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| 1 | Psychotropic drugs and liver disease:A critical review of pharmacokinetics and liver toxicity显示文摘The liver is the organ by which the majority of sub-stances are metabolized, including psychotropic drugs. There are several pharmacokinetic changes in end-stage liver disease that can interfere with the metabolization of psychotropic drugs. This fact is particularly true in drugs with extensive first--pass metabolism, highly protein bound drugs and drugs depending on phase I hepatic metabolic reactions. Psychopharmacological agents are also associated with a risk of hepatotoxicity. The evidence is insufficient for definite conclusions regarding the prevalence and severity of psychiatric drug-induced liver injury. High-risk psychotropics are not advised when there is pre-existing liver disease, and after starting a psychotropic agent in a patient with hepatic impairment, frequent liver function/lesion monitoring is advised. The authors carefully review the pharmacokinetic disturbances induced by end-stage liver disease and the potential of psychopharmacological agents for liver toxicity. | Diogo Telles-Correia António Barbosa Helena Cortez-Pinto Carlos Campos Nuno B F Rocha Sérgio Machado | 2017 | World Journal of Gastrointestinal Pharmacology and Therapeutics2017，8，1： | 3 |
| 2 | Extramedullary plasmocytoma associated with a massive deposit of amyloid in the duodenum显示文摘We report a rare case of extramedullary plasmocytoma associated with a massive deposit of amyloid in the duodenum.A 72-year-old Japanese man was admitted to our hospital presenting with a 3-mo history of epigastric pain, vomiting and weight loss.On computed tomography(CT) a wall thickening of the fourth part of the duodenum was observed.Multiple biopsies obtained from the lesion showed inflltration of plasma cells and lymphocytes, but they were not conclusive.The patient underwent resection of the lesion and, on histopathological examination, the lesion consisted of a dense and diffuse inflltrate of plasma cells and a few admixed lymphocytes with reactive follicles extending to the muscular propria.An extensive deposition of amyloid was also observed.Immunohistochemical stains revealed that a few plasmacytoid cells showed λ light chain staining, though most were κ light chain positive.These cells also were positive for CD138 and CD56 but negative for CD20 and CD79.The flndings were consistent with extramedullary plasmocytomaassociated with a massive deposit of amyloid in duodenum.A subsequent workup for multiple myeloma was completely negative.The patient showed no signs of local recurrence or dissemination of the disease after 12 mo follow-up.Because of the association of plasmocytoma and amyloidosis, the patient must be followed up because of the possible systemic involvement of the neoplasm and amyloidosis in future. | Fabiana Pirani Carneiro Maria de Nazareth Machado Sobreira Lívia Bravo Maia Alesso Cervantes Sartorelli Luiz Eduardo de Almeida Prado Franceschi Mauro Brito Brando Bárbara Wosnjuk Calaca Fernando Silva Lustosa Joo Vieira Lopes | 2009 | World Journal of Gastroenterology2009，15，28： | 2 |
| 3 | In vitro activity of Brazilian medicinal plants,naturally occurring naphthoquinones and their analogues,against methicillin-resistant staphylococcus aureus显示文摘 | MACHADO T B PINTO A V PINTO M C | 2003 | Int J Antimicrob Ag2003，21，3： | 1 |
| 4 | New oxidation catalysts based on iron(III) porphyrins immobilized on Mg-Al layered double hydroxides modified with triethanolamine 显示文摘 | CASTRO K A D F BAIL A GROSZEWICZ P B MACHADO G S SCHREINER W H WYPYCH F NAKAGAKI S | 2010 | Appl Catal A: Gen2010，386，： | 1 |
| 5 | Biocompatibility study for PVP wound dressing obtained in different conditions显示文摘 | Higa O Z Rogero S O Machado L D B | 1999 | Radiation Physics and Chemistry1999，55，56： | 1 |
| 6 | Floating photocatalysts based on TiO2 supported on high surface area exfoliated vermiculite for water decontamination显示文摘 | Machado L C R Torchia C B Lago R M | 2006 | Catal Com2006，7，： | 1 |
| 7 | STAT signaling in glioma cells 显示文摘 | Swiatek- Machado K Kaminska B | 2013 | Adv Exp Med Biol2013，986，： | 1 |
| 8 | Extraction of lemongrass essential oil with dense carbon dioxide显示文摘 | Carlson L H C Machado R A F Spricigo C B | 2001 | J Supercrit Fluids2001，21，： | 1 |
| 9 | Chronic electrical stimmulition of the contrahsional lateral cerebellar nucleus enhances recover of motor function after cerebral ischemia in rats 显示文摘 | Machado A G Baker K B Schuster D | 2009 | Brain Res2009，1280，16： | 1 |
| 10 | Evaluation of insecticidal activity of diterpenes and lignans from Aristolochia malmeana against Anticarsia gemmatalis 显示文摘 | Messiano G B Vieira L Machado M B | 2008 | JAgric Food Chem2008，56，： | 1 |
| 11 | Trace metals in man-grove seedlings : Role of iron plaque formation显示文摘 | Machado W Gueiros B Lisboa-Filho S | 2005 | Wetlands Ecol Man-ag2005，13，2： | 1 |
| 12 | Microcalcifications versus artifacts:initial evaluation of a new ultrasound image processing technique to identify breast microcalcifications in a screening population显示文摘 | Machado P Eisenbrey JR Cavanaugh B | 2014 | Ultrasound Med Biol2014，40，9： | 1 |
| 13 | Below -ground resourceslimit seedling growth in forest understories but do not alterbiomass distribution显示文摘 | Machado J L Walters M B | 2003 | Annual Forestry Science2003，60，： | 1 |
| 14 | Distribu-tion of wave crests in a non-Gaussian sea显示文摘 | BUTLER R W MACHADO U B RYCHLIK I | | 0，，： | 1 |
| 15 | Influence of the number of inserts for tool life evaluation in face milling of steels显示文摘 | RICHETTI A MACHADO A R DA SILVA M B | 2004 | International Journal of Machine Tools & Manufacture2004，44，： | 1 |
| 16 | Graphene-based materials for catalysis 显示文摘 | MACHADO B F SERP P | 2012 | Catal Sci Technol2012，2，： | 1 |
| 17 | Antimicrobial ellagitannin of punica granatumfruits显示文摘 | MACHADO T B LEAL I C AMARAL A C | 2002 | J Braz Chem Soc2002，13，5： | 1 |
| 18 | Probability density functions for nonlinear random waves and responses显示文摘 | MACHADO U B | | 0，，： | 1 |
| 19 | Sleep deprivation induced by the modified multiple platform technique: quantification of sleep loss and recovery显示文摘 | Machado R B Hipolide D C Benedito-Silva A A | 2004 | Brain Res2004，1004，12： | 1 |
| 20 | Accompanying of parameters of color, gloss and hardness on polymeric films coated with pigmented inks cured by different radiation doses of ultraviolet light 显示文摘 | Bardi M A G Machado L D B | 2012 | Radiation Physics and Chemistry2012，81，9： | 1 |
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