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| 1 | Lymph node staging in colorectal cancer:Old controversies and recent advances显示文摘Outcome prediction based on tumor stage reflected by the American Joint Committee on Cancer(AJCC)/Union for International Cancer Control(UICC)tumor node metastasis(TNM)system is currently regarded as the strongest prognostic parameter for patients with colorectal cancer.For affected patients,the indication for adjuvant therapy is mainly guided by the presence of regional lymph node metastasis.In addition to the extent of surgical lymph node removal and the thoroughness of the pathologist in dissecting the resection specimen,several parameters that are related to the pathological work-up of the dissected nodes may affect the clinical significance of lymph node staging.These include changing definitions of lymph nodes,involved lymph nodes,and tumor deposits in different editions of the AJCC/UICC TNM system as well as the minimum number of nodes to be dissected.Methods to increase the lymph node yield in the fatty tissue include methylene blue injection and acetone compression.Outcome prediction based on the lymph node ratio,defined as the number of positive lymph nodes divided by the total number of retrieved nodes,may be superior to the absolute numbers of involved nodes.Extracapsular invasion has been identified as additional prognostic factor.Adding step sectioning and immunohistochemistry to the pathological work-up may result in higher accuracy of histological diagnosis.The clinical value of more recent technical advances,such as sentinel lymph node biopsy and molecular analysis of lymph nodes tissue still remains to be defined. | Annika Resch Cord Langner | 2013 | World Journal of Gastroenterology2013，19，46： | 14 |
| 2 | Cancer risk in IBD: How to diagnose and how to manage DALM and ALM显示文摘The risk of developing neoplasia leading to colorectal cancer is significantly increased in ulcerative colitis (UC) and most likely in Crohn's disease. Several endoscopic surveillance strategies have been implemented to identify these lesions. The main issue is that colitisassociated neoplasms often occurs in flat mucosa, often being detected on taking random biopsies rather than by identification of these lesions via endoscopic imaging. The standard diagnostic procedure in long lasting UC is to take four biopsies every 10 cm. Image enhancement methods, such as chromoendoscopy and virtual histology using endomicroscopy, have greatly im- proved neoplasia detection rates and may contribute toreduced random biopsies by taking targeted 'smart' biopsies. Chromoendoscopy may effectively be performed by experienced endoscopists for routine screening of UC patients. By contrast, endomicroscopy is often only available in selected specialized endoscopic centers. Importantly, advanced endoscopic imaging has the poten- tial to increase the detection rate of neoplasia whereas the interplay between endoscopic experience and interpretation of histological biopsy evaluation allows the physician to make a proper diagnosis and to find the appropriate therapeutic approach. Colitis-associated intraepithelial neoplasms may occur in flat mucosa of endoscopically normal appearance or may arise as dysplasia-associated lesion or mass (DALM), which may be indistinguishable from sporadic adenomas in healthy or non-colitis mucosa [adenoma-like mass (ALM)]. The aim of this review was to summarize endoscopic and histological characteristics of DALM and ALM in the context of therapeutic procedures. | Helmut Neumann Michael Vieth Cord Langner Markus F Neurath Jonas Mudter | 2011 | World Journal of Gastroenterology2011，17，27： | 6 |
| 3 | Regurgitation of bile acids from leaky bile ducts causes sclerosing cholangitis in Mdr2 ( Abcb4 ) knockout mice显示文摘 | Peter Fickert Andrea Fuchsbichler Martin Wagner Gernot Zollner Arthur Kaser Herbert Tilg Robert Krause Frank Lammert Cord Langner Kurt Zatloukal Hanns-Ulrich Marschall Helmut Denk Michael Trauner | 2004 | Gastroenterology2004，，1： | 1 |
| 4 | Serrated polyps of the colon: how reproducible is their classification?显示文摘 | Arzu Ensari Banu Bilezik?i Fatima Carneiro Gülen Bülbül Do?usoy Ann Driessen Ay?e Dursun Jean-Fran?ois Flejou Karel Geboes Gert de Hertogh Anne Jouret-Mourin Cord Langner Ir?s D. Nagtegaal Johan Offerhaus Janina Orlowska Ari Ristim?ki Julian Sanz-Ortega B | 2012 | Virchows Archiv2012，，5： | 1 |
