|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Prognostic significance of tumor immune microenvironment and immunotherapy:Novel insights and future perspectives in gastric cancer显示文摘Despite a decrease in gastric cancer incidence, the development of novel biologic agents and combined therapeutic strategies, the prognosis of gastric cancer remains poor. Recently, the introduction of modern immunotherapy, especially using immune checkpoint inhibitors, led to an improved prognosis in many cancers. The use of immunotherapy was also associated with manageable adverse event profiles and promising results in the treatment of patients with gastric cancer, especially in heavily pretreated patients. These data have led to an accelerated approval of some checkpoint inhibitors in this setting. Understanding the complex relationship between the host immune microenvironment and tumor and the immune escape phenomenon leading to cancer occurrence and progression will subsequently lead to the identification of prognostic immune markers. Furthermore, this understanding will result in the discovery of both new mechanisms for blocking tumor immunosuppressive signals and pathways to stimulate the local immune response by targeting and modulating different subsets of immune cells. Due to the molecular heterogeneity of gastric cancers associated with differentclinico-biologic parameters, immune markers expression and prognosis, novel immunotherapy algorithms should be personalized and addressed to selected subsets of gastric tumors, which have been proven to elicit the best clinical responses. Future perspectives in the treatment of gastric cancer include tailored dual immunotherapies or a combination of immunotherapy with other targeted agents with synergistic antitumor effects. | Daniela Cornelia Lazǎr Mihaela Flavia Avram Ioan Romosan Mǎrioara Cornianu Sorina Tǎan Adrian Goldis | 2018 | World Journal of Gastroenterology2018，24，32： | 24 |
| 2 | Thermal stability of new vanadyl complexes with flavonoid derivatives as potential insulin-mimetic agents显示文摘 | MIHAELA B RODICA O DANA M | 2010 | J Therm Anal Calorim2010，99，3： | 1 |
| 3 | Optimization of a liquid-liquid extraction method for HPLC-DAD determination of penicillinV in human plasma 显示文摘 | Andrei M Mihaela I Constantin M | 2002 | Microchemical Journal2002，72，： | 1 |
| 4 | Impmvecl sensor network lifetime with multiple mobile sinks 显示文摘 | MIRELA M MIHAELA C | 2009 | Pervasive and Mobile Computing2009，5，5： | 1 |
| 5 | Recent pro- gress in the understanding of the structure-fuetion re- lationships o{ the globular head regions of Clq 显示文摘 | Kishore U Mihaela S K Kenneth B M R | 2002 | Immunobiol2002，205，45： | 1 |
| 6 | Trichothecenes induce accumulation of glucosylceramide in neural cells by interfering with lactosylceramide synthase activity显示文摘 | Ana K Mihaela G Gabriele M K | 2007 | Toxieol Appl Pharmacol2007，225，： | 1 |
| 7 | Inflammation in COPD: pathogenesis, local and systemic effects 显示文摘 | Cornelia B Mihaela I Man M | 2011 | Rom J Mor- phol Embryol2011，52，： | 1 |
| 8 | Investigation of organic solvent resistance mechanisms in Vibrio alginolyticus IBBCt2显示文摘 | MIHAELA M S | 2012 | Water Air and Soil Pollution2012，223，7： | 1 |
| 9 | A power quality index based on equipment sensitivity,cost,and network vulnerability显示文摘 | Geun Joon Lee Mihaela M Albu Gerald Thomas Heydt | 2004 | IEEE Transactions on Power Delivery2004，19，3： | 1 |
| 10 | Failure to Protect the Myocardium Against lschemia/Reperfusion Injury After Chronic Atorvastatin Treatment Is Recaptured by Acute Atorvastatin Treat- ment显示文摘 | Kwabena Mensah Mihaela M Derek M | 2005 | Journal of the American College of Cardiology2005，45，8： | 1 |
| 11 | Selective Voltammetric Detection of Dopamine in the Presence of Ascorbate显示文摘 | Mihaela G Damien W M A | 2004 | 21(6):7322004，21，6： | 1 |
| 12 | Design and experimental testing of a control system for a morphing wing model actuated with miniature BLDC motors显示文摘The paper deals with the design and experimental validation of the actuation mechanism control system for a morphing wing model.The experimental morphable wing model manufactured in this project is a full-size scale wing tip for a real aircraft equipped with an aileron.The morphing actuation of the model is based on a mechanism with four similar in house designed and manufactured actuators,positioned inside the wing on two parallel lines.Each of the four actuators used a BrushLess Direct Current(BLDC)electric motor integrated with a mechanical part performing the conversion of the angular displacements into linear displacements.The following have been chosen as successive steps in the design of the actuator control system:(A)Mathematical and software modelling of the actuator;(B)Design of the control system architecture and tuning using Internal Model Control(IMC)methodology;(C)Numerical simulation of the controlled actuator and its testing on bench and wind tunnel.The morphing wing experimental model is tested both at the laboratory level,with no airflow,to evaluate the components integration and the whole system functioning,but also in the wind tunnel,in the presence of airflow,to evaluate its behavior and the aerodynamic gain. | Teodor Lucian GRIGORIE Shehryar KHAN Ruxandra Mihaela BOTEZ Mahmoud MAMOU Youssef MéBARKI | 2020 | Chinese Journal of Aeronautics2020，33，4： | 1 |
| 13 | Modified SBA-15 mesoporous silica for heavy metal ions remediation显示文摘 | Mihaela M Aurora R Ioan S | 2008 | Chemosphere2008，73，9： | 1 |
| 14 | Modified SBA - 15 mesoporous silica for heavy metal ions remediation显示文摘 | MIHAELA M AURORA R IOAN S | 2008 | Chemosphere2008，73，9： | 1 |
| 15 | Incidence, management, and outcome of coronary artery perforation during percutaneous coronary intervention显示文摘 | Luis Gruberg Ellen Pinnow Roy Flood Yvonne Bonnet Mihaela Tebeica Ron Waksman Lowell F Satler Augusto D Pichard Kenneth M Kent Martin B Leon Joseph Lindsay | 2000 | The American Journal of Cardiology2000，，6： | 1 |
| 16 | Yellon postconditioning: aform of 'modified reperfusion' protects the myocardium by activating the phosphatidylinositol3 - kinase- akt pathway 显示文摘 | Tsang A Derek JH Mihaela M | 2004 | circulation Research2004，95，3： | 1 |
| 17 | The Kaldor-Kalecki stochastic model of business eyele显示文摘 | Gabriela M Mihaela N Dumitru O | 2011 | Nonlinear Analysis: Modelling and Control2011，16，： | 1 |
| 18 | A power quality index based on equipment sensitivity,cost and network vulnerability显示文摘 | Lee G J Mihaela M A Gerald T H | 2004 | IEEE Trans on Power Delivery2004，19，3： | 1 |
| 19 | Energy EfficientTarget Coverage in Wireless Sensor Networks 显示文摘 | Mihaela Cardei Thai M T Yingshu Li | 2005 | IEEE INFO-COM2005，，： | 1 |
| 20 | Pulmonary endothelial cell activation during experimental acute kidney injury显示文摘 | Carolyn M Heitham T Mihaela L | | 0，，02： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员