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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Colloidal transport: the facilitated movement of contaminants into groundwater 显示文摘 | Richards B K McCarthy J F Steenhuis T S | 2007 | Journal of Soil & Water Conservation2007，62，3： | 1 |
| 3 | Cysteamine-induced enhancement of growth hormone-releasing factor (GRF) immuno-reactivity in arcuate neurons:morphological evidence for putactive somatostatin/GRF interactions within hypothalamus 显示文摘 | Tannenbaum G S McCarthy G F | 1990 | Endocrinology1990，127，5： | 1 |
| 4 | In search of early pregnancy factor:isolation of active polypeptides from pregnant ewes' sera显示文摘 | Wilson S McCarthy R Clarke F | 1983 | J Reprod Immunol1983，5，5： | 1 |
| 5 | Characterization ofUnited States outbreak isolates of Vibrio parahaemolyticus usingenterobacterial repetitive intergenic consensus (ERIC) PCR anddevelopment of a rapid PCR method for detection of 03:K6isolates显示文摘 | Khan A A McCarthy S Wang R F ei al | 2002 | Fems Microbiology Letters2002，206，2： | 1 |
| 6 | Synthesis and characterization of a series of poly(al-kylene carbonate)macrodiols and the effect of their structure on the properties of polyurethanes 显示文摘 | Gunatillake P A Me(is G F McCarthy S J | 1998 | Journal of Applied Polymer Science1998，69，8： | 1 |
| 7 | Preparation and characterization of sol-gel derived Y2O3 thin films显示文摘 | Teowee G Mccarthy K C Mccarthy F S | 1998 | J Sol-Gel Sci Techn1998，13，13： | 1 |
| 8 | Synthesis, Charac terization, and Stability of Poly 显示文摘 | Mccarthy S J Meijs G F Gunatillake P | 1997 | J Appl Polym Sci1997，65，7： | 1 |
| 9 | A phase Ⅱ trial of docetaxel and cisplatin in patients with recurrent or metastatic nasopharyngeal carcinoma显示文摘 | McCarthy J S Tannock I F Degendorfer P | 2002 | Oral Oncol2002，38，7： | 1 |
| 10 | The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit显示文摘 | Dias A Bouvier D Crépin T McCarthy A A Hart D J Baudin F Cusack S Ruigrok R W | 2009 | Nature2009，458，7240： | 1 |
| 11 | Corporate debt capacity and capital budgeting analysis显示文摘 | Rhee S G McCarthy F L | 1982 | Financial Management1982，11，2： | 1 |
| 12 | Synthesis and characterizatioa of a series of pely(alkylene carbonate)macrodiols and the effect of their structure on the properties of polyurethanes显示文摘 | Gunatillake P A Meijs G F McCarthy S J | 1998 | Journal of Applied Polymer Science1998，69，8： | 1 |
| 13 | The conditional probability of survival of patients with primary malignant brain tumors:surveillance,epidemiology,and end results (SEER) data显示文摘 | Davis F G McCarthy B J Freels S | | 0，，2： | 1 |
| 14 | Structure of the 4He nucleus from elastic electron scattering显示文摘 | FROSCH R F McCARTHY J S RAND R E | 1967 | Phys Rev1967，160，4： | 1 |
| 15 | Evidence implicating peroxisome proliferator-activated receptor-α in the pathogenesis of preeclampsia显示文摘 | McCarthy F P Drewlo S English F A Kingdom J Johns E J Kenny L C | 2011 | Hypertension2011，58，： | 1 |
| 16 | Molecular charaeterisation of Australian bovine enteroviruses显示文摘 | Mccarthy F M Smith G A Mattick J S | 1999 | Vet Microbiol1999，68，12： | 1 |
| 17 | Progesterone facilitates chromosome instability (aneuploidy) in p53 null normal mammary epithelial cells显示文摘 | Goepfert T M McCarthy M Kittrell F S | 2000 | FASEB J2000，14，14： | 1 |
| 18 | Poly (dimethylsiloxane)/poly (hexamethylene oxide ) mixed macrodiol based polyurethane elastomers Ⅰ:Synthesis and properties显示文摘 | GUNATILLAKE P A MEIJS G F MCCARTHY S J | 2000 | Journal of Applied Polymer Science2000，76，14： | 1 |
| 19 | Peroxisome proliferator activated receptor-3, as a potential therapeutic target in the treatment of preeclampsia显示文摘 | McCarthy F P Drewlo S Kingdom J Johns E J Walsh S K Kenny L C | 2011 | Hypertension2011，58，： | 1 |
| 20 | Colloidal transport: the facilitated movement of contaminants into groundwater显示文摘 | Richards B K McCarthy J F Steenhuis T S | 2007 | Journal of Soil & Water Conservation2007，62，3： | 1 |
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