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| 1 | Clinically detected gastroenteropancreatic neuroendocrine tumors are on the rise: Epidemiological changes in Germany显示文摘AIM:To study the epidemiologic changes of gastroenteropancreatic neuroendocrine tumors(GEP-NET)in Germany,we analyzed two time periods 1976-1988 and1998-2006.METHODS:We evaluated epidemiological data of GEP-NET from the former East German National Cancer Registry(DDR Krebsregister,1976-1988)and its successor,the Joint Cancer Registry(GKR,1998-2006),which was founded after German reunification.Due to a particularly substantial database the epidemiological data from the federal states of Mecklenburg-Western Pomerania,Saxony,Brandenburg and Thuringia,covering a population of more than 10.8 million people,were analyzed.Survival probabilities were calculated using life table analysis.In addition,GEP-NET patients were evaluated for one or more second(non-GEP-NET)primary malignancies.RESULTS:A total of 2821 GEP neuroendocrine neoplasms were identified in the two registries.The overall incidence increased significantly between 1976 and2006 from 0.31(per 100.000 inhabitants per year)to2.27 for men and from 0.57 to 2.38 for women.In the later period studied(2004-2006),the small intestine was the most common site.Neuroendocrine(NE)neoplasms of the small intestine showed the largest absolute increase in incidence,while rectal NE neoplasms exhibited the greatest relative increase.Only the incidence of appendiceal NET in women showed little change between 1976 and 2006.Overall survival of patients varied for sex,tumor site and the two periods studied but improved significantly over time.Interestingly,about 20%of the GEP-NET patients developed one or more second malignancies.Their most common location was the gastrointestinal tract.GEP-NET patients without second malignancies fared better than those with one or more of them.CONCLUSION:The number of detected GEP-NET increased about 5-fold in Germany between 1976 and2006.At the same time,their anatomic distribution changed,and the survival of GEP-NET patients improved significantly.Second malignancies are common and influence the overall survival of GEP-NET patients.Thus,GEP-NET warrant our attention as well as intensive research on their tumorigenesis. | Hans Scherübl Brigitte Streller Roland Stabenow Hermann Herbst Michael Hopfner Christoph Schwertner Joachim Steinberg Jan Eick Wanda Ring Krishna Tiwari Soren M Zappe | 2013 | World Journal of Gastroenterology2013，19，47： | 16 |
| 2 | 云南省临沧市临翔区农村居民HIV检测服务利用和感染风险认知情况调查显示文摘目的了解云南临沧市临翔区农村居民对艾滋病病毒(HIV)检测的实际利用情况,以及对感染HIV风险的认知情况,为提高HIV检测服务利用提供基础信息。方法通过随机抽样方法,抽取大众人群进行面对面调查,对调查对象的一般人口统计学特征、HIV检测利用和自身感染风险等信息进行统计分析。结果 2007、2008、2009年,分别有1 153、909和899人参与。结果发现当地大众人群对HIV检测利用低于15%;超过60%的人愿意在医疗机构进行检测;超过50%的人没有意识到自身有感染HIV的风险,缺乏风险意识是影响他们不能主动进行检测的主要原因。结论当地农村居民对自身感染HIV的风险意识不足,影响了他们对HIV检测服务的利用,需对此制订干预措施来提高HIV检测率。 | 刘霞 Michael Hermann 邓邦炎 | 2011 | 中国艾滋病性病2011，17，2： | 5 |
| 3 | Guidelines for Preventing Infectious Complications among Hematopoietic Cell Transplantation Recipients: A Global Perspective显示文摘 | Marcie Tomblyn Tom Chiller Hermann Einsele Ronald Gress Kent Sepkowitz Jan Storek John R. Wingard Jo-Anne H. Young Michael A. Boeckh | 2009 | Biology of Blood and Marrow Transplantation2009，，10： | 3 |
