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| 1 | Human fetal mesenchymal stem cells differentiate into brown and white adipocytes: a role for ERRα in human UCP1 expression显示文摘我们调查了胎儿的间充质的干细胞(fMSCs ) 的能力区分进棕色、白的 adipocytes 并且比较了很多标记基因和关键规章的因素的表示。我们证明关键 adipocyte 管理者和标记的表示在另外的人、鼠科的 adipocyte 模型在区别期间类似于那,包括 PPAR 纬 2 和 FABP4 的正式就职。尤其是,我们发现 preadipocyte 标记, Pref-1,当这个过程继续,显著地在区别然后衰落早被导致,当他们承诺 adipogenic 系,建议 fMSCs 首先获得 preadipocyte 特征,在他们进成熟 adipocytes 的区别以前。在 adipogenic 正式就职以后,某干细胞孤立区分了进类似于棕色的 adipocytes 和其它进白 adipocytes 的房间。一个的详细调查孤立证明新奇棕色的胖决定的因素 PRDM16 在区别前后两个都被表示。重要地,展出的这些房间提高了基础 UCP-1 表示,它依赖于孤儿的活动原子受体犯错伪,加亮一个新奇角色为犯错在人的棕色的脂肪的伪。因此 fMSCs 代表一在 vitro 有用为人的 adipogenesis 当模特儿,并且提供机会在对 adipocyte 系的承诺以前学习阶段。他们也提供无价的卓见进人的棕色的脂肪的特征。 | Daniel L Morganstein Pensee Wu Meritxell R Mane Nick M Fisk Roger White Malcolm G Parker | 2010 | Cell Research2010，20，4： | 5 |
| 2 | Mammalian alkaline phosphatases are allosteric enzymes 显示文摘 | HOYLAERTS M F MANES T MILAN J L | 1997 | J Biol Chem1997，272，22： | 1 |
| 3 | Adeno-associated virus is associated with a lower risk of high-grade neoplasia显示文摘 | Coker A L Liu Y Mane M | 2001 | Exp Mol Pathol2001，70，： | 1 |
| 4 | 查看详情显示文摘 | Matthews D L Campbell E M Ceglio N M Hermes G Kauffman R Koppel L Lee R Manes K Rupert V Slivinsky W Turner R Ze F | | 0，，： | 1 |
| 5 | Not all arrestins are created equal: Therapeutic implications of the functional diversity of the β-arrestins in the heart显示文摘The two ubiquitous, outside the retina, G protein-coupled receptor(GPCR)adapter proteins, β-arrestin-1 and-2(also known as arrestin-2 and-3,respectively), have three major functions in cells: GPCR desensitization, i.e.,receptor decoupling from G-proteins; GPCR internalization via clathrin-coated pits; and signal transduction independently of or in parallel to G-proteins. Bothβ-arrestins are expressed in the heart and regulate a large number of cardiac GPCRs. The latter constitute the single most commonly targeted receptor class by Food and Drug Administration-approved cardiovascular drugs, with about onethird of all currently used in the clinic medications affecting GPCR function.Since β-arrestin-1 and-2 play important roles in signaling and function of several GPCRs, in particular of adrenergic receptors and angiotensin II type 1 receptors,in cardiac myocytes, they have been a major focus of cardiac biology research in recent years. Perhaps the most significant realization coming out of their studies is that these two GPCR adapter proteins, initially thought of as functionally interchangeable, actually exert diametrically opposite effects in the mammalian myocardium. Specifically, the most abundant of the two β-arrestin-1 exerts overall detrimental effects on the heart, such as negative inotropy and promotion of adverse remodeling post-myocardial infarction(MI). In contrast, β-arrestin-2 is overall beneficial for the myocardium, as it has anti-apoptotic and antiinflammatory effects that result in attenuation of post-MI adverse remodeling,while promoting cardiac contractile function. Thus, design of novel cardiac GPCRligands that preferentially activate β-arrestin-2 over β-arrestin-1 has the potential of generating novel cardiovascular therapeutics for heart failure and other heart diseases. | Anastasios Lymperopoulos Shelby L Wertz Celina M Pollard Victoria L Desimine Jennifer Maning Katie A McCrink | 2019 | World Journal of Cardiology2019，11，2： | 1 |
