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| 1 | In vitro effect of pantoprazole on lower esophageal sphincter tone in rats显示文摘AIM:To investigate the in vitro effects of pantoprazole on rat lower esophageal sphincter(LES)tone.METHODS:Rats weighing 250-300 g,provided by the Yeditepe University Experimental Research Center(Yü-DETAM),were used throughout the study.They were anesthetized before decapitation.LES tissues whose mucosal lining were removed were placed in a stan-dard 30-mL organ bath with a modif ied Krebs solution and continuously aerated with 95% oxygen-5% carbon dioxide gas mixture and kept at room temperature.The tissues were allowed to stabilize for 60 min.Sub-sequently,the contractile response to 10-6 mol/L carba-chol was obtained.Different concentrations of freshly prepared pantoprazole were added directly to the tis-sue bath to generate cumulative concentrations of 5×10-6 mol/L,5×10-5 mol/L,and 1.5×10-4 mol/L.Activi-ties were recorded on an online computer via a 4-channeltransducer data acquisition system using the software BSL PRO v 3.7,which also analyzed the data.RESULTS:Pantoprazole at 5×10-6 mol/L caused a small,but statistically insignif icant,relaxation in the car-bachol-contracted LES(2.23% vs 3.95%).The 5×10-5 mol/L concentration,however,caused a signif icant relax-ation of 10.47% compared with the control.1.5×10-4 mol/L concentration of pantoprazol caused a 19.89% relaxation in the carbachol contracted LES(P<0.001).CONCLUSION:This is the fi rst study to demonstrate that pantoprazole has a relaxing effect in isolated LESs.These results might have signif icant clinical implications for the subset of patients using proton pump inhibitors who do not receive full symptomatic alleviation from gastroesophageal reflux disease. | Mustafa Duman Mahmut zer Enver Rean Yeliz Demirci Ali E Atιcι Tahsin Dalgι Erdal B Bostancι Ece Gen | 2011 | World Journal of Gastroenterology2011，17，46： | 3 |
| 2 | The theoretical and experimental investigation of blank holder forces plate effect in deep drawing process of AL 1050 material 显示文摘 | H Ibrahim Demirci Mustafa Y Kemal Demiray b | 2008 | Materials and Design2008，29，： | 1 |
| 3 | Effect of the blank holder force on drawing of aluminum alloy square cup: theoretical and experimental investigation显示文摘 | Halil lbrahim Demirci Cemal Esner Mustafa Yasar | 2008 | Journal of Materials Processing Technology2008，206，13： | 1 |
| 4 | The impact responses and the finite element modeling of layered trapezoidal corrugated aluminum core and aluminum sheet interlayer sandwich structures显示文摘 | Cenk K?l??aslan Mustafa Güden ?smet Kutlay Odac? Alper Ta?demirci | 2013 | Materials and Design2013，，： | 1 |
| 5 | Smooth groups显示文摘 | | 2001 | Fuzzy Sets and Systems2001，117，： | 1 |
| 6 | Effect of the blank holder force on drawing of aluminum alloy square cup: Theoretical and experimental investigation显示文摘 | Halil. ?brahim Demirci Cemal Esner Mustafa Yasar | 2007 | Journal of Materials Processing Tech2007，，1： | 1 |
| 7 | An infrarenal abdominal aortic coarctation显示文摘 | Cengiz Koksal Selman Demirci Guniz Meyanci Koksal Mustafa Zengin | 2005 | Surgical and Radiologic Anatomy2005，，1： | 1 |
| 8 | Effect of the blank holder force on drawing of aluminum alloy square cup: theoretical and experimental investigation显示文摘 | Halil Ibrahim Demirci Cereal Esner Mustafa Yasar | 2008 | Journal of Materials Processing Technology2008，206，13： | 1 |
| 9 | Axiomatic theory of intuitionistic fuzzy sets显示文摘 | Mustafa Demirci | 2000 | Fuzzy Sets and Systems2000，110，： | 1 |
| 10 | Fuzzy functions and their fndamental properties显示文摘 | | 1999 | Fuzzy Sets and Systems1999，106，2： | 1 |
| 11 | Smooth groups显示文摘 | | 2001 | Fuzzy Sets and Systems2001，117，： | 1 |
| 12 | Smooth subgroups and smooth homorphism显示文摘 | | 2001 | Fuzzy Sets and Systems2001，117，3： | 1 |
| 13 | Effect of the blank holder force on drawing of aluminum alloy square cup:Theoretical and experimental investigation显示文摘 | Demirci Halil brahim Esner Cemal Yasar Mustafa | | 0，，01： | 1 |