| 4 | Comparative transcriptome analyses shed light on carotenoid production and plastid development in melon fruit显示文摘Carotenoids,such asβ-carotene,accumulate in chromoplasts of various fleshy fruits,awarding them with colors,aromas,and nutrients.The Orange(CmOr)gene controlsβ-carotene accumulation in melon fruit by posttranslationally enhancing carotenogenesis and repressingβ-carotene turnover in chromoplasts.Carotenoid isomerase(CRTISO)isomerizes yellow prolycopene into red lycopene,a prerequisite for further metabolism intoβ-carotene.We comparatively analyzed the developing fruit transcriptomes of orange-colored melon and its two isogenic EMS-induced mutants,low-β(Cmor)and yofi(Cmcrtiso).The Cmor mutation in low-βcaused a major transcriptomic change in the mature fruit.In contrast,the Cmcrtiso mutation in yofi significantly changed the transcriptome only in early fruit developmental stages.These findings indicate that melon fruit transcriptome is primarily altered by changes in carotenoid metabolic flux and plastid conversion,but minimally by carotenoid composition in the ripe fruit.Clustering of the differentially expressed genes into functional groups revealed an association between fruit carotenoid metabolic flux with the maintenance of the photosynthetic apparatus in fruit chloroplasts.Moreover,large numbers of thylakoid localized photosynthetic genes were differentially expressed in low-β.CmOR family proteins were found to physically interact with light-harvesting chlorophyll a–b binding proteins,suggesting a new role of CmOR for chloroplast maintenance in melon fruit.This study brings more insights into the cellular and metabolic processes associated with fruit carotenoid accumulation in melon fruit and reveals a new maintenance mechanism of the photosynthetic apparatus for plastid development. | Noam Chayut Hui Yuan Yuval Saar Yi Zheng Tianhu Sun Xuesong Zhou Anna Hermanns Elad Oren Adi Faigenboim Maixia Hui Zhangjun Fei Michael Mazourek Joseph Burger Yaakov Tadmor Li Li | 2021 | Horticulture Research2021，8，1： | 3 |
| 5 | 源于共同的机械、电气和自动化设计的薄板坯连铸连轧工艺开发显示文摘西马克德马格公司在冶金工业方面是一个领先的工业工厂解决方案提供商.统一设计的机械、电气和自动化方案使我们的用户无论是在产品质量、产量、生产的灵活性、工艺的稳定性以及易维护性方面,拥有了生产具有高性能的高级材料的技术.在薄板坯连铸连轧领域,这样的共同开发的例子如下:①CSP薄板坯连铸.结晶器液面控制,液压结晶器振动,用于楔形和速度优化的自动导航,带有LCR3(液芯压下)的液压扇形段调整,动态二冷水和结晶器监视系统;②CSP轧机.用于带材板形、连续凸度、平直度控制和自由轧制,采用了特定的磨辊以及相配套的串辊策略的CVC+技术;③用于实现厚度小于1mm带钢高效热轧的'薄规格技术包',包括采用'张力差活套'或'张力计活套'以及快速液压机构配合相应的自动化模块,如自动调平控制,以活套测量为基础的平直度控制,尾部监控或以楔形测量为基础的调平预设定.不仅是机械和电气的共同设计,还有共同的项目执行都将使工厂的运营者受益.例如,对于现代化改造项目和新安装的工厂,通过在交货之前在实验室内的联合测试,项目的投产时间得以优化.'工厂回路测试(PILT)'将仿真或甚至机械部件本身与真实的自动化系统(1级,2级和人机界面HMI)结合在一起.通过这样的共同解决方案,西马克德马格公司在电气和自动化领域已发展成'从电机轴一直到生产计划系统'的成套供货商和系统集成商,其目标就是致力于与其用户的长期伙伴关系,并与用户分享其所拥有的工艺经验. | Hans Esau Klassen Michael Reiner Jansen Hermann Wolters | 2004 | 钢铁2004，39，z1： | 3 |
| 6 | Physiological and Molecular Biological Characterization of Ammonia Oxidation of the Heterotrophic Nitrifier Pseudomonas putida显示文摘 | Michael Daum Wolfgang Zimmer Hans Papen Karin Kloos Kerstin Nawrath Hermann Bothe | 1998 | Current Microbiology1998，，4： | 2 |
| 7 | Peroral Endoscopic Myotomy for the Treatment of Achalasia: An International Prospective Multicenter Study显示文摘 | Daniel Von Renteln Karl–Hermann Fuchs Paul Fockens Peter Bauerfeind Melina C. Vassiliou Yuki B. Werner Gerald Fried Wolfram Breithaupt Henriette Heinrich Albert J. Bredenoord Jan F. Kersten Tessa Verlaan Michael Trevisonno Thomas R?sch | 2013 | Gastroenterology2013，，2： | 2 |
