5篇
您的检索式：作者名="Manfred Bergmann"
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| 1 | The Influence of Retarders on the Braking Behaviour of Commercial Vehicles显示文摘 | Manfred Bergmann Egon-Christian von Glasner Hartmut Marwitz | 2001 | IPC2001 E2222001，222，： | 1 |
| 2 | The Group A Streptococcus Interleukin-8 Protease SpyCEP Promotes Bacterial Intracellular Survival by Evasion of Autophagy显示文摘Autophagy serves an innate immune function in defending the host against invading bacteria,including group A Streptococcus(GAS).Autophagy is regulated by numerous host proteins,including the endogenous negative regulator calpain,a cytosolic protease.Globally disseminated serotypeM1T1 GAS strains associated with high invasive disease potential express numerous virulence factors and resist autophagic clearance.Upon in vitro infection of human epithelial cell lines with representative wild-type GAS M1T1 strain 5448(M1.5448),we observed increased calpain activation linked to a specific GAS virulence factor,the interleukin-8 protease SpyCEP.Calpain activation inhibited autophagy and decreased capture of cytosolic GAS in autophagosomes.In contrast,the serotype M6 GAS strain JRS4(M6.JRS4),which is highly susceptible to host autophagy-mediated killing,expresses low levels of SpyCEP and does not activate calpain.Overexpression of SpyCEP in M6.JRS4 stimulated calpain activation,inhibited autophagy,and significantly decreased bacterial capture in autophagosomes.These paired loss-and gain-of-function studies reveal a novel role for the bacterial protease SpyCEP in enabling GAS M1 evasion of autophagy and host innate immune clearance. | RenéBergmann Giuseppe Gulotta Federica Andreoni Tomoko Sumitomo Shigetada Kawabata Annelies S.Zinkernagel Gursharan S.Chhatwal Victor Nizet Manfred Rohde Satoshi Uchiyama | 2022 | Infectious Microbes & Diseases2022，4，3： | 1 |
| 3 | Wendtner,Hartmut Dohner,Gunter Brittinger,Bertold Emmerich,Michael Hallek and the German CLL study group:Fludarabine plus cyclophosphamide versus fludarabine abone in first-line therapy of younger patients with chronic lymphocytic leukemia显示文摘 | Barbara F Eichhorst Raymonde Busch Georg Hopfinger Rita Pasold Manfred Hensel Cordelia Steinbrecher Siegfried Siehl Ulrich Jager Mannela Bergmann Stephan Stilgenbauer Carmen Schweighofer Clemens M | 2006 | Blood2006，107，： | 1 |
| 4 | Glyceraldehyde-3-phosphate dehydrogenase of Streptococcus pneumoniae is a surface-displayed plasmino- gen binding protein显示文摘 | Simone Bergmann Manfred Rohde Sven Hammer- schmidt | 2004 | Infection and Immunity2004，72，4： | 1 |
| 5 | Extrapulmonary sarcoidosis of liver and pancreas: A case report and review of literature显示文摘Sarcoidosis is a chronic multisystemic granulomatous disease of unknown origin, which can involve nearly all organs. In the case of an infrequent gastrointestinal tract involvement in systemic sarcoidosis, granulomas of the liver are most commonly described while isolated pancreatic sarcoid lesions are rarely seen. We report a case of systemic sarcoidosis with exclusive extrapulmonal involvement of the liver and the pancreas in a 71-year- old white man. The diagnosis of liver involvement was confirmed by biopsy. Pancreatic surgery was needed because preoperative evaluation could not exclude pancreatic cancer and for biliary decompression. An extensive literature review of systemic sarcoidosis, focusing on reported cases with unusual presentation of sarcoidosis in the liver and the pancreas, its diagnosis, treatment, and prognosis was made. | Hermann Harder Markus W Büchler Boris Frhlich Philipp Strbel Frank Bergmann Wolfgang Neff Manfred V Singer | 2007 | World Journal of Gastroenterology2007，13，17： | 0 |
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