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| 1 | VEGFR-3 ligand-binding and kinase activity are required for lymphangiogenesis but not for angiogenesis显示文摘尽管 VEGFR-3 缺乏破坏血脉管的开发在早 embryogenesis 期间,内在的机制不是清楚的。在 angiogenesis 和 lymphangiogenesis 描绘它的函数,我们在这研究雇用了二个遗传上修改的鼠标模特儿,与一个 inactivation 点变化(Vegfr3TKmut ) 为 ligand 有约束力的域(Vegfr3 螖 L BD ) 或酷氨酸 kinase 域指向编码区域。我们证明淋巴的生长在 Vegfr3 螖 L BD/螖 L BD 和 Vegfr3TKmut/TKmut 老鼠被破坏,但是血容器在胚胎和蛋黄囊通常发展了。有趣地在 Vegfr3 螖 L BD/螖 L BD 然而并非 Vegfr3TKmut/TKmut 老鼠,淋巴囊是在场的,但是有发芽的 lymphangiogenic 的缺乏。我们进一步证明 VEGFR-3 的野类型、变异的形式能与 VEGFR-2 形成 heterodimers,并且减少在 endothelial 房间的 phospho-VEGFR-2 和下游的 phospho-Erk1/2 的水平当他们与 VEGF 被对待时 -- 一。这些调查结果显示发信号由它的血缘的 ligands (VEGF-C/-D ) 经由 VEGFR-3 激活调停了没为 angiogenesis 被要求,并且那 VEGFR-3 可以由 modulating VEGFR-2-mediated 信号在这个过程起一个作用。 | Luqing Zhang Fei Zhou Wencan Han Bin Shen Jincai LUO Masabumi Shibuya Yulong He | 2010 | Cell Research2010，20，12： | 7 |
| 2 | Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis显示文摘 | Masabumi Shibuya Lena Claesson-Welsh | 2005 | Experimental Cell Research2005，，5： | 2 |
| 3 | Apoptotic DNA fragmentation and upregulation of Bax induced by transient ischemia of the rat retina显示文摘 | Katsuyuki Kaneda Satoshi Kashii Takayuki Kurosawa Shuji Kaneko Akinori Akaike Yoshihito Honda Masabumi Minami Masamichi Satoh | 1999 | Brain Research1999，，1： | 2 |
| 4 | 经颅磁刺激运动诱发电位在腰椎管狭窄症临床评价中的应用价值显示文摘目的分析经颅磁刺激运动诱发电位(motor evoked potentials,MEP)在腰椎管狭窄症临床评价中的应用价值。方法23例腰椎管狭窄患者,男12例,女lI例;年龄52-83岁,平均67.9岁。单纯腰椎管狭窄症11例,合并腰椎退变性滑脱12例。就诊时平均病程31.5个月(3个月-10年)。出现单侧下肢症状者(疼痛或麻木、无力)9例,双下肢均出现者14例。所有患者均合并间歇性跛行,出现跛行前平均行走距离为302.1m(3-1000m)。MRI中最狭窄节段的硬膜囊面积值(minimum cross-sectional area,MCSA)平均0.4cm。(0.1-4).9em。)。于患者双侧跨内收肌处记录经颅磁刺激MEP潜伏期(MEP latency,MEPLT),同时收集患者治疗前JOA评分、视觉模拟评分(VAS,包括腰痛,下肢、臀部痛及麻木程度)。采用SPSS12.0软件进行统计学分析。结果MEPLT为(42.1+2.8)ms,JOA评分为(15.9+4.8)分。腰痛、下肢及臀部痛、下肢及臀部麻木感VAS分别为(6.0+2.9)分、(7.7+1.9)分、(7.3+3.0)分。MEPLT与步行距离、下肢症状类型及麻木VAS存在相关。步行距离〈500m者MEPLT明显延长(t=3.529,P〈0.05)。结论MEPLT延长在腰椎管狭窄患者出现临床体征之前即可出现,MEP可有效反映患者的主观症状。 | 刘新宇 Shunsuke Konno Masabumi Miyamoto Yoshikazu Gembun Gen Horiguchi Hiromoto Ito 郑燕平 李建民 宫良泰 | 2009 | 中华骨科杂志2009，29，1： | 2 |
| 5 | Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis显示文摘 | Masabumi Shibuya Lena Claesson-Welsh | 2005 | Experimental Cell Research2005，，5： | 1 |
| 6 | Diffusion coefficient of tritium in V ,Nb ,and Ta显示文摘 | Tomohiro K Masabumi N | 2004 | Fus Sci Techno12004，46，12： | 1 |
| 7 | Composite plating of Ni/SiC using azo-cationic surfactants and wear resistance of coatings 显示文摘 | Nabeen K Shrestha Masabumi Masuko Tetsuo Saji | 2003 | Wear2003，254，56： | 1 |
| 8 | Composite plating of Ni/SiC using azo-cationic surfactants and wear resistance of coatings显示文摘 | Nabeen K Shrestha Masabumi Masubo Tetsuo Saji | 2003 | Wear2003，254，： | 1 |
