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| 1 | Lesion-symptom mapping with NIHSS sub-scores in ischemic stroke patients显示文摘Background Lesion-symptom mapping(LSM)is a statistical technique to investigate the population-specific relationship between structural integrity and post-stroke clinical outcome.In clinical practice,patients are commonly evaluated using the National Institutes of Health Stroke Scale(NIHSS),an 11-domain clinical score to quantitate neurological deficits due to stroke.So far,LSM studies have mostly used the total NIHSS score for analysis,which might not uncover subtle structure–function relationships associated with the specific sub-domains of the NIHSS evaluation.Thus,the aim of this work was to investigate the feasibility to perform LSM analyses with sub-score information to reveal category-specific structure–function relationships that a total score may not reveal.Methods Employing a multivariate technique,LSM analyses were conducted using a sample of 180 patients with NIHSS assessment at 48-hour post-stroke from the ESCAPE trial.The NIHSS domains were grouped into six categories using two schemes.LSM was conducted for each category of the two groupings and the total NIHSS score.Results Sub-score LSMs not only identify most of the brain regions that are identified as critical by the total NIHSS score but also reveal additional brain regions critical to each function category of the NIHSS assessment without requiring extensive,specialised assessments.Conclusion These findings show that widely available sub-scores of clinical outcome assessments can be used to investigate more specific structure–function relationships,which may improve predictive modelling of stroke outcomes in the context of modern clinical stroke assessments and neuroimaging. | Deepthi Rajashekar Matthias Wilms M Ethan MacDonald Serena Schimert Michael D Hill Andrew Demchuk Mayank Goyal Sean P Dukelow Nils Daniel Forkert | 2022 | Stroke & Vascular Neurology2022，7，2： | 7 |
| 2 | In-vitro scolicidal activity of Mallotus philippinensis (Lam.) Muell Arg. fruit glandular hair extract against hydatid cyst Echinococcus granulosus显示文摘Objective: To investigate new scolicidal agent from natural resources to cope with the side effects associated with synthetic drugs in Echinococcosis. Methods: The scolicidal potential of methanolic fruit powder extract (10 and 20 mg/mL) of Mallotus philippinensis ( M. philippinensis ) was investigated. Viability of protoscoleces was confirmed by trypan blue exclusion method, where mortality was observed at concentration of 10 and 20 mg/mL in 60 min treatment against Echinococcus granulosus ( E. granulosus ), under in-vitro conditions with reference to the known standard drug Praziquantel . Results: At concentration 10 and 20 mg/mL, the mortality rate was observed 97% and 99% respectively for 60 min treatment; while up to 93% mortality was observed with 20 mg/mL for only 10 min treatment. The concentration above 20 mg/mL for above 2 h showed 100% mortality, irrespective of further incubation. Conclusions: As compared with the standard anti-parasitic drug Praziquantel our extract has significant scolicidal activity with almost no associated side effects. | Mayank Gangwar Vijay C Verma Tryambak D Singh Sushil K Singh RK Goel Gopal Nath | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，8： | 3 |
| 3 | Hydrodynamics and mass transfer characteristics of gas-liquid ejectors显示文摘 | Balamurugan S Mayank D Lad Vilas G Gaikar | 2007 | Chemical Engineering Journal2007，137，： | 1 |
| 4 | A Robust Skin Color Based Face Detection Algorithm显示文摘 | Sanjay Kr Singh D S Chauhan Mayank Vatsa | 2003 | Tamkang Journal of Science and Engineering2003，6，4： | 1 |
| 5 | 显示文摘 | Bhikhu S Mayank D | 1993 | Appl Polym Sci1993，40，： | 1 |
| 6 | A Robust Skin Color Based Face Detection Algorithm显示文摘 | Sanjay Kr Singh D S Chauhan Mayank Vatsa | 2003 | Tamkang Journal of Science and Engineering2003，6，4： | 1 |
| 7 | Nosocomial cross - transmission of Pseudomonas aeruginasa between patients in a tertiary intensive care unit显示文摘 | Mayank D Anshuman M Singh RK | 2009 | Indian J Pathol Microbiol2009，52，4： | 1 |
| 8 | Hydrodynamics and mass transfer characteristics of gas-liquid ejectors 显示文摘 | Balamurugan S Mayank D Lad Vilas G Gaikar | 2007 | Chem Eng J2007，131，13： | 1 |
| 9 | Dianthin-EGF is an effective tumor targeted toxin in combination with saponins in a xenograft model for colon carcinoma显示文摘 | Benedicta von Mallinckrodt Mayank Thakur Alexander Weng Roger Gilabert-Oriol Horst Dü rkop Winfried Brenner Mathias Lukas Nicola Beindorff Matthias F Melzig Hendrik Fuchs | 2014 | Future Oncol2014，，14： | 1 |
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