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| 1 | Predictive value of Ki67 and p53 in locally advanced rectal cancer:Correlation with thymidylate synthase and histopathological tumor regression after neoadjuvant 5-FU-based chemoradiotherapy显示文摘AIM: To investigate the predictive value of Ki67 and p53 and their correlation with thymidylate synthase (TS) gene expression in a rectal cancer patient cohort treated according to a standardized recommended neoadjuvant treatment regimen.METHODS: Formalin fixed, paraffin embedded pre-therapeutical tumor biopsies (n = 22) and post-therapeutical resection specimens (n = 40) from patients with rectal adenocarcinoma (clinical UICC stage Ⅱ/Ⅲ) receiving standardized neoadjuvant 5-fluorouracil (5-FU) based chemoradiotherapy were studied for Ki67 and p53 expression by immunohistochemistry and correlated with TS mRNA expression by quantitative TaqMan real-time PCR after laser microdissection. The results were compared with histopathological tumor regression according to a standardized semiquantitative score grading system.RESULTS: Responders (patients with high tumor regression) showed a significantly lower Ki67 expression than non-responders in the pre-therapeutical tumor biopsies (81.2% vs 16.7%; P < 0.05) as well as in the post-therapeutical resection specimens (75.8% vs 14.3%; P < 0.01). High TS mRNA expression was significantly correlated with a high Ki67 index and low TS mRNA expression was significantly correlated with a low Ki67 index in the pre-therapeutical tumor biopsies (corr. coef. = 0.46; P < 0.01) as well as in the post-therapeutical resection specimens (corr. coef. = 0.40; P < 0.05). No significant association was found between p53 and TS mRNA expression or tumor regression.CONCLUSION: Ki67 has, like TS, predictive value in rectal cancer patients after neoadjuvant 5-FU based chemoradiotherapy. The close correlation between Ki67 and TS indicates that TS is involved in active cell cycle processes. | Christiane Jakob Torsten Liersch Wolfdietrich Meyer Heinz Becker Gustavo B Baretton Daniela E Aust | 2008 | World Journal of Gastroenterology2008，14，7： | 29 |
| 2 | Decision modelling for economic evaluation of liver transplantation显示文摘As the gap between a shortage of organs and the immense demand for liver grafts persists, every available donor liver needs to be optimized for utility, urgency and equity. To overcome this challenge, decision modelling might allow us to gather evidence from previous studies as well as compare the costs and consequences of alternative options. For public health policy and clinical intervention assessment, it is a potentially powerful tool. The most commonly used types of decision analytical models include decision trees, the Markov model, microsimulation, discrete event simulation and the system dynamic model. Analytic models could support decision makers in the field of liver transplantation when facing specific problems by synthesizing evidence, comprising all relevant options, generalizing results to other contexts, extending the time horizon and exploring the uncertainty. For modeling studies of economic evaluation for transplantation, understanding the current nature of the disease is crucial, as well as the selection of appropriate modelling techniques. The quality and availability of data is another key element for the selection and development of decision analytical models. In addition, good practice guidelines should be complied, which is important for standardization and comparability between economic outputs. | Zhi Qu Christian Krauth Volker Eric Amelung Alexander Kaltenborn Jill Gwiasda Lena Harries Jan Beneke Harald Schrem Sebastian Liersch | 2018 | World Journal of Hepatology2018，10，11： | 6 |
| 3 | Tumour response and secondary resectability of colorectal liver metastases following neoadjuvant chemotherapy with cetuximab: the CELIM randomised phase 2 trial显示文摘 | Gunnar Folprecht Thomas Gruenberger Wolf O Bechstein Hans-Rudolf Raab Florian Lordick J?rg T Hartmann Hauke Lang Andrea Frilling Jan Stoehlmacher Jürgen Weitz Ralf Konopke Christian Stroszczynski Torsten Liersch Detlev Ockert Thomas Herrmann Eray Goekkurt | 2010 | Lancet Oncology2010，，1： | 3 |
