|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Cognitive disorder and dementia in type 2 diabetes mellitus显示文摘Insulin,a key pleiotropic hormone,regulates metabolism through several signaling pathways in target tissues including skeletal muscle,liver,and brain.In the brain,insulin modulates learning and memory,and impaired insulin signaling is associated with metabolic dysregulation and neurodegenerative diseases.At the receptor level,in aging and Alzheimer’s disease(AD)models,the amount of insulin receptors and their functions are decreased.Clinical and animal model studies suggest that memory improvements are due to changes in insulin levels.Furthermore,diabetes mellitus(DM)and insulin resistance are associated with age-related cognitive decline,increased levels ofβ-amyloid peptide,phosphorylation of tau protein;oxidative stress,pro-inflammatory cytokine production and dyslipidemia. Recent evidence shows that deleting brain insulin receptors leads to mildobesity and insulin resistance without influencing brain size and apoptosis development.Conversely, deleting insulin-like growth factor 1 receptor (IGF-1R) affects brain size anddevelopment, and contributes to behavior changes. Insulin is synthesized locally in the brain andis released from the neurons. Here, we reviewed proposed pathophysiological hypotheses toexplain increased risk of dementia in the presence of DM. Regardless of the exact sequence ofevents leading to neurodegeneration, there is strong evidence that mitochondrial dysfunctionplays a key role in AD and DM. A triple transgenic mouse model of AD showed mitochondrialdysfunction, oxidative stress, and loss of synaptic integrity. These alterations are comparable tothose induced in wild-type mice treated with sucrose, which is consistent with the proposal thatmitochondrial alterations are associated with DM and contribute to AD development. Alterationsin insulin/IGF-1 signaling in DM could lead to mitochondrial dysfunction and low antioxidantcapacity of the cell. Thus, insulin/IGF-1 signaling is important for increased neural processing andsystemic metabolism, and could be a specific target for therapeutic strategies to decreasealterations associated with age-related cognitive decline. | Genaro G Ortiz Miguel Huerta Héctor A González-Usigli Erandis D Torres-Sánchez Daniela LC Delgado-Lara Fermín P Pacheco-Moisés Mario A Mireles-Ramírez Blanca MG Torres-Mendoza Roxana I Moreno-Cih Irma E Velázquez-Brizuela | 2022 | World Journal of Diabetes2022，13，4： | 2 |
| 2 | N-acetyl-L-cysteine combined with mesalamine in the treatment of ulcerative colitis: Randomized,placebo-controlled pilot study显示文摘AIM: To evaluate the effectiveness and safety of oral N-acetyl-L-cysteine (NAC) co-administration with mesalamine in ulcerative colitis (UC) patients. METHODS: Thirty seven patients with mild to moderate UC were randomized to receive a four-wk course of oral mesalamine (2.4 g/d) plus N-acetyl-L-cysteine (0.8 g/d) (group A) or mesalamine plus placebo (group B). Patients were monitored using the Modified Truelove-Witts Severity Index (MTWSI). The primary endpoint was clinical remission (MTWSI ≤ 2) at 4 wk. Secondary endpoints were clinical response (defined as a reduction from baseline in the MTWSI of ≥ 2 points) and drug safety. The serum TNF-α, interleukin-6, interleukin-8 and MCP-1 were evaluated at baseline and at 4 wk of treatment. RESULTS: Analysis per-protocol criteria showed clinical remission rates of 63% and 50% after 4 wk treatment with mesalamine plus N-acetyl-L-cysteine (group A) and mesalamine plus placebo (group B) respectively (OR = 1.71; 95% CI: 0.46 to 6.36; P = 0.19; NNT = 7.7). Analysis of variance (ANOVA) of data indicated a significant reduction of MTWSI in group A (P = 0.046) with respect to basal condition without significant changes in the group B (P = 0.735) during treatment. Clinical responses were 66% (group A) vs 44% (group B) after 4 wk of treatment (OR = 2.5; 95% CI: 0.64 to 9.65; P = 0.11; NNT = 4.5). Clinical improvement in group A correlated with a decrease of IL-8 and MCP-1. Rates of adverse events did not differ significantly between both groups. CONCLUSION: In group A (oral NAC combined with mesalamine) contrarily to group B (mesalamine alone), the clinical improvement correlates with a decrease of chemokines such as MCP-1 and IL-8. NAC addition not produced any side effects. | Luis G Guijarro Jose Mate Javier P Gisbert Jose Luis Perez-Calle Ignacio Marín-Jimenez Encarna Arriaza Tomás Olleros Mario Delgado Maria S Castillejo David Prieto-Merino Venancio Gonzalez Lara Amado Salvador Pea | 2008 | World Journal of Gastroenterology2008，14，18： | 2 |
