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| 1 | Macrophage-activating lipopeptide-2 downregulates the expression of ATP-binding cassette transporter A1 by activating the TLR2/ NF-KB/ZNF202 pathway in THP-1 macrophages显示文摘 | Liangjie Peng Zizhen Zhang Min Zhang Xiaohua Yu Feng Yao Yulin Tan Dan Liu Duo Gong Huang Chong Xiaoyan Liu Xilong Zheng Guoping Tian Chaoke Tang | 2016 | Acta Biochimica et Biophysica Sinica2016，48，4： | 6 |
| 2 | Zanthoxylum-specific whole genome duplication and recent activity of transposable elements in the highly repetitive paleotetraploid Z.bungeanum genome显示文摘Zanthoxylum bungeanum is an important spice and medicinal plant that is unique for its accumulation of abundant secondary metabolites,which create a characteristic aroma and tingling sensation in the mouth.Owing to the high proportion of repetitive sequences,high heterozygosity,and increased chromosome number of Z.bungeanum,the assembly of its chromosomal pseudomolecules is extremely challenging.Here,we present a genome sequence for Z.bungeanum,with a dramatically expanded size of 4.23 Gb,assembled into 68 chromosomes.This genome is approximately tenfold larger than that of its close relative Citrus sinensis.After the divergence of Zanthoxylum and Citrus,the lineage-specific whole-genome duplication event q-WGD approximately 26.8 million years ago(MYA)and the recent transposable element(TE)burst~6.41 MYA account for the substantial genome expansion in Z.bungeanum.The independent Zanthoxylum-specific WGD event was followed by numerous fusion/fission events that shaped the genomic architecture.Integrative genomic and transcriptomic analyses suggested that prominent speciesspecific gene family expansions and changes in gene expression have shaped the biosynthesis of sanshools,terpenoids,and anthocyanins,which contribute to the special flavor and appearance of Z.bungeanum.In summary,the reference genome provides a valuable model for studying the impact of WGDs with recent TE activity on gene gain and loss and genome reconstruction and provides resources to accelerate Zanthoxylum improvement. | Shijing Feng Zhenshan Liu Jian Cheng Zihe Li Lu Tian Min Liu Tuxi Yang Yulin Liu Yonghong Liu He Dai Zujun Yang Qing Zhang Gang Wang Jisen Zhang Huifeng Jiang Anzhi Wei | 2021 | Horticulture Research2021，8，1： | 5 |
| 3 | Depression accelerates gastric cancer invasion and metastasis by inducing a neuroendocrine phenotype via the catecholamine/β_(2)-AR/MACC1 axis显示文摘Background:Depression is a common,easily ignored,accompanied disease of gastric cancer(GC)patients and is often observed with elevated plasma catecholamine levels.Depression frequently promotes GC progression and leads to poor clinical outcomes;however,the molecular mechanisms underlying depression-induced GC progression remain poorly understood.We aimed to study the effects of depression on GC progression and explore possible mechanisms mediating the action of depression-associated catecholamines on GC.Methods:Depression states of GC patients were graded using the Patient Health Questionnaire-9,and plasma catecholamine levels were examined by high performance liquid chromatography coupled with tandem mass spectrometry.Migrative and invasive GC cells were examined using transwell assays,and metastatic GC niches were imaged using bioluminescence technology in a depression mouse model established with chronic unpredictable mild stress.Mouse depression-like behaviors were assessed through sucrose preference,forced swimming,and tail suspension tests.Characteristics of the neuroendocrine phenotype were observed via RT-PCR,Western blotting,flow cytometry,and transmission electron microscopy.Results:Fifty-one GC patients(age:53.61±1.79 years;cancer duration:3.71±0.33 months;depression duration:2.37±0.38 months;male-to-female ratio:1.55:1)were enrolled in the study.Depression grade was significantly higher in GC patients showing higher plasma levels of catecholamines(epinephrine:P=0.018;noradrenaline:P=0.009),higher oncogene metastasis-associated in colon cancer-1(MACC1)level(P=0.018),and metastasis(P<0.001).Further,depression-associated catecholamine specifically bound to the beta-2 adrenergic receptor(β_(2)-AR)and upregulated MACC1 expression,and thus promoting neuroendocrine phenotypic transformation through direct binding betweenMACC1 and synaptophysin.Eventually,the neuroendocrine phenotypic transformation accelerated GC invasion in vitro and metastasis in vivo.However,β_(2)-AR antagonist ICI-118,551 or MACC1 