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| 1 | Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial显示文摘 | Yung-Jue Bang Eric Van Cutsem Andrea Feyereislova Hyun C Chung Lin Shen Akira Sawaki Florian Lordick Atsushi Ohtsu Yasushi Omuro Taroh Satoh Giuseppe Aprile Evgeny Kulikov Julie Hill Michaela Lehle Josef Rüschoff Yoon-Koo Kang | 2010 | The Lancet2010，，9742： | 20 |
| 2 | Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial显示文摘 | Yung-Jue Bang Eric Van Cutsem Andrea Feyereislova Hyun C Chung Lin Shen Akira Sawaki Florian Lordick Atsushi Ohtsu Yasushi Omuro Taroh Satoh Giuseppe Aprile Evgeny Kulikov Julie Hill Michaela Lehle Josef Rüschoff Yoon-Koo Kang | 2010 | The Lancet . 2010 (9742)2010，，9742： | 6 |
| 3 | A Sustained Virologic Response Is Durable in Patients With Chronic Hepatitis C Treated With Peginterferon Alfa-2a and Ribavirin显示文摘 | Mark G. Swain Ming–Yang Lai Mitchell L. Shiffman W. Graham E. Cooksley Stefan Zeuzem Douglas T. Dieterich Armand Abergel Mário G. Pess?a Amy Lin Andreas Tietz Edward V. Connell Moisés Diago | 2010 | Gastroenterology2010，，5： | 3 |
| 4 | Surface Charging Phenomena on HVDC Spacers for Compressed SF_(6) Insulation and Charge Tailoring Strategies显示文摘Surface flashover of spacers is a key factor limiting the application of HVDC GIS/GIL,while the charge accumula-tion on the surface of the spacer could have a potential adverse effect on the surface flashover voltage.This paper discusses the laws regarding distribution patterns of surface charges and the related mechanisms.The field-dependent property is discussed in detail to comprehensively illustrate the charge transport mecha-nism and explain the research differences regarding different surface charge patterns obtained by previous researchers.In addition,the main surface charge control methods for epoxy resin are summarized and discussed.The potential research directions of charge control methods and key points in manufacturing of spacers used in HVDC GIS/GIL are also explored. | Chuanyang Li Yuan Xu Chuanjie Lin Geng Chen Youping Tu Yao Zhou Zhipeng Lei Tao Han Simone Vincenzo Suraci Jian Wang Weidong Liu M.Tariq Nazir Shun He Andrea Cavallini Giovanni Mazzanti Davide Fabiani Jinliang He | 2020 | CSEE Journal of Power and Energy Systems2020，6，1： | 3 |
| 5 | Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial显示文摘 | Yung-Jue Bang Eric Van Cutsem Andrea Feyereislova Hyun C Chung Lin Shen Akira Sawaki Florian Lordick Atsushi Ohtsu Yasushi Omuro Taroh Satoh Giuseppe Aprile Evgeny Kulikov Julie Hill Michaela Lehle Josef Rüschoff Yoon-Koo Kang | 2010 | The Lancet2010，，9742： | 2 |
| 6 | Panda X-III: Searching for neutrinoless double beta decay with high pressure ^(136)Xe gas time projection chambers显示文摘Searching for the neutrinoless double beta decay(NLDBD)is now regarded as the topmost promising technique to explore the nature of neutrinos after the discovery of neutrino masses in oscillation experiments.Panda X-III(particle and astrophysical xenon experiment III)will search for the NLDBD of136Xe at the China Jin Ping Underground Laboratory(CJPL).In the first phase of the experiment,a high pressure gas Time Projection Chamber(TPC)will contain 200 kg,90%136Xe enriched gas operated at10 bar.Fine pitch micro-pattern gas detector(Microbulk Micromegas)will be used at both ends of the TPC for the charge readout with a cathode in the middle.Charge signals can be used to reconstruct the electron tracks of the NLDBD events and provide good energy and spatial resolution.The detector will be immersed in a large water tank to ensure~5 m of water shielding in all directions.The second phase,a ton-scale experiment,will