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| 1 | Thrombin activation and liver inflammation in advanced hepatitis C virus infection显示文摘Hepatitis C virus(HCV) infection is associated with increased thrombotic risk. Several mechanisms are involved including direct endothelial damage by the HCV virus, with activation of tissue factor, altered fibrinolysis and increased platelet aggregation and activation. In advanced stages, chronic HCV infection may evolve to liver cirrhosis, a condition in which alterations in the portal microcirculation may also ultimately lead to thrombin activation, platelet aggregation, and clot formation. Therefore in advanced HCV liver disease there is an increased prevalence of thrombotic phenomena in portal vein radicles. Increased thrombin formation may activate hepatic stellate cells and promote liver fibrosis. In addition, ischemic changes derived from vascular occlusion by microthrombi favor the so called parenchymal extinction, a process that promotes collapse of hepatocytes and the formation of gross fibrous tracts. These reasons may explain why advanced HCV infection may evolve more rapidly to end-stage liver disease than other forms of cirrhosis. | Emilio González-Reimers Geraldine Quintero-Platt Candelaria Martín-González Onán Pérez-Hernández Lucía Romero-Acevedo Francisco Santolaria-Fernández | 2016 | World Journal of Gastroenterology2016，22，18： | 5 |
| 2 | Diagnostic yield and clinical outcomes after capsule endoscopy in 100 consecutive patients with obscure gastrointestinal bleeding显示文摘 | Emilio Estévez Benito González-Conde José Luis Vázquez-Iglesias Maria de los Angeles Vázquez-Millán Sonia Pértega Pedro A. Alonso Joan Clofent Eva Santos José Luis Ulla Eloy Sánchez | 2006 | European Journal of Gastroenterology & Hepatology2006，，8： | 3 |
| 3 | Liver steatosis in hepatitis C patients显示文摘There is controversy regarding some aspects of hepatitis C virus(HCV) infection-associated liver steatosis,and their relationship with body fat stores. It has classically been found that HCV,especially genotype 3,exerts direct metabolic effects which lead to liver steatosis. This supports the existence of a so called viral steatosis and a metabolic steatosis,whichwould affect HCV patients who are also obese or diabetics. In fact,several genotypes exert metabolic effects which overlap with some of those observed in the metabolic syndrome. In this review we will analyse the pathogenic pathways involved in the development of steatosis in HCV patients. Several cytokines and adipokines also become activated and are involved in 'pure' steatosic effects,in addition to inflammation. They are probably responsible for the evolution of simple steatosis to steatohepatitis,making it difficult to explain why such alterations only affect a proportion of steatosic patients. | Emilio González-Reimers Geraldine Quintero-Platt Melchor Rodríguez-Gaspar Remedios Alemán-Valls Onán Pérez-Hernández Francisco Santolaria-Fernández | 2015 | World Journal of Hepatology2015，7，10： | 3 |
| 4 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 5 | Adipokines,cytokines and body fat stores in hepatitis Cvirus liver steatosis显示文摘AIM: To identify patients with or without liver steatosis and its severity in treatment-na?ve patients affected by hepatitis C virus(HCV) infection.METHODS: We included 56 HCV infected patients, and assessed the amount of liver fat by histomorphometry, and its relationships with fat and lean mass at different parts of the body(by densitometry), hormones [insulin, homeostatic model assessment(HOMA)], adipokines(resistin, adiponectin, leptin), and cytokines(tumor necrosis factor α, interleukin-6).RESULTS: Although the intensity of liver steatosis is related to trunk fat mass and HOMA, 33% of patients showed no liver steatosis, and this finding was not related to body mass index or genotype. Besides trunkfat mass, no other factor was related to the presence or not of