silencing effectively blocked the catecholamineinduced neuroendocrine phenotypic transformation and eliminated depressionenhanced GC migration and invasion.Moreover,β_(2)-AR blocking or MACC1 silencing prevented GC metastasis attributed to a neuroendocrine phenotype in a depression mouse model.Conclusions:Catecholamine-induced neuroendocrine phenotypes of GC cells led to depression-accelerated GC invasion and metastasis via the β_(2)-AR/MACC1 axis,while β_(2)-AR antagonist or MACC1 silencing could reverse it,showing promising potential therapeutic strategies for improving the outcome of GC patients with comorbid depression. | Changqie Pan Jianhua Wu Siting Zheng Huiying Sun Yisheng Fang Zhenhua Huang Min Shi Li Liang Jianping Bin Yulin Liao Jinzhang Chen Wangjun Liao | 2021 | Cancer Communications2021，41，10： | 4 |
| 4 | Cerebral regional and network characteristics in asthma patients: a resting-state fMRI study显示文摘Asthma is a serious health problem that involves not only the respiratory system but also the central nervous system.Previous studies identified either regional or network alterations in patients with asthma,but inconsistent results were obtained.A key question remains unclear:are the regional and neural network deficits related or are they two independent characteristics in asthma?Answering this question is the aim of this study.By collecting resting-state functional magnetic resonance imaging from 39 patients with asthma and 40 matched health controls,brain functional measures including regional activity(amplitude of low-frequency fluctuations)and neural network function(degree centrality(DC)and functional connectivity)were calculated to systematically characterize the functional alterations.Patients exhibited regional abnormities in the left angular gyrus,right precuneus,and inferior temporal gyrus within the default mode network.Network abnormalities involved both the sensorimotor network and visual network with key regions including the superior frontal gyrus and occipital lobes.Altered DC in the lingual gyrus was correlated with the degree of airway obstruction.This study elucidated different patterns of regional and network changes,thereby suggesting that the two parameters reflect different brain characteristics of asthma.These findings provide evidence for further understanding the potential cerebral alterations in the pathophysiology of asthma. | Siyi Li Peilin Lv Min He Wenjing Zhang Jieke Liu Yao Gong Ting Wang Qiyong Gong Yulin Ji Su Lui | 2020 | Frontiers of Medicine2020，14，6： | 3 |
| 5 | Geochemical Characteristics and Sedimentary Control of Pinghu Formation(Eocene)Coal-bearing Source Rocks in Xihu Depression,East China Sea Basin显示文摘Coal-bearing source rocks of the Pinghu Formation in the Xihu Depression comprise an important material basis of oil and gas resources in the East China Sea Basin.Based on drilling core observation results combined with the analysis and test results of macerals,trace/rare earth elements,and rock pyrolysis,the geochemical characteristics and sedimentary control of coal-bearing source rocks formation are discussed in a high-frequency sequence framework.The results indicate that the macerals composition of the coal-bearing source rocks of the Eocene Pinghu Formation in the Xihu Depression is dominated by vitrinite,with low-medium abundance of exinite and almost no inertinite.The coals and carbonaceous mudstones display higher amounts of total organic carbon(TOC)(14.90%-65.10%),S1+S2(39.24-136.52 mg/g),and IH(191-310 HC/g TOC)respectively,as compared to the mudstones.Organic matter is plotted in typeⅢkerogens and partially in typeⅡ;it is mainly in the low maturity stage.The trace elements results imply that the samples were deposited in a weakly reducing to weakly oxidizing environment and were occasionally affected by seawater.The coal-bearing source rocks were deposited in a relatively oxygen-containing environment.The coal-bearing source rocks development is jointly controlled by the coal accumulation environment,the water conditions affected by ocean currents in offshore basins in China,oxidation-reduction cycles of aqueous media and paleoclimate evolution in a high-frequency sequence framework. | SHEN Yulin QIN Yong CUI Min XIE Guoliang GUO Yinghai QU Zhenghui YANG Tianyang YANG Liu | 2021 | Acta Geologica Sinica(English Edition)2021，95，1： | 2 |
