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| 1 | Natural history of Barrett's esophagus显示文摘The natural history of Barrett's esophagus (BE) is difficult to quantify because,by definition,it should describe the course of the condition if left untreated.Pragmatically,we assume that patients with BE will receive symptomatic treatment with acid suppression,usually a proton pump inhibitor,to treat their heartburn.This paper describes the development of complications of stricture,ulcer,dysplasia and adenocarcinoma from this standpoint.Controversies over the definition of BE and its implications in clinical practice are presented.The presence of intestinal metaplasia and its relevance to cancer risk is discussed,and the need to measure the extent of the Barrett's epithelium (long and short segments) using the Prague guidelines is emphasized.Guidelines and international consensus over the diagnosis and management of BE are being regularly updated.The need for expert consensus is important due to the lack of randomized trials in this area.After searching the literature,we have tried to collate the important studies regarding progression of Barrett's to dysplasia and adenocarcinoma.No therapeutic studies yet reported show a clear reduction in the development of cancer in BE.The effect of pharmacological and surgical intervention on the natural history of Barrett's is a subject of ongoing research,including the Barrett's Oesophagus Surveillance Study and the aspirin and esomeprazole cancer chemoprevention trial with interesting results.The geographical variation and the wide range of outcomes highlight the difficulty of providing an individualized risk profile to patients with BE.Future studies on the interaction of genome wide abnormalities in Barrett's and their interaction with environmental factors may allow individualization of the risk of cancer developing in BE. | Rao Milind Stephen E Attwood | 2012 | World Journal of Gastroenterology2012，18，27： | 3 |
| 2 | Eosinophilic esophagitis: Updated consensus recommendations for children and adults显示文摘 | Chris A. Liacouras Glenn T. Furuta Ikuo Hirano Dan Atkins Stephen E. Attwood Peter A. Bonis A. Wesley Burks Mirna Chehade Margaret H. Collins Evan S. Dellon Ranjan Dohil Gary W. Falk Nirmala Gonsalves Sandeep K. Gupta David A. Katzka Alfredo J. Lucendo Jo | 2011 | The Journal of Allergy and Clinical Immunology2011，，1： | 3 |
| 3 | The effect of condensed tannins on the nutrition and health of ruminants fed fresh temperate forages: a review显示文摘 | B.R Min T.N Barry G.T Attwood W.C McNabb | 2003 | Animal Feed Science and Technology2003，，1： | 2 |
| 4 | Esophageal eosinophilia with dysphagia显示文摘 | Stephen E. A. Attwood Thomas C. Smyrk Tom R. Demeester James B. Jones | 1993 | Digestive Diseases and Sciences1993，，： | 2 |
| 5 | Prevention of allogeneic fetal rejection by tryptophan catabolism显示文摘 | Munn DH Zhou M Attwood JT | 1998 | Science1998，281，5380： | 1 |
| 6 | An investigation of the route and progression of encephalitozoon cuniculi infection in adult rabbits显示文摘 | Cox J C Hamilton R C Attwood H D | 1979 | J Protozool1979，26，1： | 1 |
| 7 | 显示文摘 | Attwood T E Dowson P C Freeman J L | 1981 | Polymer1981，22，： | 1 |
| 8 | Prevention of allogeneie fetal rejection by tryptophan eatabolism显示文摘 | Munn DH Zhou M Attwood JT | 1998 | Science1998，281，5380： | 1 |
| 9 | HGF mediates cell proliferation of human mesothelioma cells through a PI3K/MEK5/Fra - 1 pathway 显示文摘 | Ramos - Nino ME Blumen SR Sabo - Attwood T | 2008 | Am J Respir Cell Mol Biol2008，38，2： | 1 |
| 10 | Inhibition of t cell proliferation by macrophage tryptophan catabolism显示文摘 | Munn David H Shafizadeh Ebrahim Attwood John T | 1999 | J Exp Med1999，189，9： | 1 |
| 11 | The structure and the mechanism of action of pyruvate carboxylase显示文摘 | Attwood P V | 1995 | Int J Biochem Cell Biol1995，27，3： | 1 |
| 12 | Market Opportunities for Coal Gasification in China显示文摘 | Attwood T Fung V Clark W W | 2003 | Journal of Cleaner Production2003，11，： | 1 |
| 13 | Diet-derived 25-hydroxyvitamin D3 activates vitamin D receptor target gene expression and suppresses EGFR mutant non-small cell lung cancer growth in vitro and in vivo显示文摘 | Verone-Boyle AR Shoemaker S Attwood K | 2016 | Oncotarget2016，7，1： | 1 |
| 14 | Prevention of allogeneic fetal rejection by tryptophan catabolism 显示文摘 | Munn D H Zhou M Attwood J T | 1998 | Science1998，281，5380： | 1 |
| 15 | DNA methylation and the regulatian of gene transcription显示文摘 | Attwood JT Yung RL Richardson BC | 2002 | Cell Mol Lif Sci2002，59，： | 1 |
| 16 | Synthesis and properties of polyaryletherketones显示文摘 | Attwood T E Stanil P A | 1981 | Polymer1981，22，： | 1 |
| 17 | PRINTS prepares for the new millen-nium显示文摘 | Flower DR Lewis AP | 1999 | Nucleic Acids Res1999，27，1： | 1 |
| 18 | Value of MRI of the brain in patients with systemic lupus erythematosus and neurologic disturbance显示文摘 | Jennings JE Sundgren PC Attwood J | 2004 | Neuroradiology2004，46，1： | 1 |
| 19 | Eosinophilic esophagitis: Updated consensus recommendations for children and adults显示文摘 | Chris A. Liacouras Glenn T. Furuta Ikuo Hirano Dan Atkins Stephen E. Attwood Peter A. Bonis A. Wesley Burks Mirna Chehade Margaret H. Collins Evan S. Dellon Ranjan Dohil Gary W. Falk Nirmala Gonsalves Sandeep K. Gupta David A. Katzka Alfredo J. Lucendo Jo | 2011 | The Journal of Allergy and Clinical Immunology2011，，1： | 1 |
| 20 | Staged use of soft-tissue expansion and lower thoracic advancement flap in breast reconstruction显示文摘 | May Jr JW Attwood J Bartlett S | 1987 | Plast Reconstr Surg1987，79，2： | 1 |
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