|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Genetically modified mouse models for the study of nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD) is associated with obesity,insulin resistance,and type 2 diabetes.NAFLD represents a large spectrum of diseases ranging from(1) fatty liver(hepatic steatosis);(2) steatosis with inflammation and necrosis;to(3) cirrhosis.The animal models to study NAFLD/nonalcoholic steatohepatitis(NASH) are extremely useful,as there are still many events to be elucidated in the pathology of NASH.The study of the established animal models has provided many clues in the pathogenesis of steatosis and steatohepatitis,but these remain incompletely understood.The different mouse models can be classified in two large groups.The first one includes genetically modified(transgenic or knockout) mice that spontaneously develop liver disease,and the second one includes mice that acquire the disease after dietary or pharmacological manipulation.Although the molecular mechanism leading to the development of hepatic steatosis in the pathogenesis of NAFLD is complex,genetically modified animal models may be a key for the treatment of NAFLD.Ideal animal models for NASH should closely resemble the pathological characteristics observed in humans.To date,no single animal model has encompassed the full spectrum of human disease progression,but they can imitate particular characteristics of human disease.Therefore,it is important that the researchers choose the appropriate animal model.This review discusses various genetically modified animal models developed and used in research on NAFLD. | Perumal Nagarajan M Jerald Mahesh Kuma Ramasamy Venkatesan Subeer S Majundar Ramesh C Juyal M Jerald Mahesh Kuma | 2012 | World Journal of Gastroenterology2012，18，11： | 7 |
| 2 | Phytochemical constituents and antibacterial efficacy of the flowers of Peltophomm pterocarpum(DC.) Baker ex Heyne显示文摘Objective:To investigate the preliminary phytochemistry and antibacterial activity of the flower extract of Peltophorum pterocarpum.Methods:Phytochemical analysis was done by using the standard methods given by Harbone.The methanolic flower extract were tested against Escherichia coli,Klebsiella pneumonia,Pseudomonas aeruginosa.Staphylococcus aureus. Bacillus cereus,Salmonella typhi,Serratia marsecens,Acinetobacter baumannii.Enterobacter sp., Proteus mirabilis.Enterococcus faecalis and Streptococcus pyogenes by the agar disc diffusion method.Results:Preliminary phytochemical screening of flower extract showed the presence of phenolic compounds,flavonoids.saponins,steroids,tannins,xanthoproteic,carboxylic acids, coumarins and carbohydrates.The flower extract of Peltophorum pteroearpum showed significant activity against four gram positive(Staphylococcus aureus.Bacillus cereus.Enlerococcus faecalis and Streptococcus pyogenes) and three gram negative bacteria(Proteus mirabilis,Acinetohacter baumannii and Serratia marsecens).out of 12 pathogenic bacteria studied.Conclusion:The findings of the present study confirm the presence of significant antibacterial activity against human pathogens in the flowers of Peltophorum pleracarpum. | Sukumaran S Kiruba S Mahesh M Nisha SR Miller Paul Z Ben CP Jeeva S | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，9： | 4 |
| 3 | Hemoglobin A1c in early postpartum screening of women with gestational diabetes显示文摘AIM:To assess the utility of hemoglobin A1c(HbA1c) in the early postpartum screening of women with gestational diabetes mellitus(GDM).METHODS:Over a 3 years period,HbA1c estimations were undertaken in addition to and simultaneously with the traditional oral glucose tolerance test(OGTT),in 203 women with GDM as a part of early postpartum screening for dysglycaemia,at 6 wk post-partum.World Health Organization criteria was used for diagnosing diabetes:fasting blood glucose(FBG) ≥ 7.0 mmol/Land/or 2-h postprandial blood glucose(PPBG) ≥ 11.1 mmol/L and/or HbA1c ≥ 48 mmol/mol;and impaired glycaemiastate:impaired fasting glucose 6.1-6.9 mmol/L and/or impaired glucose tolerance 7.8-11.0 mmol/L and/or HbA1c:42-47 mmol/mol.RESULTS:Mean FBG,2-h PPBG and HbA1c were 4.9 ± 0.7 mmol/L,5.6 ± 2.0 mmol/L and 