| 6 | Efficient CO2 to CO conversion at moderate temperatures enabled by the cobalt and copper co-doped ferrite oxygen carrier显示文摘Chemical looping technology holds great potential on efficient CO2 splitting with much higher CO production and CO2 splitting rate than photocatalytic processes.Conventional oxygen carrier requires high temperature(typically 850–1000°C)to ensure sufficient redox activity,but the stable and high CO2 conversion is favored at a lower temperature,leading to the degrading on the reaction kinetics as well as the low CO production and CO2 splitting rate.In this paper,we prepared several ternary spinels and demonstrated their performance for chemical looping CO2 splitting at moderate temperatures.Using the promotion effect of Cu to cobalt ferrite reduction and reversible phase change of the reduced metals,Cu0.4 Co0.6 Fe2 O4 exhibits high CO2 splitting rate(144.6μmol g–1 min–1)and total CO production(9100μmol g–1)at 650°C.The high performance of this earth-abundant spinel material is also consistent in repeated redox cycles,enabling their potential in industrial use. | Yu Qiu Li Ma Dewang Zeng Min Li Dongxu Cui Yulin Lv Shuai Zhang Rui Xiao | 2020 | Journal of Energy Chemistry2020，29，7： | 2 |
| 7 | Graphene-nickel nitride hybrids supporting palladium nanoparticles for enhanced ethanol electrooxidation显示文摘Electrocatalysts for ethanol oxidation reaction(EOR)are generally limited by their poor durability because of the catalyst poisoning induced by the reaction intermediate carbon monoxide(CO).Therefore,the rapid oxidation removal of CO intermediates is crucial to the durability of EOR-based catalysts.Herein,in order to effectively avoiding the catalyst CO poisoning and improve the durability,the graphene-nickel nitride hybrids(AG-Ni_(3)N)were designed for supporting palladium nanoparticles(Pd/AG-Ni_(3)N)and then used for ethanol electrooxidation.The density functional theory(DFT)calculations demonstrated the introduction of AG-Ni_(3)N depresses the CO absorption and simultaneously promotes the adsorption of OH species for CO oxidation removal.The fabricated Pd/AG-Ni_(3)N catalyst distinctively exhibits excellent electroactivity with the mass catalytic activity of 3499.5 m A mg^(-1) on EOR in alkaline media,which is around 5.24 times higher than Pd/C(commercial catalyst).Notably,the Pd/AG-Ni_(3)N hybrids display excellent stability and durability after chronoamperometric measurements with a total operation time of 150,000 s. | Tong Wu Xiao Wang Ahmet Emrehan Emre Jinchen Fan Yulin Min Qunjie Xu Shigang Sun | 2021 | Journal of Energy Chemistry2021，30，4： | 2 |
| 8 | A small biomoleculeassisted synthesis of iron sulfide nanostructures and magnetic properties 显示文摘 | MIN Yulin CHEN Youcun ZHAO Yingguo | 2009 | Solid State Sci2009，11，： | 1 |
| 9 | Metastasis‐associated in colon cancer‐1 upregulation predicts a poor prognosis of gastric cancer, and promotes tumor cell proliferation and invasion显示文摘 | Lin Wang Yajun Wu Li Lin Pengmin Liu Hui Huang Wenjun Liao Dayong Zheng Qiang Zuo Li Sun Na Huang Min Shi Yulin Liao Wangjun Liao | 2013 | Cancer2013，，6： | 1 |
| 10 | 显示文摘 | Min Yulin Zhang Kan Chen Youcun | 2012 | Ultrasonics Sonochemistry2012，19，4： | 1 |
| 11 | Ionic liquid assisting synthesis of ZnO/graphene heterostructure photocatalysts withtunable photoresponse properties显示文摘 | Min Yulin Zhang Kan Chen Lihua | 2012 | Diamond & Related Materials2012，26，： | 1 |
| 12 | 显示文摘 | Wang S B Min Yulin Yu S H | 2007 | J Phys Chem C2007，111，： | 1 |
| 13 | Identification of genes related to heart failure using global gene expression profiling of human failing myocardium显示文摘 | Kyung-Duk Min Masanori Asakura Yulin Liao Kenji Nakamaru Hidetoshi Okazaki Tomoko Takahashi Kazunori Fujimoto Shin Ito Ayako Takahashi Hiroshi Asanuma Satoru Yamazaki Tetsuo Minamino Shoji Sanada Osamu Seguchi Atsushi Nakano Yosuke Ando Toshiaki Otsuka Hi | 2010 | Biochemical and Biophysical Research Communications2010，，1： | 1 |
| 14 | Synthesis of nanostructured ZnO/Bi2WO6 heterojunction for photocatalysis application显示文摘 | Min Yulin Zhang Kan Chen Youcun | 2012 | Sep Purif Technol2012，92，1： | 1 |
