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| 1 | Nonalcoholic fatty liver disease in patients with inflammatory bowel disease: Beyond the natural history显示文摘BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is a frequently reported condition in patients with inflammatory bowel disease(IBD).Both intestinal inflammation and metabolic factors are believed to contribute to the pathogenesis of IBDassociated NAFLD.AIM To evaluate the prevalence of steatosis and liver fibrosis(LF)in a cohort of IBD patients and the identification of metabolic-and IBD-related risk factors for NAFLD and LF.METHODS IBD patients were consecutively enrolled from December 2016 to January 2018.Demographic,anthropometric and biochemical data were collected so as eating habits.Abdominal ultrasound and transient elastography were performed to evaluate the presence of NAFLD and LF respectively.RESULTS A total of 178 consecutive patients were enrolled and included in the analysis(95 Ulcerative colitis,83 Crohn’s disease).NAFLD was detected by imaging in 72(40.4%)patients.Comparison between patients with and without NAFLD showed no significant differences in terms of IBD severity,disease duration,location/extension,use of IBD-related medications(i.e.,steroids,anti-TNFs,and immunomodulators)and surgery.NAFLD was significantly associated with the presence of metabolic syndrome[MetS;odds ratio(OR):4.13,P=0.001]and obesity defined by body mass index(OR:9.21,P=0.0002).IBD patients with NAFLD showed higher caloric intake and lipid consumption than those without NAFLD,regardless disease activity.At the multivariate analysis,male sex,advanced age and high lipid consumption were independent risk factors for the development of NAFLD.An increased liver stiffness was detected in 21 patients(16%)and the presence of MetS was the only relevant factor associated to LF(OR:3.40,P=0.01).CONCLUSION In this study,we demonstrate that risk factors for NAFLD and LF in the IBD population do not differ from those in the general population. | Salvatore Magrì Danilo Paduano Fabio Chicco Arianna Cingolani Cristiana Farris Giovanna Delogu Francesca Tumbarello Mariantonia Lai Alessandro Melis Laura Casula Massimo C Fantini Paolo Usai | 2019 | World Journal of Gastroenterology2019，25，37： | 8 |
| 2 | Impact of laparoscopic surgery training laboratory on surgeon's performance显示文摘Minimally invasive surgery has been replacing the open standard technique in several procedures. Similar or even better postoperative outcomes have been described in laparoscopic or robot-assisted procedures when compared to open surgery. Moreover, minimally invasive surgery has been providing less postoperative pain, shorter hospitalization, and thus a faster return to daily activities. However, the learning curve required to obtain laparoscopic expertise has been a barrier in laparoscopic spreading. Laparoscopic surgery training laboratory has been developed to aid surgeons to overcome the challenging learning curve. It may include tutorials, inanimate model skills training(box models and virtual reality simulators), animal laboratory, and operating room observation. Several different laparoscopic courses are available with specific characteristics and goals. Herein, we aim to describe the activities performed in a dry and animal-model training laboratory and to evaluate the impact of different kinds of laparoscopic surgery training courses on surgeon's performance. Several tasks are performed in dry and animal laboratory to reproduce a real surgery. A short period of training can improve laparoscopic surgical skills, although most of times it is not enough to confer laparoscopic expertise for participants. Nevertheless, this short period of training is able to increase the laparoscopic practice of surgeons in their communities. Full laparoscopic training in medical residence or fellowship programs is the best way of stimulating laparoscopic dissemination. | Fabio C M Torricelli Joao Arthur B A Barbosa Giovanni S Marchini | 2016 | World Journal of Gastrointestinal Surgery2016，8，11： | 6 |
| 3 | Celiac disease serology in patients with different pretest probabilities: Is biopsy avoidable?显示文摘AIM: To establish the diagnostic performance of sev-eral serological tests, individually and in combination, for diagnosing celiac disease (CD) in patients with different pretest probabilities, and to explore potential se- rological algorithms to reduce the necessity for biopsy. METHODS: We prospectively performed duodenal biopsy and serology in 679 adults who had either high risk (n = 161) or low risk (n = 518) for CD. Blood samples were tested using six assays (enzyme-linked immunosorbent assay) that detected antibodies to tissue transglutaminase (tTG) and deamidated gliadin peptide (DGP). RESULTS: CD prevalence was 39.1% in the high-risk population and 3.3% in the low-risk group. In high-risk patients, all individual assays had a high diagnostic efficacy [area under receiving operator characteristic curves (AU ROC): 0.968 to 0.999]. In contrast, assays had a lower diagnostic efficacy (AU ROC: 0.835 to 0.972) in the low-risk group. Using assay combinations, it would be possible to reach or rule out diagnosis of CD without biopsy in 92% of cases in both pretest populations. We observed that the new DGP/tTG Screen assay resulted in a surplus compared to more conventional assays in any clinical situation. CONCLUSION: The DGP/tTG Screen assay could be considered as the best initial test for CD. Combinations of two tests, including a DGP/tTG Screen, might be able to diagnose CD accurately in different clinical scenarios making biopsy avoidable in a high proportion of subjects. | Emilia Sugai María L Moreno Hui J Hwang Ana Cabanne Adriana Crivelli Fabio Nach-man Horacio Vázquez Sonia Niveloni Julio Argonz Roberto Mazure Graciela La Motta María E Caniggia Edgardo Smecuol Néstor Chopita Juan C Gómez Eduardo Maurińo Julio C Bai | 2010 | World Journal of Gastroenterology2010，16，25： | 4 |
