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| 1 | 烟酰胺磷酸核糖基转移酶促进肺血管重塑,是肺动脉高压的治疗靶点显示文摘肺动脉高压(pulmonary arterial hypertension,PAH)是一种严重的进行性疾病,其标志之一是肺血管重塑。烟酰胺磷酸核糖基转移酶(nicotinamide phosphoribosyl transferase,NAMPT)是调节细胞内烟酰胺腺嘌呤二核苷酸水平、细胞氧化还原状态,调节组蛋白脱乙酰酶,促进细胞增殖和抑制凋亡的一种细胞酶。研究人员假设NAMPT可促进肺血管重塑, | Chen J Sysol JR Singla S Zhao S Yamamura A Valdez-Jasso D Abbasi T Shioura KM Sahni S Reddy V Sridhar A Gao H Torres J Camp SM Tang H Ye SQ Comhair S Dweik R Hassoun P Yuan JX Garcia JG Machado RF 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，2： | 10 |
| 2 | Expression Profiling Identifies Candidate Genes for Fiber Yield and Quality显示文摘Gene expression profiling at early stages(0~2 DPA) of fiber development in Gossypium hirsutum identified a number of transcription factors which were down regulated in fiberless mutants relative to wild type controls and which could play a role in controlling early fiber development.Chief among these was GhMYB25,a Mixta-like MYB gene.Transgenic GhMYB25-silenced cotton | LLEWELLYN D J MACHADO A AI-GHAZI Y DENNIS E S | 2008 | 棉花学报2008，20，S1： | 3 |
| 3 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 4 | Psychotropic drugs and liver disease:A critical review of pharmacokinetics and liver toxicity显示文摘The liver is the organ by which the majority of sub-stances are metabolized, including psychotropic drugs. There are several pharmacokinetic changes in end-stage liver disease that can interfere with the metabolization of psychotropic drugs. This fact is particularly true in drugs with extensive first--pass metabolism, highly protein bound drugs and drugs depending on phase I hepatic metabolic reactions. Psychopharmacological agents are also associated with a risk of hepatotoxicity. The evidence is insufficient for definite conclusions regarding the prevalence and severity of psychiatric drug-induced liver injury. High-risk psychotropics are not advised when there is pre-existing liver disease, and after starting a psychotropic agent in a patient with hepatic impairment, frequent liver function/lesion monitoring is advised. The authors carefully review the pharmacokinetic disturbances induced by end-stage liver disease and the potential of psychopharmacological agents for liver toxicity. | Diogo Telles-Correia António Barbosa Helena Cortez-Pinto Carlos Campos Nuno B F Rocha Sérgio Machado | 2017 | World Journal of Gastrointestinal Pharmacology and Therapeutics2017，8，1： | 3 |
| 5 | Systems for therapeutic angiogenesis in tissue engineering显示文摘 | Soker S Machado M Atala A | 2000 | World J Urol2000，18，： | 1 |
| 6 | Selective synthesis of glycerol monolaurate with zeolitic molecular sieves显示文摘 | M da S Machado J P6rez - Pariente E Sastre | 2000 | Applied Catalysis A : General2000，203，2： | 1 |
| 7 | Impact of lipoxin-mediated regulation on immune response to infectious disease显示文摘 | Fabiana S Machado JA | 2006 | Immunol Res2006，35，3： | 1 |
| 8 | Analysis of the Consumption of Artistic- cultural Goods and Services in Brazil 显示文摘 | Diniz S C Machado A F | 2011 | Journal of Cultural Eco- nomics2011，35，1： | 1 |
| 9 | Osmotic response in Lactobacillus casei ATCC 393:biochemical and biophysical characteristics of membrane显示文摘 | Machado M C Lopez C S Heras H | 2004 | Arch Biochem Biophy2004，422，： | 1 |
| 10 | New oxidation catalysts based on iron(III) porphyrins immobilized on Mg-Al layered double hydroxides modified with triethanolamine 显示文摘 | CASTRO K A D F BAIL A GROSZEWICZ P B MACHADO G S SCHREINER W H WYPYCH F NAKAGAKI S | 2010 | Appl Catal A: Gen2010，386，： | 1 |
| 11 | Selective Synthesis of Glycerol Monolaurate with Zeolitie Molecular Sieves显示文摘 | MACHADO M S PEREZ-PARIENTE J SASTRE E | 2000 | Applied Catalysis A:Gen- eral2000，203，2： | 1 |
| 12 | Ten - year experience using antegrade enemas in children显示文摘 | Mugie S M Machado R S Mousa H M | 2012 | J Pediatr2012，161，4： | 1 |
| 13 | Biocompatibility study for PVP wound dressing obtained in different conditions显示文摘 | Higa O Z Rogero S O Machado L D B | 1999 | Radiation Physics and Chemistry1999，55，56： | 1 |
| 14 | Mitochondrial distribution and adenosine triphosphate content of bovine ooctyes before and after in vitro maturation:correlation with morphological criteria and developmental capacity after in vitro fertilization and culture 显示文摘 | STOJKOVIC M MACHADO S A STOJKOVIC P | 2001 | Biol Reprod2001，64，3： | 1 |
| 15 | Break-even price for upstream activities in Brazil: Evaluation of the opportunity cost of oil production delay in a non-mature sedimentary production region显示文摘 | Szklo A S Carneiro J T G Machado G | 2008 | Energy2008，33，： | 1 |
| 16 | Defunctioning stoma in low anterior resection with colonic pouch for rectal cancer:a compari-son between two hospitals with a differentpolicy 显示文摘 | Machado M Hallbook O Goldman S et al | 2002 | Dis Colon Rec-tum2002，45，7： | 1 |
| 17 | InterleukinlB and InterleukinlRN polymorphism are associated with increased risk of gastric carcinoma显示文摘 | Machado JC Pharoah P Sousa S | 2001 | Gastroenterology2001，121，4： | 1 |
| 18 | Tactics for vascular protection after acute ischemic stroke 显示文摘 | Fagan S C Hess D C Machado L S | 2005 | Pharmacotherapy2005，25，3： | 1 |
| 19 | Trace metals in man-grove seedlings : Role of iron plaque formation显示文摘 | Machado W Gueiros B Lisboa-Filho S | 2005 | Wetlands Ecol Man-ag2005，13，2： | 1 |
| 20 | Elimination of marker genes from transformed filamentous fungi by unselected transient transfec- tion with a Cre-expressing plasmid 显示文摘 | Florea S Andreeva K Machado C | 2009 | Fungal Genetics and Biology2009，46，10： | 1 |
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