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| 1 | Gastrointestinal radiation injury:Symptoms,risk factors and mechanisms显示文摘Ionising radiation therapy is a common treatment modality for different types of cancer and its use is expected to increase with advances in screening and early detection of cancer.Radiation injury to the gastrointestinal tract is important factor working against better utility of this important therapeutic modality.Cancer survivors can suffer a wide variety of acute and chronic symptoms following radiotherapy,which significantly reduces their quality of life as well as adding an extra burden to the cost of health care.The accurate diagnosis and treatment of intestinal radiation injury often represents a clinical challenge to practicing physicians in both gastroenterology and oncology.Despite the growing recognition of the problem and some advances in understanding the cellular and molecular mechanisms of radiation injury,relatively little is known about the pathophysiology of gastrointestinal radiation injury or any possible susceptibility factors that could aggravate its severity.The aims of this review are to examine the various clinical manifestations of post-radiation gastrointestinal symptoms,to discuss possible patient and treatment factors implicated in normal gastrointestinal tissue radiosensitivity and to outline different mechanisms of intestinal tissue injury. | Abobakr K Shadad Frank J Sullivan Joseph D Martin Laurence J Egan | 2013 | World Journal of Gastroenterology2013，19，2： | 35 |
| 2 | Gastrointestinal radiation injury:Prevention and treatment显示文摘With the recent advances in detection and treatment of cancer,there is an increasing emphasis on the efficacy and safety aspects of cancer therapy.Radiation therapy is a common treatment for a wide variety of cancers,either alone or in combination with other treatments.Ionising radiation injury to the gastrointestinal tract is a frequent side effect of radiation therapy and a considerable proportion of patients suffer acute or chronic gastrointestinal symptoms as a result.These side effects often cause morbidity and may in some cases lower the efficacy of radiotherapy treatment.Radiation injury to the gastrointestinal tract can be minimised by either of two strategies:technical strategies which aim to physically shift radiation dose away from the normal intestinal tissues,and biological strategies which aim to modulate the normal tissue response to ionising radiation or to increase its resistance to it.Although considerable improvement in the safety of radiotherapy treatment has been achieved through the use of modern optimised planning and delivery techniques,biological techniques may offer additional further promise.Different agents have been used to prevent or minimize the severity of gastrointestinal injury induced by ionising radiation exposure,including biological,chemical and pharmacological agents.In this review we aim to discuss various technical strategies to prevent gastrointestinal injury during cancer radiotherapy,examine the different therapeutic options for acute and chronic gastrointestinal radiation injury and outline some examples of research directions and considerations for prevention at a pre-clinical level. | Abobakr K Shadad Frank J Sullivan Joseph D Martin Laurence J Egan | 2013 | World Journal of Gastroenterology2013，19，2： | 32 |