| 15 | Comparison of four clinical scores for the predicting lower limb deep venous thrombosis in Chinese patients显示文摘Objective:To evaluate Wells,Kahn,St.Andréand Constans scores for the prediction of deep venous thrombosis in Chinese patients. Methods:One hundred and seventy-two patients,prospectively,blinded referred for evaluation with four clinical-score systems for suspected deep venous thrombosis,were examined by ultrasonography. Sensitivity,specificity,positive predictive value,nega-tive predictive value and receiver operation curves were calculated for four clinical scores. The difference between areas of the ROC curve for each of the scores was compared with others and reference line. Results:Forty-six of 172 patients had deep venous throm-bosis proven by sonography. The sensitivity,specificity,positive predictive value and negative predictive value for Wells score was 91.3%,57.1%,43.8% and 94.7%,respectively,for Kahn score; 65.2%,71.4%,45.5% and 84.9%,respectively,for St.Andréscore; 63%,38.9%,27.4% and 74.2% respectively,for Constans score; 95.7%,34.9%,34.9% and 95.7% respectively. Area under ROV curve of Constans score was 0.814,which was similar to that of Wells score,then followed by Kahn score and that of St.Andréscore was no difference with the reference line. Conclusion:Based on the results of our study,the sensitivity,negative prediction value and area under ROC curve are larger for Constans score and Wells score in Chinese hospitalized patients than that of Kahn score or St.Andréscore. Considering the aim of the clinical assessment,Constans score and Wells score are more efficient for Chinese hospitalized patients. | Li Zhu Min Liu Xiaojuan Guo Jianguo Wang Youmin Guo Chen Wang Hongxia Ma Yulin Guo | 2008 | Journal of Nanjing Medical University2008，22，4： | 1 |
| 16 | Enhanced chemical interaction between TiO 2 and graphene oxide for photocatalytic decolorization of methylene blue显示文摘 | YuLin Min Kan Zhang Wei Zhao FangCai Zheng YouCun Chen YuanGuang Zhang | 2012 | Chemical Engineering Journal2012，，： | 1 |
| 17 | Safety evaluation of highway based on the traffic conflict technique显示文摘 | ZHOU Junchang CHANG Yulin GUO Min | 2011 | Journal of Chongqing Jiaotong University(Natural Science)2011，30，5： | 1 |
| 18 | Evolution of tumor microenvironment in colorectal liver metastases under treatment stress显示文摘Dear editor,The tumor microenvironment(TME)heavily impacts disease biology and may influence responses to systemic treatments,and thereby,affects patients’prognosis.In our previous study,we found that immune features could predict prognosis and guide the therapy choices for stage I-III colon cancer[1,2].Increasing evidence shows that therapyinduced TME changes can promote tumor progression,metastasis,and the development of resistance[3,4].However,the TME dynamics in colorectal liver metastases(CRLM)under treatment are still incompletely clear. | Na Huang Dongqiang Zeng Xiaoxiang Rong Chunlin Wang Zhenzhen Wu Jian Guo Yuqi Wang Jin Li Jing Li Jiao Wang Siting Zheng Genjie Huang Jianping Bin Yulin Liao Qian Li Xin Yi Wangjun Liao Min Shi | 2022 | Cancer Communications2022，42，5： | 1 |
| 19 | An efficient precursor method to porous hematite architectures and their photocatalytic properties显示文摘 | YuLin Min FangCai Zheng YingGuo Zhao YouCun Chen | 2011 | Solid State Sciences2011，，5： | 1 |
| 20 | Rational design of a hollow porous structure for enhancing diffusion kinetics of K ions in edge-nitrogen doped carbon nanorods显示文摘The high electrical conductivity makes it possible for one-dimensional(1D)carbon materials to be used as the promising anodes for potassium ion batteries(PIBs),however,the sluggish diffusion kinetics caused by large-sized potassium ions(K^(+))limits their practical applications in energy storage systems.In this work,hollow carbon nanorods were rationally designed as a case to verify the superiority of 1D hollow structure to improve the diffusion kinetics of K^(+).Simultaneously,edge-N(pyridinic-N and pyrrolic-N)atoms were also introduced into 1D hollow carbon structure,which can provide ample active sites and defects in graphitic lattices to adsorb K^(+),providing extra capacitive storage capacity.As expected,the optimized edge-N doped hollow carbon nanorods(ENHCRs)exhibits a high reversible capacity of 544 mAh·g^(−1)at 0.1 A·g^(−1)after 200 cycles.Even at 5 A·g^(−1),it displays a long-term cycling stability with 255 mAh·g^(−1)over 10,000 cycles.The electrochemical measurements confirm that the hollow structure is favorable to improve the transfer kinetics of K^(+)during cycling.And the theoretical calculations demonstrate that edge-N doping can enhance the local electronegativity of graphitic lattices to adsorb much more K^(+),where edge-N doping synergizes with 1D hollow structure to achieve enhanced K^(+)-storage performances. | Ping Niu Yang Yang Zhiqiang Li Gaohui Ding Lingzhi Wei Ge Yao Helin Niu Yulin Min Fangcai Zheng Qianwang Chen | 2022 | Nano Research2022，15，9： | 1 |
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