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| 1 | Association of the GNAS1 T393C polymorphism with tumor stage and survival in gastric cancer显示文摘AIM:To analyze the impact of the GNAS1 T393C polymorphism on prognosis and histopathology of gastric cancer.METHODS:Genomic DNA was extracted from paraffinembedded tissues of 122 patients with primary gastric carcinoma and from the blood of 820 healthy white individuals.Allelic discrimination was performed by quantitative real-time polymerase chain reaction.Genotyping was correlated with histopathologic parameters and with overall survival according to the Kaplan-Meier approach and with multivariate analysis by multiple stepwise regression.RESULTS:Thirty-nine(32%) patients displayed a CC genotype,57(46.7%) a CT genotype and 26(21.3%) a TT genotype.The frequency of the C allele(fC) in the patient group was 0.55,which was not signif icantly different from that of healthy blood donors.The distribution was compatible with the Hardy-Weinberg equilibrium.Analysis of clinicopathological parameters did not show any signif icant correlation of the T393C genotype with gender(P=0.50),differentiation(P=0.29),pT-category(P=0.19),pN-category(P=0.30),pM-category(P=0.25),R-category(P=0.95),the classifications according to WHO(P=0.34),Laurén(P=0.16),Goseki(P=1.00) and Ming(P=0.74).Dichotomization between C+(CC+CT) and C-genotypes(TT),however,revealed signif icantly more advanced tumor stages(P=0.023) and lower survival rates(P=0.043) for C allele carriers.CONCLUSION:The present study provides strong evidence to suggest that the GNAS1 T393C allele carrier status influences tumor progression and survival in gastric cancer with higher tumor stages and a worse outcome for C allele carriers. | Hakan Alakus Stefan P Mnig Ute Warnecke-Eberz Gül Alakus Günther Winde Uta Drebber Klaus J Schmitz Kurt W Schmid Kathrin Riemann Winfried Siffert Elfriede Bollschweiler Arnulf H Hlscher Ralf Metzger | 2009 | World Journal of Gastroenterology2009，15，48： | 3 |
| 2 | Vital staining of cardiac myocytes during embryonic stem cell cardiogenesis in vitro显示文摘 | LIN W I SAMUELSON L C | 1996 | Circ Res1996，78，4： | 1 |
| 3 | The transcriptional coactivator FHL2 transmits Rho signals from the cell membrane into the nucleus显示文摘 | MULLR J M METZGER E GRESCHIK H | 2002 | EMBO J2002，21，4： | 1 |
| 4 | Responding to emergencies:lessons learned and the need for analysis显示文摘 | Larson R C Metzger M D Cahn M F | 2006 | Interfaces2006，36，6： | 1 |
| 5 | On the growth of highly ordered pores in anodized aluminumoxide显示文摘 | LI F Y ZHANG L METZGER R M | 1998 | Chem Mater1998，10，： | 1 |
| 6 | A multidisci- plinary multi-scale framework for assessing vulnerabilities to global change显示文摘 | METZGER M J LEEMANS R SCHROTER D | 2005 | International Journal of Applied Earth Ob- servation and Geoinformation2005，7，4： | 1 |
| 7 | Relation between circulating levels of 25 ( OH ) vitamin D and parathyroid hormone in chronic kidney disease: quest for a threshold 显示文摘 | Metzger M Houillier P Gauci C | 2013 | J Clin Endocrinol Metab2013，98，7： | 1 |
| 8 | Influence of particle size on the magnetic viscosity and activation volume of ct-Fe nanowires in alumite films 显示文摘 | LI F Y METZGER R M DOYLE W D | 1997 | IEEE transactions on Magnetics1997，33，5： | 1 |
| 9 | The credibility of volunteered geograph- ic information 显示文摘 | Flanagin A J Metzger M J | 2008 | GeoJouma12008，72，34： | 1 |
| 10 | The vulnerability of ecosystem services to land use change 显示文摘 | METZGER M J ROUNSEVEL M D A ACOSTA-MICH- LIK L | 2006 | Agriculture Ecosystems Environment2006，114，1： | 1 |
| 11 | CD44 functions in Wnt sig- naling by regulating LRP6 localization and activation 显示文摘 | Schmitt M Metzger M Gradl D | 2015 | Cell Death Differ2015，22，4： | 1 |
| 12 | On the growth of highly ordered pores in anodized aluminum oxide 显示文摘 | LI F ZHANG L METZGER R M | 1998 | ChemMater1998，10，： | 1 |
| 13 | Influence of particle size on the magnetic viscosity and activation volume of (-Fe nanowires in alumite films显示文摘 | FEIYUE LI ROBERT M METZGER DOYLE W D | 1997 | IEEE Transactions on Magnetics1997，33，： | 1 |
| 14 | The vulnerability of ecosystem services to land use change显示文摘 | Metzger M J Rounsevell M D | 2006 | Agriculture Ecosystems and Environment2006，114，： | 1 |
| 15 | Ethanol withdrawal provokes opening of the mitoehondrial membrane permeability transition pore in an estrogen-preventable manner显示文摘 | Jung M E Wilson A M Ju X Wen Y Metzger D B Simpkins J W | 2009 | J Pharmacol Exp Ther2009，328，： | 1 |
| 16 | Impact of transfer for primary percutaneous coronary intervention on survival and clinical outcomes (from the HORIZONS-AMI Trial) 显示文摘 | Wohrle J Desaga M Metzger C | 2010 | Am J Cardiol2010，106，9： | 1 |
| 17 | A new post-disaster mine communication system显示文摘 | RISTENBATT M P HOLLAND M E METZGER K | 1988 | IEEE Transac- tions on Industry Applications1988，2，24： | 1 |
| 18 | Clostridium difficile in- fection: risk factors,medical and surgical management显示文摘 | Klingler P Metzger P Seelig M | 2000 | Dig Dis2000，18，： | 1 |
| 19 | Working on a chain:E3s ganging up for ubiquitylation显示文摘 | Metzger M B Weissman A M | 2010 | Nat Cell Biol2010，12，12： | 1 |
| 20 | Credibility and trust of infor- mation in online environments: The use of cognitive heu- ristics显示文摘 | Metzger M J Flanagin A J | 2013 | Journal of Pragmatics2013，59，： | 1 |
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