| 5 | Regurgitation of bile acids from leaky bile ducts causes sclerosing cholangitis in Mdr2 ( Abcb4 ) knockout mice显示文摘 | Peter Fickert Andrea Fuchsbichler Martin Wagner Gernot Zollner Arthur Kaser Herbert Tilg Robert Krause Frank Lammert Cord Langner Kurt Zatloukal Hanns-Ulrich Marschall Helmut Denk Michael Trauner | 2004 | Gastroenterology2004，，1： | 1 |
| 6 | Expression of p27 and its ubiquitin ligase subunit Skp2 in upper urinary tract transitional cell carcinoma显示文摘 | Cord Langner Reinhard von Wasielewski Manfred Ratschek Peter Rehak Richard Zigeuner | 2004 | Urology2004，，3： | 1 |
| 7 | Solitary Giant Splenic Metastasis in a Patient with Metachronous Gastric Cancers显示文摘 | Sandra Sunitsch Thomas Eberl Michael Jagoditsch Ute Filipot J?rg Tschmelitsch Cord Langner | 2009 | Southern Medical Journal2009，，8： | 1 |
| 8 | Tumor Budding is an Independent Predictor of Outcome in AJCC/UICC Stage II Colorectal Cancer显示文摘 | Johannes Betge Peter Kornprat Marion J. Pollheimer Richard A. Lindtner Andrea Schlemmer Peter Rehak Michael Vieth Cord Langner | 2012 | Annals of Surgical Oncology2012，，12： | 1 |
| 9 | Concomitant carcinoma in situ is a feature of aggressive disease in patients with organ confined urothelial carcinoma following radical nephroureterectomy显示文摘 | Jeffery C. Wheat Alon Z. Weizer J. Stuart Wolf Yair Lotan Mesut Remzi Vitaly Margulis Christopher G. Wood Francesco Montorsi Marco Roscigno Eiji Kikuchi Richard Zigeuner Cord Langner Christian Bolenz Theresa M. Koppie Jay D. Raman Mario Fernández Pierre K | 2012 | Urologic Oncology: Seminars and Original Investigations2012，，3： | 1 |
| 10 | Prognostic Effect of Urinary Bladder Carcinoma In Situ on Clinical Outcome of Subsequent Upper Tract Urothelial Carcinoma显示文摘 | Ramy F. Youssef Shahrokh F. Shariat Yair Lotan Christopher G. Wood Arthur I. Sagalowsky Richard Zigeuner Cord Langner Francesco Montorsi Christian Bolenz Vitaly Margulis | 2011 | Urology2011，，4： | 1 |
| 11 | IGF-1R, IGF-1 and IGF-2 expression as potential prognostic and predictive markers in colorectal-cancer显示文摘 | Gerrit Peters Silvia Gongoll Cord Langner Michael Mengel Pompiliu Piso Jürgen Klempnauer Josef Rüschoff Hans Kreipe Reinhard Wasielewski | 2003 | Virchows Archiv2003，，2： | 1 |
| 12 | Clinical significance of pT sub-classification in surgical pathology of colorectal cancer显示文摘 | Marion J. Pollheimer Peter Kornprat Verena S. Pollheimer Richard A. Lindtner Andrea Schlemmer Peter Rehak Cord Langner | 2010 | International Journal of Colorectal Disease2010，，2： | 1 |
| 13 | Serrated polyps of the colon: how reproducible is their classification?显示文摘 | Arzu Ensari Banu Bilezik?i Fatima Carneiro Gülen Bülbül Do?usoy Ann Driessen Ay?e Dursun Jean-Fran?ois Flejou Karel Geboes Gert de Hertogh Anne Jouret-Mourin Cord Langner Ir?s D. Nagtegaal Johan Offerhaus Janina Orlowska Ari Ristim?ki Julian Sanz-Ortega B | 2012 | Virchows Archiv2012，，5： | 1 |
| 14 | Tumor necrosis as prognostic indicator in transitional cell carcinoma of the upper urinary tract 显示文摘 | LANGNER CORD HUTTERER GEORG CHROMECKI ct al | 2006 | J Urol2006，176，3： | 1 |
| 15 | Biological significance of p27 and Skp2 expression in renal cell carcinoma. A systematic analysis of primary and metastatic tumour tissues using a tissue microarray technique显示文摘 | Cord Langner Reinhard Wasielewski Manfred Ratschek Peter Rehak Richard Zigeuner | 2004 | Virchows Archiv2004，，6： | 1 |
| 16 | Histology of microscopic colitis—review with a practical approach for pathologists显示文摘 | Cord Langner Daniela Aust Arzu Ensari Vincenzo Villanacci Gabriel Becheanu Stephan Miehlke Karel Geboes Andreas Münch | 2015 | Histopathology2015，，5： | 1 |
| 17 | p63 immunoreactivity distinguishes upper urinary tract transitional-cell carcinoma and renal-cell carcinoma even in poorly differentiated tumors显示文摘 | Cord Langner Manfred Ratschek Oleksiy Tsybrovskyy | 2003 | J Histochem Cytochem2003，51，： | 1 |
| 18 | IGF-1R, IGF-1 and IGF-2 expression as potential prognostic and predictive markers in colorectal-cancer显示文摘 | Gerrit Peters Silvia Gongoll Cord Langner Michael Mengel Pompiliu Piso Jürgen Klempnauer Josef Rüschoff Hans Kreipe Reinhard Wasielewski | 2003 | Virchows Archiv2003，，2： | 1 |
| 19 | Tumor necrosis as prognostic indicator in transitional cell carcinoma of the upper urinary tract显示文摘 | Langner Cord Hutterer Georg Chromecki | 2006 | The Journal of Urology2006，176，3： | 1 |
| 20 | Prognostic value of keratin subtyping in transitional cell carcinoma of the upper urinary tract显示文摘 | Cord Langner Beate J. Wegscheider Peter Rehak Manfred Ratschek Richard Zigeuner | 2004 | Virchows Archiv2004，，5： | 1 |
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