consist of five TPCs in the same water tank,with improved energy resolution and better control over backgrounds. | Xun Chen Chang Bo Fu Javier Galan Karl Giboni Franco Giuliani Ling Hui Gu Ke Han Xiang Dong Ji Heng Lin Jiang Lai Liu Kai Xiang Ni Hiroki Kusano Xiang Xiang Ren Shao Bo Wang Yong Yang Dan Zhang Tao Zhang Li Zhao Xiang Ming Sun Shou Yang Hu Si Yu Jian Xing Long Li Xiao Mei Li Hao Liang Huan Qiao Zhang Ming Rui Zhao Jing Zhou Ya Jun Mao Hao Qiao Si Guang Wang Ying Yuan Meng Wang Amir N.Khan Neill Raper Jian Tang Wei Wang Jia Ning Dong Chang Qing Feng Cheng Li Jian Bei Liu Shu Bin Liu Xiao Lian Wang Dan Yang Zhu Juan F.Castel Susana Cebri'an Theopisti Dafni Javier G.Garza Igor G.Irastorza Francisco J.Iguaz Gloria Luz ′on Hector Mirallas Stephan Aune Eric Berthoumieux Yann Bedfer Denis Calvet Nicole d'Hose Alain Delbart Maria Diakaki Esther Ferrer-Ribas Andrea Ferrero Fabienne Kunne Damien Neyret Thomas Papaevangelou Franck Sabatie Maxence Vanderbroucke AnDi Tan Wick Haxton Yuan Mei Chinorat Kobdaj Yu-Peng Yan | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，6： | 2 |
| 7 | Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial显示文摘 | Yung-Jue Bang Eric Van Cutsem Andrea Feyereislova Hyun C Chung Lin Shen Akira Sawaki Florian Lordick Atsushi Ohtsu Yasushi Omuro Taroh Satoh Giuseppe Aprile Evgeny Kulikov Julie Hill Michaela Lehle Josef Rüschoff Yoon-Koo Kang | 2010 | 2010 (9742)2010，，9742： | 2 |
| 8 | A potato late blight resistance gene protects against multiple Phytophthora species by recognizing a broadly conserved RXLR-WY effector显示文摘Species of the genus Phytophthora,the plant killer,cause disease and reduce yields in many crop plants.Although many Resistance to Phytophthora infestans(Rpi)genes effective against potato late blight have been cloned,few have been cloned against other Phytophthora species.Most Rpi genes encode nucleotide-binding domain,leucine-rich repeat-containing(NLR)immune receptor proteins that recognize RXLR(Arg-X-Leu-Arg)effectors.However,whether NLR proteins can recognize RXLR effectors from multiple Phytophthora species has rarely been investigated.Here,we identified a new RXLR-WY effector AVRamr3 from P.infestans that is recognized by Rpi-amr3 from a wild Solanaceae species Solanum americanum.Rpi-amr3 associates with AVRamr3 in planta.AVRamr3 is broadly conserved in many different Phytophthora species,and the recognition of AVRamr3 homologs by Rpi-amr3 activates resistance against multiple Phytophthora pathogens,including the tobacco black shank disease and cacao black pod disease pathogens P.parasitica and P.palmivora.Rpi-amr3 is thus the first characterized resistance gene that acts against P.parasitica or P.palmivora.These findings suggest a novel path to redeploy known R genes against different important plant pathogens. | Xiao Lin Andrea Olave-Achury Robert Heal Marina Pais Kamil Witek Hee-Kyung Ahn He Zhao Shivani Bhanvadia Hari S.Karki Tianqiao Song Chih-hang Wu Hiroaki Adachi Sophien Kamoun Vivianne G.A.A.Vleeshouwers Jonathan D.G.Jones | 2022 | Molecular Plant2022，15，9： | 2 |
| 9 | Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial显示文摘 | Yung-Jue Bang Eric Van Cutsem Andrea Feyereislova Hyun C Chung Lin Shen Akira Sawaki Florian Lordick Atsushi Ohtsu Yasushi Omuro Taroh Satoh Giuseppe Aprile Evgeny Kulikov Julie Hill Michaela Lehle Josef Rüschoff Yoon-Koo Kang | 2010 | The Lancet2010，，9742： | 1 |
| 10 | Coracoid graft osteolysis after the Latarjet procedure for anteroinferior shoulder instability: a computed tomography scan study of twenty-six patients显示文摘 | Giovanni Di Giacomo Alberto Costantini Nicola de Gasperis Andrea De Vita Bernard K.H. Lin Marco Francone Mario A. Rojas Beccaglia Marco Mastantuono | 2011 | Journal of Shoulder and Elbow Surgery2011，，6： | 1 |