| 9 | Dacryocystorhinostomy for ddacryocystitis caused by methicillin~resistant staphylococcus aureus:report of four cases显示文摘 | | 2002 | Jpa J Ophthalmol2002，46，2： | 1 |
| 10 | Chemokines and their receptors in the brain: Pathophysiological roles in ischemic brain injury显示文摘 | Masabumi Minami Masamichi Satoh | 2003 | Life Sciences2003，，2： | 1 |
| 11 | Influence of lubricant additive and surface texture on the sliding friction characteristics of steel under varying speeds ranging from ultra low to moderate 显示文摘 | Masabumi Masuko Saiko Aoki Akihito Suzuki | 2005 | Tribology Transaction2005，48，： | 1 |
| 12 | Vascular endothelial growth factor and its receptor system: physiological functions in angiogenesis and pathological roles in various diseases显示文摘 | Masabumi Shibuya | 2013 | JBiochem2013，153，1： | 1 |
| 13 | Vascular endothelial growth factor- dependent and - independent regulation of angiogenesis显示文摘 | MASABUMI SHIBUYA | 2008 | BMB reports2008，41，4： | 1 |
| 14 | 显示文摘 | TOMOHIRO K MASABUMI N | 2004 | Fusion Science and Technology2004，46，12： | 1 |
| 15 | Japanese Orthopaedic Association Cervical Myelopathy Evaluation Questionnaire (JOACMEQ): part 4. Establishment of equations for severity scores显示文摘 | Mitsuru Fukui Kazuhiro Chiba Mamoru Kawakami Shinichi Kikuchi Shinichi Konno Masabumi Miyamoto Atsushi Seichi Tadashi Shimamura Osamu Shirado Toshihiko Taguchi Kazuhisa Takahashi Katsushi Takeshita Toshikazu Tani Yoshiaki Toyama Kazuo Yonenobu Eiji Wada T | 2008 | Journal of Orthopaedic Science2008，，1： | 1 |
| 16 | A Vacuum Four-Ball Tribometer to Evaluate Liquid Lubricants for Space Applications显示文摘 | Jones William R | 1994 | Lubr Eng1994，50，11： | 1 |
| 17 | An outcome measure for patients with cervical myelopathy: Japanese Orthopaedic Association Cervical Myelopathy Evaluation Questionnaire (JOACMEQ): Part 1显示文摘 | Mitsuru Fukui Kazuhiro Chiba Mamoru Kawakami Shin-ichi Kikuchi Shin-ichi Konno Masabumi Miyamoto Atsushi Seichi Tadashi Shimamura Osamu Shirado Toshihiko Taguchi Kazuhisa Takahashi Katsushi Takeshita Toshikazu Tani Yoshiaki Toyama Eiji Wada Kazuo Yonenobu | 2007 | Journal of Orthopaedic Science2007，，3： | 1 |
| 18 | VEGF-VEGFR System as a Target for Suppressing Inflammation and other Diseases显示文摘 | Masabumi Shibuya | 2015 | Endocrine, Metabolic & Immune Disorders-Drug Targets2015，，2： | 1 |
| 19 | Development of Toyotag 'New Super CVT显示文摘 | Nishigaya Masabumi | 2010 | SAE paper2010，，1： | 1 |
| 20 | Vascular Endothelial Growth Factor (VEGF) and Its Receptor (VEGFR) Signaling in Angiogenesis: A Crucial Target for Anti - and Pro - Angiogenic Therapies 显示文摘 | Masabumi Shibuya | 2011 | Genes and cancer2011，2，12： | 1 |
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