liver steatosis, or to the intensity of it, by multivariate analysis. Lean mass was not related to liver steatosis. Adiponectin levels were lower among patients. No differences were observed in leptin and resistin.CONCLUSION: Steatosis in HCV infection is common(67.2%), and closely related to trunk fat, and insulin resistance, but not with leg fat mass or adipokines. | emilio gonzález-reimers javier lópez-prieto geraldine quintero-platt ricardo pelazas-gonzález m remedios alemán-valls onán pérez-hernández m joséde-la-vega-prieto m angeles gómez-rodríguez candelaria martín-gonzález francisco santolaria-fernández | 2016 | World Journal of Hepatology2016，8，1： | 2 |
| 6 | Bird communities as hioindicators: The focal species concept in agricultural land- scape 显示文摘 | Emilio P D Marco B Renato M | 2006 | Ecological Indicators2006，，6： | 1 |
| 7 | International inequality in energy intensity levels and the role of production composition and energy efficiency: an analysis of OECD countries 显示文摘 | Juan A D Vicent A Emilio P | 2010 | Ecological Economics2010，69，12： | 1 |
| 8 | Fijianolides,polyketide heterocyclics from a marine sponge 显示文摘 | Emilio E Kakou Y Crews P | 1988 | J Org Chem1988，53，15： | 1 |
| 9 | Phyto- plankton size structure and primary production in a highly dynamic coastal ecosystem (Riade Vigo, NW- Spain): Seasonal and short-time scale variability显示文摘 | PEDRO C EMILIO M VALESCA P | 2006 | Estuarine Coastal and Shelf Science2006，67，12： | 1 |
| 10 | Phytoplankton size structure and primary production in a highly dynamic coastal ecosystem (Ri'a de Vigo,NW-Spain):seasonal and short-time scale variability显示文摘 | Pedro C Emilio M Valesca P | 2006 | Estuarine Coastal and Shelf Science2006，67，： | 1 |
| 11 | Phenotypic and genotypic characterization of Streptococcus pyogenes isolates displaying the MLSB phenotype of maerolide resistance in Spain, 1999 to 2005显示文摘 | EMILIO P T MONTES M ORDEN B | 2007 | Antimicrob Agents Chemother2007，51，4： | 1 |
| 12 | Mutual GuaranteeInstitutions and Small Business Finance显示文摘 | Columba F Gambacorta L Emilio P | 2010 | Journal of financialstability2010，，6： | 1 |
| 13 | Comparison of vis- ual and quantitative analysis for characterization of insona ted liver tumors after microbubble contrast injection显示文摘 | Emilio Q Alessandro P Stefania R | 2006 | AJR2006，86，： | 1 |
| 14 | Response of parasitoids Dendrosoter protuberans and Cheiropachus quadrum to attractants of Phloeotribus scarabaeoides in an olfactometer显示文摘 | Carlos L Emilio G Aranzazu P | 2000 | Journal of Chemical Ecology2000，26，3： | 1 |
| 15 | Instantaneous quantitative and qualitative assessment of pear quality using near infrared spectroscopy显示文摘 | Patricia Paz María-Teresa Sánchez Dolores Pérez-Marín José Emilio Guerrero Ana Garrido-Varo | 2009 | Computers and Electronics in Agriculture2009，，1： | 1 |
| 16 | Origin of vesicle layering and double imbrication by endogenous growth in the Birkett basalt flow (Columbia river plateau)显示文摘 | George P L Walker Edgardo Canon-Tapia Emilio Herrero-Bervera | 1999 | Journal of Volcanology and Geothermal Research1999，88，： | 1 |
| 17 | Toluene and styrene removal from air in biofilters显示文摘 | Mario Z Emilio P Luciane S | 2001 | Process Biochemistry2001，37，4： | 1 |
| 18 | Non-destructive determination of quality parameters in nectarines during on-tree ripening and postharvest storage显示文摘 | Dolores Pérez-Marín María-Teresa Sánchez Patricia Paz María-Auxiliadora Soriano José-Emilio Guerrero Ana Garrido-Varo | 2008 | Postharvest Biology and Technology2008，，2： | 1 |
| 19 | Marketed new antiepileptic drugs: Are they better than old-generation agents 显示文摘 | Emilio P | 2002 | Therapeutic Drug Monitoring2002，24，1： | 1 |
| 20 | Comparison of visual and quantitative analysis for characterization of insonated liver tumors after microbubble contrast injection 显示文摘 | Emilio Q Alessandro P Stefania R | 2006 | AJR2006，186，： | 1 |
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