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| 1 | Quality of life:A critical outcome for all surgical treatmentsof gastric cancer显示文摘Surgery represents the main curative therapeutic modality for gastric cancer, and it is occasionally considered for palliation as well as prophylaxis. Most frequently, surgical outcomes are conveyed in terms of oncological outcomes such as recurrence and survival.However, quality of life(Qo L) is also important and should be considered when making treatment decisions- including the extent of and approach to surgery. Measurement of Qo L usually involves the application of questionnaires. While there are multiple Qo L questionnaires validated for use in oncology patients, there are very few that have been validated for use in those with gastric cancer. In this review, we discuss and compare the current status of Qo L questionnaires in gastric cancer. More importantly, the impact of surgery for treatment, palliation and prophylaxis of gastric cancer on Qo L will be described. These data should inform the surgeon on the optimal approach to treating gastric cancer, taking into account oncological outcomes. Knowledge gaps are also identified, providing a roadmap for future studies. | Michael D McCall Peter J Graham Oliver F Bathe | 2016 | World Journal of Gastroenterology2016，22，3： | 7 |
| 2 | Solitary necrotic nodule of the liver: A riddle that is difficult to answer显示文摘 | Jonathan Koea M.D. F.R.A.C.S. Graeme Taylor F.R.C.P.A. Mary Miller F.R.C.P.A. Michael Rodgers F.R. A.C. S. John McCall M.D. F.R.A.C.S | 2003 | Journal of Gastrointestinal Surgery2003，，5： | 1 |
| 3 | Risk of Dissemination With Biopsy of Colorectal Liver Metastases显示文摘 | Michael S. Rodgers F.R.A.C.S. M.B.Ch.B. Rowan Collinson M.B.Ch.B. Shashank Desai F.R.A.C.S. M.B.Ch.B. Richard S. Stubbs F.R.A.C.S. M.D. John L. McCall F.R.A.C.S. M.D | 2003 | Diseases of the Colon & Rectum2003，，4： | 1 |
| 4 | Endogenous signals released from necrotic cells augment inflammatory responses to bacterial endotoxin显示文摘 | Rabab El Mezayen Mohamed El Gazzar Michael C. Seeds Charles E. McCall Stephen C. Dreskin Mark R. Nicolls | 2007 | Immunology Letters2007，，1： | 1 |
| 5 | Positron Emission Tomography/Computed Tomographic Scans Compared to Computed Tomographic Scans for Detecting Colorectal Liver Metastases: A Systematic Review显示文摘 | Seema Patel Michael McCall Arto Ohinmaa David Bigam Donna M. Dryden | 2011 | Annals of Surgery2011，，4： | 1 |
| 6 | Increased CD4/CD8 Lymphocyte ratio predicts favourable neoadjuvant treatment response in gastric cancer:A prospective pilot study显示文摘BACKGROUND Despite optimal neoadjuvant chemotherapy only 40%of gastric cancer tumours achieve complete or partial treatment response.In the absence of treatment response,neoadjuvant chemotherapy in gastric cancer contributes to adverse events without additional survival benefit compared to adjuvant treatment or surgery alone.Additional strategies and methods are required to optimize the allocation of existing treatment regimens such as FLOT chemotherapy(5-Fluorouracil,Leucovorin,Oxaliplatin and Docetaxel).Predictive biomarkers detected using immunohistochemistry(IHC)methods may provide useful data regarding treatment response.AIM To investigate the utility of CD4,CD8,Galectin-3 and E-cadherin in predicting neoadjuvant FLOT chemotherapy tumour response in gastric adenocarcinoma.METHODS Forty-three adult patients with gastric adenocarcinoma,of which 18 underwent neoadjuvant chemotherapy,were included in a prospective clinical cohort.Endoscopic biopsies were obtained from gastric cancer and normal adjacent gastric mucosa.Differences in expression of Galectin-3,Ecadherin,CD4^(+)and CD8^(+)molecules between tumours with and without treatment response to neoadjuvant chemotherapy were assessed with IHC.Treatment response was graded by clinical pathologists using the Tumour Regression Score according to the College of American Pathologists criteria.Treatment response was defined as complete or near complete tumour response,whereas partial or poor/no response was defined as incomplete.Digital IHC images were annotated and quantitatively assessed using QuPath 0.3.1.Biomarker expression between responsive and incomplete response tumours was assessed using a two-sided Wilcoxon test.Biomarker expression was also compared between normal and cancer tissue and between 15 paired tumour