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| 1 | Risk factors and clinical responses of pneumonia patients with colistin-resistant Acinetobacter baumannii-calcoaceticus显示文摘BACKGROUND Nosocomial infections with carbapenem-resistant Acinetobacter baumanniicalcoaceticus complex(ABC)strains are great problem for intensive care units.ABC strains can develop resistance to all the antibiotics available.Carbapenem resistance is common and colistin resistance is rare in our country.Knowing the risk factors for colistin resistance is important since colistin seems to be the only remaining therapeutic option for the patients with pneumonia due to extensively drug resistant ABC for our country.AIM To investigate the comparison of clinical responses and outcomes between pneumonia patients with colistin-susceptible and-resistant Acinetobacter sp.Strains.METHODS During the study period,108 patients with pneumonia due to colistin-susceptible strains and 16 patients with colistin-resistant strains were included retrospectively.Continuous variables were compared with the Mann-Whitney U test,and categorical variables were compared using Pearson’s chi-square test or Fisher’s Exact chi-square test for two groups.A binary logistic regression model was developed to identify the potential independent factors associated with colistin resistance in patients with colistin-resistant strains.RESULTS High Acute Physiology and Chronic Health Evaluation II scores(OR=1.9,95%CI:1.4-2.7;P<0.001)and prior receipt of teicoplanin(OR=8.1,95%CI:1.0-63.3;P=0.045)were found to be independent risk factors for infection with colistin-resistant Acinetobacter sp.Different combinations of antibiotics including colistin,meropenem,ampicillin/sulbactam,amikacin and trimethoprim/sulfamethoxazole were used for the treatment of patients with colistin-resistant strains.Although the median duration of microbiological cure(P<0.001)was longer in the colistin-resistant group,clinical(P=0.703),laboratory(P=0.277),radiological(P=0.551),microbiological response(P=1.000)and infection related mortality rates(P=0.603)did not differ between the two groups.Among the patients with infections due to colistin-resistant strains,seven were treated with antibiotic combinations that included sulbactam.Clinical(6/7)and microbiological(5/7)response rates were quite high in these patients.CONCLUSION The optimal therapy regimen is unclear for colistin-resistant Acinetobacter sp.infections.Although combinations with sulbactam seems to be more effective in our study patients,data supporting the usefulness of combinations with sulbactam is very limited. | Hande Aydemir Hande Idil Tuz Nihal Piskin Guven Celebi Canan Kulah Furuzan Kokturk | 2019 | World Journal of Clinical Cases2019，7，10： | 7 |
| 2 | Dentoalveolar distraction osteogenesis for rapid orthodontic canine retraction 显示文摘 | Kisnisci R S Iseri H Tuz H H | 2002 | J Oral Maxillofac Surg2002，60，4： | 1 |
| 3 | Dentoalveolar distraction osteogenesis for rapid orthodontic canine retraction 显示文摘 | KISNISCI R ISERI H TUZ H | 2002 | J Oral Maxillofac Surg2002，60，4： | 1 |
| 4 | Otitis media with effusion and histopathologic properties of adenoid tissue显示文摘 | Yasan H Dogru H Tuz M | 2003 | Int J Pedi- atr Otorhinolaryngol2003，67，： | 1 |
| 5 | Dentoalveolar distraction osteogenesis for rapid orthodontic canine retraction显示文摘 | Kisnisci RS Iseri H Tuz HH | 2002 | J Oral Maxillofac Surg2002，60，： | 1 |
| 6 | Improvement in bone conduction threshold after tympanoplasty显示文摘 | Tuz M Dogur H Uygur K | 2000 | Otolayngol Head Neck Stag2000，123，： | 1 |
| 7 | Transient locked-in syndrome resulting from stellate ganglion block in the treatment of patients with sudden hearing loss显示文摘 | Tuz M Dodru H Uyguer K | 2003 | Acta Anaesthesiol Scand2003，47，4： | 1 |
| 8 | Immunolocalization of androgen receptors in testicular cells of prepubertal and pubertal pigs显示文摘 | Kotula M Tuz R Fr czek B | 2000 | Folia Histochem Cytobiol2000，38，： | 1 |
| 9 | Villonodular synovitis of the temporomandibular joint:Case report显示文摘 | Kisnisci RS Tuz HH Gunhan O | 2001 | J Oral Maxillofac Surg2001，59，12： | 1 |
| 10 | Subjective pulsatile tinnitus associated with extensive pneumatization of temporal bone 显示文摘 | TUZ M DO(~RU H YESILDAG A | 2003 | Auris Nasus Larynx2003，30，2： | 1 |
| 11 | Reproductive performance of polish large white sows in intensive production-Effect of parity and season 显示文摘 | Schwarz T Nowicki J Tuz R | 2009 | Annals of Animal Science2009，9，3： | 1 |
| 12 | Otitis media with effusion and histopathologic properties of adenoid tissue 显示文摘 | Yasan H Dogru H Tuz M | 2003 | Int J Pediatr Otorhinolaryngol2003，67，11： | 1 |
| 13 | Subjective pulsatile tinnitus associatedwith extensive pneumatization of temporal bone 显示文摘 | Tuz M Dogru H Yesildag A | 2003 | Auris NasusLarynx2003，30，2： | 1 |
| 14 | The correlation between septal deviation and concha bullosa显示文摘 | UYGUR K TUZ M DOGRU H | 2003 | Otolaryngol Head Neck Surg2003，129，： | 1 |
| 15 | Reproductive perform- ance of Polish of Large White sows in intensive production- effect of parity and season 显示文摘 | SCHWARZ T NOWICKI J TUZ R | 2009 | Annals of Animal Science2009，9，3： | 1 |
| 16 | Reproductive performance of polish large white sows in intensive production - - Effect of parity and season 显示文摘 | Schwarz T Nowicki J Tuz R | 2009 | Ann Anim Sci2009，9，3： | 1 |
| 17 | Reproductive performance of polish large white sows in intensive production-Effect of parity and season显示文摘 | Schwarz T Nowicki J Tuz R | 2009 | Annals of Animal Science2009，9，3： | 1 |
| 18 | Reproductive performance of polish large white sows in intensive production-Effect of parity and season显示文摘 | Schwarz T Nowicki J Tuz R | 2009 | Ann Anita Sci2009，9，3： | 1 |
| 19 | Dentoalveolar distraction osteogenesis for rapid orthodontic canine retraction显示文摘 | Kisnisci RS Iseri H Tuz HH | 2002 | J Oral Maxillofac Surg2002，60，4： | 1 |
| 20 | Improvement in bone conduction threshold after tympanoplasty显示文摘 | Tuz M Dopru H Uvqur K | 2000 | Otolaryngol Head Neck Surg2000，123，6： | 1 |
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