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| 1 | Preemptive mechanical ventilation can block progressive acute lung injury显示文摘Mortality from acute respiratory distress syndrome(ARDS) remains unacceptable, approaching 45% in certain high-risk patient populations. Treating fulminant ARDS is currently relegated to supportive care measures only. Thus, the best treatment for ARDS may lie with preventing this syndrome from ever occurring. Clinical studies were examined to determine why ARDS has remained resistant to treatment over the past several decades. In addition, both basic science and clinical studies were examined to determine the impact that early, protective mechanical ventilation may have on preventing the development of ARDS in at-risk patients. Fulminant ARDS is highly resistant to both pharmacologic treatment and methods of mechanical ventilation. However, ARDS is a progressive disease with an early treatment window that can be exploited. In particular, protective mechanical ventilation initiated before the onset of lung injury can prevent the progression to ARDS. Airway pressure release ventilation(APRV) is a novel mechanical ventilation strategy for delivering a protective breath that has been shown to block progressive acute lung injury(ALI) and prevent ALI from progressing to ARDS. ARDS mortality currently remains as high as 45% in some studies. As ARDS is a progressive disease, the key to treatment lies with preventing the disease from ever occurring while it remains subclinical. Early protective mechanical ventilation with APRV appears to offer substantial benefit in this regard and may be the prophylactic treatment of choice for preventing ARDS. | Benjamin Sadowitz Sumeet Jain Michaela Kollisch-Singule Joshua Satalin Penny Andrews Nader Habashi Louis A Gatto Gary Nieman | 2016 | World Journal of Critical Care Medicine2016，5，1： | 9 |
| 2 | Superior Properties of Mg–4Y–3RE–Zr Alloy Prepared by Powder Metallurgy显示文摘Magnesium alloys are important materials for application in the automotive and aviation industries. During the last few years, the number of possible applications as biodegradable implants in medicine has grown. Mg–RE(rare earth) alloys belong to the most advanced group of products, offering the best combination of mechanical properties and corrosion resistance. Among these materials, WE43(Mg–Y–Nd)is a very well-known commercial alloy that has been extensively studied for applications at increased temperatures and also in organisms. Although this material has been described, there are still possibilities to improve its properties and subsequently expand its applicability. Powder metallurgy has already been used for the preparation of magnesium alloys with superior mechanical properties and occasionally superior corrosion properties. Therefore, the present paper is oriented toward the preparation of Mg–4Y–3RE–Zr(WE43) alloy by the powder metallurgy technique(WE43-PM) and comparison of the final properties with the product of extrusion of as-cast ingot(WE43-IM). Our processing leads to a partial improvement in the mechanical properties and superior corrosion resistance of WE43-PM. The texture strength of WE43-PM was low, and therefore, anisotropy of mechanical properties was suppressed. | Jirí Kubásek Drahomír Dvorsky Miroslav Cavojsky Dalibor Vojtěch Nad'a Beronská Michaela Fousová | 2017 | Journal of Materials Science & Technology2017，33，7： | 4 |
| 3 | Tenascin C upregulates interleukin-6 expression in human cardiac myofibroblasts via toll-like receptor 4显示文摘AIM:To investigate the effect of Tenascin C(TNC)on the expression of pro-inflammatory cytokines and matrixmetalloproteinases in human cardiac myofibroblasts(CMF).METHODS:CMF were isolated and cultured from patients undergoing coronary artery bypass grafting.Cultured cells were treated with either TNC(0.1μmol/L,24 h)or a recombinant protein corresponding to different domains of the TNC protein;fibrinogen-like globe(FBG)and fibronectin typeⅢ-like repeats(TNⅢ5-7)(both 1μmol/L,24 h).The expression of the proinflammatory cytokines;interleukin(IL)-6,IL-1β,TNFαand the matrix metalloproteinases;MMPs(MMP1,2,3,9,10,MT1-MMP)was assessed using real time RT-PCR and western blot analysis.RESULTS:TNC increased both IL-6 and MMP3(P<0.01)mR NA levels in cultured human CMF but had no significant effect on the other markers