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| 1 | Synthesis of Na A and-X zeolites from oil shale ash 显示文摘 | Machado N R C F Miotto D M M | 2005 | Fuel2005，84，： | 1 |
| 2 | In vitro activity of Brazilian medicinal plants,naturally occurring naphthoquinones and their analogues,against methicillin-resistant staphylococcus aureus显示文摘 | MACHADO T B PINTO A V PINTO M C | 2003 | Int J Antimicrob Ag2003，21，3： | 1 |
| 3 | Osmotic response in Lactobacillus casei ATCC 393:biochemical and biophysical characteristics of membrane显示文摘 | Machado M C Lopez C S Heras H | 2004 | Arch Biochem Biophy2004，422，： | 1 |
| 4 | ApoB genehaplo type is associated with lipid profile of higher risk forcoronary heart disease in Caucasian Brazilian men 显示文摘 | Machado M O H irata M H Bertolami M C | 2001 | J Clin LabAnal2001，15，1： | 1 |
| 5 | Floating photocatalysts based on TiO2 supported on high surface area exfoliated vermiculite for water decontamination显示文摘 | Machado L C R Torchia C B Lago R M | 2006 | Catal Com2006，7，： | 1 |
| 6 | Simultaneous follow-up of mouse colon lesions by colonoscopy and endoluminal ultrasound biomicroscopy显示文摘AIM:To evaluate the potential use of colonoscopy and endoluminal ultrasonic biomicroscopy(eUBM)to track the progression of mouse colonic lesions.METHODS:Ten mice were treated with a single azoxy-methane intraperitoneal injection(week 1)followed by seven days of a dextran sulfate sodium treatment in their drinking water(week 2)to induce inflammationassociated colon tumors.eUBM was performed simultaneously with colonoscopy at weeks 13,17-20 and21.A 3.6-F diameter 40 MHz mini-probe catheter was used for eUBM imaging.The ultrasound mini-probe catheter was inserted into the accessory channel of a pediatric flexible bronchofiberscope,allowing simultaneous acquisition of colonoscopic and eUBM images.During image acquisition,the mice were anesthetized with isoflurane and kept in a supine position over a stainless steel heated surgical waterbed at 37℃.Both eUBM and colonoscopic images were captured and stored when a lesion was detected by colonoscopy or when the eUBM image revealed a modified colon wall anatomy.During the procedure,the colon was irrigated with water that was injected through a flush port on the mini-probe catheter and that acted as the ultrasound coupling medium between the transducer and the colon wall.Once the acquisition of the last eUBM/colonoscopy section for each animal was completed,the colons were fixed,paraffin-embedded,and stained with hematoxylin and eosin.Colon images acquired at the first time-point for each mouse were compared with subsequent eUBM/colonoscopic images of the same sites obtained in the following acquisitions to evaluate lesion progression.RESULTS:All 10 mice had eUBM and colonoscopic images acquired at week 13(the first time-point).Two animals died immediately after the first imaging acquisition and,consequently,only 8 mice were subjected to the second eUBM/colonoscopy imaging acquisition(at the second time-point).Due to the advanced stage of colonic tumorigenesis,5 animals died after the second time-point image acquisition,and thus,only three were subjected to the third eUBM/colonoscopy imaging acquisition(the third time-point).eUBM was able to detect the four layers in healthy segments of colon:the mucosa(the first hyperechoic layer moving away from the mini-probe axis),followed by the muscularis mucosae(hypoechoic),the submucosa(the second hyperechoic layer)and the muscularis externa(the second hypoechoic layer).Hypoechoic regions between the mucosa and the muscularis externa layers represented lymphoid infiltrates,as confirmed by the corresponding histological images.Pedunculated tumors were represented by hyperechoic masses in the mucosa layer.Among the lesions that decreased in size between the first and third time-points,one of the lesions changed from a mucosal hyperplasia with ulceration at the top to a mucosal hyperplasia with lymphoid infiltrate and,finally,to small signs of mucosal hyperplasia and lymphoid infiltrate.In this case,while lesion regression and modification were observable