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| 1 | Treatment with dimethyl fumarate ameliorates liver ischemia/reperfusion injury显示文摘AIM To investigate the hypothesis that treatment with dimethyl fumarate(D MF) mayame liorate liver ischemia/reperfusion injury(I/RI).METHODS Rats were divided into 3 groups: sham, control(CTL), and DMF. DMF(25 mg/kg, twice/d) was orally administered for 2 d before the procedure. The CTL and DMF rats were subjected to ischemia for 1 h and reperfusion for 2 h. The serum alanine aminotransferase(ALT) and malondialdehyde(MDA) levels, adenosine triphosphate(ATP), NO × metabolites, anti-oxidant enzyme expression level, antiinflammatory effect, and anti-apoptotic effect were determined.RESULTS Histological tissue damage was significantly reduced in the DMF group(Suzuki scores: sham: 0 ± 0; CTL: 9.3± 0.5; DMF: 2.5 ± 1.2; sham vs CTL, P < 0.0001; CTL vs DMF, P < 0.0001). This effect was associated with significantly lower serum ALT(DMF 5026 ± 2305 U/L vs CTL 10592 ± 1152 U/L, P = 0.04) and MDA(DMF 18.2 ± 1.4 μmol/L vs CTL 26.0 ± 1.0 μmol/L, P = 0.0009). DMF effectively improved the ATP content(DMF 20.3 ± 0.4 nmol/mg vs CTL 18.3 ± 0.6 nmol/mg, P = 0.02), myeloperoxidase activity(DMF 7.8 ± 0.4 m U/m L vs CTL 6.0 ± 0.5 m U/m L, P = 0.01) and level of endothelial nitric oxide synthase expression(DMF 0.38 ± 0.05-fold vs 0.17 ± 0.06-fold, P = 0.02). The higher expression levels of anti-oxidant enzymes(catalase and glutamatecysteine ligase modifier subunit and lower levels of key inflammatory mediators(nuclear factor-kappa B and cyclooxygenase-2 were confirmed in the DMF group.CONCLUSION DMF improved the liver function and the anti-oxidant and inflammation status following I/RI. Treatment with DMF could be a promising strategy in patients with liver I/RI. | Chie Takasu Nosratola D Vaziri Shiri Li Lourdes Robles Kelly Vo Mizuki Takasu Christine Pham Seyed H Farzaneh Mitsuo Shimada Michael J Stamos Hirohito Ichii | 2017 | World Journal of Gastroenterology2017，23，25： | 3 |
| 2 | Priming with GGSF effectively enhances low-dose Ara-G-induced in vivo apoptosis in myeloid leukemiacells 显示文摘 | Hiroshi K Mitsuo H | 1999 | Exp Hematol1999，27，： | 1 |
| 3 | The matrix metalloproteinase regulator RECK in combination with MMP-9 serves as an informative prognostic indicator for colorectal cancer 显示文摘 | Taku T Michiyoshi H Mitsuo N | 2004 | Clin Cancer Res2004，10，8： | 1 |
| 4 | Phylogenetic rela- tionships of Ralstonia solanacearum species complex- strains from Asia and other continents based on 16S rDNA, endoglucanase, and hrpB gene sequences显示文摘 | Joselito E Tsuchiya K Mitsuo H | 2005 | Bacterial and Phytoplasma Diseases2005，71，1： | 1 |
| 5 | Priming with G-CSF effectively enhances low-dose Ara-C-induced in vivo apoptosis in myeloid leukemia cells显示文摘 | AMUGULENG B HIROSHI K MITSUO H | 1999 | Exp Hematol1999，27，2： | 1 |
| 6 | The membrane-anchored matrix metalloproteinase (MMP) regulator RECK in combination with MMP-9 serves as an informative prognostic indicator for colorectal cancer显示文摘 | Taku T Miehiyoshi H Mitsuo N | 2004 | Clin Cancer Res2004，10，8： | 1 |
| 7 | Priming with G- CSF effectively enhances low-dose Ara-c induced in vivo apoptosis in myeloid leukemia cells 显示文摘 | Amuguleng B Hiroshi K Mitsuo H | 1999 | Exp Hematol1999，27，： | 1 |
| 8 | Antimutagenic activity of flavonoids from Chrysanthemum morifolium 显示文摘 | Mitsuo M Masayoshi H | 2003 | Biosci Biotechnol Biochem2003，67，10： | 1 |
| 9 | Auto power and coherence analysis of delta-theta band EEG during the waking-sleeping transition period 显示文摘 | Toshio M Mitsuo H Tadao H | 1997 | Eleetroen- cephalography and Clinical Neurophysiology1997，103，6： | 1 |
| 10 | PCR-based specific detection of Ralstonia solanacearum race 4 strains显示文摘 | Mitsuo H Kazutaka Y Kenichi T | 2004 | Journal of Genernal Plant Pathology2004，70，： | 1 |
| 11 | PCR-based specific detection of Ralstonia solanacearum race 4 strains 显示文摘 | Mitsuo H Kazutaka Y Kenichi T | 2004 | Journal of General Plant Pathology2004，70，： | 1 |
| 12 | Priming with G - CSF effectively enhances low - lose Ara - C induced in vivo apoptosis in myeloid leukemia cells 显示文摘 | Amuguleng B Hiroshi K Mitsuo H | 2003 | Exp Hematol2003，27，2： | 1 |
| 13 | Combination of granu - locyte colony - stimulating factor and low - dose cytosine arabinoside further enhances myeloid differentiation in leukemia cell in vitro显示文摘 | Katagiri T Miyawa K Mitsuo H | 2002 | Leuk Lymophoma2002，39，12： | 1 |
| 14 | Baicalin,an inhibitor of HIV-1 production in vitro显示文摘 | Katsuhiko K Mitsuo H Hitomi Y | 1998 | Antivral Research1998，37，2： | 1 |
| 15 | PCR-based specific detection of Ralstonia solanacearum race 4 stains显示文摘 | Mitsuo H Kazutaka Y Kenichi Y | 2004 | Journal of General Plant Pathology2004，70，： | 1 |
| 16 | An integrated model for the design of end-of-aisle order picking system and the determination of unit load sizes of AGVs显示文摘 | HARK H SEONGWOO M MITSUO G | 2002 | Computer & Industrial Engineering2002，42，24： | 1 |
| 17 | Electro microscopic and amino acid studies on the outer and inner shell layers of haliotis rufescens显示文摘 | Nakahara H Bevelander G Kakei Mitsuo K | 1982 | Venus1982，41，1： | 1 |
| 18 | Priming with G-CSF effectively enhances low-dose Ara-C-induced in vivo apoptosis in myeloid leukemia cells显示文摘 | Amuguleng B Hiroshi K Mitsuo H | 1999 | Exp Hematol1999，27，2： | 1 |
| 19 | 3-Ethyl-7-hydroxyphthalide from Forsythia japonica 显示文摘 | Hiromu K Mitsuo M Kaname H | 1975 | Phytochemistry1975，14，： | 1 |
| 20 | DNA-PKcs is critical for telomere capping显示文摘 | David G Hiromi TM Prakash H Akihiro K Gloria CL Mitsuo O | 2001 | Proc Natl Acad Sci USA2001，98，15： | 1 |
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