| 8 | Concept and proof for an all-silicon MEMS micro speaker utilizing air chambers显示文摘MEMS-based micro speakers are attractive candidates as sound transducers for smart devices,particularly wearables and hearables.For such devices,high sound pressure levels,low harmonic distortion and low power consumption are required for industrial,consumer and medical applications.The ability to integrate with microelectronic circuitry,as well as scalable batch production to enable low unit costs,are the key factors benchmarking a technology.The Nanoscopic Electrostatic Drive based,novel micro speaker concept presented in this work essentially comprises inplane,electrostatic bending actuators,and uses the chip volume rather than the its surface for sound generation.We describe the principle,design,fabrication,and first characterization results.Various design options and governing equations are given and discussed.In a standard acoustical test setup(ear simulator),a MEMS micro speaker generated a sound pressure level of 69 dB at 500 Hz with a total harmonic distortion of 4.4%,thus proving the concept.Further potential on sound pressure as well as linearity improvement is outlined.We expect that the described methods can be used to enhance and design other MEMS devices and foster modeling and simulation approaches. | Bert Kaiser Sergiu Langa Lutz Ehrig Michael Stolz Hermann Schenk Holger Conrad Harald Schenk Klaus Schimmanz David Schuffenhauer | 2019 | Microsystems & Nanoengineering2019，5，1： | 2 |
| 9 | A new anchor electrode design for continuous neuromonitoring of the recurrent laryngeal nerve by vagal nerve stimulations 显示文摘 | Rick Schneider Joanna Przybyl Michael Hermann | 2009 | Langenbecks Arch Surg2009，394，5： | 1 |
| 10 | Phase I-II Trial of Cetuximab, Capecitabine, Oxaliplatin, and Radiotherapy as Preoperative Treatment in Rectal Cancer显示文摘 | Claus R?del Dirk Arnold Matthias Hipp Torsten Liersch Kathrin Dellas Igors Iesalnieks Robert Michael Hermann Florian Lordick Axel Hinke Werner Hohenberger Rolf Sauer | 2008 | International Journal of Radiation Oncology Biology Physics2008，，4： | 1 |
| 11 | Borders without barriers-Structural functionality and green infrastructure in the Austrian-Hungarian transboundary region of Lake Neusiedl显示文摘 | MICHAEL KUTTNER CHRISTA HAINZRENETZEDER ANNA HERMANN | 2013 | Ecological Indicators2013，31，： | 1 |
| 12 | CRP and CD14 polymorphisms correlate with coronary plaque volume in patients with coronary artery disease – IVUS substudy of the ENCORE trials显示文摘 | Matthias Hermann Dieter Fischer Michael M. Hoffmann Theo Gasser Kurt Quitzau Thomas Meinertz Thomas Münzel Thomas F. Lüscher | 2011 | Atherosclerosis2011，，1： | 1 |
| 13 | German Association of Endocrine Surgeons practice guideline for the surgical management of malignant thyroid tumors显示文摘 | Henning Dralle Thomas J. Musholt Jochen Schabram Thomas Steinmüller Andreja Frilling Dietmar Simon Peter E. Goretzki Bruno Niederle Christian Scheuba Thomas Clerici Michael Hermann Jochen Ku?mann Kerstin Lorenz Christoph Nies Peter Schabram Arnold Trupka | 2013 | Langenbeck’s Archives of Surgery2013，，3： | 1 |
| 14 | Genetic diversity in sweetpotato [Ipomoea batatas (L.) Lam.] in relationship to geographic sources as assessed with RAPD markers显示文摘 | Simon Templar Gichuki Maria Berenyi Dapeng Zhang Michael Hermann Josef Schmidt Josef Gl?ssl Kornel Burg | 2003 | Genetic Resources and Crop Evolution2003，，4： | 1 |
