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| 1 | Hyperferritinemia is a risk factor for steatosis in chronic liver disease显示文摘AIM: To investigate the relationship between ferritin and steatosis in patients with chronically abnormal liver function tests (LFTs) and high ferritin level. METHODS: One hundred and twenty-four consecutive patients with hyperferritinemia (male > 300 ng/mL, female > 200 ng/mL) were evaluated; clinical, biochemical and serological data, iron status parameters, HFE gene mutations and homeostasis model assessment score were obtained. Steatosis was graded by ultrasound as absent or present. Histology was available in 53 patients only. RESULTS: Mean level of ferritin was 881 ± 77 ng/mL in men and 549 ± 82 ng/mL in women. The diagnosis was chronic hepatitis C in 53 (42.7%), non-alcoholic fatty liver disease/non-alcoholic steatohepatitis in 57 (45.9%), and cryptogenic liver damage in 14 (11.3%). None was diagnosed as hereditary hemochromatosis (HH). Hepatic siderosis on liver biopsy was present in 17 of 54 (32%) patients; grade 1 in eight and grade 2 in nine. Overall, 92 patients (74.2%) had steatosis. By logistic regression, ferritin and γ-glutamyltransferase were independent predictors of steatosis. Ferritin levels were signifi cantly related to low platelet count, steatosis and hepatitis C virus infection. CONCLUSION: In a non-obese cohort of non-alcoholic patients with chronically abnormal LFTs without HH, high serum ferritin level is a risk factor for steatosis. | Anna Licata Maria Elena Nebbia Giuseppe Cabibbo Giovanna Lo Iacono Francesco Barbaria Virna Brucato Nicola Alessi Salvatore Porrovecchio Vito Di Marco Antonio Craxì Calogero Cammà | 2009 | World Journal of Gastroenterology2009，15，17： | 6 |
| 2 | Targeting of acute myeloid leukaemia by cytokine‐induced killer cells redirected with a novel CD 123‐specific chimeric antigen receptor显示文摘 | Sarah Tettamanti Virna Marin Irene Pizzitola Chiara F. Magnani Greta M. P. Giordano Attianese Elisabetta Cribioli Francesca Maltese Stefania Galimberti Angel F. Lopez Andrea Biondi Dominique Bonnet Ettore Biagi | 2013 | Br J Haematol2013，，3： | 3 |
| 3 | Prevalence of nonalco?holic fatty liver disease in patients with type 2 diabetes mellitus显示文摘 | Prashanth M Ganesh HK Virna MV et at | 2009 | J Assoc Physicians India2009，57，： | 1 |
| 4 | Research activation of HER family members in gastric carcinoma cells mediates resistance to MET inhibition 显示文摘 | Simona C Elena G Virna C | 2010 | Mol Cancer2010，121，9： | 1 |
| 5 | The immunological basis of the hygiene hypothesis 显示文摘 | Renz H Blumer N Virna S | 2006 | Chem Immunol Allergy2006，，91： | 1 |
| 6 | Inhibition of AP-1 Transcriptional Activity Blocks the Migration, Invasion, and Experimental Metastasis of Murine Osteosarcoma显示文摘 | Virna D. Leaner Jeffrey F. Chick Howard Donninger Ilona Linniola Arnulfo Mendoza Chand Khanna Michael J. Birrer | 2009 | The American Journal of Pathology2009，，1： | 1 |
| 7 | Serum ionized magnesium in diabetic older persons显示文摘 | Mario Barbagallo Giovanna Di Bella Virna Brucato Daniela D’Angelo Provvidenza Damiani Alfredo Monteverde Mario Belvedere Ligia J. Dominguez | 2013 | Metabolism2013，，： | 1 |
