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| 1 | Understanding the molecular mechanisms of cancer prevention by dietary phytochemicals:From experimental models to clinical trials显示文摘Chemoprevention is one of the cancer prevention approaches wherein natural/synthetic agent(s) are prescribed with the aim to delay or disrupt multiple pathways and processes involved at multiple steps, i.e., initiation, promotion, and progression of cancer. Amongst environmental chemopreventive compounds, diet/beverage-derived components are under evaluation, because of their long history of exposure to humans, high tolerability, low toxicity, and reported biological activities. This compilation briefly covers and compares the available evidence on chemopreventive efficacy and probable mechanism of chemoprevention by selected dietary phytochemicals(capsaicin, curcumin, diallyl sulphide, genistein, green/black tea polyphenols, indoles, lycopene, phenethyl isocyanate, resveratrol, retinoids and tocopherols) in experimental systems and clinical trials. All the dietary phytochemicals covered in this review have demonstrated chemopreventive efficacy against spontaneous or carcinogen-induced experimental tumors and/or associated biomarkers and processes in rodents at several organ sites. The observed anti-initiating, anti-promoting and anti-progression activity of dietary phytochemicals in carcinogen-induced experimental models involve phytochemical-mediated redox changes, modulation of enzymes and signaling kinases resulting to effects on multiple genes and cell signaling pathways. Results from clinical trials using these compounds have not shown them to be chemopreventive. This may be due to our:(1) inability to reproduce the exposure conditions, i.e., levels, complexity, other host and lifestyle factors; and(2) lack of understanding about the mechanisms of action and agent-mediated toxicity in several organs and physiological processes in the host. Current research efforts in addressing the issues of exposure conditions, bioavailability, toxicity and the mode of action of dietary phytochemicals may help address the reason for observed mismatch that may ultimately lead to identification of new chemopreventive agents for protection against broad spectrum of exposures. | Girish B Maru Rasika R Hudlikar Gaurav Kumar Khushboo Gandhi Manoj B Mahimkar | 2016 | World Journal of Biological Chemistry2016，7，1： | 2 |
| 2 | Hot air and fuel ageing of poly (vinyl chloride)/nitrile rubber and poly (vinyl chloride)/hydrogenated nitrile rubber blends显示文摘 | N R Manoj | 1994 | Polymer Degradation and Stability1994，4，1： | 1 |
| 3 | The electrchromic response of polyaniline and its copolymeric systems 显示文摘 | Manoj K R Elisabetta M Claudio N | 1997 | Thin Solid Films1997，303，： | 1 |
| 4 | Escherichia coli aspartate-a-decarboxylase :preprotein processing and observation of reaction intermediates by electrospray mass spectrometry 显示文摘 | Manoj K R Ulrich G Chris A et ol | 1997 | Biochem J1997，323，： | 1 |
| 5 | Influence of target to substrate spacingon the properties of ITO thin films显示文摘 | Antony A Nisha M Manoj R | 2004 | Applied Surface Science2004，225，： | 1 |
| 6 | Dual control mechanism in a Belousov-Zhabotinskii (B-Z) oscillator with glucose and oxalic acid as a double substrate显示文摘 | Rastogi R P Prem Chand Manoj K Pandey | 2005 | Phys Chem A2005，109，20： | 1 |
| 7 | Epi- taxial growth of high quality ZnO : A1 film on silicon with a thin '-AlzO3 buffer layer显示文摘 | MANOJ K MEHRA R M WAKHARA A | 2003 | J Appl Phys2003，93，7： | 1 |
| 8 | The effect of the pH value on the growth and properties of chemical-bath-deposited ZnS thin films显示文摘 | ANTONY A MURALI K V MANOJ R | 2005 | Materials Chemistry and Physics2005，90，： | 1 |
| 9 | Electron Transfer Mechanism of Cytochrome c at Graphene Electrode显示文摘 | Subbiah A Rakesh K J Manoj K R | 2010 | Applied Physics Letters2010，96，26： | 1 |
| 10 | Electrochemical, DNA sensor for Neisseria meningitidis detection 显示文摘 | MANOJ K P PRATIMA R S ASHOK K el al | 2010 | Biosens Bioelect2010，25，12： | 1 |
| 11 | Evolutionary history of the neu- ropeptide S receptor/neuropeptide S system显示文摘 | Valsalan R Manoj N | 2014 | Gen Comp Endocrinol2014，209，： | 1 |
| 12 | Analytical quality by design approach for development of UV spectrophotometric methods in the estimation of trospium chloride from capsule dosage form 显示文摘 | Monika L Jadhav Santosh R Tambe Manoj V Girase | 2014 | International Journal of Pharmacy and Pharmaceutical Sciences2014，6，10： | 1 |
| 13 | High slew-rate CMOS operational amplifier 显示文摘 | Subramaniam P C Manoj C R | 2003 | Electronics letter 17th2003，39，8： | 1 |
| 14 | CogNet:a cognitivecomplete knowledge network system显示文摘 | MANOJ B S RAO R R ZORZI M | 2008 | IEEE WirelessCommunications2008，15，6： | 1 |
| 15 | Refining of a Low-grade molybdenite concentrate 显示文摘 | Manoj K Mankhand T R Murthy D S R | 2007 | Hydrometallurgy2007，86，3： | 1 |
| 16 | 显示文摘 | Manoj K R Ozlem avuz Matt Aldissi | 2005 | Synthetic Metals2005，151，： | 1 |
| 17 | Physicochemical Studies on Reverse Micelles of Sodium bis (2-ethylhexyl) Sulfosuccinate at Low Water Content 显示文摘 | Manoj K M Jayakumar R Rakshit S K | 1996 | Langmuir1996，12，17： | 1 |
| 18 | Effect of oxygen intercalation on properties of sputtered CuYO2 for potential use as p-type transparent conducting films显示文摘 | MANOJ R NISHA M VANAJA K A | 2008 | Bulletin of Materials Science2008，31，1： | 1 |
| 19 | Clay-reinforced epoxy nanocomposites显示文摘 | Ratna D Manoj NR Varley R | 2003 | Polymer International2003，52，3： | 1 |
| 20 | Characterization of anti-N-acetyl-d-glucosamine antibodies elicited through haptenated liposomes 显示文摘 | Manoj K D Samir K R Debi P S | 1984 | Carbohydrate Research1984，128，2： | 1 |
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