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| 1 | Interferon-β induced in female genital epithelium by HIV-1 glycoprotein 120 via Toll-like-receptor 2 pathway acts to protect the mucosal barrier显示文摘More than 40%of HIV infections occur via female reproductive tract(FRT)through heterosexual transmission.Epithelial cells that line the female genital mucosa are the first line of defense against HIV-1 and other sexually transmitted pathogens.These sentient cells recognize and respond to external stimuli by induction of a range of carefully balanced innate immune responses.Previously,we have shown that in response to HIV-1 gp120,the genital epithelial cells(GECs)from upper reproductive tract induce an inflammatory response that may facilitate HIV-1 translocation and infection.In this study,we report that the endometrial and endocervical GECs simultaneously induce biologically active interferon-β(IFNβ)antiviral responses following exposure to HIV-1 that act to protect the epithelial tight junction barrier.The innate antiviral response was directly induced by HIV-1 envelope glycoprotein gp120 and addition of gp120 neutralizing antibody inhibited IFNβproduction.Interferon-βwas induced by gp120 in upper GECs through Toll-like receptor 2 signaling and required presence of heparan sulfate on epithelial cell surface.The induction of IFNβwas dependent upon activation of transcription factor IRF3(interferon regulatory factor 3).The IFNβwas biologically active,had a protective effect on epithelial tight junction barrier and was able to inhibit HIV-1 infection in TZM-bl indicator cells and HIV-1 replication in T cells.This is the first report that recognition of HIV-1 by upper GECs leads to induction of innate antiviral pathways.This could explain the overall low infectivity of HIV-1 in the FRT and could be exploited for HIV-1 prophylaxis. | Aisha Nazli Sara Dizzell Muhammad Atif Zahoor Victor H Ferreira Jessica Kafka Matthew William Woods Michel Ouellet Ali A Ashkar Michel J Tremblay Dawn ME Bowdish Charu Kaushic | 2019 | Cellular & Molecular Immunology2019，16，2： | 2 |
| 2 | Microsatellite analysis of genetic diversity in four populations of Populus tremuloids in Quebec显示文摘 | Wyman J Bruneau A Tremblay M F | 2003 | Can J Bot2003，81，： | 1 |
| 3 | Evaluation of the California mastitls test as a precalving treatment selection tool for Holstein heifers显示文摘 | Roy J P Du Tremblay D Descoteaux L | 2009 | Vet Microbiol2009，134，12： | 1 |
| 4 | Inhibition of Na+, K+ pump assecets nucleic acid synthesis and smooth muscle cell proliferation via elevation of the i/J ratio: Possible implication in vascular remodeling显示文摘 | Orlov SN Taurin S Tremblay J | 2001 | J Hypertens2001，19，9： | 1 |
| 5 | Active Video Games and Health Indicators in Children and Youth: A Systematic Review 显示文摘 | LeBlanc A Chaput J Tremblay M | 2013 | Plos ONE2013，，6： | 1 |
| 6 | Annual follow-up of gross diffusive carbon dioxide and methane emissions from a boreal reservoir and two nearby lakes in Qu@bec, Canada 显示文摘 | DEMARTY M BASTIEN J TREMBLAY A | 2011 | Biogeosciences2011，8，1： | 1 |
| 7 | Precocious puberty in adolescent girls: a biomarker of later psychosocial adjustment problems显示文摘 | Tremblay L Frigon J | 2005 | Child Psychiatry and Human Development2005，36，1： | 1 |
| 8 | On the sleeving of electrical insulation 显示文摘 | Beland B Tremblay J | 1993 | Fire & Arson Investigator1993，43，4： | 1 |
| 9 | Effects of temperature, salinity, and dissolved substance on the sorption of polycyclic aromatic hydrocarbons to estuarine particles显示文摘 | Tremblay L Kohl S D Rice J L | 2005 | Mar Chem2005，96，： | 1 |
| 10 | Genes of aging 显示文摘 | Hamet P Tremblay J | 2003 | Metabolism2003，52，102： | 1 |
| 11 | The pan-pituitary activator of transcription,Ptx1(pituitary homeobox 1),acts in synergy with SF-1 and Pit-1 and is an upstream regulator of the lim-homeodomain gene Lim3/Lhx3显示文摘 | Tremblay J J Lancto T C Drouin J | | 0，，： | 1 |
| 12 | Anatomy-driven design of a prototype video laryngoscope for extremely low birth weight infants显示文摘 | K Baker E Tremblay J Karp | 2010 | Journal of biomedical optics2010，15，6： | 1 |
| 13 | Atorvastatin increa- ses intestinal expression of NPC1 L! in hyperlipidemic men 显示文摘 | Tremblay A J Lamarche B Lemelin V | 2011 | J Lipid Res2011，52，3： | 1 |
| 14 | Atrophic facial scars secondary to discoid lupus erythematous: treatment using the Erbium: YAG laser 显示文摘 | TREMBLAY J F CAREY W | 2001 | Dermatol Surg2001，27，7： | 1 |
| 15 | P-nitrophenol-α -glucopyramoside as substract for measurement of maltase activityin human semen显示文摘 | CHAPDELAINE P TREMBLAY R R DUBE J Y | 1978 | Clinical Chemcical Chemistry1978，24，： | 1 |
| 16 | Physical aggression during early childhood:Trajectories and predictors显示文摘 | TREMBLAY R E NAGIN D S SEGUIN J R | | 0，，01： | 1 |
| 17 | The relation- ship between physical activity, self-esteem and academic a- chievement in 12-year-old children显示文摘 | TREMBLAY M S INMAN J W WILLMS J 12) | 2000 | Pediatri Exe Sci2000，12，31： | 1 |
| 18 | Discovery of a potent and orally active hedgehog pathway antagonist(IPI-926)显示文摘 | Tremblay M R Lescarbeau A Grogan M J | 2009 | Journal of Medicinal Chemistry2009，52，14： | 1 |
| 19 | Children's persistent lying,gender differences,and disruptive behaviours:A longitudinal perspective显示文摘 | Tremblay R E Gervai L D | 2000 | International Journal of Behavioral Development2000，，2： | 1 |
| 20 | Ectopical and abnormalhormone receptors in adrenal Cushing,s syndrome显示文摘 | Lacroix A Ndiaye N Tremblay J | | Endocr Rev0，22，1： | 1 |
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