samples before and after chemotherapy.We performed a preliminary multivariate analysis and power analysis to guide future study.Statistical analyses were completed using R 4.1.2.RESULTS The ratio between CD4^(+)and CD8^(+)lymphocytes was significantly greater in treatment responsive tumours(Wilcoxon,P=0.03).In univariate models,CD4^(+)/CD8^(+)ratio was the only biomarker that significantly predicted favourable treatment response(Accuracy 86%,P<0.001).Using a glmnet multivariate model,high CD4^(+)/CD8^(+)ratio and low Galectin-3 expression were the most influential variables in predicting a favourable treatment response.Analyses of paired samples found that FLOT chemotherapy also results in increased expression of CD4^(+)and CD8^(+)tumour infiltrating lymphocytes(Paired Wilcoxon,P=0.002 and P=0.008,respectively).Our power analysis suggests future study requires at least 35 patients in each treatment response group for CD8 and Galectin-3 molecules,whereas 80 patients in each treatment response group are required to assess CD4 and E-cadherin biomarkers.CONCLUSION We demonstrate that an elevated CD4^(+)/CD8^(+)Ratio is a promising IHC-based biomarker to predict favourable treatment response to FLOT neoadjuvant chemotherapy in locally advanced gastric cancer. | Daniel Skubleny Andrea Lin Saurabh Garg Ross McLean Michael McCall Sunita Ghosh Jennifer L Spratlin Daniel Schiller Gina Rayat | 2023 | World Journal of Gastrointestinal Oncology2023，15，2： | 1 |
| 7 | Nutritional supplementation with MyoVive repletes essential cardiac myocyte nutrients and reduces left ventricular size in patients with left ventricular dysfunction显示文摘 | Farida Jeejeebhoy Mary Keith Michael Freeman Aiala Barr Michele McCall Regina Kurian David Mazer Lee Errett | 2002 | American Heart Journal2002，，6： | 1 |
| 8 | Solitary necrotic nodule of the liver: A riddle that is difficult to answer显示文摘 | Jonathan Koea M.D. F.R.A.C.S. Graeme Taylor F.R.C.P.A. Mary Miller F.R.C.P.A. Michael Rodgers F.R. A.C. S. John McCall M.D. F.R.A.C.S | 2003 | Journal of Gastrointestinal Surgery2003，，5： | 1 |
| 9 | Metabolic engineering of Aspergillus oryzae NRRL 3488 for increased production of l -malic acid显示文摘 | Stephen H. Brown Lena Bashkirova Randy Berka Tyler Chandler Tammy Doty Keith McCall Michael McCulloch Sarah McFarland Sheryl Thompson Debbie Yaver Alan Berry | 2013 | Applied Microbiology and Biotechnology2013，，20： | 1 |
| 10 | Renal artery embolization prior to nephrectomy for locally advanced renal cell carcinoma显示文摘 | Homayoun Zargar Ben Addison John McCall Adam Bartlett Brendan Buckley Michael Rice | 2014 | ANZ J Surg . 2014 (7-8)2014，，： | 1 |
| 11 | Reduced Transdermal Absorption of N,N-Diethyl- m -toluamide from a New Topical Insect Repellent Formulation显示文摘 | Hongchun Qiu H. Won Jun Michael Dzimianski John McCall | 1997 | Pharmaceutical Development and Technology1997，，1： | 1 |
| 12 | Sensors, empowerment, and accountability: a Digital Earth view from East Africa显示文摘Several innovative‘participatory sensing’initiatives are under way in East Africa.They can be seen as local manifestations of the global notion of Digital Earth.The initiatives aim to amplify the voice of ordinary citizens,improve citizens’capacity to directly influence public service delivery and hold local government accountable.The popularity of these innovations is,among other things,a local reaction to the partial failure of the millennium development goals(MDGs)to deliver accurate statistics on public services in Africa.Empowered citizens,with access to standard mobile phones,can‘sense’via text messages and report failures in the delivery of local government services.The public disclosure of these reports on the web and other mass media may pressure local authorities to take remedial action.In this paper,we outline the potential and research challenges of a‘participatory sensing’platform,which we call a‘human sensor web.’Digital Africa’s first priority could be to harness continent-wide and national data as well as local information resources,collected by citizens,in order to monitor,measure and forecast MDGs. | Yola Georgiadou Benson Bana Robert Becht Robert Hoppe Justinian Ikingura Menno-Jan Kraak Kate Lance Rob Lemmens Juma Hemed Lungo Michael McCall Gianluca Miscione Jeroen Verplanke | 2011 | International Journal of Digital Earth2011，4，4： | 0 |
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