studied.The increase in IL-6 mR NA expression was mirrored by an increase in protein secretion as assessed by enzymelinked immunosorbant assay(P<0.01).Treating CMF with the recombinant protein FBG increased IL-6mR NA and protein(P<0.01)whereas the recombinant protein TNⅢ5-7 had no effect.Neither FBG nor TNⅢ5-7 had any significant effect on MMP3 expression.The expression of toll-like receptor 4(TLR4)in human CMF was confirmed by real time RT-PCR,western blot and immunohistochemistry.Pre-incubation of cells with TLR4neutralising antisera attenuated the effect of both TNC and FBG on IL-6 mR NA and protein expression.CONCLUSION:TNC up-regulates IL-6 expression in human CMF,an effect mediated through the FBG domain of TNC and via the TLR4 receptor. | Azhar Maqbool Emma J Spary Iain W Manfield Michaela Ruhmann Lorena Zuliani-Alvarez Filomena O Gamboa-Esteves Karen E Porter Mark J Drinkhill Kim S Midwood Neil A Turner | 2016 | World Journal of Cardiology2016，8，5： | 4 |
| 4 | Unstable sternoclavicular joint : Indications for reconstruction 显示文摘 | Steven P MichaelA Charles A | 2002 | Tech Shoulder Elbow Surg2002，3，： | 1 |
| 5 | Identification of cyclic AMP- Regulated genes in Mycobactefium tuberculosis complex bacteria under Low- Oxygen conditions 显示文摘 | Michaela A Gazdik A Kathleen A | 2005 | Journal of Bacteriology2005，187，8： | 1 |
| 6 | In vitro models of inhala- tion toxicity and disease显示文摘 | Kelly B Michaela A Damien B | 2009 | ATLA2009，37，1： | 1 |
| 7 | Elimination of endemic measles transmission in Australia 显示文摘 | Anita E Heywood Heather F Gidding Michaela A Riddell | 2009 | Bull WHO2009，87，1： | 1 |
| 8 | How can SEMs effectively implement the CSR agenda? a UK case study perspective 显示文摘 | Pavel C Michaela A B Christopher J B | 2004 | Corporate Social Responsibility and Environmental Management2004，11，3： | 1 |
| 9 | Isolation of a cDNA form the virus responsible for entericallytransmitted non-A,non-B hepatitis 显示文摘 | Gregory R R Michaela A P Jungsuhp K | 1990 | Science1990，16，： | 1 |
| 10 | Combined exposure to hydrogen peroxide and lights selectiveeffects on Cyanobacteria, green algae ,and diatoms显示文摘 | Michaela D A Wim A Blahoslav M | 2007 | Environ Sci Technol2007，41，1： | 1 |
| 11 | A new approach to determine method detection limits for compound-specific isotope analysis of volatile organic compounds显示文摘 | Jochmann A Blessing Michaela Haderlein Stefan B | 2006 | Rapid Commun Mass Spectrom2006，20，24： | 1 |
| 12 | Long-term results after video-assisted thoracoscopic surgery for first-time and recurrent spontaneous pneumothorax显示文摘 | Rudolf A Hatz Michaela F Kaps Georgios Meimarakis Florian Loehe Christian Müller Heinrich Fürst | 2000 | The Annals of Thoracic Surgery2000，，1： | 1 |
| 13 | Reduced expression of the inducible nitric oxide synthase after infection with Toxoplasma gondii facilitates parasite replication in activated murine macrophages显示文摘 | CARSTEN G K MICHAELA A CHRISTINE L | 2003 | International Journal for Parasitology2003，33，： | 1 |
| 14 | Isolation of a eDNA from the virus responsible for enterically transmitted non-A, non-B hepatitis 显示文摘 | GREGORY R R MICHAELA A P JUNGSUHP K | 1990 | Science1990，16，： | 1 |
| 15 | Analysis of Benzopyrene metabolites Formed by Rat Hepatic Microsomes using High Pressure Liquid Chromatography :Optimization of the Method显示文摘 | Michaela M V e ra K Dagmar A | 2009 | Interdisc Toxicol2009，2，4： | 1 |
| 16 | Stressful 'Memories'of plants: Evidence and possible mecha- nisms显示文摘 | BRUCE J A MICHAELA C M JOHNATHAN A N | 2007 | Plant Science2007，173，： | 1 |
| 17 | Stressful 'memories' of plants: Evidence and possible mechanisms 显示文摘 | Bruce J A Michaela C M Johnathan A N | 2007 | Plant Sci- ence2007，173，： | 1 |
| 18 | ERK-dependent and-inde-pendent pathways trigger human neural progenitor cell migration显示文摘 | Michaela M Jason EC Josef A | 2007 | Toxicol Appl Pharmacol2007，221，1： | 1 |
| 19 | Silica coating on colloidal maghemite particles显示文摘 | Michaela K Andre A Christian G | 1999 | Journal of Colloid and Interface Science1999，220，： | 1 |
| 20 | Reduced expression of the inducible nitric oxide synthase after infection with Toxoplasma gondii facilitates parasite replication in activated routine macrophages显示文摘 | Carsten G K Michaela A Christine L | 2003 | International Journal for Parasitology2003，33，： | 1 |
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