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| 1 | 多器官床旁即时超声在新型冠状病毒肺炎中的应用:国际专家共识显示文摘新型冠状病毒肺炎(简称新冠肺炎,COVID-19)自首次报道以来,已造成全球超一亿人感染,给各国的公共卫生体系造成了巨大威胁。新冠肺炎的临床表现以呼吸系统体征和症状为主,80%的患者症状轻微,约5%为危重症患者,常表现为急性呼吸窘迫综合征(ARDS)。前期,由于缺乏相关研究,面对日益紧迫的临床困境,医务人员不得不借鉴采取一些经验性措施以应对疫情。 | 王臻(译) Arif Hussain Gabriele Via Lawrence Melniker Alberto Goffi Guido Tavazzi Luca Neri Tomas Villen Richard Hoppmann Francesco Mojoli Vicki Noble Laurent Zieleskiewicz Pablo Blanco Irene W.Y.Ma Mahathar Abd.Wahab Abdulmohsen Alsaawi Majid AI Salamah Martin Balik Diego Barca Karim Bendjelid Belaid Bouhemad Pablo Bravo-Figueroa Raoul Breitkreutz Juan Calderon Jim Connolly Roberto Copetti Francesco Corradi Anthony J.Dean AndréDenault Deepak Govil Carmela Graci Young-Rock Ha Laura Hurtado Toru Kameda Michael Lanspa Christian B Laursen Francis Lee Rachel Liu Massimiliano Meineri Miguel Montorfano Peiman Nazerian Bret P.Nelson Aleksandar N.Neskovic Ramon Nogue Adi Osman JoséPazeli Elmo Pereira-Junior Tomislav Petrovic Emanuele Pivetta Jan Poelaert Susanna Price Gregor Prosen Shalim Rodriguez Philippe Rola Colin Royse Yale Tung Chen Mike Wells Adrian Wong Wang Xiaoting Wang Zhen Yaseen Arabi | 2021 | 中国呼吸与危重监护杂志2021，20，2： | 5 |
| 2 | Ex Vivo bone formation in bovine trabecular bone cultured in a dynamic 3D bioreactor is enhanced by compressive mechanical strain显示文摘 | David V Guignandon A Martin A Malaval L Lafage-Proust MH Rattner A Mann V Noble B Jones DB Vico L | | 0，，： | 1 |
| 3 | Type l diabetes risk for human leukocyte antigen (HLA)-DR3 haplotypes depends on genotypic context:association of DPBI and HLA class Ⅰ loci among DR3-and DR4-matched Italian patients and controls 显示文摘 | Noble JA Martin A Valdes AM | 2008 | Hum Immunol2008，69，45： | 1 |
| 4 | Behavioural indicators of welfare in farmed fish显示文摘 | MARTINS CIM GALHARDO L NOBLE C | | 0，，01： | 1 |
| 5 | Ozonation of a recirculating rainbow trout culture system I. Effects on bacterial gill disease and heterotrophic bacteria显示文摘 | Graham L. Bullock Steven T. Summerfelt Alicia C. Noble Amy L. Weber Martin D. Durant Joseph A. Hankins | 1997 | Aquaculture1997，，1： | 1 |
| 6 | Gefitinib Versus Placebo in Completely Resected Non–Small-Cell Lung Cancer: Results of the NCIC CTG BR19 Study显示文摘 | Glenwood D. Goss Chris O’Callaghan Ian Lorimer Ming-Sound Tsao Gregory A. Masters James Jett Martin J. Edelman Rogerio Lilenbaum Hak Choy Fadlo Khuri Katherine Pisters David Gandara Kemp Kernstine Charles Butts Jonathan Noble Thomas A. Hensing Kendrith Ro | 2013 | Journal of Clinical Oncology2013，，27： | 1 |
| 7 | Cyclin-dependent kinases: inhibition and substrate recognition显示文摘 | Jane A Endicott Martin EM Noble Julie A Tucker | 1999 | Current Opinion in Structural Biology1999，，6： | 1 |
| 8 | Probing the architecture of the Mycobacterium marinum arylamine N-acetyltransferase active site显示文摘Treatment of latent tuberculosis infection remains an important goal of global TB eradication.To this end,targets that are essential for intracellular survival of Mycobacterium tuberculosis are particularly attractive.Arylamine N-acetyltransferase(NAT)represents such a target as it is,along with the enzymes encoded by the associated gene cluster,essential for mycobacterial survival inside macrophages and involved in cholesterol degradation.Cholesterol is likely to be the fuel for M.tuberculosis inside macrophages.Deleting the nat gene and inhibiting the NAT enzyme prevents survival of the microorganism in macrophages and induces cell wall alterations,rendering the mycobacterium sensitive to antibiotics to which it is normally resistant.To date,NAT from M.marinum(MMNAT)is considered the best available model for NAT from M.tuberculosis(TBNAT).The enzyme catalyses the acetylation and propionylation of arylamines and hydrazines.Hydralazine is a good acetyl and propionyl acceptor for both MMNAT and TBNAT.The MMNAT structure has been solved to 2.1Åresolution following crystallisation in the presence of hydralazine and is compared to available NAT structures.From the mode of ligand binding,features of the binding pocket can be identified,which point to a novel mechanism for the acetylation reaction that results in a 3-methyltriazolo[3,4-a]phthalazine ring compound as product. | Areej M.Abuhammad Edward D.Lowe Elizabeth Fullam Martin Noble Elspeth F.Garman Edith Sim | 2010 | Protein & Cell2010，1，4： | 1 |
| 9 | Key features of the interaction between Pefll CID and RNA polymerase H CTD显示文摘 | Noble C G Hollingworth D Martin S R | 2005 | Nat Struet Mol Biol2005，12，： | 1 |
| 10 | WONCA研究论文摘要汇编——紧急入院的哮喘和获得初级保健:横断面分析显示文摘背景由于针对哮喘急性发作的早期治疗可以预防疾病恶化,因此获得全科医疗可能是哮喘患者紧急入院的一个决定性因素。目的分析获得基层医疗是否与哮喘患者紧急入院相关。设计与环境横断面分析2010—2011年英国实践的数据。方法采用负二项回归法,探讨哮喘患者紧急入院与全科医生提供的全科医疗服务—调查中患者自述获得7项全科医疗服务措施,实践中控制研究对象的一般特征。计算发生率比(IRR)。结果具备所有项目数据者7 806例(95%)。3 134 106例哮喘患者中共55 570例因哮喘紧急入院。具有较高的综合分数的研究对象入院率较低[调整IRR=0.679,95%CI(0.665,0.708)]。研究对象中白人所占比例较高,在质量和结果框架指标'过去15个月内的哮喘评估'中表现欠佳者入院率较高。假设这些关联有因果关系,对于本次研究,10%的综合分数较高与每年减少的17 837例入院患者有关。结论实践中综合分数较高的哮喘患者紧急入院率较低。政策制定者应考虑改善基层医疗的可及性,作为帮助预防哮喘患者紧急入院的一种可能方式。 | FLEETCROFT R NOBLE M MARTIN A 本刊编辑部 | 2016 | 中国全科医学2016，19，33： | 1 |
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