| 14 | Effect of the blank holder force on drawing of aluminum alloy square eltp: theo- retical and experimental investigation 显示文摘 | Halil Ibrahim Demirci Cereal Esner Mustafa Yasar | 2008 | Journal of Materials Processing Teehnolo ''2008，206，13： | 1 |
| 15 | Mechanically Corner- Coupled Square Microresonator Array for Reduced Series Motional Resistance 显示文摘 | Mustafa U Demirci Clark T C Nguyen | 2006 | Journal of Microelectromechanical Systems2006，15，6： | 1 |
| 16 | Microbiologic findings of sinusitis by a novel method for obtaining culture显示文摘 | Murat Yariktas Mustafa Demirci Fehmi Doner Mustafa Tuz Giray Aynali | 2007 | Diagnostic Microbiology & Infectious Disease2007，，1： | 1 |
| 17 | Axiomatic theory of intuitionistic fuzzy sets显示文摘 | Mustafa Demirci | 2000 | Fuzzy Sets and Systems2000，，220： | 1 |
| 18 | Smooth groop显示文摘 | MUSTAFA DEMIRCI | 2001 | Fuzzy Sets and Systems2001，117，： | 1 |
| 19 | Does Fasciola hepatica infection modify the response of acute hepatitis C virus infection to IFN-α treatment?显示文摘Immunologic response to acute hepatitis C is mainly a Th1 response, whereas fasciolopsiasis is associated with a diverse T-cell response. Interferon-alpha has immunomodulatory effects and enhances Th1 immune response. Fasciola infection could theoretically interfere with the Th1 immune response, even when acquired after an initial response to interferon-alpha treatment for acute hepatitis C virus (HCV) infection. We report here the case of a male patient who acquired Fasciola hepatica infection after an initial response to IFN-alpha therapy with a favorable | Mehmet Sahin Mehmet Isler Altug Senol Mustafa Demirci Zeynep Dilek Aydin | 2005 | World Journal of Gastroenterology2005，11，48： | 0 |
| 20 | Impact of adjuvant treatment modalities on survival outcomes in curatively resected pancreatic and periampullary adenocarcinoma显示文摘Background: We examined the impact of adjuvant modalities on resected pancreatic and periampullary adenocarcinoma(PAC).Methods: A total of 563 patients who were curatively resected for PAC were retrospectively analyzed between 2003 and 2013.Results: Of 563 patients, 472 received adjuvant chemotherapy(CT) alone, chemoradiotherapy(CRT) alone, and chemoradiotherapy plus chemotherapy(CRT-CT) were analyzed. Of the 472 patients, 231 were given CRT-CT, 26 were given CRT, and 215 were given CT. The median recurrence-free survival(RFS) and overall survival(OS) were 12 and 19 months, respectively. When CT and CRT-CT groups were compared, there was no significant difference with respect to both RFS and OS, and also there was no difference in RFS and OS among CRT-CT, CT and CRT groups. To further investigate the impact of radiation on subgroups, patients were stratified according to lymph node status and resection margins. In node-positive patients, both RFS and OS were significantly longer in CRT-CT than CT. In contrast, there was no significant differencebetween groups when patients with node-negative disease or patients with or without positive surgical margins were considered.Conclusions: Addition of radiation to CT has a survival benefit in patients with node-positive disease following pancreatic resection. | Nedim Turan Mustafa Benekli Olcun Umit Unal ?lkay Tugba Unek Didem Tastekin Faysal Dane Efnan Alg?n Sukran Ulger Tulay Eren Turkan Ozturk Topcu Esma Turkmen Nalan Akgül Babacan Gulnihal Tufan Zuhat Urakci Basak Oven Ustaalioglu Ozlem Sonmez Uysal Ozlem Balvan Ercelep Burcu Yapar Taskoylu Asude Aksoy Mustafa Canhoroz Umut Demirci Erkan Dogan Veli Berk Ozan Balakan Ahmet ?iyar Ekinci Mukremin Uysal ?brahim Petekkaya Sel?uk Cemil Ozturk ?nder Tonyal? Bülent ?etin Mehmet Naci Aldemir Kaan Helvac? Nuriye Ozdemir ?lhan Oztop Ugur Coskun Aytug Uner Ahmet Ozet Suleyman Buyukberber | 2015 | Chinese Journal of Cancer Research2015，27，4： | 0 |
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