| 6 | Molecular mechanism of uncompetitive inhibition of human placental and germ-cell alkaline phosphatase显示文摘 | HOYLAERTS M F MANES T MILLAN J L | 1992 | Biochem J1992，286，： | 1 |
| 7 | Effect of sulfated beta- cyclodextrin, a water soluble cycloamylose, on the promotion and/ or inhibition of angiogenesis 显示文摘 | Strauss L Fuenzalida M manes J | 2002 | Pathol Oncol Res2002，8，1： | 1 |
| 8 | Effective connectivity among the working memory regions during preparation for and during performance of the n-back task显示文摘 | MANELIS A REDE L M | 2014 | Frontiers in Human Neuroscience2014，8，： | 1 |
| 9 | The national ignition facility wavefront requirements and optical architecture 显示文摘 | M L Spaeth K R Maned C C Widmayer | 2004 | SPIE2004，5341，： | 1 |
| 10 | Mammalian alkaline phosphatases are allosteric enzymes显示文摘 | Hoylaerts M F Manes T Milan J L | 1997 | J Biol Chem1997，272，22： | 1 |
| 11 | National Ignition Facility wavefront requirements and optical architecture显示文摘 | Spaeth M L Manes K R Widmayer C C | 2004 | Opt Eng2004，43，12： | 1 |
| 12 | 显示文摘 | Horrillo M C Serrini P Manes L | 1997 | Sensors and Actuators1997，45，： | 1 |
| 13 | The National Ignition Facility Wavefront Require- ments and Optical Architecture显示文摘 | Spaeth M L Manes K R Widmayer C C | 2004 | Optical Engi- neering2004，43，12： | 1 |
| 14 | National Ignition Facility wavefront requirements and optical architecture显示文摘 | Spaeth M L Manes K T Widamayer C C | 2004 | Opt Eng2004，43，12： | 1 |
| 15 | Molecular mechanism of uncompetitive inhibition of human placental andg- erm cell alkaline phosphatase显示文摘 | HOYLAERTS M F MANES T MILLAN J L | 1992 | Biochem1992，286，： | 1 |
| 16 | Structural and Magnetic Behaviour of Aluminium Doped Barium Hexaferrite Nanoparticles Synthesized by Solution Combustion Technique显示文摘 | Dhage V N Mane M L Keche A P | 2011 | Physica B2011，406，： | 1 |
| 17 | Effect of the degree of cross-linking on the properties of different CLEAs of penicillin acylase显示文摘 | Wilson I Manes A Soler L Henriquez M J | 2009 | Process Biochemistry2009，44，3： | 1 |
| 18 | Influence of chromium substitution on structural and magnetic properties of BaFel2Ol9 powder prepared by sol-gel auto combustion method 显示文摘 | Dhage V N Mane M L Babrekar M K | 2011 | J Alloys Compds2011，509，12： | 1 |
| 19 | The genome of woodland strawberry (Fragaria vesca) 显示文摘 | SHULAEV V SARGENT D J CROWHURST R N MOCKLER T C FOLKERTS O DELCHER A L JAISWAL P MOCKAITIS K LISTON A MANE S P BURNS P DAVIS T M SLOVIN J P BASSIL N HELLENS R P EVANS C HARKINS T KODIRA C DESANY B CRASTA O R JENSEN R V ALLAN A C MICHAEL T P SETUBAL J C CELTON J M REES D J WILLIAMS K P HOLT S H ROJAS J J CHATI'ERJEE M LIU B SILVA H MEISEL L ADATO A FILICHKIN S A TROGGIO M VIOLA R ASHMAN T L WANG H DHARMAWARDHANA P ELSER J RAJA R PRIEST H D BRYANT DW J R FOX S E GIVAN S A WILHELM L J NAITHANI S CHRISTOFFELS A SALAMA D Y CARTER J GIRONA E L ZDEPSKI A WANG W KERSTETTER R A SCHWAB W KORBAN S S DAVIK J MONFORT A DENOYES-ROTHAN B ARUS P MITTLER R FLINN B AHARONI A BENNETZEN J L SALZBERG S L DICKERMAN A W VELASCO R BORODOVSKY M VEILLEUX R E FOLTA K M | 2011 | Nat Genet2011，43，2： | 1 |
| 20 | The national ignition facility wavefront requirements and optical architecture显示文摘 | SPAETH M L MANES K R WIDMAYER C C | 2004 | SPIE2004，5341，： | 1 |
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