose tolerance ability(with sex effect) in response to diets and/or infection, showing opposite responses despite sharing the same environmental conditions. The combination of diet and infection enhances BW accumulation for IL1912, while restraints it for IL72. As for glucose tolerance ability, only females(both lines) were deteriorated in response to infection.Conclusions: This study emphasizes the power of the CC mouse population for the characterization of host genetic makeup for defining the susceptibility of the individual to development of obesity and/or impaired glucose tolerance. | Luna Karkar Hanifa JAbu-Toamih Atamni Asal Milhem Yael Houri-Haddad Fuad A.Iraqi | 2020 | Animal Models and Experimental Medicine2020，3，2： | 5 |
| 2 | Studying host genetic background effects on multimorbidity of intestinal cancer development,type 2 diabetes and obesity in response to oral bacterial infection and high-fat diet using the collaborative cross(CC)lines显示文摘Background:Multimorbidity of intestinal cancer(IC),type 2 diabetes(T2D)and obesity is a complex set of diseases,affected by environmental and genetic risk factors.High-fat diet(HFD)and oral bacterial infection play important roles in the etiology of these diseases through inflammation and various biological mechanisms.Methods:To study the complexity of this multimorbidity,we used the collaborative cross(CC)mouse genetics reference population.We aimed to study the multimorbidity of IC,T2D,and obesity using CC lines,measuring their responses to HFD and oral bacterial infection.The study used 63 mice of both sexes generated from two CC lines(IL557 and IL711).For 12 weeks,experimental mice were maintained on specific dietary regimes combined with co-infection with oral bacteria Porphyromonas gingivalis and Fusobacterium nucleatum,while control groups were not infected.Body weight(BW)and results of a intraperitoneal glucose tolerance test(IPGTT)were recorded at the end of 12 weeks,after which length and size of the intestines were assessed for polyp counts.Results:Polyp counts ranged between 2 and 10 per CC line.The combination of HFD and infection significantly reduced(P<.01)the colon polyp size of IL557 females to 2.5 cm 2,compared to the other groups.Comparing BW gain,IL557 males on HFD gained 18 g,while the females gained 10 g under the same conditions and showed the highest area under curve(AUC)values of 40000-45000(min mg/dL)in the IPGTT.Conclusion:The results show that mice from different genetic backgrounds respond differently to a high fat diet and oral infection in terms of polyp development and glucose tolerance,and this effect is gender related. | Asal Milhem Hanifa J.Abu Toamih-Atamni Luna Karkar Yael Houri-Haddad Fuad A.Iraqi | 2021 | Animal Models and Experimental Medicine2021，4，1： | 4 |
| 3 | A positive antinuclear antibody test predicts for a poor response to initial steroid therapy in adults with idiopathic thrombocyto- penie purpura显示文摘 | Abbasi SY Milhem M Zaru L | 2008 | Ann Hematol2008，87，： | 1 |
| 4 | Phase 1 results of a phase I b/2, multicenter, open-label trial to evaluate safety and efficacy of talimogene laherparepvee (T-VEC) and ipilimumab(ipi) vs ipi alone in previously untreated, unresccted stage IIIB-IV melanoma 显示文摘 | Igor Puzanov Mohammed Milhem Robert Andtbacka | 2013 | J Immunother2013，1，1： | 1 |
| 5 | Polyamidoamine starburst dendrimers as solubility enhancers 显示文摘 | Milhem O M Myles C McKeown N B | 2000 | Inter J of Pharm2000，197，3： | 1 |
| 6 | Survival, safety, and response patterns in a phase 1 b muhicenter trial of talimogene laherparepvec( T-VEC ) and ipilimumab ( ipi ) in previously un- treated, unresected stage Ⅲ B-Ⅳ melanoma 显示文摘 | Puzanov I Milhem MM Andtbacka RHI | 2015 | J Clin Oncol2015，33，15： | 1 |
| 7 | A positive antinuclear antibody test predicts for a poor response to initial steroid therapy in adults with idiopathic thrombocytopenic purpura显示文摘 | Abbasi SY Milhem M Zaru L | 2008 | Ann Hematol2008，87，3： | 1 |
| 8 | Cytotoxicity evaluation of dental resin composites and their flowable derivatives显示文摘 | Al-Hiyasat AS Darmani H Milhem MM | 2005 | Clin Oral Invest2005，9，1： | 1 |
| 9 | Modification of hematopoietic stem cell fate by 5aza 2'deoxycytidine and trichostatin A 显示文摘 | Milhem M Mahmud N Lavelle D | 2004 | Blood2004，103，11： | 1 |
| 10 | Polyamidoamine starburstR dendrimers as solubility enhancers显示文摘 | Milhem O M Myles C McKeown N B | 2000 | Int Pharm2000，197，： | 1 |
| 11 | Polyamidoamine starburst dendrimers as solubility enhancers显示文摘 | MILHEM O M MYLES C ATTWOOD D | | 0，，1： | 1 |
| 12 | Modification of hematopoietic stem cell fate by 5aza 2 deoxycytidine and triehostatin A显示文摘 | Milhem M Mahmud N Lavelle D | 2004 | Blood2004，103，11： | 1 |
| 13 | Correlation of MTDH/AEG-1 and HOTAIR Expression with Metastasis and Response to Treatment in Sarcoma Patients显示文摘 | Milhem MM Knutson T Yang S | 2011 | J Cancer Sci Ther2011，5，4： | 1 |
| 14 | Identification of the cellular mechanisms that modulate trafficking of frizzled family receptor 4 ( FZD4 ) missense mutants associated with familial exudative vitreoretinopathy显示文摘 | Milhem RM Ben-Salem S AI-Gazali L Ali BR | 2014 | Invest Ophthalmol Vis Sci2014，55，6： | 1 |
| 15 | A positive antinuclear antibody test predicts for a poor response to initial steroid therapy in adults with idiopathic thrombocytopenic purpura显示文摘 | Salah Yousef Abbasi Mohammed Milhem Luna Zaru | 2008 | Annals of Hematology2008，，6： | 1 |
| 16 | Correlation of MTDI-I/AEG-1 and HOTAIR expression with metastasis and response to treatment in sarcoma patients 显示文摘 | Mohammed M Milhem T Knutson T | 2011 | Cancer Sci Ther2011，5，4： | 1 |
| 17 | Polyamidoamine starburst dendrimers as solubility enhancers 显示文摘 | Milhem OM Myles C McKeown NB | 2000 | Int J Pharm2000，197，12： | 1 |
| 18 | Polyamidoamine starburst dendrimers as solubility enhancers显示文摘 | Milhem OM Myles C McKeown NB | 2000 | Int J Pharm2000，197，： | 1 |
| 19 | Modification of hematopoietic stern cell fate by 5aza 2'deoxycytidine and trichostatin A显示文摘 | Milhem M Mahmud N Lavelle D | 2004 | Blood2004，103，11： | 1 |
| 20 | Expansion of human umbilical cord blood SC1D-repopulating cells using chromatin-modifying agents 显示文摘 | Araki H Mahmud N Milhem M | 2006 | Exp Hematol2006，34，2： | 1 |
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