| 3 | Elderly patients on dialysis: Epidemiology of an epidemic显示文摘 | GIUSEPPE P MARIO S BARBARA P G | 1996 | Nephrol Dail Transplant1996，11，9： | 1 |
| 4 | Aerothermodynamic study of UHTC-based thermal protection systems显示文摘 | RAFFAELE S MARIO S F DIEGO P | 2005 | Aerosp Sci Technol2005，9，： | 1 |
| 5 | High-resolution CT in silicosis correlation with radiographic findings and functional impairment显示文摘 | VINICIUS C S A GERMANIA A P MARIO T F | 2005 | J Comput Assist Tomogr2005，29，： | 1 |
| 6 | bcl- 2 expression and progrosis in squamous-cell carcinoma of the esophagus 显示文摘 | Mario S Fernando B Rainer P | 1996 | Int J Cancer1996，145，： | 1 |
| 7 | Nanotechnology for the progress of lithium batteries R & D显示文摘 | Stefania P Bruno S Mario W | 2004 | J Power Sources2004，129，1： | 1 |
| 8 | Toluene and styrene removal from air in biofilters显示文摘 | Mario Z Emilio P Luciane S | 2001 | Process Biochemistry2001，37，4： | 1 |
| 9 | Dural arteriovenous fistula at the craniocervical junction with perimedullary venous drainage 显示文摘 | Mario M Fabio S Daniele P | 1996 | AJNR Am J Neuroradiol1996，17，6： | 1 |
| 10 | Toluene and styrene removal from air in biofilters 显示文摘 | Mario Z Emilio P Luciane S | 2001 | Process Biochem2001，37，4： | 1 |
| 11 | Biosorption of humie and fulvie acids to live activated sludge biomass 显示文摘 | Mario E S Westerhoff P | 2003 | Water Research2003，37，： | 1 |
| 12 | Aerothermodynamic study of UHTC-based thermal protection systems 显示文摘 | RAFFAELE S MARIO S F DIEGO P | 2005 | Aerospace Sci Technol2005，9，： | 1 |
| 13 | Physiological functions of beneficial elements显示文摘 | Elizabeth A H P S Colin F Q Wiebke T Mario M Michela S | 2009 | Current Opinion in Plant Biology2009，12，3： | 1 |
| 14 | Role of V-ATPases in solid tumors : importance of the subunit C : review 显示文摘 | Mario P S Abel G G Maria D R L | 2009 | Int J Oncol2009，34，6： | 1 |
| 15 | Is perfect discrimination really efficient? welfare and existence in general equilibrium显示文摘 | Epelbaum Mario Heller Walter P | 1998 | Econometrica1998，66，4： | 1 |
| 16 | Antifibrotic and fibrolytic properties of celecoxib in liver damage induced by carbon tetrachloride in the rat显示文摘 | EnriqueChávez JoséSegovia MinekoShibayama VictorTsutsumi PaulaVergara LuisCastro‐Sánchez Eduardo PérezSalazar Mario G.Moreno PabloMuriel | 2010 | Liver International2010，，7： | 1 |
| 17 | Phases of inquiry-based learning: Definitions and the inquiry cycle显示文摘 | Margus P Mario M Leo A S | 2015 | Educational Research Review2015，，14： | 1 |
| 18 | Chain ladder method: Bayesian bootstrap versus classical bootstrap显示文摘 | Gareth W P Mario V W Pavel V S | 2010 | Insurance: Mathematics and Economics2010，47，1： | 1 |
| 19 | Antifungal ellagitannin isolated from Euphorbia antisyphilitica Zucc显示文摘Objective:To study antifungal activity of a new ellagitannin isolated from the plant residues of Euphorbia antisyphilitica(E.antisyphilitica)Zucc in the wax extraction process.Methods:An extract was prepared from dehydrated and pulverized residues and fractionated by liquid chromatography on Amberilte XAD-16,until obtained an ellagitannin-rich ethanolic fraction which was treated by rotaevaporation to recover the ellagitannin as fine powder.An aqueous solution was prepared and treated through ionic exchange liquid chromatography(Q XL)and gel permeation chromatography(G 25).The ellagitannin-rich fraction was thermogravimetrically evaluated(TGA and DTA)to test the thermo-stability of ellagic acid(monomeric unit).Then ellagitannin powder was analyzed by infrared spectrospcopy to determinate the functional groups and.also mass spectroscopy was used to determine the molecular ion.Results:The principal functional groups of ellagitannin were determined,the molecular weight was 860.7 g/mol;and an effective antifungal activity against phytopathogenic fungi was demonstrated.Conclusions:It can be concluded that the new ellagitannin(860.7 g/mol)isolated from E.antisyphilitica Zucc is an effective antifungal agent against Alternaria alternata,Fusarium oxyzporum,Colletotrichum gloeosporoides and Rhizoctnia solani. | Juan Ascacio-Valdés Edgardo Burboa Antonio F Aguilera-Carbo Mario Aparicio Ramón Pérez-Schmidt Raúl Rodríguez Cristóbal N Aguilar | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，1： | 1 |
| 20 | Tonoplast vesicles of Beta vulgaris storage root show functional aquaporins regulated by protons显示文摘 | MOIRA S KARINA A MARIO P | 2005 | Biol Cell2005，97，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员