| 11 | Wnt pathway component LEF1 mediates tumor cell invasion and is expressedin human and murine breast cancers lacking ErbB2 (her-2/neu) overexpression显示文摘 | Anthony Nguyen Andrea Rosner Tatjana Milovanovic Christopher Hope Kestutis Planutis Baisakhi Saha Benjaporn Chaiwun Fritz Lin S. Imam J. Marsh Randall Holcombe | 2005 | International Journal of Oncology2005，，4： | 1 |
| 12 | Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial显示文摘 | Yung-Jue Bang Eric Van Cutsem Andrea Feyereislova Hyun C Chung Lin Shen Akira Sawaki Florian Lordick Atsushi Ohtsu Yasushi Omuro Taroh Satoh Giuseppe Aprile Evgeny Kulikov Julie Hill Michaela Lehle Josef Rüschoff Yoon-Koo Kang | 2010 | The Lancet2010，，9742： | 1 |
| 13 | input data requirements Lagrangian trajectory models显示文摘 | BOWMAN K P LIN J C ANDREAS S | 2013 | Bulletin of the American Meteorological Society2013，94，7： | 1 |
| 14 | Dynamic changes in O-GlcNAcylation regulate osteoclast differentiation and bone loss via nucleoporin 153显示文摘Bone mass is maintained by the balance between osteoclast-induced bone resorption and osteoblast-triggered bone formation.In inflammatory arthritis such as rheumatoid arthritis(RA),however,increased osteoclast differentiation and activity skew this balance resulting in progressive bone loss.O-GlcNAcylation is a posttranslational modification with attachment of a single O-linkedβ-D-N-acetylglucosamine(O-GlcNAc)residue to serine or threonine residues of target proteins.Although O-GlcNAcylation is one of the most common protein modifications,its role in bone homeostasis has not been systematically investigated.We demonstrate that dynamic changes in O-GlcNAcylation are required for osteoclastogenesis.Increased O-GlcNAcylation promotes osteoclast differentiation during the early stages,whereas its downregulation is required for osteoclast maturation.At the molecular level,O-GlcNAcylation affects several pathways including oxidative phosphorylation and cell-cell fusion.TNFαfosters the dynamic regulation of O-GlcNAcylation to promote osteoclastogenesis in inflammatory arthritis.Targeted pharmaceutical or genetic inhibition of O-GlcNAc transferase(OGT)or O-GlcNAcase(OGA)arrests osteoclast differentiation during early stages of differentiation and during later maturation,respectively,and ameliorates bone loss in experimental arthritis.Knockdown of NUP153,an O-GlcNAcylation target,has similar effects as OGT inhibition and inhibits osteoclastogenesis.These findings highlight an important role of O-GlcNAcylation in osteoclastogenesis and may offer the potential to therapeutically interfere with pathologic bone resorption. | Yi-Nan Li Chih-Wei Chen Thuong Trinh-Minh Honglin Zhu Alexandru-Emil Matei Andrea-Hermina Györfi Frederic Kuwert Philipp Hubel Xiao Ding Cuong Tran Manh Xiaohan Xu Christoph Liebel Vladyslav Fedorchenko Ruifang Liang Kaiyue Huang Jens Pfannstiel Min-Chuan Huang Neng-Yu Lin Andreas Ramming Georg Schett Jörg H.W.Distler | 2022 | Bone Research2022，10，4： | 1 |
| 15 | Regulation of Macrophage Migration Inhibitory Factor Expression by Glucocorticoids in Vivo显示文摘 | Gunter Fingerle-Rowson Peter Koch Rachel Bikoff Xinchun Lin Christine N. Metz Firdaus S. Dhabhar Andreas Meinhardt Richard Bucala | 2003 | The American Journal of Pathology2003，，1： | 1 |
| 16 | P190 BCR-ABL mRNA is expressed at low levels in P210-positive chronic myeloid and acute lymphoblastic leukemias 显示文摘 | Andreas Hochhaus Feng Lin | 1996 | Blood1996，879，12： | 1 |