| 3 | Genetic factors in intervertebral disc degeneration显示文摘Low back pain(LBP)is a major cause of disability and imposes huge economic burdens on human society worldwide.Among many factors responsible for LBP,intervertebral disc degeneration(IDD)is the most common disorder and is a target for intervention.The etiology of IDD is complex and its mechanism is still not completely understood.Many factors such as aging,spine deformities and diseases,spine injuries,and genetic factors are involved in the pathogenesis of IDD.In this review,we will focus on the recent advances in studies on the most promising and extensively examined genetic factors associated with IDD in humans.A number of genetic defects have been correlated with structural and functional changes within the intervertebral disc(IVD),which may compromise the disc’s mechanical properties and metabolic activities.These genetic and proteomic studies have begun to shed light on the molecular basis of IDD,suggesting that genetic factors are important contributors to the onset and progression of IDD.By continuing to improve our understanding of the molecular mechanisms of IDD,specific early diagnosis and more effective treatments for this disabling disease will be possible in the future. | Yi Feng Brian Egan Jinxi Wang | 2016 | Genes & Diseases2016，3，3： | 10 |
| 4 | 香豆精类化合物的药理、代谢、分析及应用显示文摘香豆精类化合物是许多植物和挥发油中存在的一类天然成分。此类成分在1822年由Voleg 首先从零陵香豆(Dipteryx odorata)中分离得到,并在1868年由 Perkin 合成。香豆精曾用于治疗癌症、烧伤、地中海热、风湿症,并被用作解痉药。本世纪50年代根据动物实验结果,香豆精曾被认为有致癌作用和肝毒性而遭禁用。后来发现它对人体无害,并表现出抗凝、抑制肿瘤和免疫调节等作用。有些香豆精类化合物如华法林已在临床上广泛应用。本文对此类化合物的药理、代谢、分析等方面的研究工作进行综述。 | Egan D 方唯硕 | 1991 | 国外医学(药学分册)1991，18，5： | 7 |
| 5 | 揭秘美国出口管制黑名单显示文摘企业提出的取消黑名单制裁或对政府机关做出的不利决定的异议申清,应建立在对事实信息的评估、美国政府机构采用的法律标准、先前的行政决策历史以及相关判例的基础上。 | Edward J.Krauland 黄迎 Brian Egan | 2018 | 中国外汇2018，，20： | 6 |
| 6 | Risk Factors for Opportunistic Infections in Patients With Inflammatory Bowel Disease显示文摘 | Murat Toruner Edward V. Loftus W. Scott Harmsen Alan R. Zinsmeister Robert Orenstein William J. Sandborn Jean–Frederic Colombel Laurence J. Egan | 2008 | Gastroenterology2008，，4： | 6 |
| 7 | Determination of microcapsule physicochemical, structural, and mechanical properties显示文摘 | Andrew Gray Stefan Egan Serafim Bakalis Zhibing Zhang | 2016 | Particuology2016，14，1： | 6 |
| 8 | 美国1988-2008期间高血压的发生情况、认识水平、治疗和控制显示文摘 | 张玲玉 叶鹏 Egan BM Zhao Y Axon RN | 2010 | 中华高血压杂志2010，18，9： | 6 |
| 9 | Football injuries of the ankle: A review of injury mechanisms, diagnosis and management显示文摘Football is the most popular sport worldwide and is associated with a high injury rate, most of which are the result of trauma from player contact. Ankle injuries are among the most commonly diagnosed injuries in the game. The result is reduced physical activity and endurance levels, lost game time, and considerable medical cost. Sports medicine professionals must employ the correct diagnostic tools and effective treatments and rehabilitation protocols to minimize the impact of these injuries on the player. This review examines the diagnosis, treatment, and postoperative rehabilitation for common football injuries of the ankle based on the clinical evidence provided in the current literature. | Raymond J Walls Keir A Ross Ethan J Fraser Christopher W Hodgkins Niall A Smyth Christopher J Egan James Calder John G Kennedy | 2016 | World Journal of Orthopedics2016，7，1： | 5 |
| 10 | IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer显示文摘 | Florian R. Greten Lars Eckmann Tim F. Greten Jin Mo Park Zhi-Wei Li Laurence J. Egan Martin F. Kagnoff Michael Karin | 2004 | Cell2004，，3： | 4 |