| 8 | Regulation of Toxoplasma gondii specific CD8^+T-cell responses by CD4^+T cells显示文摘 | Sonja Lütjen Sabine Soltek Simona Virna | 2006 | Infect Immun2006，74，10： | 1 |
| 9 | Angiotensin-Converting Enzyme Inhibition Prevents the Release of Monocytes From Their Splenic Reservoir in Mice With Myocardial Infarction显示文摘 | Florian Leuschner Peter Panizzi Isabel Chico-Calero Won Woo Lee Takuya Ueno Virna Cortez-Retamozo Peter Waterman Rostic Gorbatov Brett Marinelli Yoshiko Iwamoto Aleksey Chudnovskiy Jose-Luiz Figueiredo David E. Sosnovik Mikael J. Pittet Filip K. Swirski R | 2010 | Circulation Research2010，，： | 1 |
| 10 | Cyclic flexure and laminar flow synergistically accelerate mesenchymal stem cell-mediated engineered tissue formation: Implications for engineered heart valve tissues显示文摘 | George C. Engelmayr Virna L. Sales John E. Mayer Michael S. Sacks | 2006 | Biomaterials2006，，36： | 1 |
| 11 | Perinatal maternal application of Lactobacillus rhamnosus GG suppresses allergic airway inflammation in mouse offspring 显示文摘 | Blamer N Sel S Virna S | 2007 | Clin Exp Allergy2007，37，3： | 1 |
| 12 | TNF is important for pathogen control and limits brain damage in murine cerebral listeriosis显示文摘 | Virna S Deckert M Ltitjen S | 2006 | J Immunol2006，177，6： | 1 |
| 13 | Es- thetic rehabilitation of a severely compromised anterior area:Combined periodontal and restorative approach显示文摘 | Rachele Censi Virna Vavassori Andrea Enrico | 2014 | Case Reports in Dentistry2014，，1： | 1 |
| 14 | TNF is important for pathogen control and limits brain damage in murine cerebral listeriosis显示文摘 | Virna S Deckert M Lütjen S | | 0，，6： | 1 |
| 15 | The immunological basis of the hygene hypothesis显示文摘 | Renz H Blumer N Virna S | | 0，，05： | 1 |
| 16 | Angiotensin-Converting Enzyme Inhibition Prevents the Release of Monocytes From Their Splenic Reservoir in Mice With Myocardial Infarction显示文摘 | Florian Leuschner Peter Panizzi Isabel Chico-Calero Won Woo Lee Takuya Ueno Virna Cortez-Retamozo Peter Waterman Rostic Gorbatov Brett Marinelli Yoshiko Iwamoto Aleksey Chudnovskiy Jose-Luiz Figueiredo David E. Sosnovik Mikael J. Pittet Filip K. Swirski R | 2010 | Circulation Research2010，，11： | 1 |
| 17 | TNF is important for pathogen control and limits brain damage in murine cerebral listeriosis显示文摘 | Virna S Decker M Lütjen S Soltek S Foulds KE Shen H K(o)rner H Sedgwick JD Schlüter D | | 0，，06： | 1 |
| 18 | A sensitive and robust LC- MS/MS method with monolithic column and electrospray ionization for the quantitation of efavirenz in human plasma: application to a bioequivalence study 显示文摘 | Danilo B Jose F Virna R | 2011 | Qulm Nova2011，34，6： | 1 |
| 19 | Anti-p53 antibodies in patients with Barrett’s esophagus or esophageal carcinoma can predate cancer diagnosis显示文摘 | Helen M. Cawley * Stephen J. Meltzer ? Virna M.G. de Benedetti * Monica C. Hollstein § Karl–Rudolf Muehlbauer § Linda Liang * William P. Bennett * Rhonda F. Souza ? Bruce D. Greenwald ? John Cottrell ∥ Audrey Salabes ∥ Helmut Bartsch § Glenwood E. Trivers | 1998 | Gastroenterology1998，，1： | 1 |
| 20 | Perinatal maternal application of Lactobacillus rhamnosus GG suppressesallergic airway inflammation in mouse offspring显示文摘 | BLMER N SEL S VIRNA S | 2007 | Clin Exp Allergy2007，37，： | 1 |
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