in the eUBM images,colonoscopy was only able to detect the lesion at the first and second time-points,without the capacity to demonstrate the presence of lymphoid infiltrate.Regarding the lesions that increased in size,one of them started as a small elevation in the mucosa layer and progressed to a pedunculated tumor.In this case,while eUBM imaging revealed the lesion at the first time-point,colonoscopy was only able to detect it at the second time-point.All colonic lesions(tumors,lymphoid infiltrate and mucosal thickening)were identified by eUBM,while colonoscopy identified just76%of them.Colonoscopy identified all of the colonic tumors but failed to diagnose lymphoid infiltrates and increased mucosal thickness and failed to differentiate lymphoid infiltrates from small adenomas.During the observation period,most of the lesions(approximately67%)increased in size,approximately 14%remained unchanged,and 19%regressed.CONCLUSION:Combining eUBM with colonoscopy improves the diagnosis and the follow-up of mouse colonic lesions,adding transmural assessment of the bowel wall. | Rossana C Soletti Kelly Z Alves Marcelo AP de Britto Dyanna G de Matos Mnica Soldan Helena L Borges Joo C Machado | 2013 | World Journal of Gastroenterology2013，19，44： | 1 |
| 7 | MSI-L gastric carcinomas share the hMLH1 methylation status of MSI-H carcinomas but not their clinicopathological profile 显示文摘 | Oliveira C Machado JC | 2000 | Lab Invest2000，80，12： | 1 |
| 8 | Neonatal screening of hemoglobinopathies in a population residing in Portugal显示文摘 | Peres M J Carreiro M H Machado M C | 1996 | Acta Med Port1996，9，46： | 1 |
| 9 | Removal of heavy metals using a brewer's yeast strain of Saccharomyces cerevisiae:The flocculation as a separation process显示文摘 | MACHADO M D SANTOS M S F GOUVEIA C | 2008 | Bioresource Technol2008，99，7： | 1 |
| 10 | Gene expression profiling of jejunal Peyer's patches in ju- venile and adult pigs显示文摘 | Machado J G Hyland K A Dvorak C M | 2005 | Mammalian Genome2005，16，8： | 1 |
| 11 | Effect of light and temperature on the formation of glyeoalkaloids in potato tubers 显示文摘 | Machado R M D Toledo M C F Garcia L C | 2007 | Food Control2007，18，5： | 1 |
| 12 | Morphology development and phase inversion during dynamic vuleanisation of EPDM/PP blends 显示文摘 | ANTUNES C F MACHADO A V VAN DU1N M | 2011 | European Polymer Journal2011，47，7： | 1 |
| 13 | Effects of starvation, refeeding and insulin on energy-linked metabolic process in catfish(Rhamdia hilarii) adapted to a carbohydrate-rich diet 显示文摘 | Machado C R Garotalo M A R Migtiorini R H | 1988 | Gen Comp Endocrinol1988，71，3： | 1 |
| 14 | Effects of starvation refeeding and insulin on energy linked metabolic process in catfish Rhamdio hilarii adapted to a carbohydrate rich diet显示文摘 | Machado C R Garofalo M A R Miglioroni R H | 1988 | General and Comparative Endocrinology1988，71，3： | 1 |
| 15 | Monitoring program for the first steel catenary riser installed in a moored floating platform in deep water显示文摘 | Machado R Z Mourelle M M Franciss R Silva R M Lima C S Eisemberg R Oliveira D | 1999 | Oceans Conference Record (IEEE)1999，2，： | 1 |
| 16 | Influence of fluoride exposure on reaction time and visuospatial organization in children 显示文摘 | Jaqneli C Machado B Navarro M | 2000 | Epidemiology2000，11，4： | 1 |
| 17 | Zolpidem arousing effect in persistent vegetative state patients :autonomic,EEG and behavioral assessment 显示文摘 | Machado C Estevez M Rodriguez R | 2014 | Curr Pharm Des2014，20，26： | 1 |
| 18 | Child and part ner abuse: Self-reported prevalence and attitudes in the north of Portugal显示文摘 | Machado C Goncalves M Matos M | 2007 | Child Abuse & Neglect2007，31，： | 1 |
| 19 | Osmotic response in Lactobacillus casei ATCC 393:biochemical and biophysical characteristics of membrane显示文摘 | Machado M C Lopez C S | | 0，，01： | 1 |
| 20 | Micro- structure characterization and the effect of phase transforma- tion on toughness of the UNS $31803 duplex stainless steel aged treated at 850 ~C 显示文摘 | ZUCATO I MOREIRA M C MACHADO I F | 2002 | Mater Res2002，5，38： | 1 |
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