| 17 | 饮用水中砷减少与皮肤损害改善:孟加拉国的后续研究显示文摘摘要:[背景]慢性砷暴露与皮肤损害相关。然而,尚不知道减少砷暴露是否会改善皮肤损害。[目的]评估随时间的推移,砷暴露减少与皮肤损害恢复之间的关联。[方法]在2001-2003年间孟加拉国登记的基线皮肤损害病例(n=900)的基础上,于2009-2011年随访研究550名患者。确定基线及随访时饮用水和脚趾甲中的砷与皮肤损伤的状态及严重程度。 | Wei Jie Seow Wen-Chi Pan Molly L.Kile Andrea A.Baccarelli Quazi Quamruzzaman Mahmuder Rahman Golam Mahiuddin Golam Mostofa Xihong Lin David C.Christiani | 2013 | 环境与职业医学2013，30，3： | 1 |
| 18 | Crucial role of stromal cell-derived factor-1α in neointima formation after vascular injury in apolipoprotein E-deficient mice显示文摘 | Andreas Schober Sandra Knarren Micheal Lietz Lin EA Christian Weber | 2003 | Circulation2003，108，： | 1 |
| 19 | Pharmacological treatment of inhalation injury after nuclear or radiological incidents: The Chinese and German approach显示文摘Inhalation injury is often associated with burns and significantly increases morbidity and mortality. The main toxic components of fire smoke are carbon monoxide, hydrogen cyanide, and irritants. In the case of an incident at a nuclear power plant or recycling facility associated with fire, smoke may also contain radioactive material. Medical treatments may vary in different countries, and in this paper, we discuss the similarities and differences in the treatments between China and Germany. Carbon monoxide poisoning is treated by 100% oxygen administration and,if available, hyperbaric oxygenation in China as well as in Germany. In addition, antidotes binding the cyanide ions and relieving the respiratory chain are important. Methemoglobin-forming agents(e.g., nitrites, dimethylaminophenol)or hydroxocobalamin(Vitamin B12) are options. The metabolic elimination of cyanide may be enhanced by sodium thiosulfate. In China, sodium nitrite with sodium thiosulfate is the most common combination. The use of dimethylaminophenol instead of sodium nitrite is typical for Germany, and hydroxocobalamin is considered the antidote of choice if available in cases of cyanide intoxications by fire smoke inhalation as it does not further reduce oxygen transport capacity. Systematic prophylactic use of corticosteroids to prevent toxic pulmonary edema is not recommended in China or Germany. Stable iodine is indicated in the case of radioiodine exposure and must be administered within several hours to be effective. The decorporation of metal radionuclides is possible with Ca(DTPA)or Prussian blue that should be given as soon as possible. These medications are used in both countries, but it seems that Ca(DTPA) is administered at lower dosages in China. Although the details of the treatment of inhalation injury and radionuclide(s) decorporation may vary, the general therapeutic strategy is very similar in China and Germany. | Tian-Tian Yan Guo-An Lin Min-Jie Wang Andreas Lamkowski Matthias Port Alexis Rump | 2019 | Military Medical Research2019，6，2： | 1 |
| 20 | 2021年ISHNE/HRS/EHRA/APHRS关于移动医疗心律失常管理共识:心脏节律专业人员的数字医疗工具显示文摘国际动态心电图和无创心电图学会/心律学会/欧洲心律协会/亚太心律协会制定的'关于移动医疗心律失常管理共识'描述了移动医疗(mHealth)技术在心律失常管理中的现状,涉及数字医疗工具范围,以及可能应用于心律失常的诊断和协助临床决策。合并症和生活方式管理(日益公认在心律失常中起作用)以及患者自我管理赋予了mHealth新的内容。共识对预测分析的承诺,以及嵌入了mHealth的常规临床关怀的操作面临的挑战,进行了探讨。 | Niraj Varma Iwona Cygankiewicz Mintu Turakhia Hein Heidbuchel Yufeng Hu Lin Yee Chen Jean-Philippe Couderc Edmond M.Cronin Jerry D.Estep Lars Grieten Deirdre A.Lane Reena Mehra Alex Page Rod Passman Jonathan Piccini Ewa Piotrowicz Ryszard Piotrowicz Pyotr G.Platonov Antonio Luiz Ribeiro Robert E.Rich Andrea M.Russo David Slotwiner Jonathan S.Steinberg Emma Svennberg 蔡星星(翻译) 陈牧(翻译) 陈泰中(翻译) 费聿东(翻译) 费振涛(翻译) 龚畅祺(翻译) 胡晓亮(翻译) 李澄(翻译) 练小铭(翻译) 莫斌峰(翻译) 王海成(翻译) 王倩(翻译) 卫郅星(翻译) 徐全福(翻译) 杨眉(翻译) 杨钰粒(翻译) 于怡驰(翻译) 张睿(翻译) 赵铭哲(翻译) 赵晏(翻译) 李毅刚(审校) 王群山(审校) | 2021 | 中国心脏起搏与心电生理杂志2021，35，2： | 1 |
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