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| 1 | Role for urinary biomarkers in diagnosis of acute rejection in the transplanted kidney显示文摘Despite the introduction of potent immunosuppressive medications within recent decades, acute rejection still accounts for up to 12% of all graft losses, and is generally associated with an increased risk of late graft failure. Current detection of acute rejection relies on frequent monitoring of the serum creatinine followed by a diagnostic renal biopsy. This strategy is flawed since an alteration in the serum creatinine is a late clinical event and significant irreversible histologic damage has often already occurred. Furthermore, biopsies are invasive procedures that carry their own inherent risk. The discovery of non-invasive urinary biomarkers to help diagnose acute rejection has been the subject of a significant amount of investigation. We review the literature on urinary biomarkers here, focusing on specific markers perforin and granzyme B m RNAs, FOXP3 m RNA, CXCL9/CXCL10 and mi RNAs. These and other biomarkers are not yet widely used in clinical settings, but our review of the literature suggests that biomarkers may correlate with biopsy findings and provide an important early indicator of rejection, allowing more rapid treatment and better graft survival. | Basma Merhi George Bayliss Reginald Y Gohh | 2015 | World Journal of Transplantation2015，5，4： | 4 |
| 2 | BW775C,a dual lipoxygenasel,cyclooxygenase inhibitor,reduces mural platelet and neutrophil deposition and vasoconstriction after angioplasty injury pigs显示文摘 | Merhi Y | 1996 | J Pharmacol Exp Ther1996，227，1： | 1 |
| 3 | CD40 ligand: a neo - inflammatory molecule in vascular diseases 显示文摘 | HASSAN G S MERHI Y MOURAD W | 2012 | Immunobiology2012，217，5： | 1 |
| 4 | Increase of neutrophil adhesion and vasoconstriction with platelet deposition after deep arterial injury by angioplasty显示文摘 | Merhi Y Guidoin R Provost P | 1995 | Am Heart J1995，129，3： | 1 |
| 5 | Biodegradable membrane-covered stent from chitosan-based polymers 显示文摘 | Thierry B Merhi Y Silver J | 2005 | J Biomed Mater Res A2005，75，3： | 1 |
| 6 | 显示文摘 | Provost P Tremblay J Merhi Y | 1997 | Arterioscler Thromb Vasc Biol1997，17，9： | 1 |
| 7 | CD154 and itsreceptors in inflammatory vascular pathologies显示文摘 | Hassan G S Merhi Y Mourad W M | 2009 | Trends Immunol2009，30，4： | 1 |
| 8 | CD40 ligand: a neo-inflammato- ry molecule in vascular diseases 显示文摘 | Hassan GS Merhi Y Mourad W | 2012 | Immunobiology2012，217，5： | 1 |
| 9 | Biodegradable membrane-covered stent from chitosan-based polymers显示文摘 | Thierry B Merhi Y Silver J | 2005 | J Biomedical Mater Res Part A2005，75，3： | 1 |
| 10 | Bioactive coatings of endovascular stents based on polyelectrolyte multilayers 显示文摘 | Thierry B Winnik F M Merhi Y | 2003 | Biomacromolecules2003，4，6： | 1 |
| 11 | Biodegradable membrane-covered stent from chitosan-based polymers显示文摘 | Thierry B Merhi Y Silver J | 2005 | J Biomed Mater Res2005，75，： | 1 |
| 12 | CD154 and its receptors in inflammatory vascular pathologies显示文摘 | Hassan GS Merhi Y Mourad WM | 2009 | Trends Immunol2009，30，4： | 1 |
| 13 | CD40 Ligand: a neo-inflammatory molecule in vascular diseases 显示文摘 | Hassan G S Merhi Y Mourad W | 2012 | Immunobiology2012，217，5： | 1 |
| 14 | CD40 Ligand:A neo-inflammatory molecule in vascular diseases显示文摘 | Hassan GS Merhi Y Mourad W | | 0，，01： | 1 |
| 15 | The antiadhesive and antithromboric effects of the nitric oxide donor SIN - Ⅰ are combined with a decreased vasoconstriction in a porcine model of balloon angioplasty 显示文摘 | Tremblay J Merhi Y | 1997 | Arterioscler Throm Vasc Biol1997，17，： | 1 |
| 16 | CD40ligand:a neoinflammatory molecule in vascular diseases显示文摘 | HASSAN GS MERHI Y MOURAD W | 2012 | Immunobiology2012，217，5： | 1 |
| 17 | In vitro and in vivo characterization of an impervious polyester arterial prosthesis: the gelseal triaxial graft显示文摘 | Guidoin R Marceau D Rao T J King M Merhi Y Roy PE | 1987 | Biomaterials1987，8，： | 1 |
| 18 | The effect of varying A1203 percentage in hydroxyapatite/A1203 composite materials: morphological, chemical and cytotoxic evaluation显示文摘 | LM Epure S Dimitrievska Y Merhi | 2007 | Journal of Biomedical Material Research PartA2007，83，： | 1 |
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