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| 1 | The spatial variation of soil bacterial community assembly processes affects the accuracy of source tracking in ten major Chinese cities显示文摘Urban soils harbor billions of bacterial cells and millions of species.However,the distribution patterns and assembly processes of bacterial communities remain largely uncharacterized in urban soils.It is also unknown if we can use the bacteria to track soil sources to certain cities and districts.Here,Illumina MiSeq sequencing was used to survey soil bacterial communities from 529 random plots spanning 61 districts and 10 major cities in China.Over a 3,000 km range,community similarity declined with increasing geographic distance(Mantel r=0.62),and community composition was clustered by city(R^(2)=0.50).Within cities(<100 km),the aforementioned biogeographic patterns were weakened.Process analysis showed that homogenizing dispersal and dispersal limitation dominated soil bacterial assembly at small and large spatial scales,respectively.Accordingly,the probabilities of accurately tracking random soil sources to certain cities and districts were 90.0% and 66.7%,respectively.When the tested samples originated from cities that were more than 1,265 km apart,the soil sources could be identified with nearly 100% accuracy.Overall,this study demonstrates the strong distance-decay relationship and the clear geographic zoning of urban soil bacterial communities among cities.The varied importance of different community assembly processes at multiple spatial scales strongly affects the accuracy of microbial source tracking. | Teng Yang Yu Shi Jun Zhu Chang Zhao Jianmei Wang Zhiyong Liu Xiao Fu Xu Liu Jiangwei Yan Meiqing Yuan Haiyan Chu | 2021 | Science China(Life Sciences)2021，64，9： | 4 |
| 2 | Inhibitory effect of apolipoprotein A-I on matrix metalloproteinase-2 expression in vivo and in vitro显示文摘在现在的学习,我们调查了 apolipoprotein A-I 的效果(apoA -- 我) 在矩阵 metalloproteinase-2 (MMP-2 ) 上在 vivo 并且在 vitro 的表示。首先,我们检测了 apoA 的效果 -- 我在主动脉 MMP-2 上,激活 proliferator 的受体 /(PPAR /) , cyclooxygenase-2 (COX-2 ) ,和在动脉粥样硬化患者兔子的原子因素 kappa B (NF-B ) 表情用 immunohistochemical 方法建模的 peroxisome。结果证明 MMP-2, COX-2,和 NF-B 的表情在与 apoA 对待的动脉粥样硬化患者兔子的主动脉被减少 -- 我,当 PPAR / 表示被增加时。然后,我们选择了重要发炎房间,在 vitro 证明那些效果的巨噬细胞。巨噬细胞被划分成六个组并且与 apoA 的不同集中对待 -- 我, MMP-2 的 mRNA 表情, PPAR / ,和 COX-2 然后用 PPAR 的反向抄写的聚合酶链反应,和蛋白质表示被决定, NF-B 被西方的污点分析检测。在有教养的上层清液的 MMP-2 和 PPAR 的层次用连接酶的 immunosorbent 试金被决定。有趣地,在里面 vitro 结果类似于结果在里面 vivo 学习。在有 apoA 的孵化以后 -- 我为 24 h, MMP-2 的表情, COX-2,和 NF-B 被减少,当 PPAR / 表示被增加时。在他们在在 vivo 并且在 vitro 做匾马厩的进程的特别角色的考虑,我们推测 apoA 的禁止的效果 -- 我可以与 apoA 的效果在 MMP-2 表示上有一种靠近的关系 -- 我在 PPAR / , COX-2,和 NF-B 表达式上。尽管进一步的研究被需要澄清这些效果的内在的机制,我们的调查结果提供新奇卓见进 apoA 的反动脉粥样硬化患者匾破裂效果 -- 我。 | Weina Wang Xunlong Shi Yuan Yuan Haiyan Zhu Wei Zhou Hai Huang Meiqing Feng | 2013 | Acta Biochimica et Biophysica Sinica2013，45，3： | 2 |
| 3 | A biogeographic map of soil bacterial communities in wheats field of the North China Plain显示文摘The vast diversity of soil bacteria provides essential ecosystem services that support agricultural production.Variation in the diversity and composition of soil biota may have predictive values for soil nutrient cycling and resilience of ecosystem services,thus providing valuable insights to improve food production.The North China Plain(NCP)is one of the world’s key agricultural regions,supplying more than 50% of the cereal consumed in Asia.However,it is unknown whether soil microbial diversity is predictable across the NCP.Using the MiSeq Illumina platform,we examined bacterial community variation in relation to spatial and environmental factors from 243 soils in wheat-maize double cropping rotation fields across the NCP,which cover nearly 0.3 million km^(2).Based on observed bacterial communities and their relationships with environmental factors,we generated a map of bacterial communities across the NCP.The highest bacterial diversity was found in the middle part of the NCP,with most of the variation in diversity attributable to differences in the community similarity of Actinobacteria and Alphaproteobacteria.These findings provide important baseline information for analyzing the relationships between microbial community,soil functionality and crop yields. | Yu Shi Yuntao Li Meiqing Yuan Jonathan M.Adams Xianzhang Pan Yunfeng Yang Haiyan Chu | 2019 | Soil Ecology Letters2019，1，1： | 2 |
| 4 | Microbial produc-tion of medium-chain-length 3-hydroxyalkanoic acids by recombinant Pseudomonas putida KT2442 harboring genes fadL, fadD and phaZ显示文摘 | YUAN Meiqing SHI Zhengyu WEI Xiaoxing | 2008 | FEMS Microbiology Letters2008，283，2： | 1 |
| 5 | Establishing a cat model of chronic optic nerve compression injury显示文摘BACKGROUND:An animal model of chronic optic nerve injury is necessary to further understand the pathological mechanisms involved. OBJECTIVE:To establish a stabilized,chronic,optic nerve crush model,which is similar to the clinical situation to explore histopathological and optic electrophysiological changes involved in this injury. DESIGN,TIME AND SETTING:A randomized and controlled animal trial was performed at Shanghai Institute of Neurosurgery from May to October 2004. MATERIALS:A BAL3XRAY undetachable balloon and Magic-BD catheter were provided by BLAT, France;JX-2000 biological signal processing system by Second Military Medical University of Chinese PLA,China;inverted phase contrast microscopy by Olympus,Japan. METHODS:A total of twenty normal adult cats were