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| 1 | Association between endotoxemia and histological features of nonalcoholic fatty liver disease显示文摘AIM To assess whether surrogate biomarkers of endotoxemia were correlated with the histological features ofnonalcoholic fatty liver disease(NAFLD).METHODS One hundred twenty-six NAFLD patients who had undergone percutaneous liver biopsy were enrolled. Serum lipopolysaccharide(LPS)-binding protein(LBP) and anti-endotoxin core immunoglobulin G(Endo Cab Ig G) antibody concentrations at the time of liver biopsy were measured using the enzyme-linked immunosorbent assays to examine for relationships between biomarker levels and histological scores. RESULTS Serum LBP concentration was significantly increased in nonalcoholic steatohepatitis(NASH) patients as compared with nonalcoholic fatty liver(NAFL) subjects and was correlated with steatosis(r = 0.38, P < 0.0001) and ballooning scores(r = 0.23, P = 0.01), but not with the severity of lobular inflammation or fibrosis. Multivariate linear regression analysis revealed that LBP was associated with steatosis score and circulating C-reactive protein, aspartate aminotransferase, and fibrinogen levels. Serum Endo Cab Ig G concentration was comparable between NASH and NAFL patients. No meaningful correlations were detected between Endo Cab Ig G and histological findings. CONCLUSION LBP/Endo Cab Ig G were not correlated with lobular inflammation or fibrosis. More accurate LPS biomarkers are required to stringently assess the contribution of endotoxemia to conventional NASH. | Hiroyuki Kitabatake Naoki Tanaka Naoyuki Fujimori Michiharu Komatsu Ayaka Okubo Kyogo Kakegawa Takefumi Kimura Ayumi Sugiura Tomoo Yamazaki Soichiro Shibata Yuki Ichikawa Satoru Joshita Takeji Umemura Akihiro Matsumoto Masayoshi Koinuma Kenji Sano Toshifumi Aoyama Eiji Tanaka | 2017 | World Journal of Gastroenterology2017，23，4： | 5 |
| 2 | Phase II study of S-1, docetaxel and cisplatin combination chemotherapy in patients with unresectable metastatic gastric cancer显示文摘 | Yasushi Sato Tetsuji Takayama Tamotsu Sagawa Yasuo Takahashi Hiroyuki Ohnuma Syunichi Okubo Naoaki Shintani Shingo Tanaka Masaya Kida Yasuhiro Sato Hidetoshi Ohta Koji Miyanishi Tsutomu Sato Rishu Takimoto Masayoshi Kobune Koji Yamaguchi Koichi Hirata Yos | 2010 | Cancer Chemotherapy and Pharmacology2010，，4： | 2 |
| 3 | Influence of hydrophilic–lipophilic balance of nonionic emulsifiers on emulsion copolymerization of styrene and methacrylic acid显示文摘 | Masayoshi Okubo Amorn Chaiyasat Masahiro Yamada Toyoko Suzuki Hiroshi Kobayashi | 2007 | Colloid and Polymer Science2007，，15： | 1 |
| 4 | Incorporation of nonionic emulsifier inside methacrylic polymer particles in emulsion polymerization显示文摘 | Amorn Chaiyasat Hiroshi Kobayashi Masayoshi Okubo | 2007 | Colloid and Polymer Science2007，，5： | 1 |
| 5 | Estimation of distribution state of carboxyl groups within submicron-sized, carboxylated polymer particle with isothermal titration calorimeter显示文摘 | Masayoshi Okubo Toyoko Suzuki Naoki Tsuda | 2006 | Colloid and Polymer Science2006，，11： | 1 |
| 6 | Influence of nonionic emulsifier included inside carboxylated polymer particles on the formation of multihollow structure by the alkali/cooling method显示文摘 | Masahiro Okada Takumi Matoba Masayoshi Okubo | 2003 | Colloid and Polymer Science2003，，2： | 1 |
| 7 | Heterogeneity among multihollow polymer particles prepared by the alkali/cooling method under partial neutralization conditions显示文摘 | Masayoshi Okubo Masahiro Okada Kenjin Shiba | 2002 | Colloid and Polymer Science2002，，9： | 1 |