| 4 | Preoperative chemoradiotherapy and postoperative chemotherapy with fluorouracil and oxaliplatin versus fluorouracil alone in locally advanced rectal cancer: initial results of the German CAO/ARO/AIO-04 randomised phase 3 trial显示文摘 | Claus R?del Torsten Liersch Heinz Becker Rainer Fietkau Werner Hohenberger Torsten Hothorn Ullrich Graeven Dirk Arnold Marga Lang-Welzenbach Hans-Rudolf Raab Heiko Sülberg Christian Wittekind Sergej Potapov Ludger Staib Clemens Hess Karin Weigang-K?hler G | 2012 | Lancet Oncology2012，，7： | 2 |
| 5 | Gain of chromosome 8q23-24 is a predictive marker for lymph node positivity in colorectal cancer显示文摘 | Ghadimi B M Grade M Liersch T | 2003 | Clin Cancer Res2003，9，5： | 1 |
| 6 | Angiogenesis inhibition in cancer therapy:platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) and their receptors:biological functions and role in malignancy显示文摘 | Appelmann I Liersch R Kessler T | | 0，，： | 1 |
| 7 | Fungal foot infections in pa- tients with diabetes mellitus-results of two independent investiga- tions 显示文摘 | Eckhard M Lengler A Liersch J | 2007 | Mycoses2007，50，2： | 1 |
| 8 | Efficacy and toxicity of a rituximab and metliotrexate based regimen (GMALL B-ALL/NHL 2002 protocol)in Bukritt,s and primary mediastinal large B-cell lymplioma显示文摘 | Pohlen M Gertli HU Liersch R | | 0，，12： | 1 |
| 9 | UltraCision or high-frequency knife in transanal endoscopic microsurgery (TEM)? Advantages of a new procedure显示文摘 | Langer C Markus P Liersch T | | 0，，05： | 1 |
| 10 | Phase I-II Trial of Cetuximab, Capecitabine, Oxaliplatin, and Radiotherapy as Preoperative Treatment in Rectal Cancer显示文摘 | Claus R?del Dirk Arnold Matthias Hipp Torsten Liersch Kathrin Dellas Igors Iesalnieks Robert Michael Hermann Florian Lordick Axel Hinke Werner Hohenberger Rolf Sauer | 2008 | International Journal of Radiation Oncology Biology Physics2008，，4： | 1 |
| 11 | Lymph node status and TS gene expression are prognostic markers in stage Ⅱ/Ⅲ rectal cancer after neoadjuvant fluorouracilbased chemoradiothempy显示文摘 | Liersch T Langer C Ghadimi BM | 2006 | J Clin Oncol2006，24，25： | 1 |
| 12 | Preoperative chemoradiothera- py and postoperative chemotherapy with fluorouracil andoxaliplatin versus fluorouracil alone in locally advanced rectal cancer: initial results of the German CAO/ARO/AIO-0d randomised phase 3 trial 显示文摘 | Rsdel C Liersch T Becker H | 2012 | Lancet Oncol2012，13，7： | 1 |
| 13 | Angiogenesis inhibition in cancer therapy: platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) and their receptors: biological functions and role in malignancy显示文摘 | Appelmann I Liersch R Kessler T | 2010 | Recent Results Cancer Res2010，180，： | 1 |
| 14 | Lymphangiogenesis in cancer:current perspectives显示文摘 | LIERSCH R BIERMANN C MESTERS RM | 2010 | Recent Results Cancer Res2010，180，1： | 1 |
| 15 | Combined anti-PDG- FRalpha and PDGFRbeta targeting in non-small cell lung cancer显示文摘 | Reinmuth N Liersch R Raedel M | 2009 | Int J Cancer2009，124，7： | 1 |
| 16 | Lymphangiogenesis in cancer:current perspectives显示文摘 | Liersch R Biermann C Mesters RM | | Recent Results in Cancer Research0，，： | 1 |
| 17 | Fungal foot infections in patients with diabetes mellitus--results of two independent investigations显示文摘 | Eckhard M Lengler A Liersch J | 2007 | Mycoses2007，502，： | 1 |
| 18 | Flood pro- jections within the Niger River Basin under future land use and climate change 显示文摘 | Valentin Aich Stefan Liersch Tobias Vetter | 2016 | Science of the Total Environment2016，，562： | 1 |
| 19 | Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer: results of the German CAO/ARO/AIO-94 randomized phase III trial after a median follow-up of 11 years 显示文摘 | Saner R Liersch T Merkel S | 2012 | J Clin Oncol2012，30，： | 1 |
| 20 | Preoperative ehemoradiotherapy and postoperative chemotherapy with fluorouracil and oxaliplatin versus fluorouracil alone in lo- cally advanced rectal cancer: initial results of the German CAO/ARO/AIO-04 randomised phase 3 trial显示文摘 | Rodel C Liersch T Becker H | 2012 | Lancet Onco12012，13，： | 1 |
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