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| 1 | Systematic review of periprosthetic tibia fracture after total knee arthroplasties显示文摘AIM: To investigate the known incidences, treatment options, and related outcomes of periprosthetic tibia fractures after total knee arthroplasty(TKA).METHODS: A literature search was done to identify studies that fit the inclusion criteria. The database search yielded 185 results, which were further reduced by the exclusion criteria to 13 papers, totaling 157 patients that met these criteria. Incidence rates of the different types of periprosthetic tibia fractures were determined and their treatments were subsequently analyzed based on the fracture's subclass, with patient outcomes being overall favorable.RESULTS: Of the 144 documented patients, 54(37.5%) had a subclass C fracture, which are frequently seen in revision arthroplasties or when using cement intraoperatively. The fractures of subclasses A and B occur postoperatively. There were 90 subclass A and B fractures with incidences of 18.75% and 43.75% respectively. When broken down by type, 62(55.36%) were type 1, 24(21.4%) were type 2, 24(21.4%) were type 3, and 2(1.8%) were type 4. Furthermore, from the studies that included origin of injury, the types were further classified as having non-traumatic or traumatic origins. Type 1 had 78%(40/51) non-traumatic origin and 22%(11/51) traumatic origin. Fifteen fractures were type 2, but 5 were falls and 1 through a motor vehicle accident, giving a trauma causation of 40%(6/15). Of the 24 type 3 fractures, 12 were falls and 2 vehicular accidents, leading to a trauma causation of 58%(14/24).CONCLUSION: Type 1 fractures were the most common. Subclass A was treated with locking plates, B required a revision TKA, and C was treated intraoperatively or nonoperatively. | Nabil A Ebraheim Joseph R Ray Meghan E Wandtke Grant S Buchanan Chris G Sanford Jiayong LiuZ | 2015 | World Journal of Orthopedics2015，6，8： | 4 |
| 2 | Comparisons of stake- holder perceptions of tourism impacts in rural eastern North Carolina显示文摘 | Erick T B Holly E B Meghan G D | 2009 | Tourism Management2009，30，5： | 1 |
| 3 | Metrics for ranking the performance of supercomputers显示文摘 | Tzu Y C Meghan G Beth S | 2006 | CTWatch2006，2，4： | 1 |
| 4 | Reactive sorption of chlorinated VOCs on ZSM-5 zeolites at ambient and elevated temperatures显示文摘 | MEGHAN E S HOWARD L G SYED Q | 2004 | Appl Catal B: Environ2004，52，2： | 1 |
| 5 | Comparisons Of Stakeholder Perceptions Of Tourism Impacts In Rural Eastern North Car- olina显示文摘 | Erick T B Holly E B Meghan G D | 2009 | Tourism Management2009，30，5： | 1 |
| 6 | Comparisons of stake- holder perceptions of tourism impacts in rural eastern North Carolina 显示文摘 | Erick T B Holly E B Meghan G D | 2009 | Tourism Management2009，30，5： | 1 |
| 7 | Volumetric reductions in the subgenual anterior cingulate cortex in adolescents with bipolar I disorder显示文摘 | Manpreet K Singh Kiki D Chang Michael C Chen Ryan G Kelley Amy Garrett Myles M Mitsunaga Layla Bararpour Meghan Howe Allan L Reiss Ian H Gotlib | 2012 | Bipolar Disorders2012，，6： | 1 |
| 8 | Comparisons of stakeholder perceptions of tourism impacts in rural eastern North Carolina 显示文摘 | Erick T B Holly E B Meghan G D | 2009 | Tourism Management2009，30，5： | 1 |
| 9 | Comparisons Of Stakeholder Perceptions Of Tourism Impacts In Rural Eastern North Carolina显示文摘 | Erick T B Holly E B Meghan G D | 2009 | Tourism Management2009，30，5： | 1 |
| 10 | Pancreatic intraductal papillary mucinous neoplasm in a patient with Lynch syndrome显示文摘Intraductal papillary mucinous neoplasm(IPMN) is a mucin-producing epithelial neoplasm that carries a risk of progression to invasive pancreatic ductal adenocarcinoma.Lynch syndrome is an autosomal dominant condition caused by germline mutations in mismatch repair genes such as MSH2 that lead to microsatellite instability and increased risk of tumor formation.Although families with Lynch syndrome have an increased risk of pancreatic cancer, a clear connection between Lynch syndrome and IPMN has not been drawn.We present a report of a 58 year-old Caucasian woman with multiple cancers and a germline mutation of MSH2 consistent with Lynch syndrome.A screening abdominal computed tomography scan revealed a dilated main pancreatic duct and cystic ductular structure in the uncinate process that were consistent with IPMN of the main pancreatic duct on excision.Immunohistochemistry and polymerase chain reaction of the patient's pancreas specimen did not reveal microsatellite instability or mismatch repair gene loss of expression or function.Our findings may be explained by the fact that loss of mismatch repair function and microsatellite instability is a late event in neoplastic transformation.Given the relative rarity of main duct IPMN, its appearance in the setting of somatic MSH2 mutation suggests that IPMN may fit into the constellation of Lynch syndrome related malignancies. | Meghan R Flanagan Arjun Jayaraj Wei Xiong Matthew M Yeh Wendy H Raskind Venu G Pillarisetty | 2015 | World Journal of Gastroenterology2015，21，9： | 1 |
| 11 | Neonatal pneumothorax in congenital diaphragmatic hernia:Be wary of high ventilatory pressures显示文摘Background Patients with congenital diaphragmatic hernia(CDH)require invasive respiratory support and higher ventilator pressures may be associated with barotrauma.We sought to evaluate the risk factors associated with pneumothorax in CDH neonates prior to repair.Methods Weretrospectivelyreviewednewborns born withCDHbetween 2014and 2019who developeda pneumothorax,and we matched these cases to patients with CDH without pneumothorax.Results Twenty-sixpatientswere included(n=13per group).The pneumothorax group required extracorporeal life support(ECLS)more frequently(85%vs 54%,p=0.04),particularly among type A/B defects(31%vs 7%,p=0.01).The pneumothorax group had higher positive end-expiratory pressure(PEEP)within 1 hour of birth(p=0.02),at pneumothorax diagnosis(p=0.003),and at ECLS(p=0.02).The pneumothorax group had a higher mean airway pressure(Paw)at birth(p=0.01),within 1 hour of birth(p=0.01),and at pneumothorax diagnosis(p=0.04).Using multiple logistic regression with cluster robust SEs,higher Paw(OR 2.2,95%Cl 1.08 to 3.72,p=0.03)and PEEP(OR 1.8,95%CI 1.15 to 3.14,p=0.007)were associated with an increased risk of developing pneumothorax.There was no difference in survival(p=0.09).Conclusions Development of a pneumothorax in CDH neonates is independently associated with higher Paw and higher PEEP.A pneumothorax increases the likelihood of treated with ECLS,even with smaller defect. | Nathan Rubalcava Gabriella A Norwitz Aimee G Kim Gary Weiner Niki Matusko Meghan A Arnold George B Mychaliska Erin E Perrone | 2022 | World Journal of Pediatric Surgery2022，5，3： | 0 |
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