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| 1 | Association of the GNAS1 T393C polymorphism with tumor stage and survival in gastric cancer显示文摘AIM:To analyze the impact of the GNAS1 T393C polymorphism on prognosis and histopathology of gastric cancer.METHODS:Genomic DNA was extracted from paraffinembedded tissues of 122 patients with primary gastric carcinoma and from the blood of 820 healthy white individuals.Allelic discrimination was performed by quantitative real-time polymerase chain reaction.Genotyping was correlated with histopathologic parameters and with overall survival according to the Kaplan-Meier approach and with multivariate analysis by multiple stepwise regression.RESULTS:Thirty-nine(32%) patients displayed a CC genotype,57(46.7%) a CT genotype and 26(21.3%) a TT genotype.The frequency of the C allele(fC) in the patient group was 0.55,which was not signif icantly different from that of healthy blood donors.The distribution was compatible with the Hardy-Weinberg equilibrium.Analysis of clinicopathological parameters did not show any signif icant correlation of the T393C genotype with gender(P=0.50),differentiation(P=0.29),pT-category(P=0.19),pN-category(P=0.30),pM-category(P=0.25),R-category(P=0.95),the classifications according to WHO(P=0.34),Laurén(P=0.16),Goseki(P=1.00) and Ming(P=0.74).Dichotomization between C+(CC+CT) and C-genotypes(TT),however,revealed signif icantly more advanced tumor stages(P=0.023) and lower survival rates(P=0.043) for C allele carriers.CONCLUSION:The present study provides strong evidence to suggest that the GNAS1 T393C allele carrier status influences tumor progression and survival in gastric cancer with higher tumor stages and a worse outcome for C allele carriers. | Hakan Alakus Stefan P Mnig Ute Warnecke-Eberz Gül Alakus Günther Winde Uta Drebber Klaus J Schmitz Kurt W Schmid Kathrin Riemann Winfried Siffert Elfriede Bollschweiler Arnulf H Hlscher Ralf Metzger | 2009 | World Journal of Gastroenterology2009，15，48： | 3 |
| 2 | Challenges for land system science显示文摘 | Mark D.A. Rounsevell Bas Pedroli Karl-Heinz Erb Marc Gramberger Anne Gravsholt Busck Helmut Haberl S?ren Kristensen Tobias Kuemmerle Sandra Lavorel Marcus Lindner Hermann Lotze-Campen Marc J. Metzger David Murray-Rust Alexander Popp Marta Pérez-Soba Anett | 2012 | Land Use Policy2012，，4： | 2 |
| 3 | Chelex 100 as a medium for simple extraction of DNA for PCR-based typing from forensic material 显示文摘 | Walsh P S Metzger D A Higuchi R | 1991 | Bio Techniques1991，10，： | 2 |
| 4 | Chelex 100 as a medium for simple extraction of DNA for PCR based typing from forensic material 显示文摘 | Walsh P S Metzger D A | 1991 | Biotechniques1991，10，4： | 1 |
| 5 | Effects of roads,topography,and land use on forest cover dynamics in the BrazilianAtlantic Forest显示文摘 | FREITAS S R HAWBAKER T J METZGER J P | 2010 | Forest Ecology and Management2010，259，3： | 1 |
| 6 | Chelex 100 as a medium for simple extraction of DNA for PCR based typing from forensic material显示文摘 | Walsh P S Metzger D A Higuchi R | 1991 | Bio Techniques1991，10，： | 1 |
| 7 | Properties of Rodlike Polymers In Solution显示文摘 | BERRY G C METZGER P C VENKATRAMAN S | 1979 | Polymer Preprints Division of Polymer Chemistry1979，20，1： | 1 |
| 8 | The use of a throm- bus-specific ultrasound contrast agent to detect thrombus in ar- teriovenous fistulae显示文摘 | Unger E Metzger P Krupinski E | 2000 | Invest Radiol2000，35，1： | 1 |
| 9 | Relation between circulating levels of 25 ( OH ) vitamin D and parathyroid hormone in chronic kidney disease: quest for a threshold 显示文摘 | Metzger M Houillier P Gauci C | 2013 | J Clin Endocrinol Metab2013，98，7： | 1 |
| 10 | Chelex-100as a medium for simple extraction of DNA for PCR-Based typ-ing from forensic marerial显示文摘 | WALSH P S METZGER D A HIGUCHI R | 1991 | Biotevhniques1991，10，9： | 1 |
| 11 | Chelex-100 as a medium for simple extraction of DNA for PER-based typing from forensic material 显示文摘 | Walsh P S Metzger D A Higuchi R | 1991 | Biotechniques1991，10，： | 1 |
| 12 | Chelex 100 as a medium for simple extraction of DNA for PCR-based typing from forensic material显示文摘 | Walsh P S Metzger D A Higuchi R | 1991 | Biotechniques1991，10，4： | 1 |
| 13 | A new post-disaster mine communication system显示文摘 | RISTENBATT M P HOLLAND M E METZGER K | 1988 | IEEE Transac- tions on Industry Applications1988，2，24： | 1 |
| 14 | Chelex-100 as a medium for simple extraction of DNA for PCR-based typing from forensic material显示文摘 | Walsh P S Metzger D A Higuchi R | 1991 | Bio Techniques1991，10，4： | 1 |
| 15 | Clostridium difficile in- fection: risk factors,medical and surgical management显示文摘 | Klingler P Metzger P Seelig M | 2000 | Dig Dis2000，18，： | 1 |
| 16 | Hyperglycemia and adverse pregnancy outcomes 显示文摘 | HAPO Study Cooperative Research Group Metzger BE Lowe L P | 2008 | N Engl J Med2008，358，19： | 1 |
| 17 | Botryococcus braunii: a rich source for hydrocarbons and related ether lipids 显示文摘 | Metzger P Largeau C | 2005 | Applied Microbiology and Biotechnology2005，66，5： | 1 |
| 18 | Site-and time-specific gene targeting in the mouse显示文摘 | Metzger D Chambon P | 2001 | Methods2001，24，1： | 1 |
| 19 | Persistent low-level engraftment of rhesus peripheral blood progenitor cells transduced with the fanconi anemia C gene after conditioning with low-dose irradiation显示文摘 | Kang EM Hanazano Y Frare P Vanin EF De Witte M Metzger M | 2001 | Mol Ther2001，3，6： | 1 |
| 20 | Chelex 100 as a medium for simple extraction of DNA for PCR-based typing from forensic material 显示文摘 | Walsh P S Metzger D A Hiquchi R | 1991 | Biotechniques1991，10，4： | 1 |
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