| 8 | Effeet of hydrophilicity of polymerparticles on their glass transition temperatures in the emulsion state 显示文摘 | MASAYOSHI OKUBO MAYUKO INOUE TOYOKO SUZUKI | 2004 | Colloid Polym Sci2004，，282： | 1 |
| 9 | Preparation of block copolymer particles by two-stepatom transfer radical polymerization in aqueous media andits unique morphology显示文摘 | Yasuyuki Kagawa Hideto Minami Masayoshi Okubo etal | 2005 | Polymer2005，46，4： | 1 |
| 10 | Phase II study of S-1, docetaxel and cisplatin combination chemotherapy in patients with unresectable metastatic gastric cancer显示文摘 | Yasushi Sato Tetsuji Takayama Tamotsu Sagawa Yasuo Takahashi Hiroyuki Ohnuma Syunichi Okubo Naoaki Shintani Shingo Tanaka Masaya Kida Yasuhiro Sato Hidetoshi Ohta Koji Miyanishi Tsutomu Sato Rishu Takimoto Masayoshi Kobune Koji Yamaguchi Koichi Hirata Yos | 2010 | Cancer Chemotherapy and Pharmacology2010，，4： | 1 |
| 11 | Preparation of block copolymer particles by two-step atom transfer radical polymerization in aqueous media and its unique morphology显示文摘 | Yasuyuki Kagawa Hideto Minami Masayoshi Okubo Jian Zhou | 2004 | Polymer2004，，4： | 1 |
| 12 | Mechanical properties of cross-linked polymer particles prepared by nitroxide- mediated radical polymerization in aqueous micro-suspension 显示文摘 | Takuya Tanaka Toyoko Suzuki Yuichi Saka Per B Zetterlund Masayoshi Okubo | 2007 | Polymer2007，48，： | 1 |
| 13 | Preparation of Carboxylated Polymer Emulsion Particles in Which Carboxyl Groups Are Predominantly Localized at Surface Layer by Using the Seeded Emulsion Polymerization Technique显示文摘 | Masayoshi Okubo Kenta Kanaida Tsunetaka Matsumoto | 1987 | J of Appl Polym Sci1987，33，： | 1 |
| 14 | Production of polyacrylonitrile particles by precipitation polymerization in supercritical carbon dioxide显示文摘 | Masayoshi Okubo Syuji Fujii Hiroshi Maenaka Hideto Minami | 2003 | Colloid and Polymer Science2003，，10： | 1 |
| 15 | Phase II study of S-1, docetaxel and cisplatin combination chemotherapy in patients with unresectable metastatic gastric cancer显示文摘 | Yasushi Sato Tetsuji Takayama Tamotsu Sagawa Yasuo Takahashi Hiroyuki Ohnuma Syunichi Okubo Naoaki Shintani Shingo Tanaka Masaya Kida Yasuhiro Sato Hidetoshi Ohta Koji Miyanishi Tsutomu Sato Rishu Takimoto Masayoshi Kobune Koji Yamaguchi Koichi Hirata Yos | 2010 | Cancer Chemotherapy and Pharmacology2010，，4： | 1 |
| 16 | Single Stage Plasma-Chemical Process for Particulates,NOx,and SOx Simultaneous Removal显示文摘 | Tomoyuki Kuroki Masayoshi Takahashi Masaaki Okubo | 2002 | IEEE Transactions On Industry Applications2002，38，5： | 1 |
| 17 | Morphology of polystyrene/polystyrene- block -poly(methyl methacrylate)/poly(methyl methacrylate) composite particles显示文摘 | Masayoshi Okubo Naohiko Saito Ryu Takekoh Hiroshi Kobayashi | 2004 | Polymer2004，，4： | 1 |
| 18 | Production of micron-sized, monodisperse polystyrene/poly ( n-butyl methacrylate ) composite particles having hamburger-like morphology by seeded polymerization 显示文摘 | Masayoshi Okubo Hiroshi Yonchara Toru Kurino | 2004 | Progr Colloid Polym Sci2004，124，： | 1 |
| 19 | Effects of Stirring Prior to Starting Emulsion Polymerization of Styrene with Nonionic Emulsifier on Particle Formation and Its Incorporation显示文摘 | Matsusaka Nami Suzuki Toyoko Okubo Masayoshi | 2012 | Colloid Polym Sci2012，290，6： | 1 |
| 20 | Preparation of nanostructured platinum/yttria- stabilized zirconia cermet by the Sol -Gel method 显示文摘 | Hidemoto Shiga Tatsuya Okubo Masayoshi Sadakata | 1996 | Ind Eng Chem Res1996，35，： | 1 |
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