randomly assigned to control(n=5) and model (n=15) groups,according to different doses of contrast agent injected through balloons as follows: 0.2 mL injection,0.25 mL injection,and 0.35 mL injection,with each group containing 5 animals. Imitating the clinical pterion approach,the optic nerves were exposed using micro-surgical methods. An engorged undetachable balloon was implanted beneath the nerve and connected to a catheter. Balloon size was controlled with a contrast agent injection(0.1 mL/10 min) to form an occupying lesion model similar to sellar tumors. MAIN OUTCOME MEASURES:The visually evoked potential examination was used to study optical electrophysiology changes in pre-post chronic optical nerve injury.Ultrastructural pathological changes to the optic nerve were analyzed by electron microscopy. RESULTS:During the early period(day 11 after modeling),visually evoked potential demonstrated no significant changes.In the late period(day 51 after modeling),recorded VEP demonstrated that P1 wave latency was prolonged and P1 wave amplitude was obviously reduced.Following injury, the endoneurium,myelin sheath,lamella,axolemma,and axon appeared disordered. CONCLUSION:Results demonstrated that the chronic,intracranial,optical nerve crush model was stable and could simulate optic nerve lesions induced by sellar tumors.Under the condition of chronic optical nerve crush,visually evoked potentials were aggravated. | Feng Yu Shaoji Yuan Rongwei Zhang Yicheng Lu Meiqing Lou | 2009 | Neural Regeneration Research2009，4，6： | 0 |
| 6 | Efficacy of comprehensive cognitive health management for Shanghai community older adults with mild cognitive impairment显示文摘Background The management of modifiable risk factors and comorbidities may impact the future trajectory of cognitive impairment,but easy-to-implement management methods are lacking.Aims This study investigated the effects of simple but comprehensive cognitive health management practices on the cognitive function of older adults in the community with normal cognition(NC)and mild cognitive impairment(MCI).Methods The comprehensive cognitive health management programme included a psychiatric assessment of the cognitive risk factors for those in the intervention groups and individualised recommendations for reducing the risks through self-management supported by regular medical professional follow-up.The intervention groups for this study included 84 elderly participants with NC and 43 elderly participants with MCI who received comprehensive cognitive health management.The control groups included 84 elderly participants with NC and 43 elderly participants with MCI who matched the intervention group’s general characteristics and scale scores using the propensity matching score analysis.The Montreal Cognitive Assessment(MoCA)scale and Geriatric Depression Scale(GDS)scores were compared after a 1-year follow-up.Results For older adults with MCI in the intervention group,MoCA scores were higher at the 1-year followup than at baseline(24.07(3.674)vs 22.21(3.052),p=0.002).For the MoCA subscales,the intervention group’s abstract and delayed memory scores had significantly increased during the 1-year follow-up.Furthermore,in a generalised linear mixed model analysis,the interaction effect of group×follow-up was statistically significant for the MCI group(F=6.61,p=0.011;coefficients=5.83).Conclusions After the comprehensive cognitive health management intervention,the older adults with MCI in the community showed improvement at the 1-year follow-up.This preliminary study was the first to demonstrate an easy-to-implement strategy for modifying the cognitive risk factors of elderly individuals with MCI in the community,providing new insight into early-stage intervention for dementia. | Jiayuan Qiu Lu Zhao Shifu Xiao Shaowei Zhang Ling Li Jing Nie Li Bai Shixing Qian Yang Yang Michael Phillips Meiqing Sheng Yuan Fang Xia Li | 2022 | General Psychiatry2022，35，4： | 0 |
| 7 | Supplementary Control for Mitigation of Successive Commutation Failures Considering the Influence of PLL Dynamics in LCC-HVDC Systems显示文摘Line commutated converter based high voltage direct current(LCC-HVDC)links are widely employed for long distance bulk power transmission and asynchronous alternating current(AC)grid connections.However,LCC-HVDC systems often suffer from commutation failures when AC voltage is distorted,oscillating or reduced by AC faults,which leads to overheating of converter valves and interruptions in transmitted power.All of which can have an adverse impact on the safety and stability of the entire power system.This paper proposes a supplementary control for mitigation of successive commutation failures on the basis of analyzing the influence of phase-locked loop(PLL)dynamics on the commutation process.By analyzing the impact of PLL dynamics on the actual leading angle,it is found that changes in the AC voltage phase remarkably influence commutation.Accordingly,the error between the AC voltage phase and PLL’s output angle is added to the output of the extinction angle or DC voltage control to mitigate the successive commutation failures of LCC-HVDC stations.Simulations conducted on the CIGRE benchmark model in PSCAD/EMTDC validate the performance of the supplementary control,which effectively mitigates successive commutation failures. | Jun Lu Xiaoming Yuan Meiqing Zhang Jiabing Hu | 2022 | CSEE Journal of Power and Energy Systems2022，8，3： | 0 |
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