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| 1 | Clinical-pathological and molecular characterization of long-term survivors with advanced non-small cell lung cancer显示文摘Objective:Long-term survivors(LS)of non-small cell lung cancer(NSCLC)without driver alterations,displaying an overall survival(OS)of more than 3 years,comprise around 10%of cases in several series treated with chemotherapy.There are classical prognosis factors for these cases[stage,Eastern Cooperative Oncology Group(ECOG),etc.],but more data are required in the literature.In this multi-center study,we focused on LS of advanced NSCLC with OS above 36 months to perform a clinical-pathological and molecular characterization.Methods:In the first step,we conducted a clinical-pathological characterization of the patients.Afterwards,we carried out a genetic analysis by comparing LS to a sample of short-term survivors(SS)(with an OS less than 9 months).We initially used whole-genome RNA-seq to identify differentiating profiles of LS and SS,and later confirmed these with reverse transcription-polymerase chain reaction(RT-PCR)for the rest of the samples.Results:A total of 94 patients were included,who were mainly men,former smokers,having adenocarcinoma(AC)-type NSCLC with an ECOG of 0-1.We obtained an initial differential transcriptome expression,displaying 5 over-and 33 under-expressed genes involved in different pathways:namely,the secretin receptor,surfactant protein,trefoil factor 1(T FF1),serpin,Ca-channels,and Tolllike receptor(TLRs)families.Finally,RT-PCR analysis of 40(20 LS/20 SS)samples confirmed that four genes(surfactant proteins and SFTP)were significantly down-regulated in SS compared to LS by using an analysis of covariance(ANCOVA)model:SFTPA1(P=0.023),SFTPA2(P=0.027),SFTPB{P=0.02),and SFT PC(P=0.047).Conclusions:We present a sequential genetic analysis of a sample of NSCLCLS with no driver alterations,obtaining a differential RNA-seq/RT-PCR profile showing an abnormal expression of SF genes. | Juan Moreno-Rubio Santiago Ponce Rosa Alvarez Maria Eugenia Olmedo Sandra Falagan Xabier Mielgo Fatima Navarro Patricia Cruz Luis Cabezon-Gutierrez Carlos Aguado Gonzalo Colmenarejo Marta Munoz-Fernandez de Leglaria Ana Belen Enguita Maria Cebollero Amparo Benito Isabel Alemany Carolina del Castillo Ricardo Ramos Ana Ramirez de Molina Enrique Casado Maria Sereno | 2020 | Cancer Biology & Medicine2020，17，2： | 4 |
| 2 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 3 | Wettability, ageing and recovery process of plasma-treated polyamide 6 显示文摘 | CRISTINA Canal MOLINA Ricardo BERTRAN Enric | 2004 | Journal Adhesion Science Technology2004，18，9： | 1 |
| 4 | Free radical formation in wool fibers treated by low temperature plasma显示文摘 | Molina Ricardo | 2003 | Textile Research Journal2003，，11： | 1 |
| 5 | Development of a framework for fire risk assessment using remote sensing and geographic information system technologies显示文摘 | Emilio Chuvieco Inmaculada Aguado Marta Yebra Héctor Nieto Javier Salas M. Pilar Martín Lara Vilar Javier Martínez Susana Martín Paloma Ibarra Juan de la Riva Jaime Baeza Francisco Rodríguez Juan R. Molina Miguel A. Herrera Ricardo Zamora | 2008 | Ecological Modelling2008，，1： | 1 |
| 6 | Free radical formation in wool fibers treated by low temperature plasma显示文摘 | MOLINA Ricardo ERRA Pilaf | 2003 | Textile Research Journal2003，73，11： | 1 |
| 7 | Could wild rabbits ( Oryctolagus cuniculus ) be reservoirs for Leishmania infantum in the focus of Madrid, Spain?显示文摘 | Maribel Jiménez Estela González Inés Martín-Martín Sonia Hernández Ricardo Molina | 2014 | Veterinary Parasitology2014，，3： | 1 |
| 8 | Detection of Leishmania infantum and identification of blood meals in Phlebotomus perniciosus from a focus of human leishmaniasis in Madrid, Spain显示文摘 | Maribel Jiménez Estela González Andrés Iriso Elisa Marco Ana Alegret Fernando Fúster Ricardo Molina | 2013 | Parasitology Research2013，，： | 1 |