| 15 | Challenges in the Detection and Attribution of Northern Hemisphere Surface Temperature Trends Since 1850显示文摘Since 2007,the Intergovernmental Panel on Climate Change(IPCC)has heavily relied on the comparison between global climate model hindcasts and global surface temperature(ST)estimates for concluding that post-1950s global warming is mostly human-caused.In Connolly et al.,we cautioned that this approach to the detection and attribution of climate change was highly dependent on the choice of Total Solar Irradiance(TSI)and ST data sets.We compiled 16 TSI and five ST data sets and found by altering the choice of TSI or ST,one could(prematurely)conclude anything from the warming being“mostly human-caused”to“mostly natural.”Richardson and Benestad suggested our analysis was“erroneous”and“flawed”because we did not use a multilinear regression.They argued that applying a multilinear regression to one of the five ST series re-affirmed the IPCC's attribution statement.They also objected that many of the published TSI data sets were out-of-date.However,here we show that when applying multilinear regression analysis to an expanded and updated data set of 27 TSI series,the original conclusions of Connolly et al.are confirmed for all five ST data sets.Therefore,it is still unclear whether the observed warming is mostly human-caused,mostly natural or some combination of both. | Ronan Connolly Willie Soon Michael Connolly Sallie Baliunas Johan Berglund C.J.Butler Rodolfo Gustavo Cionco Ana G.Elias Valery M.Fedorov Hermann Harde Gregory W.Henry Douglas V.Hoyt Ole Humlum David R.Legates Nicola Scafetta Jan-Erik Solheim LászlóSzarka Víctor M.Velasco Herrera Hong Yan Weijia Zhang | 2023 | Research in Astronomy and Astrophysics2023，23，10： | 1 |
| 16 | Small-animal PET: A promising, non-invasive tool in pre-clinical research显示文摘 | Uta Schn?ckel Sven Hermann Lars Stegger Marilyn Law Michael Kuhlmann Otmar Schober Klaus Sch?fers Michael Sch?fers | 2009 | European Journal of Pharmaceutics and Biopharmaceutics2009，，1： | 1 |
| 17 | c-Met Confers Protection Against Chronic Liver Tissue Damage and Fibrosis Progression After Bile Duct Ligation in Mice显示文摘 | Arne Giebeler Mark V. Boekschoten Christian Klein Malgorzata Borowiak Carmen Birchmeier Nikolaus Gassler Hermann E. Wasmuth Michael Müller Christian Trautwein Konrad L. Streetz | 2009 | Gastroenterology2009，，1： | 1 |
| 18 | Compliance with Therapy in Patients with Chronic Hepatitis C: Associations with Psychiatric Symptoms, Interpersonal Problems, and Mode of Acquisition显示文摘 | Michael Rupert Kraus Arne Sch?fer Herbert Csef Hermann Faller Hubert M?rk Michael Scheurlen | 2001 | Digestive Diseases and Sciences2001，，10： | 1 |
| 19 | Neuromonitoring in Thyroid Surgery: Prospective Evaluation of Intraoperative Electrophysiological Responses for the Prediction of Recurrent Laryngeal Nerve Injury显示文摘 | Michael Hermann Christa Hellebart Michael Freissmuth | 2004 | Annals of Surgery2004，，1： | 1 |
| 20 | Ca2+/calmodulin‐dependent kinase II contributes to inhibitor of nuclear factor‐kappa B kinase complex activation in Helicobacter pylori infection显示文摘 | Gunter Maubach Olga Sokolova Markus Wolfien Hermann‐Josef Rothk?tter Michael Naumann | 2013 | Cancer2013，，6： | 1 |
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