| 4 | Acute fatty liver of pregnancy associated with severe acute pancreatitis:A case report显示文摘Acute fatty liver of pregnancy is a rare disease that affects women in the third trimester of pregnancy. Although infrequent, the disease can cause maternal mortality. The diagnosis is not always clear until the pregnancy is terminated, and significant complications, such as acute pancreatitis, can occur. Pancreatic involvement typically only occurs in severe cases after the development of hepatic and renal impairment. To date, little knowledge is available regarding how the disease causes pancreatitis. Treatment involves supportive measures and pregnancy interruption. In this report, we describe a case of a previously healthy 26-year-old woman at a gestational age of 27 wk and 6 d who was admitted with severe abdominal pain and vomiting. This case illustrates the clinical and laboratory overlap between acute fatty liver of pregnancy and pancreatitis, highlighting the difficulties in differentiating each disease. Furthermore, the hypothesis for this overlapping is presented, and the therapeutic options are discussed. | Cássio Vieira de Oliveira Alecsro Moreira Julio P Baima Leticia de C Franzoni Talles B Lima Fabio da S Yamashiro Kunie Yabuki Rabelo Coelho Ligia Y Sassaki Carlos Antonio Caramori Ferno G Romeiro Giovanni F Silva | 2014 | World Journal of Hepatology2014，6，7： | 3 |
| 5 | Phase II study of cetuximab in combination with FOLFIRI in patients with untreated advanced gastric or gastroesophageal junction adenocarcinoma ( FOLCETUX study) 显示文摘 | PINTO C DI FABIO F SIENA S | 2007 | Ann Oncol2007，18，3： | 1 |
| 6 | Phase Ⅱ study of cetuximab plus FOLFIRI as first-line treatment in patients with unresectable/metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma (FOLCETUX study):preliminary results显示文摘 | Pinto C Di Fabio F Siena S | 2006 | J Clin Oncol2006，24，18： | 1 |
| 7 | Class I infrared eye blinking detector显示文摘 | FABIO L C | 2008 | Sensors and Actuators A:Physical2008，148，2： | 1 |
| 8 | Percutaneous calcaneo- plasty in displaced intraarticular calcaneal fractures 显示文摘 | Biggi F Di Fabio S D'Antimo C | 2013 | J Ortho- paed Traumatol2013，14，4： | 1 |
| 9 | Phase Ⅱ study of cetuximab in combination with FOLFIRI in patients with untreated advanced gastric or gastroesophageal junction adenocarcinoma (FOLCETUX study)显示文摘 | Pinto C Fabio F D Siena S | 2007 | Annals of Oncology2007，18，3： | 1 |
| 10 | Tibial plateau fractures : Inter- nal fixation with locking plates and the MIPPO technique显示文摘 | Biggi F Di Fabio S D' Antimo C | 2010 | Injury2010，41，11： | 1 |
| 11 | Capecitabine plus oxaliplatin(xelox)versus protracted5-fluorouracil venous infusion plus oxaliplatin(pvifox)as first-line treatment in advanced colorectal cancer:A GOAM phase II randomised study(FOCA trial)显示文摘 | Martonia AA Pinto C Di Fabio F | 2006 | Eur J Cancer2006，42，18： | 1 |
| 12 | Optimization of the determination of organic acids and sugars in fruit juices by ion-exclusion liquid chromatography显示文摘 | Fabio C Umberto S Claudio R | 2005 | Journal of Food Composition and Analysis2005，18，： | 1 |
| 13 | Phase Ⅱ study of cetuximab in combination with FOLFIRI in patients with untreated advanced gastric or gastroesophageal junction adenocarcinoma (FOLCETUX study)显示文摘 | Pinto C Di Fabio F Siena S | 2007 | Ann Oncol2007，18，3： | 1 |
| 14 | A Comprehensive and Automated Approach to Intelligent Business Process Execution Analysis显示文摘 | Malu C Fabio C Umeshwar D | 2004 | Distributed and Parallel Database2004，16，3： | 1 |
| 15 | Estimation of green grass/herb biomass from airborne hyperspectral imagery using spectral indices and partial least squares regression显示文摘 | Moses A C Andrew S Fabio C | 2007 | Inter national Journal of Applied Earth Observation and Geoinfor marion2007，9，4： | 1 |
| 16 | Protein-Nanoparticle Interaction:Identification of the Ubiquitin-Gold Nanoparticle Interaction Site显示文摘 | Luigi C Fabio F Douglas G | | 0，，： | 1 |
| 17 | Somatic mosaicism ofthe androgen receptor CAG repeats in colorectal carcinomaepithelial cells from men显示文摘 | Di Fabio F Alvarado C Gologan A | 2009 | J Surg Res2009，154，1： | 1 |
| 18 | Clinical Stabilometry Standardization Basic Definitions-Acquisition Interval-Sampling Frequency显示文摘 | Fabio S Roberto C Michele G | 2014 | Gait and Posture2014，39，： | 1 |
| 19 | Balance and eye movement training to improve gait in people with progressive supranuclear palsy:quasi-randomized clinical trial显示文摘 | Zampieri C Di Fabio RP | 2008 | Phys Ther2008，88，12： | 1 |
| 20 | Tibial plateau fractures : internal fixation with locking plates and the MI- PO technique显示文摘 | Biggi F Di Fabio S D' Antimo C | 2010 | Injury2010，41，11： | 1 |
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