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| 1 | Depression in patients with irritable bowel syndrome in Jos,Nigeria显示文摘AIM: To study the brain-gut interaction and the effect of behavioral or psychiatric conditions on irritable bowel syndrome (IBS) in an African population. METHODS: IBS was diagnosed using the Rome Ⅱ diagnostic criteria. The entry of each patient was confirmed following detailed explanations of the questions. Four hundred and eighteen patients were studied. Subjects satisfying the Rome Ⅱ criteria for IBS were physically examined and stool microscopy was done to identify the presence of “alarm factors”. Depression was diagnosed using the symptom-check list adapted from the Research Diagnostic Criteria (DSM-Ⅳ) of the American Psychiatric Association. RESULTS: Seventy-five (56.8%) of the 132 IBS patients were depressed whereas only 54 (20.1%) of the 268 non-IBS patients were depressed. There was a significant relationship between IBS and depression (χ2 = 54.29, Odds ratio = 5.21, 56.8 ± 8.4 vs 20.1 ± 5.2, P = 0.001). Even though constipation predominant IBS patients were more likely to be depressed, no significant relationship was found between the subtype of IBS and depression (χ2 = 0.02, OR = 0.95, P = 0.68). CONCLUSION: IBS is significantly associated with major depression but not gender and bowel subtypes of the patients. Patients with IBS need to be evaluated for depression due to the highly significant relationship between the two conditions. | Nimzing G Ladep Taiwo J Obindo Moses D Audu Edith N Okeke Abraham O Malu | 2006 | World Journal of Gastroenterology2006，12，48： | 22 |
| 2 | Thiopurine metabolites variations during co-treatment with aminosalicylates for inflammatory bowel disease:Effect of N-acetyl transferase polymorphisms显示文摘AIM: To evaluate variation of the concentration of thiopurine metabolites after 5-aminosalicylate(5-ASA) interruption and the role of genetic polymorphisms of N-acetyl transferase(NAT) 1 and 2. METHODS: Concentrations of thioguanine nucleotides(TGN) and methymercaptopurine nucleotides(MMPN), metabolites of thiopurines, were measured by high performance liquid chromatography in 12 young patients(3 females and 9 males, median age 16 years) with inflammatory bowel disease(6 Crohn's disease and 6 ulcerative colitis) treated with thiopurines(7 mercaptopurine and 5 azathioprine) and 5-ASA. Blood samples were collected one month before and one month after the interruption of 5-ASA. DNA was extracted and genotyping of NAT1, NAT2, inosine triphosphate pyrophosphatase(ITPA) and thiopurine methyl transferase(TPMT) genes was performed using PCR assays. RESULTS: Median TGN concentration before 5-ASA interruption was 270 pmol/8 x 108 erythrocytes(range: 145-750); after the interruption of the aminosalicylate, a 35% reduction in TGN mean concentrations(absolutemean reduction 109 pmol/8 × 108 erythrocytes) was observed(median 221 pmol/8 × 108 erythrocytes, range: 96-427, P value linear mixed effects model 0.0011). Demographic and clinical covariates were not related to thiopurine metabolites concentrations. All patients were wild-type for the most relevant ITPA and TPMT variants. For NAT1 genotyping, 7 subjects presented an allele combination corresponding to fast enzymatic activity and 5 to slow activity. NAT1 genotypes corresponding to fast enzymatic activity were associated with reduced TGN concentration(P value linear mixed effects model 0.033), putatively because of increased 5-ASA inactivation and consequent reduced inhibition of thiopurine metabolism. The effect of NAT1 status on TGN seems to be persistent even after one month since the interruption of the aminosalicylate. No effect of NAT1 genotypes was shown on MMPN concentrations. NAT2 genotyping revealed that 6 patients presented a genotype corresponding to fast enzymatic activity and 6 to slow activity; NAT2 genotypes were not related to thiopurine metabolites concentration in this study. CONCLUSION: NAT1 genotype affects TGN levels in patients treated with thiopurines and aminosalicylates and could therefore influence the toxicity and efficacy of these drugs; however the number of patients evaluated is limited and this has to be considered a pilot study. | Gabriele Stocco Eva Cuzzoni Sara De Iudicibus Diego Favretto Noelia Malusà Stefano Martelossi Elena Pozzi Paolo Lionetti Alessandro Ventura Giuliana Decorti | 2015 | World Journal of Gastroenterology2015，21，12： | 5 |