38 ± 5 mmol/mol respectively.FBG,2-h PPBG and HbA1c detected 6(3%),7(3.5%) and 11(5.4%) cases of diabetes respectively,and 11(5.4%),25(12.3%) and 23(11.3%) cases of pre-diabetes state respectively.HbA1c values ≥ 48 mmol/mol(≥ 6.5%) showed a diagnostic sensitivity of 71.4% and specificity of 98.5% for diabetes in comparison to OGTT in receiver operating characteristics curve analysis.At HbA1c cut-off 44 mmol/mol,sensitivity and specificity were 100% and 92.3% respectively [area under the curve:0.98(95%CI:0.96-1.00)].Sensitivity and specificity for detecting high risk 'impaired glycaemia' state [HbA1c 42 mmol/mol(6.0%)] were 28% and 80%,respectively.CONCLUSION:HbA1c level ≥ 48 mmol/mol(≥ 6.5%) has reasonable sensitivity and high specificity in comparison to OGTT for early postpartum screening of diabetes in GDM.At 6 th week postpartum screening,if FBG is normal and HbA1c < 44 mmol/mol OGTT is not recommended. | Mahesh V Katreddy Joseph M Pappachan Sarah E Taylor Radha Indusekhar Ananth U Nayak Alan M Nevill | 2013 | World Journal of Diabetes2013，4，3： | 2 |
| 4 | Chemotherapy options in elderly and frail patients with metastatic colorectal cancer (MRC FOCUS2): an open-label, randomised factorial trial显示文摘 | Matthew T Seymour Lindsay C Thompson Harpreet S Wasan Gary Middleton Alison E Brewster Stephen F Shepherd M Sinead O’Mahony Timothy S Maughan Mahesh Parmar Ruth E Langley | 2011 | The Lancet2011，，9779： | 2 |
| 5 | Ferroelectricity in a pure BiFeO3 ceramic 显示文摘 | MAHESH K M PALKARA V R SRINIVAS K | 2000 | Appl Phys Lett2000，76，19： | 1 |
| 6 | Next-generation x-ray CT units will provide <500msec images with 3dresolution comparable to today's projection radiography显示文摘 | Mahesh M Cody D | 2003 | Med Phys2003，30，7： | 1 |
| 7 | Synthesis and characterization of nylon 6 triblock copolymer using new hybrid soft segment 显示文摘 | Pandya M V Mahesh Subramaniyam Desai M R | 1997 | Eur Polym J1997，33，： | 1 |
| 8 | Posterior epistaxis identification of common bleeding sites 显示文摘 | Theoraton M A Mahesh B N Lang J | 2005 | Laryngol Scope2005，115，4： | 1 |
| 9 | Effect of mineral phosphates on growth and nitrogen fixation of diazotro- phie eyanobaeteria Anabaena variabilis and Westiellopsis prolifica 显示文摘 | Mahesh S Yandigeri Arvind K Yadav K K M | 2010 | Antonie van Leeuwenhoek2010，，97： | 1 |
| 10 | Modeling of an industrialwet grinding operation using data-driven techniques显示文摘 | Kishalay M Mahesh G | 2006 | Computers & Chemical Engineering2006，30，3： | 1 |
| 11 | Modeling of droplet dynamic and thermal behavior during spray deposition 显示文摘 | MAHESH N S MENDONCA J MURALIDHARA M K | 2003 | Indian Academy of Sciences2003，26，3： | 1 |
| 12 | Modeling of droplet dynamic and thermal behavior during spray deposition 显示文摘 | Mendonca Johnson Mahesh N S Muralidhara M K | 2003 | Mater Science Bull2003，26，3： | 1 |
| 13 | E-Business Models in B2B :Process Based Categorization and Analysis of B2B Models 显示文摘 | MAHESH S R TURAN M LIJIE Z | 2005 | International Journal of E-Business Research2005，1，1： | 1 |
| 14 | Is iterative reconstruction ready for MDCT?显示文摘 | Xu J Mahesh M Tsui B M | 2009 | J Am Coll Radiol2009，6，： | 1 |
| 15 | Endopyeloplasty versus endopyelotomy versus laparoscopic pyeloplasty for primary ureteropelvic junction obstruction显示文摘 | Mihir M Desai Mahesh R Desai Inderbir S Gill | 2004 | Urology2004，，1： | 1 |
| 16 | Performance comparison of Gaussian-based filters using information measures显示文摘 | MAHESH V MONICA F B Petar M D | 2007 | IEEE Signal Processing Letters2007，14，12： | 1 |
| 17 | Zirconium(IV)chloride catalyzed one-pot sunthesis of3 , 4-dihudropyrimidin-2- (1H )-ones 显示文摘 | REDDY C V MAHESH M RAJU P V K | 2002 | TetrahedronLett2002，43，14： | 1 |
| 18 | Association of IL-4 and Adam33 gene polymorphisms with asthma in an Indian population显示文摘 | Bijanzadeh M Ramachandra NB Mahesh PA | | 0，，05： | 1 |
| 19 | Ferroelectricity in a pure BiFeO3 ceramic显示文摘 | Mahesh Kumar M Palkar V R Srinivas K | 2000 | Appl Phys Lett2000，76，19： | 1 |
| 20 | Thermomechanical behavior of Ti-rich NiTi shape memory alloys 显示文摘 | Paula A S Mahesh K K Dos Santos C M L | 2007 | Materials Science and EngineeringA2007，，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员