| 11 | 散失与累积:明清时期《漱玉词》篇数增多问题显示文摘在今天为人们所普遍接受的李清照词作中,有很大一部分出现较晚,而当代学者对这部分作品缺乏应有的关注。将这些来历不明的作品不加鉴别地归于李清照名下,在很大程度上模糊了人们对李清照杰出才华的感受。目前李清照词的很大一部分值得怀疑。这部分作品之所以被认可,原因很多,总之是晚清时期人们对李清照阅读与接受的方式所导致的。 | 艾朗诺(Ronald Egan) | 2012 | 中国韵文学刊2012，26，1： | 4 |
| 12 | An official ATS/ERS/JRS/ALAT statement:idiopathic pulmonary fibrosis:evidence-based guidelines for diagnosis and management显示文摘 | Raghu G Collard HR Egan J J | | 0，，06： | 3 |
| 13 | Optimal time for delivery with preterm premature rupture of membranes from 32 to 36 6/7 weeks显示文摘 | Christopher Nold Naveed Hussain Kathleen Smith Winston Campbell Adam Borgida James Egan | 2011 | Journal of Maternal-Fetal and Neonatal Medicine2011，，7： | 3 |
| 14 | Effects of domestication on genetic diversity in Chimonanthus praecox: Evidence from chloroplast DNA and amplified fragment length polymorphism data显示文摘Chimonanthus praecox L。连接是在有长耕作历史的中国的广泛地栽培的地方性的冬季花植物。基因差异和基因结构在野蛮、栽培的组之间被比较用叶绿体 DNA cpDNA 序列揭示栽培遗传型的地理起源并且放大了碎片长度多型性 AFLP 标记。九 haplotypes 用三联合叶绿体碎片被识别。与栽培的组相比基于叶绿体数据,给更大的基因变化看的野蛮的组和基因区别和基因流动的一项更低的措施。AFLP 标记也支持了这个趋势。超过 40% cpDNA haplotypes 在野蛮、栽培的组之间被分享,与从多重野人口发源的分享的 haplotypes,建议栽培植物的多重起源。而且, AFLP 标记的主要并列分析, UPGMA,和结构分析表明二张野人口与大多数 Ch 的栽培人口聚类。praecox,建议栽培人口的那个大多数主要从这二张人口发源。联合 cpDNA 和 AFLP 结果显示了那现代栽培 Ch。praecox 经历了包含二地理起源,东方中国 Tianmu 山和西南的中国的起源的多重事件 Hunan-Guangxi-Sichuan-Guizhou 的边阶。 | Yi-Jun Lu Chuan Chen Rui-Hong Wang Ashley N. Egan Cheng-Xin Fu | 2015 | Journal of Systematics and Evolution2015，53，3： | 2 |
| 15 | Reinvestigating the Oil Price-Stock Market Nexus: Evidence from Chinese Industry Stock Returns显示文摘 | Sheng Fang Xinsheng Lu Paul G. Egan | 2018 | China & World Economy2018，26，3： | 2 |
| 16 | 感官兴趣视角下的暴力犯罪行为显示文摘感官兴趣(sensational interests)是指个体对极端话题和材料的偏爱,例如对暴力、变态、残杀、极端犯罪、超自然现象等话题的兴趣。这种兴趣广泛存在于暴力罪犯的心理和行为之中。感官兴趣测量结果表明其包含两个主要维度,军事(militarism)和暴力神秘(violent-occult-ism)。研究表明感官兴趣可能存在特定的神经生理基础并且和人格特质、求偶努力以及幻想风格等变量相关,这种相关可以在一定程度上解释和预测暴力犯罪行为。今后的研究应当采用更加系统的研究方法,在更为深入的社会背景中对这种关联的内部机制进行解释。 | 郭昫澄 郭永玉 Vincent Egan | 2012 | 心理学探新2012，32，2： | 2 |
| 17 | ASGE guideline: the role of endoscopy in the surveillance of premalignant conditions of the upper GI tract显示文摘 | William K. Hirota Marc J. Zuckerman Douglas G. Adler Raquel E. Davila James Egan Jonathan A. Leighton Waqar A. Qureshi Elizabeth Rajan Robert Fanelli Jo Wheeler-Harbaugh Todd H. Baron Douglas O. Faigel | 2006 | Gastrointestinal Endoscopy2006，，4： | 2 |
| 18 | A Prospective Randomized Trial of Intravitreal B evacizumab o r L aser T herapy in the Management of Diabetic Macular Edema (BOLT Study)显示文摘 | Michel Michaelides Andrew Kaines Robin D. Hamilton Samantha Fraser-Bell Ranjan Rajendram Fahd Quhill Christopher J. Boos Wen Xing Catherine Egan Tunde Peto Catey Bunce R. David Leslie Philip G. Hykin | 2010 | Ophthalmology2010，，6： | 2 |
| 19 | ASGE Guideline: the role of endoscopy in the patient with lower-GI bleeding显示文摘 | Raquel E. Davila Elizabeth Rajan Douglas G. Adler James Egan William K. Hirota Jonathan A. Leighton Waqar Qureshi Marc J. Zuckerman Robert Fanelli Jo Wheeler-Harbaugh Todd H. Baron Douglas O. Faigel | 2005 | Gastrointestinal Endoscopy2005，，： | 2 |
| 20 | 才女的重担:李清照《词论》中的思想与早期对她的评论(上)显示文摘本文从女权主义批评理论的视角,用文本细读法和历史还原法,重新建构李清照的历史语境,指出宋代男性作家对女性写作普遍持轻视态度,所以不少人对李清照质疑、攻击甚至是辱骂。李清照的《词论》就体现了她在这种困境中的抗争和希望。 | 艾朗诺(Ronald Egan) 郭勉愈(译) | 2009 | 长江学术2009，，2： | 2 |
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