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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Intra-event variability of Escherichia coli and total suspended solids in ur- ban stormwater runoff显示文摘 | McCarthy D T Hathaway J M Hunt W F | 2012 | Water Research2012，46，20： | 1 |
| 3 | Nutrient data on chestnuts consumed in the United States显示文摘 | McCARTHY M A MEREDITH F I | 1988 | Economic Botany1988，42，1： | 1 |
| 4 | Bolt-hole clearance effects and strength criteria in single-bolt, single-lap, composite bolted joints显示文摘 | MCCARTHY M A LAWLOR V P STANLEY W F | 2002 | Composite Science and Technology2002，62，1011： | 1 |
| 5 | Mobility of natural organic-matter in a sandy aquifer 显示文摘 | McCarthy J F Williams T M Liang L Y | 1993 | Environmental Science Technology1993，27，： | 1 |
| 6 | Investigation of some factors affecting non flame generation and suppression of SO3显示文摘 | Zetlmeisl M J McCarthy K J Laurence D F | 1983 | Industrial Engineering and Chemistry Product Research and Development1983，，22： | 1 |
| 7 | Subsurface transport of contaminants:binding to mobile and immobile phases in groundwater aquifers显示文摘 | McCarthy J F Zachara J M | 1989 | Environment Science Technology1989，23，： | 1 |
| 8 | Subsurface transport of contaminants显示文摘 | McCarthy J F Zachara J M 1989 | 1989 | Environ Sci Technol1989，23，： | 1 |
| 9 | Genetic analysis of bovine viral diarrhoea viruses from Australia显示文摘 | Mahony T J McCarthy F M Gravel J L | 2005 | Vet Microbiol2005，106，： | 1 |
| 10 | Mechanisms of dissolved organic carbon adsorption on soil 显示文摘 | Jardine P M Mccarthy J F Weber N L | 1989 | Soil Science Society of A-merica Journal1989，53，5： | 1 |
| 11 | Bolt-hole clearance effects and strength criteria in single-bolt, single-lap, composite bolted joints显示文摘 | Mccarthy M A Lawlor V P Stanley W F | 2002 | Composite Science and Technology2002，62，1011： | 1 |
| 12 | Analysis of Bovine Viral Diarrhea Viruses-infected monocytes:identification of cytopathic and non-cytopathic biotype differences显示文摘 | Ammari M McCarthy F M Nanduri B | | 0，，6： | 1 |
| 13 | Experiences with modeling friction in composite bolted joints显示文摘 | MCCARTHY C T MCCARTHY M A STANLEY W F | 2005 | Journal of Composite Materials2005，39，21： | 1 |
| 14 | Using reverse osmosis to obtain organic matter from surface and ground waters显示文摘 | Sun L Perdue E M McCarthy J F | 1995 | Wat Res1995，29，6： | 1 |
| 15 | Genetic analysis of bovine viral diarrhea viruses from Australia显示文摘 | Mahony T J McCarthy F M Gravel J L | 2005 | Vet Micro- biol2005，106，1： | 1 |
| 16 | Subsurface transport of contaminants显示文摘 | MCCARTHY J F ZACHARA J M | 1989 | Environmental Science and Technology1989，，23： | 1 |
| 17 | Right ventricular dysfunction mad dilatation, similar to left ventricular changes, characterize the cardiac depression of septic shock in humans显示文摘 | PARKER M M MCCARTHY K E OGNIBENE F P | 1990 | Chest1990，97，1： | 1 |
| 18 | maternal plasma leptin is increased in preeclampsia and positively correlates with fetal cord concentration显示文摘 | McCarthy J F Misra D N Roberts J M | 1999 | Am J Obstet Gynecol1999，180，3： | 1 |
| 19 | High speed imaging of the flow during close-coupled gas atomization: Effect of melt delivery nozzle geometry 显示文摘 | MULLIS A M MCCARTHY I N COCHRANE R F | 2011 | Journal of Materials Processing Technology2011，211，9： | 1 |
| 20 | Modeling a whole organ using proteomics: The avian bursa of Fabricius 显示文摘 | McCARTHY F M COOKSEY A M WANG N | 2006 | Proteomics2006，6，： | 1 |
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