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| 1 | Association of the GNAS1 T393C polymorphism with tumor stage and survival in gastric cancer显示文摘AIM:To analyze the impact of the GNAS1 T393C polymorphism on prognosis and histopathology of gastric cancer.METHODS:Genomic DNA was extracted from paraffinembedded tissues of 122 patients with primary gastric carcinoma and from the blood of 820 healthy white individuals.Allelic discrimination was performed by quantitative real-time polymerase chain reaction.Genotyping was correlated with histopathologic parameters and with overall survival according to the Kaplan-Meier approach and with multivariate analysis by multiple stepwise regression.RESULTS:Thirty-nine(32%) patients displayed a CC genotype,57(46.7%) a CT genotype and 26(21.3%) a TT genotype.The frequency of the C allele(fC) in the patient group was 0.55,which was not signif icantly different from that of healthy blood donors.The distribution was compatible with the Hardy-Weinberg equilibrium.Analysis of clinicopathological parameters did not show any signif icant correlation of the T393C genotype with gender(P=0.50),differentiation(P=0.29),pT-category(P=0.19),pN-category(P=0.30),pM-category(P=0.25),R-category(P=0.95),the classifications according to WHO(P=0.34),Laurén(P=0.16),Goseki(P=1.00) and Ming(P=0.74).Dichotomization between C+(CC+CT) and C-genotypes(TT),however,revealed signif icantly more advanced tumor stages(P=0.023) and lower survival rates(P=0.043) for C allele carriers.CONCLUSION:The present study provides strong evidence to suggest that the GNAS1 T393C allele carrier status influences tumor progression and survival in gastric cancer with higher tumor stages and a worse outcome for C allele carriers. | Hakan Alakus Stefan P Mnig Ute Warnecke-Eberz Gül Alakus Günther Winde Uta Drebber Klaus J Schmitz Kurt W Schmid Kathrin Riemann Winfried Siffert Elfriede Bollschweiler Arnulf H Hlscher Ralf Metzger | 2009 | World Journal of Gastroenterology2009，15，48： | 3 |
| 2 | Vital staining of cardiac myocytes during embryonic stem cell cardiogenesis in vitro显示文摘 | LIN W I SAMUELSON L C | 1996 | Circ Res1996，78，4： | 1 |
| 3 | On the growth of highly ordered pores in anodized aluminumoxide显示文摘 | LI F Y ZHANG L METZGER R M | 1998 | Chem Mater1998，10，： | 1 |
| 4 | Laparoscopic management of small bowel obstruction: indications and outcome显示文摘 | Leon E L Metzger A Tsiotos G G | 1998 | J Gastrointest Surg1998，2，2： | 1 |
| 5 | The vulnerability of ecosystem services to land use change 显示文摘 | METZGER M J ROUNSEVEL M D A ACOSTA-MICH- LIK L | 2006 | Agriculture Ecosystems Environment2006，114，1： | 1 |
| 6 | On the growth of highly ordered pores in anodized aluminum oxide 显示文摘 | LI F ZHANG L METZGER R M | 1998 | ChemMater1998，10，： | 1 |
| 7 | Alveolar macrophage peiming by intravenous administration of chitin particles,polymers of N-acetyl-D-gluco-samine,in mice显示文摘 | Shibata Y Foster L A Metzger W J | 1977 | Infect Immun1977，65，5： | 1 |
| 8 | Hyperglycemia and adverse pregnancy outcomes 显示文摘 | HAPO Study Cooperative Research Group Metzger BE Lowe L P | 2008 | N Engl J Med2008，358，19： | 1 |
| 9 | Process cheese:scientific and technological aspects a review显示文摘 | KAPOOR R METZGER L E | 2008 | Comprehensive Reviews in Food Science and Food Safety2008，7，： | 1 |
| 10 | Exopolysaccharides modify func- tional properties of whey protein concentrate显示文摘 | Deep G Hassan A N Metzger L | 2012 | Journal of Dairy Science2012，95，11： | 1 |
| 11 | Regulation of force development studied by photol- ysis of caged ADP in rabbit skinned psoas fibers 显示文摘 | Zhe lu Dad R Swartz Joseph M Metzger Richard L Moss Jef- fery W Walker | 2001 | Biophys J2001，81，： | 1 |
| 12 | Laparoscopic management of small bowel obstruction:indications and outcome显示文摘 | Léon EL Metzger A Tsiotos GG | 1998 | J Gastrointrst Surg1998，2，2： | 1 |
| 13 | On the growth of highly ordered pores in anodized aluminum oxide显示文摘 | LI F ZHANG L Metzger R M | 1998 | Chem Mater1998，10，： | 1 |
| 14 | Heat transfer between an impingement jet and a rotating disk显示文摘 | Metzger D E Grochowsky L D | 1997 | Journal of Heat Transfer1997，101，： | 1 |
| 15 | Do Children 'D/R-M' Like Adults? False Memory Production in Children显示文摘 | Metzger R L Warren A R Price I D | 2008 | Developmental Psychology2008，44，： | 1 |
| 16 | Effect of temperature on seed dormancy of wheat 显示文摘 | Reddy L V Metzger R J Ching T M | 1985 | Crop Sci1985，25，3： | 1 |
| 17 | Stability and identification of ocean acoustic multipaths显示文摘 | SPIESBERGER J L SPINDEL R C METZGER K | 1980 | J Acoust Soc Am1980，67，6： | 1 |
| 18 | Hyperglycemia and adverse pregnancy outcomes显示文摘 | Metzger B E Lowe L P Dyer A R | 2008 | N Engl J Med2008，358，： | 1 |
| 19 | Oxaliplatin pharmacokinetics and Chronopharmacological Aspects 显示文摘 | Metzger G Massari C | 2000 | Clin Pharmacokinet2000，38，1： | 1 |
| 20 | Recent findings on the formation and decomposition of PCDD/PCDF in municipal solia waste incineration 显示文摘 | Vogg H Metzger M Stieglitz L | 1987 | Waste Management and Research1987，5，3： | 1 |
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