| 3 | Long-Term Conservation Agriculture and Intensified Cropping Systems:Effects on Growth,Yield,Water,and Energy-use Efficiency of Maize in Northwestern India显示文摘Conservation agriculture(CA)-based best-bet crop management practices may increase crop and water productivity, while conserving and sustaining natural resources. We evaluated the performance of rainy season maize during 2014 under an ongoing long-term trial(established in 2008) with three tillage practices, i.e., permanent bed(PB), zero tillage(ZT), and conventional tillage(CT) as main plots, and four intensified maize-based cropping systems, i.e., maize-wheat-mungbean, maize-chickpea-Sesbania(MCS), maizemustard-mungbean, and maize-maize-Sesbania) as subplot treatments. In the seventh rainy season of the experiment, maize growth parameters, yield attributes, yield, and water-and energy-use efficiency were highest at fixed plots under ZT. Maize growth parameters were significantly(P < 0.05) superior under ZT and PB compared with CT. Maize yield attributes, including cobs per m^2(7.8), cob length(0.183 m), grain rows per cob(13.8), and grains per row(35.6), were significantly higher under ZT than CT; however, no significant effect of cropping systems was found on maize growth and yield attributes. Zero tillage exhibited the highest maize productivity(4 589 kg ha^(-1)). However, among the cropping systems, MCS exhibited the highest maize productivity(4 582 kg ha^(-1)). In maize, water use was reduced by 80.2–120.9 mm ha-1under ZT and PB compared with CT, which ultimately enhanced the economic water-use efficiency by 42.0% and 36.6%, respectively. The ZT and PB showed a 3.5%–31.8% increase in soil organic carbon(SOC) at different soil depths(0–0.45 m), and a 32.3%–39.9% increase in energy productivity compared with CT. Overall, our results showed that CA-based ZT and PB practices coupled with diversified maize-based cropping systems effectively enhanced maize yield and SOC,as well as water-and energy-use efficiency, in northwestern India. | Chiter M.PARIHAR Malu R.YADAV Shankar L.JAT Aditya K.SINGH Bhupender KUMAR Vijay POONIYA Sanatan PRADHAN Rakesh K.VERMA Mangi L.JAT Raj K.JAT Muli D.PARIHAR Hari S.NAYAK Yashpal S.SAHARAWAT | 2018 | Pedosphere2018，28，6： | 3 |
| 4 | A Comprehensive and Automated Approach to Intelligent Business Process Execution Analysis显示文摘 | Malu C Fabio C Umeshwar D | 2004 | Distributed and Parallel Database2004，16，3： | 1 |
| 5 | The role of leptin in the respiratory system: an overview 显示文摘 | MALU F PAPAIOANNOU A I GOURGOUUANIS K I et at | 2010 | Respir Res2010，11，： | 1 |
| 6 | E-business Process Modeling:The Next Big Step显示文摘 | Aissi S Malu P Srinivasan K | 2002 | IEEE Computer2002，35，5： | 1 |
| 7 | Ectopic pregnancy显示文摘 | Al-Jabri S Malus M Tulandi T | | 0，，03： | 1 |
| 8 | Ectopic pregnancy显示文摘 | Al-Jabri S Malus M Tulandi T | | 0，，： | 1 |
| 9 | Comparison of written reports of mammography, sonography and magnetic resonance mammography for preoperative evaluation of breast lesions,with special emphasis on magnetic resonance mammography显示文摘 | Wurdinger S Moritz A | 2001 | Breast Cancer Res2001，3，： | 1 |
| 10 | An effective test suite reduction using priority cost technique 显示文摘 | Rout J P Mishra R Malu R | 2013 | International Journal of Computer Science & Engineering Technology2013，4，4： | 1 |
| 11 | Sentinel lymph node detectionin patients with cer-vical cancer 显示文摘 | Malus S Krause N Kohler C | 2001 | Gynecol Oncol2001，80，2： | 1 |
| 12 | E-Business Process Modeling:The Next Big Step显示文摘 | Selim Aissi Pallavi Malu Krishnamurthy Srinivasan | 2002 | IEEE Computer2002，35，5： | 1 |
| 13 | E-business process modeling:the next big step显示文摘 | AISSI S MALU P SRINIVASAN K | 2002 | IEEE Computer2002，35，5： | 1 |
| 14 | Neuroinflammation in Parkinson's disease: its role in neuronal death and implications for therapeutic intervention 显示文摘 | Malu GT Matthew SG | 2010 | Neurobiol Dis2010，37，3： | 1 |
| 15 | Representation of conceptual ETL designs in natural language using Semantic Web technology显示文摘 | Alkis S Dimitrios S Malu C | 2010 | Data&Knowledge Engineering2010，69，1： | 1 |
| 16 | Business Process Intelligence显示文摘 | Daniela Grigoria Fabio C asati Malu Castellanosb | 2004 | Computers in Industry2004，53，3： | 1 |
| 17 | Effect of rhizospheric microorganisms inoculum on sweet pepper quality显示文摘 | F. Rosso F. Zoppellari G. Sala B. Bergesio E. Malusà L. Bardi | 2010 | Journal of Biotechnology2010，，： | 1 |
| 18 | Upper gastrointestinal endocopic findings in patients with HIV/AIDS at the jos university teaching hospital Nigeria显示文摘 | Okeke EN Agaba EI Malu AO | 2003 | Niger J Med2003，12，4： | 1 |
| 19 | Business process intelligence显示文摘 | Origori Daniela Casati Fabio Castellanos Malu | 2004 | Computers in Industry2004，53，3： | 1 |
| 20 | Representation of conceptual ETL designs in natural language using semantic Web technol- ogy显示文摘 | Alkis S Dimitrios S Malu C | 2010 | Data & Knowledge Engineering2010，69，1： | 1 |
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