| 9 | Intelligent collision risk detection in medium-sized cities of developing countries,using naturalistic driving:A review显示文摘Traffic accidents are one of the most serious problems worldwide,being one of the leading causes of death and economic loss in the world.Low-and middle-income countries,mainly their medium-sized cities,are among the most affected by this problem.93%of traffic accidents occur in low and middle-income countries,even though these countries have approximately 60%of the world’s vehicles.This occurs mainly because in these types of countries,especially in medium-sized cities(target context),there are no ideal conditions for driving,such as adequate road infrastructure,good condition of vehicles,and rigorous safety policies.Advanced data analysis techniques including machine learning(ML)have increasingly been used to solve this problem.Naturalistic driving(ND)can be applied as a data collection method that provides information on traffic accidents.ND commonly uses a vehicle’s kinematic data to detect high-risk driving behaviors that could cause an accident.The objectives of this document are to present a review of different alternatives that help in data collection and creation of intelligent solutions related to detection of possible traffic accidents,principally using ND;and to propose an intelligent collision risk detection system(ICRDS)for identification of areas with a high probability of TA in the target context.Through the review,it was possible to analyze and evaluate the devices,variables and algorithms that help characterize a risk event in driving,considering the target context.The development of a prototype of an ICRDS for a medium-sized city in a developing country is considered viable,considering the identified components,with the aim of identifying risk events in driving,and areas of high probability of accidents in the city. | Juan Jose Paredes Santiago Felipe Yepes Ricardo Salazar-Cabrera Alvaro Pachon dela Cruz Juan Manuel Madrid Molina | 2022 | Journal of Traffic and Transportation Engineering(English Edition)2022，9，6： | 0 |
| 10 | 热带干旱森林恢复过程中栽培树木对缓解火灾的效用:案例研究显示文摘在制定森林系统恢复计划时总是需要考虑火灾的威胁。在波多黎各干旱森林恢复项目执行时,曾于2006年和2007年发生了两次野火事件。该项目的最初目的是确定乡土树种在栽培的银合欢(Leucaena leucocephala)树下与在开阔地(林窗)中的不同生长响应。项目根据树种叶子的习性、演替状态以及火前环境条件抗性的研究,评估了林木的生长、死亡率和对火灾的响应。结果表明,无论树种叶子的习性和演替状态如何,在栽培树木之下都能长得更高,死亡率也更低。在开阔地带,树木对林火最常见的响应是发芽;成熟林和常绿树种的火后存活机率比先锋树种和落叶树种更高。虽然一般在再造林项目中使用栽培树木来调节养分或光环境,但它们看上去也附带了次级效益——通过减少可燃物,从而降低火灾的损失。 | Ricardo J.Santiago-García Sandra Molina Coloón Phillip Sollins Skip J. Van Bloem 马泽清 哈艳梅 | 2008 | AMBIO-人类环境杂志2008，37，7： | 0 |
| 11 | Sustainable transit vehicle tracking service,using intelligent transportation system services and emerging communication technologies:A review显示文摘The most salient problems of transit vehicle service in Latin American intermediate cities include:the high number of passengers involved in traffic accidents;traffic congestion caused by transit vehicles,and pollution generated by these vehicles,which increases in high congestion scenarios.To improve upon this situation,a research was conducted on the transit vehicle tracking service,which is a basic service for implementing mobility solutions for the aforementioned problems,the most relevant characteristics of this service for the context of Latin American intermediate cities were identified,and an implementation was proposed.This paper presents the four stages of the study:(a)a review of the state-of-the-art of services or systems related to vehicle tracking,including wireless communications technologies,implemented sustainability approaches,usage of special algorithms for efficiency improvement,and the intelligent transportation system(ITS)architecture used as a basis;(b)the process of identifying relevant characteristics of the service for a given context;(c)proposal of an ITS architecture for this service in an intermediate city,its requirements and the suggested technologies;and(d)development of experiments for validating usage of the key suggested technologies.The review allowed to identify the main service characteristics,with regard to vehicle positioning technologies,the recommended wireless communication technology(long range,LoRa),energy consumption considerations,and use of artificial intelligence(AI)to calculate waiting time of users at bus stops.Finally,an ITS architecture for the city of Popayan(Colombian city)considering the aforementioned characteristics is proposed,and the experiments related to the use of these technologies are described in detail. | Ricardo Salazar-Cabrera álvaro Pachón de la Cruz Juan Manuel Madrid Molina | 2020 | Journal of Traffic and Transportation Engineering(English Edition)2020，7，6： | 0 |
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