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| 1 | Aquaporins:Their role in cholestatic liver disease显示文摘This review focuses on current knowledge on hepato-cyte aquaporins(AQPs)and their significance in bile formation and cholestasis.Canalicular bile secretion results from a combined interaction of several solute transporters and AQP water channels that facilitate water flow in response to the osmotic gradients created. During choleresis,hepatocytes rapidly increase their canalicular membrane water permeability by modulating the abundance of AQP8.The question was raised as to whether the opposite process,i.e.a decreased canalicular AQP8 expression would contribute to the development of cholestasis.Studies in several experimental models of cholestasis,such as extrahepatic obstructive cholestasis,estrogen-induced cholestasis, and sepsis-induced cholestasis demonstrated that the protein expression of hepatocyte AQP8 was impaired. In addition,biophysical studies in canalicular plasma membranes revealed decreased water permeability associated with AQP8 protein downregulation.The combined alteration in hepatocyte solute transporters and AQP8 would hamper the efficient coupling of osmotic gradients and canalicular water flow.Thus cholestasis may result from a mutual occurrence of impaired solute transport and decreased water permeability. | Guillermo L Lehmann Maria C Larocca Leandro R Soria Raúl A Marinelli | 2008 | World Journal of Gastroenterology2008，14，46： | 8 |
| 2 | Patients'Knowledge, Attitudes, and Behavior Toward Hospital-associated Infections in Italy显示文摘 | Abbate R Di Giuseppe G Marinelli E | 2008 | Am J Infect Control2008，36，1： | 1 |
| 3 | A phospholipid-PEG2000 conjugate of a vascular endothelial growth factor receptor 2 (VEGFR2)-targeting heterodimer peptide for eontrast-enhanced ultrasound imaging of angiogenesis 显示文摘 | Pillai R Marinelli ER Fan H | 2010 | Bioconjug Chem2010，21，： | 1 |
| 4 | Healthcare work- ers and health care - associated infections :knowledge, atti- tudes, and behavior in emergency departments in Italy 显示文摘 | Parmeggiani C Abbate R Marinelli P | 2010 | BMC Infection Diseases2010，23，10： | 1 |
| 5 | Patients' knowledge, attitudes, and behavior toward hospital-associated infections in Italy显示文摘 | Abbate R Di Giuseppe G Marinelli P | 2008 | Am J Infect Control2008，36，1： | 1 |
| 6 | Water transpor ting properties of hepatoeyte basolateral and eanalicular plas ma membrane domains显示文摘 | Marinelli R A Tietz P S Caride A J etal | 2003 | JBiolChem2003，278，43： | 1 |
| 7 | The pastaphase within density dependent hadronic models显示文摘 | Avancini S S Brito L Marinelli J R | 2009 | Physical Review C2009，79，03： | 1 |
| 8 | Knowledge, attitudes, and practice of avian influenza, poultry workers, Italy 显示文摘 | Abbate R Di Giuseppe G Marinelli P Angelillo IF | 2006 | Emerz Infect Dis2006，12，11： | 1 |
| 9 | Peritoneojugular shunt in the treatment of idiopathic ascites in the hemodialyzed patient:a clinical case显示文摘 | Massari R Marinelli S Fulgente R | 1995 | Chir Ital1995，47，1： | 1 |
| 10 | Videolaparoscopy as rescue therapy and placement of peritoneal dialysis catheters a thirty-two ease single centre Experience显示文摘 | Santarelli S Zeiler M Marinelli R | 2006 | Nephml Dial Transplant2006，21，5： | 1 |
| 11 | Healthcare Workers and Health CareAssociated Infections: Knowledge, Attitudes,and Behavior in Emergency Departments in Italy显示文摘 | Parmeggiani C Abbate R Marinelli P | 2010 | BMC Infect Dis2010，23，10： | 1 |
| 12 | Human dermal matrix scaffold augmentation for large and massive rotator cuff repairs: preliminary clinical and MRI results at 1-year follow-up显示文摘 | Rotini R Marinelli A Guerra E | 2011 | Musculoskelet Surg2011，95，1： | 1 |
| 13 | Liver pathology in cytomegalovirus infection associated with hepatitis B virus显示文摘 | Marinelli RM Delle Monache M Gerardi R | 1993 | J Int Med Res1993，21，4： | 1 |
| 14 | Angiotensin-Converting Enzyme Inhibition Prevents the Release of Monocytes From Their Splenic Reservoir in Mice With Myocardial Infarction显示文摘 | Florian Leuschner Peter Panizzi Isabel Chico-Calero Won Woo Lee Takuya Ueno Virna Cortez-Retamozo Peter Waterman Rostic Gorbatov Brett Marinelli Yoshiko Iwamoto Aleksey Chudnovskiy Jose-Luiz Figueiredo David E. Sosnovik Mikael J. Pittet Filip K. Swirski R | 2010 | Circulation Research2010，，： | 1 |
| 15 | Surface states and buried interface states studies in semiconductors by photothermal deflection spectroscopy显示文摘 | Zammit U Marinelli M Pizzoferrato R | 1991 | J Appl Phys1991，69，5： | 1 |
| 16 | Patients' knowledge, attitudes, and behavior toward hospital-associated infections in Italy 显示文摘 | Abbate R Di G G Marinelli P | 2008 | American Journal of Infection Control2008，36，1： | 1 |
| 17 | An invivopr of ile of betaendorp hin release in the arcuate nucleus and nucleus accum- bens following exposure to stress or alcohol 显示文摘 | Marinelli P W Qurion R Gianoulakis C | 2004 | Neuroscience2004，127，3： | 1 |
| 18 | An in vivo profile of betaendorphin release in the arcuate nucleus and nucleus accumbens following exposure to stress or alcohol显示文摘 | Marinelli P W Quirion R Gianoulakis C | 2004 | Neuroscience2004，127，3： | 1 |
| 19 | Anterior discolored teeth restored with procera all-ceramic restorations:a clinical evaluation of the esthetic outcome based on the thickness of the core selected显示文摘 | Fabbri G Mancini R Marinelli V | 2011 | Eur J Esthet Dent2011，6，1： | 1 |
| 20 | Carnegie Mellon's Entertainment Technology Center: combining the left and right brain 显示文摘 | PAUSCH R MARINELLI D | 2007 | Communications of the ACM2007，50，7： | 1 |
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